ZA200801893B - Amorphous solid dispersions of 7-chloro-N,N, 5-Trimethyl-4-Oxo-3-phenyl-3, 5,-dihydro-4H-pyridazino [4,5-B] indole-1-acetamide - Google Patents

Amorphous solid dispersions of 7-chloro-N,N, 5-Trimethyl-4-Oxo-3-phenyl-3, 5,-dihydro-4H-pyridazino [4,5-B] indole-1-acetamide

Info

Publication number: ZA200801893B
Authority: ZA; South Africa
Prior art keywords: pyridazino; acetamide; indole; dihydro; trimethyl
Prior art date: 2005-08-29

Application number

ZA200801893A

Other languages

English (en)

Inventor

Irwin C Jacobs

John D Higgins

Guillot Micael

Nancy M Franson

William L Rocco

Abu-Izza Khawla Abdullah

Original Assignee

Sanofi Aventis Us Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-29

Filing date

2006-08-24

Publication date

2009-08-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37499538&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200801893(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-08-24 Application filed by Sanofi Aventis Us Llc filed Critical Sanofi Aventis Us Llc

2009-08-26 Publication of ZA200801893B publication Critical patent/ZA200801893B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

ZA200801893A 2005-08-29 2006-08-24 Amorphous solid dispersions of 7-chloro-N,N, 5-Trimethyl-4-Oxo-3-phenyl-3, 5,-dihydro-4H-pyridazino [4,5-B] indole-1-acetamide ZA200801893B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71215005P	2005-08-29	2005-08-29

Publications (1)

Publication Number	Publication Date
ZA200801893B true ZA200801893B (en)	2009-08-26

Family

ID=37499538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200801893A ZA200801893B (en)	2005-08-29	2006-08-24	Amorphous solid dispersions of 7-chloro-N,N, 5-Trimethyl-4-Oxo-3-phenyl-3, 5,-dihydro-4H-pyridazino [4,5-B] indole-1-acetamide

Country Status (30)

