ZA200903175B - Spiro-piperidine derivatives - Google Patents
Spiro-piperidine derivativesInfo
- Publication number
- ZA200903175B ZA200903175B ZA200903175A ZA200903175A ZA200903175B ZA 200903175 B ZA200903175 B ZA 200903175B ZA 200903175 A ZA200903175 A ZA 200903175A ZA 200903175 A ZA200903175 A ZA 200903175A ZA 200903175 B ZA200903175 B ZA 200903175B
- Authority
- ZA
- South Africa
- Prior art keywords
- spiro
- piperidine derivatives
- piperidine
- derivatives
- Prior art date
Links
- JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical class C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125645 | 2006-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200903175B true ZA200903175B (en) | 2010-03-31 |
Family
ID=39201604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200903175A ZA200903175B (en) | 2006-12-07 | 2009-05-07 | Spiro-piperidine derivatives |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8022213B2 (xx) |
| EP (1) | EP2099799B1 (xx) |
| JP (1) | JP2010511654A (xx) |
| KR (1) | KR101111022B1 (xx) |
| CN (1) | CN101541797A (xx) |
| AR (1) | AR064136A1 (xx) |
| AT (1) | ATE469899T1 (xx) |
| AU (1) | AU2007329066B2 (xx) |
| BR (1) | BRPI0720246A2 (xx) |
| CA (1) | CA2670671A1 (xx) |
| CL (1) | CL2007003483A1 (xx) |
| DE (1) | DE602007006989D1 (xx) |
| ES (1) | ES2343286T3 (xx) |
| IL (1) | IL198549A0 (xx) |
| MX (1) | MX2009005507A (xx) |
| NO (1) | NO20091766L (xx) |
| PE (1) | PE20081489A1 (xx) |
| RU (1) | RU2009119393A (xx) |
| TW (1) | TW200843758A (xx) |
| WO (1) | WO2008068159A1 (xx) |
| ZA (1) | ZA200903175B (xx) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1931680B1 (en) * | 2005-09-28 | 2010-11-17 | F. Hoffmann-La Roche AG | Indol-3-yl-carbonyl-azaspiro derivatives as vasopressin receptor antagonists |
| JP5399518B2 (ja) * | 2009-01-30 | 2014-01-29 | エフ．ホフマン−ラ ロシュ アーゲー | Ｎｋ３レセプターアンタゴニストとしてのピペリジン誘導体 |
| US8324250B2 (en) * | 2009-03-19 | 2012-12-04 | Hoffmann-La Roche Inc. | Piperidine derivatives as NK3 receptor antagonists |
| PL3083633T3 (pl) * | 2013-12-19 | 2018-04-30 | F.Hoffmann-La Roche Ag | Spirooksazolony |
| KR102765806B1 (ko) * | 2017-09-05 | 2025-02-10 | 블랙손 테라퓨틱스, 인크. | 바소프레신 수용체 길항제 및 그와 관련된 제품 및 방법 |
| WO2020048830A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| WO2020048826A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds |
| AR116020A1 (es) | 2018-09-03 | 2021-03-25 | Bayer Ag | COMPUESTOS DE 3,9-DIAZAESPIRO[5.5]UNDECANO COMO INHIBIDORES DE GGTasa I Y SU USO PARA EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS |
| WO2020048831A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5150201A1 (es) | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
| CZ301464B6 (cs) | 2000-05-12 | 2010-03-10 | Solvay Pharmaceuticals B. V. | Piperazinové a piperidinové slouceniny, zpusob jejich prípravy a farmaceutické prostredky, které je obsahují |
| EP1551811A1 (en) | 2002-10-17 | 2005-07-13 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
| WO2005063754A1 (en) * | 2003-12-22 | 2005-07-14 | Pfizer Limited | Triazole derivatives as vasopressin antagonists |
| US7351706B2 (en) * | 2006-01-05 | 2008-04-01 | Hoffmann-La Roche Inc. | Indol-3-yl-carbonyl-spiro-piperidine derivatives |
-
2007
- 2007-11-27 JP JP2009539698A patent/JP2010511654A/ja not_active Ceased
- 2007-11-27 WO PCT/EP2007/062857 patent/WO2008068159A1/en not_active Ceased
- 2007-11-27 RU RU2009119393/04A patent/RU2009119393A/ru not_active Application Discontinuation
- 2007-11-27 ES ES07847384T patent/ES2343286T3/es active Active
- 2007-11-27 MX MX2009005507A patent/MX2009005507A/es active IP Right Grant
- 2007-11-27 CA CA002670671A patent/CA2670671A1/en not_active Abandoned
- 2007-11-27 EP EP07847384A patent/EP2099799B1/en not_active Not-in-force
- 2007-11-27 DE DE602007006989T patent/DE602007006989D1/de active Active
- 2007-11-27 AT AT07847384T patent/ATE469899T1/de active
- 2007-11-27 KR KR1020097011663A patent/KR101111022B1/ko not_active Expired - Fee Related
- 2007-11-27 BR BRPI0720246-6A patent/BRPI0720246A2/pt not_active IP Right Cessation
- 2007-11-27 AU AU2007329066A patent/AU2007329066B2/en not_active Ceased
- 2007-11-27 CN CNA2007800432751A patent/CN101541797A/zh active Pending
- 2007-11-30 US US11/947,836 patent/US8022213B2/en not_active Expired - Fee Related
- 2007-11-30 US US11/947,822 patent/US7432259B2/en not_active Expired - Fee Related
- 2007-12-04 TW TW096146110A patent/TW200843758A/zh unknown
- 2007-12-04 CL CL200703483A patent/CL2007003483A1/es unknown
- 2007-12-05 AR ARP070105427A patent/AR064136A1/es unknown
- 2007-12-06 PE PE2007001737A patent/PE20081489A1/es not_active Application Discontinuation
-
2009
- 2009-05-04 IL IL198549A patent/IL198549A0/en unknown
- 2009-05-05 NO NO20091766A patent/NO20091766L/no not_active Application Discontinuation
- 2009-05-07 ZA ZA200903175A patent/ZA200903175B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2670671A1 (en) | 2008-06-12 |
| PE20081489A1 (es) | 2008-10-30 |
| AU2007329066B2 (en) | 2012-04-12 |
| CN101541797A (zh) | 2009-09-23 |
| WO2008068159A1 (en) | 2008-06-12 |
| BRPI0720246A2 (pt) | 2013-12-31 |
| EP2099799A1 (en) | 2009-09-16 |
| CL2007003483A1 (es) | 2008-07-04 |
| EP2099799B1 (en) | 2010-06-02 |
| KR20090080112A (ko) | 2009-07-23 |
| US8022213B2 (en) | 2011-09-20 |
| US20080161298A1 (en) | 2008-07-03 |
| DE602007006989D1 (en) | 2010-07-15 |
| JP2010511654A (ja) | 2010-04-15 |
| AU2007329066A1 (en) | 2008-06-12 |
| US20080161299A1 (en) | 2008-07-03 |
| TW200843758A (en) | 2008-11-16 |
| AR064136A1 (es) | 2009-03-18 |
| RU2009119393A (ru) | 2011-01-20 |
| NO20091766L (no) | 2009-07-06 |
| US7432259B2 (en) | 2008-10-07 |
| ES2343286T3 (es) | 2010-07-27 |
| IL198549A0 (en) | 2010-02-17 |
| ATE469899T1 (de) | 2010-06-15 |
| MX2009005507A (es) | 2009-06-03 |
| KR101111022B1 (ko) | 2012-03-14 |
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