BRPI0812856A2 - Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa. - Google Patents

Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa.

Info

Publication number: BRPI0812856A2
Authority: BR; Brazil
Prior art keywords: adjuvant; antigen; vaccine compositions; water stage; emulsion vaccine
Prior art date: 2007-06-20

Application number

BRPI0812856-1A2A

Other languages

English (en)

Inventor

David Leon Lutz

Jeffrey Harold Rodenberg

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-20

Filing date

2008-06-19

Publication date

2014-12-09

2008-06-19 Application filed by Wyeth Llc filed Critical Wyeth Llc

2014-12-09 Publication of BRPI0812856A2 publication Critical patent/BRPI0812856A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16171—Demonstrated in vivo effect

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Epidemiology (AREA)
Virology (AREA)
Microbiology (AREA)
Mycology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dispersion Chemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)

BRPI0812856-1A2A 2007-06-20 2008-06-19 Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa. BRPI0812856A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US93657107P	2007-06-20	2007-06-20
PCT/US2008/067433 WO2008157659A1 (en)	2007-06-20	2008-06-19	Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase

Publications (1)

Publication Number	Publication Date
BRPI0812856A2 true BRPI0812856A2 (pt)	2014-12-09

Family

ID=39720537

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0812856-1A2A BRPI0812856A2 (pt)	2007-06-20	2008-06-19	Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa.

Country Status (26)

Country	Link
US (2)	US8980288B2 (pt)
EP (1)	EP2164510B1 (pt)
JP (2)	JP5457340B2 (pt)
KR (1)	KR101569218B1 (pt)
CN (2)	CN101790378A (pt)
AR (1)	AR067087A1 (pt)
AU (1)	AU2008265745B2 (pt)
BR (1)	BRPI0812856A2 (pt)
CA (1)	CA2692098C (pt)
CL (1)	CL2008001806A1 (pt)
CO (1)	CO6251273A2 (pt)
CY (1)	CY1114451T1 (pt)
DK (1)	DK2164510T3 (pt)
ES (1)	ES2429296T3 (pt)
HK (1)	HK1218717A1 (pt)
HR (1)	HRP20130939T1 (pt)
ME (1)	ME01527B (pt)
MX (1)	MX2009014070A (pt)
NZ (1)	NZ582132A (pt)
PL (1)	PL2164510T3 (pt)
PT (1)	PT2164510E (pt)
RS (1)	RS52947B (pt)
SI (1)	SI2164510T1 (pt)
TW (1)	TWI507214B (pt)
WO (1)	WO2008157659A1 (pt)
ZA (1)	ZA200909173B (pt)

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CL2008001806A1 (es) *	2007-06-20	2008-09-05	Wyeth Corp	Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
CN104758929B (zh)	2008-06-27	2018-05-25	硕腾有限责任公司	新颖的佐剂组合物
US9603919B2 (en)	2009-03-31	2017-03-28	Japan As Represented By The Director-General Of National Institute Of Infectious Diseases	Method for prophylaxis of influenza using vaccine for intranasal administration
WO2011094334A1 (en)	2010-01-29	2011-08-04	Donaldson Company, Inc.	Water separator assembly for use with air cleaner; assembly; components; systems; and, methods
CN101829323A (zh) *	2010-04-28	2010-09-15	洛阳普莱柯生物工程有限公司	一种禽用油乳剂疫苗及其制备方法
MX2013012045A (es)	2011-04-12	2014-05-27	Uniao Brasiliense De Educacao E Cultura Ubec	Péptidos con actividad antimicrobiana, composiciones farmacéuticas para la profilaxis y el tratamiento de animales, composiciones para la profilaxis y el tratamiento de vegetales, usos de esos péptidos y usos del extracto de paenibacillus elgii ourofinensis.
KR20190009840A (ko)	2013-09-19	2019-01-29	조에티스 서비시즈 엘엘씨	유성 아쥬반트
CN105916493A (zh) *	2013-12-06	2016-08-31	高级生物营养公司	用于经口递送生物活性剂的组合物
SI3244920T1 (sl)	2015-01-16	2023-09-29	The United States of America, represented by The Secretary of Agriculture, United States Department of Agriculture	Cepivo proti slinavki in parkljevki
GB201506948D0 (en) *	2015-04-23	2015-06-10	Croda Int Plc	Emulsions for injectable formulations
CN106177939B (zh) *	2015-06-01	2021-01-19	普莱柯生物工程股份有限公司	一种疫苗用佐剂及其应用
CN106344920B (zh) *	2015-07-16	2020-11-27	普莱柯生物工程股份有限公司	一种疫苗用佐剂及其应用
CN107281482B (zh) *	2016-04-05	2021-06-11	普莱柯生物工程股份有限公司	一种免疫佐剂组合物及其制备方法
CN112243373B (zh) *	2018-03-13	2023-09-22	胶囊技术私人有限公司	疫苗组合物
CN110404065B (zh) *	2018-04-27	2023-06-16	洛阳赛威生物科技有限公司	一种猪用佐剂组合物及其制备方法
US11813321B2 (en)	2018-07-13	2023-11-14	Biomune Company	Vaccines against avian reoviruses
CA3107319A1 (en)	2018-07-27	2020-01-30	Research Development Foundation	Chimeric immunogenic polypeptides
WO2020078958A1 (en)	2018-10-16	2020-04-23	Intervet International B.V.	Stable emulsions of bacterial antigens
CN114306585A (zh) *	2021-12-30	2022-04-12	广西壮族自治区水产科学研究院	一种鱼类高纯度抗原乳剂的制备方法
WO2025006564A1 (en)	2023-06-26	2025-01-02	Research Development Foundation	Immunoreactive peptides
TW202517283A (zh) *	2023-07-19	2025-05-01	南韓商優特力克斯有限公司	包含源自蜂房哈夫尼菌的脂多糖及卡波姆的免疫增強用組合物
CN119656300A (zh) *	2024-12-17	2025-03-21	长江大学	一种猪繁殖与呼吸综合征灭活苗专用油佐剂及其制备方法和应用