Country	Link
US (1)	US7713548B2 (xx)
EP (1)	EP1926476B1 (xx)
JP (1)	JP5026426B2 (xx)
KR (1)	KR20080061354A (xx)
CN (1)	CN101272767B (xx)
AR (1)	AR055615A1 (xx)
AU (1)	AU2006285111B8 (xx)
BR (1)	BRPI0615609A2 (xx)
CA (1)	CA2619438A1 (xx)
CR (1)	CR9750A (xx)
DK (1)	DK1926476T3 (xx)
EA (1)	EA015715B1 (xx)
EC (1)	ECSP088203A (xx)
ES (1)	ES2414434T3 (xx)
HN (1)	HN2008000360A (xx)
HR (1)	HRP20130533T1 (xx)
IL (1)	IL189587A (xx)
MA (1)	MA29783B1 (xx)
ME (1)	ME01560B (xx)
NO (1)	NO20081364L (xx)
NZ (1)	NZ566313A (xx)
PL (1)	PL1926476T3 (xx)
PT (1)	PT1926476E (xx)
RS (1)	RS52914B (xx)
SI (1)	SI1926476T1 (xx)
TN (1)	TNSN08069A1 (xx)
TW (1)	TWI398250B (xx)
UA (1)	UA93517C2 (xx)
WO (1)	WO2007027494A2 (xx)
ZA (1)	ZA200801893B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI2007756T1 (sl)	2006-04-07	2015-11-30	Vertex Pharmaceuticals Incorporated	Modulatorji prenašalcev z atp-vezavno kaseto
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
WO2008138755A2 (en) *	2007-05-11	2008-11-20	F. Hoffmann-La Roche Ag	Pharmaceutical compositions for poorly soluble drugs
MX2010009344A (es) *	2008-03-11	2012-09-28	Reddys Lab Ltd Dr	Preparacion de lenalidomida.
RU2011110241A (ru) *	2008-08-18	2012-09-27	САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи (US)	СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФА 7-ХЛОР-N,N,5-ТРИМЕТИЛ-4-ОКСО-3-ФЕНИЛ-3,5-ДИГИДРО-4Н-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-АЦЕТАМИДА
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
CN106083832A (zh) *	2010-03-25	2016-11-09	弗特克斯药品有限公司	(r)‑1(2,2‑二氟苯并[d][1,3]间二氧杂环戊烯‑5‑基)‑n‑(1‑(2,3‑二羟基丙基)‑6‑氟‑2‑(1‑羟基‑2‑甲基丙‑2‑基)‑1h‑吲哚‑5‑基)环丙烷甲酰胺的固体形式
IN2012DE00674A (xx)	2012-03-07	2015-08-21	Nat Inst Of Pharmaceutical Education And Res Niper
KR101986683B1 (ko) *	2012-12-13	2019-06-10	한미약품 주식회사	테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체
US9965611B2 (en) *	2013-08-30	2018-05-08	Entit Software Llc	Comparing real-time movements to pattern profile background
CA2943024A1 (en) *	2014-03-18	2015-09-24	Takeda Pharmaceutical Company Limited	Solid dispersion
DK3925607T3 (da)	2014-04-15	2023-08-21	Vertex Pharma	Farmaceutiske sammensætninger til behandlingen af cystisk fibrosetransmembrankonduktansregulator-medierede sygdomme
JP6577143B2 (ja)	2016-02-29	2019-09-18	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	ブルトンチロシンキナーゼの阻害剤を含む剤形組成物
WO2019007317A1 (zh) *	2017-07-04	2019-01-10	江苏恒瑞医药股份有限公司	一种药物组合物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5091381A (en) *	1991-04-12	1992-02-25	Biomeasure, Inc.	2H-1,3,4-benzotriazepin-2-ones
TW487582B (en) *	1995-08-11	2002-05-21	Nissan Chemical Ind Ltd	Method for converting sparingly water-soluble medical substance to amorphous state
FR2766823B1 (fr)	1997-07-30	1999-10-08	Synthelabo	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
PT901786E (pt) *	1997-08-11	2007-08-07	Pfizer Prod Inc	Disperções farmacêuticas sólidas com biodisponibilidade melhorada
AUPP278498A0 (en) *	1998-04-03	1998-04-30	Australian Nuclear Science & Technology Organisation	Peripheral benzodiazepine receptor binding agents
FR2788696B1 (fr) *	1999-01-26	2004-03-05	Synthelabo	Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
EP1027885B1 (en)	1999-02-09	2008-07-09	Pfizer Products Inc.	Basic drug compositions with enhanced bioavailability
ATE404178T1 (de) *	1999-02-10	2008-08-15	Pfizer Prod Inc	Vorrichtung mit matrixgesteuerter wirkstofffreisetzung
DE60039379D1 (de)	1999-02-10	2008-08-21	Pfizer Prod Inc	Pharmazeutische feste Dispersionen
EP1120109A3 (en) *	2000-01-24	2002-07-10	Pfizer Products Inc.	Rapidly disintegrating and fast dissolving solid dosage form
FR2829939B3 (fr) *	2001-09-21	2003-11-28	Sanofi Synthelabo	Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide
CL2004001884A1 (es)	2003-08-04	2005-06-03	Pfizer Prod Inc	Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
WO2005034999A2 (en) *	2003-10-10	2005-04-21	Bvm Holding Co.	Composition comprising association complex of a pharmaceutical and a poloxamer

