ZA200909173B - Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase - Google Patents

Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase

Info

Publication number: ZA200909173B
Authority: ZA; South Africa
Prior art keywords: adjuvant; antigen; aqueous phase; vaccine compositions; emulsion vaccine
Prior art date: 2007-06-20

Application number

ZA200909173A

Other languages

English (en)

Inventor

David Leon Lutz

Jeffrey Harold Rodenberg

Evan James Diehl

Mahesh Kumar

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-20

Filing date

2009-12-22

Publication date

2010-08-25

2009-12-22 Application filed by Wyeth Llc filed Critical Wyeth Llc

2010-08-25 Publication of ZA200909173B publication Critical patent/ZA200909173B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16171—Demonstrated in vivo effect

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Epidemiology (AREA)
Virology (AREA)
Microbiology (AREA)
Mycology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Dispersion Chemistry (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)

ZA200909173A 2007-06-20 2009-12-22 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase ZA200909173B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US93657107P	2007-06-20	2007-06-20

Publications (1)

Publication Number	Publication Date
ZA200909173B true ZA200909173B (en)	2010-08-25

Family

ID=39720537

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200909173A ZA200909173B (en)	2007-06-20	2009-12-22	Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase

Country Status (26)

Country	Link
US (2)	US8980288B2 (xx)
EP (1)	EP2164510B1 (xx)
JP (2)	JP5457340B2 (xx)
KR (1)	KR101569218B1 (xx)
CN (2)	CN105148268A (xx)
AR (1)	AR067087A1 (xx)
AU (1)	AU2008265745B2 (xx)
BR (1)	BRPI0812856A2 (xx)
CA (1)	CA2692098C (xx)
CL (1)	CL2008001806A1 (xx)
CO (1)	CO6251273A2 (xx)
CY (1)	CY1114451T1 (xx)
DK (1)	DK2164510T3 (xx)
ES (1)	ES2429296T3 (xx)
HK (1)	HK1218717A1 (xx)
HR (1)	HRP20130939T1 (xx)
ME (1)	ME01527B (xx)
MX (1)	MX2009014070A (xx)
NZ (1)	NZ582132A (xx)
PL (1)	PL2164510T3 (xx)
PT (1)	PT2164510E (xx)
RS (1)	RS52947B (xx)
SI (1)	SI2164510T1 (xx)
TW (1)	TWI507214B (xx)
WO (1)	WO2008157659A1 (xx)
ZA (1)	ZA200909173B (xx)