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US3639577A (en) *	1968-02-23	1972-02-01	Haver Lockhart Lab Inc	Injectable adjuvant,method of preparing same and compositions including such adjuvant
NZ221306A (en) *	1986-08-15	1990-02-26	Commw Scient Ind Res Org	2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
DE3768232D1 (de) *	1986-12-19	1991-04-04	Duphar Int Res	Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension.
US5951988A (en) *	1993-03-30	1999-09-14	University Of Saskatchewan	Adjuvant formulation with enhanced immunogenic activity, and related compositions and methods
BE1008977A5 (fr) *	1994-12-27	1996-10-01	Solvay	Adjuvants pour vaccins.
US5744137A (en) *	1995-02-06	1998-04-28	The United States Of America As Represented By The Secretary Of The Agriculture	Oil emulsion vaccines prepared with animal, vegetable, and synthetic oils using a mixture of nonionic surfactants
DE69804671T2 (de) *	1997-12-16	2002-11-21	Chiron Corp N D Ges D Staates	Verwendung von mikropartikeln mit submikron öl/wasser emulsionen
FR2775601B1 (fr) *	1998-03-03	2001-09-21	Merial Sas	Vaccins vivants recombines et adjuves
FR2776928B1 (fr) *	1998-04-03	2000-06-23	Merial Sas	Vaccins adn adjuves
WO2001089559A2 (en) *	2000-05-24	2001-11-29	Merial	Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
FR2810888B1 (fr) *	2000-06-29	2004-07-30	Merial Sas	Vaccin contre la fievre aphteuse
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US7018638B2 (en) *	2000-12-19	2006-03-28	Wyeth	Mycoplasma hyopneumoniae bacterin vaccine
US6676958B2 (en) *	2001-06-19	2004-01-13	Advanced Bioadjuvants, Llc	Adjuvant composition for mucosal and injection delivered vaccines
US20030129161A1 (en) *	2001-09-17	2003-07-10	Hsien-Jue Chu	Interleukin-12 as a veterinary vaccine adjuvant
JP3812814B2 (ja) *	2001-10-19	2006-08-23	株式会社微生物化学研究所	動物用多価オイルアジュバントワクチン
US7862821B2 (en) *	2006-06-01	2011-01-04	Merial Limited	Recombinant vaccine against bluetongue virus
CL2008001806A1 (es) *	2007-06-20	2008-09-05	Wyeth Corp	Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.