2006
- 2006-08-24 EP EP06802215.1A patent/EP1926476B1/en active Active
- 2006-08-24 ES ES06802215T patent/ES2414434T3/es active Active
- 2006-08-24 HR HRP20130533TT patent/HRP20130533T1/hr unknown
- 2006-08-24 UA UAA200803944A patent/UA93517C2/ru unknown
- 2006-08-24 CN CN2006800317142A patent/CN101272767B/zh not_active Expired - Fee Related
- 2006-08-24 AU AU2006285111A patent/AU2006285111B8/en not_active Ceased
- 2006-08-24 NZ NZ566313A patent/NZ566313A/en not_active IP Right Cessation
- 2006-08-24 DK DK06802215.1T patent/DK1926476T3/da active
- 2006-08-24 SI SI200631605T patent/SI1926476T1/sl unknown
- 2006-08-24 KR KR1020087004952A patent/KR20080061354A/ko not_active Abandoned
- 2006-08-24 JP JP2008529117A patent/JP5026426B2/ja not_active Expired - Fee Related
- 2006-08-24 ZA ZA200801893A patent/ZA200801893B/xx unknown
- 2006-08-24 WO PCT/US2006/033022 patent/WO2007027494A2/en not_active Ceased
- 2006-08-24 RS RS20130288A patent/RS52914B/sr unknown
- 2006-08-24 CA CA002619438A patent/CA2619438A1/en not_active Abandoned
- 2006-08-24 PT PT68022151T patent/PT1926476E/pt unknown
- 2006-08-24 BR BRPI0615609-6A patent/BRPI0615609A2/pt not_active IP Right Cessation
- 2006-08-24 EA EA200800713A patent/EA015715B1/ru not_active IP Right Cessation
- 2006-08-24 PL PL06802215T patent/PL1926476T3/pl unknown
- 2006-08-24 ME MEP-2013-80A patent/ME01560B/me unknown
- 2006-08-28 AR ARP060103739A patent/AR055615A1/es not_active Application Discontinuation
- 2006-08-29 TW TW095131682A patent/TWI398250B/zh not_active IP Right Cessation
2008
- 2008-02-12 US US12/029,691 patent/US7713548B2/en not_active Expired - Fee Related
- 2008-02-13 TN TNP2008000069A patent/TNSN08069A1/en unknown
- 2008-02-18 IL IL189587A patent/IL189587A/en not_active IP Right Cessation
- 2008-02-19 EC EC2008008203A patent/ECSP088203A/es unknown
- 2008-02-21 CR CR9750A patent/CR9750A/es unknown
- 2008-02-28 HN HN2008000360A patent/HN2008000360A/es unknown
- 2008-03-14 NO NO20081364A patent/NO20081364L/no not_active Application Discontinuation
- 2008-03-17 MA MA30752A patent/MA29783B1/fr unknown

Also Published As

Publication number	Publication date
CA2619438A1 (en)	2007-03-08
ES2414434T3 (es)	2013-07-19
TWI398250B (zh)	2013-06-11
AR055615A1 (es)	2007-08-29
JP2009506114A (ja)	2009-02-12
JP5026426B2 (ja)	2012-09-12
CN101272767B (zh)	2012-08-29
PT1926476E (pt)	2013-07-10
CR9750A (es)	2008-06-18
IL189587A (en)	2012-12-31
HK1124785A1 (en)	2009-07-24
NZ566313A (en)	2011-04-29
NO20081364L (no)	2008-04-03
WO2007027494A2 (en)	2007-03-08
AU2006285111B2 (en)	2012-04-26
SI1926476T1 (sl)	2013-07-31
US20080160080A1 (en)	2008-07-03
KR20080061354A (ko)	2008-07-02
EA015715B1 (ru)	2011-10-31
TNSN08069A1 (en)	2009-07-14
CN101272767A (zh)	2008-09-24
HN2008000360A (es)	2011-05-31
DK1926476T3 (da)	2013-07-01
MA29783B1 (fr)	2008-09-01
EA200800713A1 (ru)	2008-10-30
AU2006285111A1 (en)	2007-03-08
WO2007027494A3 (en)	2007-08-02
EP1926476A2 (en)	2008-06-04
EP1926476B1 (en)	2013-04-10
RS52914B (sr)	2014-02-28
PL1926476T3 (pl)	2013-08-30
ECSP088203A (es)	2008-06-30
ME01560B (me)	2014-04-20
UA93517C2 (xx)	2011-02-25
BRPI0615609A2 (pt)	2011-05-24
AU2006285111B8 (en)	2012-05-17
HRP20130533T1 (xx)	2013-07-31
US7713548B2 (en)	2010-05-11
TW200727902A (en)	2007-08-01
IL189587A0 (en)	2008-08-07

Publication	Publication Date	Title
IL189587A0 (en)	2008-08-07	Morphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3,5, dihydro-4h-pyridazino[4,5-b]indole-1-acetamide
IL186881A0 (en)	2008-02-09	Pyrido [2, 3 - d] pyrimidines useful as hcv inhibitors, and methods for the preparation thereof
IL195238A0 (en)	2009-08-03	Pyrazolo [1,5-a]pyrimidines as cdk inhibitors
IL192236A0 (en)	2008-12-29	Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives
IL206466A0 (en)	2010-12-30	PYRAZOLO [1,5-a]PYRIMIDINES, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF
EP2223921B8 (en)	2013-02-20	2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents
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