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CL2008001806A1 (es) *	2007-06-20	2008-09-05	Wyeth Corp	Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
ES2728949T3 (es)	2008-06-27	2019-10-29	Zoetis Services Llc	Composiciones adyuvantes novedosas
US9603919B2 (en)	2009-03-31	2017-03-28	Japan As Represented By The Director-General Of National Institute Of Infectious Diseases	Method for prophylaxis of influenza using vaccine for intranasal administration
BR112012018640B1 (pt)	2010-01-29	2020-12-15	Donaldson Company, Inc.	Montagens de separador de água de fluxo de ar de entrada e método de separar água de um fluxo de ar de entrada
CN101829323A (zh) *	2010-04-28	2010-09-15	洛阳普莱柯生物工程有限公司	一种禽用油乳剂疫苗及其制备方法
CN103649107A (zh)	2011-04-12	2014-03-19	奥鲁非努合资股份有限公司	具有抗菌活性的肽、用于动物的预防和治疗的药物组合物、用于植物的预防和治疗的组合物、所述肽的用途以及类芽孢杆菌elgii ourofinensis提取物的用途
US10117921B2 (en)	2013-09-19	2018-11-06	Zoetis Services Llc	Oil-based adjuvants
RU2688136C1 (ru) *	2013-12-06	2019-05-20	Интервет Интернэшнл Б.В.	Композиция для пероральной доставки биоактивных агентов
AU2016206525A1 (en)	2015-01-16	2017-07-13	United States Of America, As Represented By The Secretary Of Agriculture	Foot-and-mouth disease vaccine
GB201506948D0 (en) *	2015-04-23	2015-06-10	Croda Int Plc	Emulsions for injectable formulations
CN106177939B (zh) *	2015-06-01	2021-01-19	普莱柯生物工程股份有限公司	一种疫苗用佐剂及其应用
CN106344920B (zh) *	2015-07-16	2020-11-27	普莱柯生物工程股份有限公司	一种疫苗用佐剂及其应用
CN107281482B (zh) *	2016-04-05	2021-06-11	普莱柯生物工程股份有限公司	一种免疫佐剂组合物及其制备方法
US11351249B2 (en) *	2018-03-13	2022-06-07	Capsular Technologies Pty Ltd	Vaccine compositions comprising a water-in-oil emulsion, immunogen-loaded hydrogel particles, and cationic polymer
CN110404065B (zh) *	2018-04-27	2023-06-16	洛阳赛威生物科技有限公司	一种猪用佐剂组合物及其制备方法
CA3106341A1 (en) *	2018-07-13	2020-01-16	Biomune Company	New vaccines against avian reoviruses
BR112021001420A2 (pt)	2018-07-27	2021-05-04	Research Development Foundation	polipeptídeos imunogênicos quiméricos
WO2020078958A1 (en)	2018-10-16	2020-04-23	Intervet International B.V.	Stable emulsions of bacterial antigens
CN114306585A (zh) *	2021-12-30	2022-04-12	广西壮族自治区水产科学研究院	一种鱼类高纯度抗原乳剂的制备方法
WO2025006564A1 (en)	2023-06-26	2025-01-02	Research Development Foundation	Immunoreactive peptides
WO2025018848A1 (ko) *	2023-07-19	2025-01-23	주식회사 유틸렉스	하프니아 알베이 유래 지질다당류 및 카보머를 포함하는 면역증강용 조성물
CN119656300A (zh) *	2024-12-17	2025-03-21	长江大学	一种猪繁殖与呼吸综合征灭活苗专用油佐剂及其制备方法和应用

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MXPA02011545A (es) *	2000-05-24	2003-06-06	Merial Sas	Virus del sindrome respiratorio y reproductor porcino (peesv), vacuna recombinante para el virus de la viruela.
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2008
- 2008-06-18 CL CL200801806A patent/CL2008001806A1/es unknown
- 2008-06-19 AU AU2008265745A patent/AU2008265745B2/en not_active Ceased
- 2008-06-19 RS RS20130408A patent/RS52947B/sr unknown
- 2008-06-19 MX MX2009014070A patent/MX2009014070A/es active IP Right Grant
- 2008-06-19 JP JP2010513396A patent/JP5457340B2/ja not_active Expired - Fee Related
- 2008-06-19 KR KR1020107001106A patent/KR101569218B1/ko not_active Expired - Fee Related
- 2008-06-19 HR HRP20130939AT patent/HRP20130939T1/hr unknown
- 2008-06-19 PT PT87714283T patent/PT2164510E/pt unknown
- 2008-06-19 WO PCT/US2008/067433 patent/WO2008157659A1/en not_active Ceased
- 2008-06-19 PL PL08771428T patent/PL2164510T3/pl unknown
- 2008-06-19 ES ES08771428T patent/ES2429296T3/es active Active
- 2008-06-19 CN CN201510450651.5A patent/CN105148268A/zh active Pending
- 2008-06-19 SI SI200831038T patent/SI2164510T1/sl unknown
- 2008-06-19 BR BRPI0812856-1A2A patent/BRPI0812856A2/pt not_active IP Right Cessation
- 2008-06-19 CN CN200880024112A patent/CN101790378A/zh active Pending
- 2008-06-19 US US12/142,160 patent/US8980288B2/en active Active
- 2008-06-19 NZ NZ582132A patent/NZ582132A/en not_active IP Right Cessation
- 2008-06-19 DK DK08771428.3T patent/DK2164510T3/da active
- 2008-06-19 EP EP08771428.3A patent/EP2164510B1/en active Active
- 2008-06-19 CA CA2692098A patent/CA2692098C/en not_active Expired - Fee Related
- 2008-06-19 ME MEP-2013-101A patent/ME01527B/me unknown
- 2008-06-20 TW TW097123236A patent/TWI507214B/zh not_active IP Right Cessation
- 2008-06-20 AR ARP080102641A patent/AR067087A1/es not_active Application Discontinuation
2009
- 2009-12-17 CO CO09144676A patent/CO6251273A2/es not_active Application Discontinuation
- 2009-12-22 ZA ZA200909173A patent/ZA200909173B/xx unknown
2010
- 2010-11-09 HK HK16106725.1A patent/HK1218717A1/zh unknown
2013
- 2013-10-03 CY CY20131100855T patent/CY1114451T1/el unknown
2014
- 2014-01-09 JP JP2014002096A patent/JP5802285B2/ja not_active Expired - Fee Related
2015
- 2015-02-10 US US14/618,628 patent/US9545439B2/en active Active