2008
- 2008-06-18 CL CL200801806A patent/CL2008001806A1/es unknown
- 2008-06-19 DK DK08771428.3T patent/DK2164510T3/da active
- 2008-06-19 MX MX2009014070A patent/MX2009014070A/es active IP Right Grant
- 2008-06-19 CN CN200880024112A patent/CN101790378A/zh active Pending
- 2008-06-19 WO PCT/US2008/067433 patent/WO2008157659A1/en not_active Ceased
- 2008-06-19 ES ES08771428T patent/ES2429296T3/es active Active
- 2008-06-19 HR HRP20130939AT patent/HRP20130939T1/hr unknown
- 2008-06-19 CA CA2692098A patent/CA2692098C/en not_active Expired - Fee Related
- 2008-06-19 JP JP2010513396A patent/JP5457340B2/ja not_active Expired - Fee Related
- 2008-06-19 EP EP08771428.3A patent/EP2164510B1/en active Active
- 2008-06-19 NZ NZ582132A patent/NZ582132A/en not_active IP Right Cessation
- 2008-06-19 SI SI200831038T patent/SI2164510T1/sl unknown
- 2008-06-19 AU AU2008265745A patent/AU2008265745B2/en not_active Ceased
- 2008-06-19 US US12/142,160 patent/US8980288B2/en active Active
- 2008-06-19 BR BRPI0812856-1A2A patent/BRPI0812856A2/pt not_active IP Right Cessation
- 2008-06-19 KR KR1020107001106A patent/KR101569218B1/ko not_active Expired - Fee Related
- 2008-06-19 RS RS20130408A patent/RS52947B/sr unknown
- 2008-06-19 PL PL08771428T patent/PL2164510T3/pl unknown
- 2008-06-19 CN CN201510450651.5A patent/CN105148268A/zh active Pending
- 2008-06-19 ME MEP-2013-101A patent/ME01527B/me unknown
- 2008-06-19 PT PT87714283T patent/PT2164510E/pt unknown
- 2008-06-20 TW TW097123236A patent/TWI507214B/zh not_active IP Right Cessation
- 2008-06-20 AR ARP080102641A patent/AR067087A1/es not_active Application Discontinuation
2009
- 2009-12-17 CO CO09144676A patent/CO6251273A2/es not_active Application Discontinuation
- 2009-12-22 ZA ZA200909173A patent/ZA200909173B/xx unknown
2010
- 2010-11-09 HK HK16106725.1A patent/HK1218717A1/zh unknown
2013
- 2013-10-03 CY CY20131100855T patent/CY1114451T1/el unknown
2014
- 2014-01-09 JP JP2014002096A patent/JP5802285B2/ja not_active Expired - Fee Related
2015
- 2015-02-10 US US14/618,628 patent/US9545439B2/en active Active

Also Published As

Publication number	Publication date
DK2164510T3 (da)	2013-09-23
US8980288B2 (en)	2015-03-17
TW200906448A (en)	2009-02-16
AR067087A1 (es)	2009-09-30
JP2010530877A (ja)	2010-09-16
JP5457340B2 (ja)	2014-04-02
SI2164510T1 (sl)	2013-11-29
US20150297710A1 (en)	2015-10-22
PL2164510T3 (pl)	2014-03-31
NZ582132A (en)	2012-04-27
EP2164510A1 (en)	2010-03-24
WO2008157659A1 (en)	2008-12-24
HRP20130939T1 (hr)	2013-11-22
KR20100022115A (ko)	2010-02-26
CY1114451T1 (el)	2016-10-05
ME01527B (me)	2014-04-20
JP5802285B2 (ja)	2015-10-28
TWI507214B (zh)	2015-11-11
CO6251273A2 (es)	2011-02-21
CA2692098A1 (en)	2008-12-24
PT2164510E (pt)	2013-10-07
EP2164510B1 (en)	2013-07-17
AU2008265745B2 (en)	2013-05-30
US9545439B2 (en)	2017-01-17
JP2014088423A (ja)	2014-05-15
CA2692098C (en)	2016-06-14
HK1218717A1 (zh)	2017-03-10
ES2429296T3 (es)	2013-11-14
US20090017067A1 (en)	2009-01-15
ZA200909173B (en)	2010-08-25
KR101569218B1 (ko)	2015-11-13
MX2009014070A (es)	2010-05-19
CN101790378A (zh)	2010-07-28
AU2008265745A1 (en)	2008-12-24
CN105148268A (zh)	2015-12-16
CL2008001806A1 (es)	2008-09-05
RS52947B (sr)	2014-02-28

Publication	Publication Date	Title
BRPI0812856A2 (pt)	2014-12-09	Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa.
BRPI0813892A2 (pt)	2017-05-09	composições que compreendem antígenos pneumococcal
BRPI0814594A2 (pt)	2015-01-20	Composições e métodos adjuvantes de antígeno
BRPI0813527A2 (pt)	2014-12-30	Expressão diferencial de micro-rnas em corações humanos que não falham versus que falham
EP2127635A4 (en)	2015-04-01	OIL-IN-WATER EMULSION COMPOSITION
DK1991564T3 (da)	2013-12-16	Virosomlignende vesikler omfattende gp41-afledte antigener
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