Also Published As

Publication number	Publication date
CA2692098A1 (en)	2008-12-24
HK1218717A1 (zh)	2017-03-10
CO6251273A2 (es)	2011-02-21
WO2008157659A1 (en)	2008-12-24
CN101790378A (zh)	2010-07-28
US20090017067A1 (en)	2009-01-15
JP2014088423A (ja)	2014-05-15
EP2164510B1 (en)	2013-07-17
JP2010530877A (ja)	2010-09-16
ES2429296T3 (es)	2013-11-14
TWI507214B (zh)	2015-11-11
EP2164510A1 (en)	2010-03-24
US8980288B2 (en)	2015-03-17
KR20100022115A (ko)	2010-02-26
BRPI0812856A2 (pt)	2014-12-09
SI2164510T1 (sl)	2013-11-29
JP5802285B2 (ja)	2015-10-28
TW200906448A (en)	2009-02-16
AR067087A1 (es)	2009-09-30
RS52947B (sr)	2014-02-28
ME01527B (me)	2014-04-20
US20150297710A1 (en)	2015-10-22
HRP20130939T1 (hr)	2013-11-22
KR101569218B1 (ko)	2015-11-13
PL2164510T3 (pl)	2014-03-31
US9545439B2 (en)	2017-01-17
CN105148268A (zh)	2015-12-16
JP5457340B2 (ja)	2014-04-02
CY1114451T1 (el)	2016-10-05
DK2164510T3 (da)	2013-09-23
MX2009014070A (es)	2010-05-19
CA2692098C (en)	2016-06-14
NZ582132A (en)	2012-04-27
PT2164510E (pt)	2013-10-07
CL2008001806A1 (es)	2008-09-05
AU2008265745A1 (en)	2008-12-24
AU2008265745B2 (en)	2013-05-30

Publication	Publication Date	Title
ZA200909173B (en)	2010-08-25	Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase
EP1988918A4 (en)	2010-04-28	ADJUVANZ AND VACCINE COMPOSITIONS
IL213795A (en)	2013-05-30	An immunogenic preparation containing at least two different saccharides and a compound containing the aforementioned immunogenic preparation
IL197512A0 (en)	2011-08-01	Vaccine comprising an oil in water emulsion adjuvant
IL211131A0 (en)	2011-04-28	Inhbb epitope and vaccines containing the same
IL193397A0 (en)	2011-08-01	Hpv antigens, vaccine compositions, and related methods
BRPI0815662A2 (pt)	2016-09-27	vacinas, antígenos, composições, e métodos profilácticos e terapêuticos para gripe
IL200859A0 (en)	2010-05-17	Oil-in-water emulsion influenza vaccine
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