UA93517C2 - Amorphous solid dispersion formulations comprising 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide - Google Patents

Amorphous solid dispersion formulations comprising 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide

Info

Publication number: UA93517C2
Authority: UA; Ukraine
Prior art keywords: pyridazino; acetamide; indole; dihydro; trimethyl
Prior art date: 2005-08-29

Application number

UAA200803944A

Other languages

English (en)

Inventor

Ирвин K. Джейкобс

Джон Д. Хиггинс

Микаэл Гюилло

Нэнси M. Френсон

Уильям Л. Рокко

Хавла Абдулла Абу-Изза

Original Assignee

САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-29

Filing date

2006-08-24

Publication date

2011-02-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37499538&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA93517(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-08-24 Application filed by САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи filed Critical САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи

2011-02-25 Publication of UA93517C2 publication Critical patent/UA93517C2/ru

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Cardiology (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

UAA200803944A 2005-08-29 2006-08-24 Amorphous solid dispersion formulations comprising 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide UA93517C2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71215005P	2005-08-29	2005-08-29

Publications (1)

Publication Number	Publication Date
UA93517C2 true UA93517C2 (en)	2011-02-25

Family

ID=37499538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200803944A UA93517C2 (en)	2005-08-29	2006-08-24	Amorphous solid dispersion formulations comprising 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide

Country Status (30)

Country	Link
US (1)	US7713548B2 (ru)
EP (1)	EP1926476B1 (ru)
JP (1)	JP5026426B2 (ru)
KR (1)	KR20080061354A (ru)
CN (1)	CN101272767B (ru)
AR (1)	AR055615A1 (ru)
AU (1)	AU2006285111B8 (ru)
BR (1)	BRPI0615609A2 (ru)
CA (1)	CA2619438A1 (ru)
CR (1)	CR9750A (ru)
DK (1)	DK1926476T3 (ru)
EA (1)	EA015715B1 (ru)
EC (1)	ECSP088203A (ru)
ES (1)	ES2414434T3 (ru)
HN (1)	HN2008000360A (ru)
HR (1)	HRP20130533T1 (ru)
IL (1)	IL189587A (ru)
MA (1)	MA29783B1 (ru)
ME (1)	ME01560B (ru)
NO (1)	NO20081364L (ru)
NZ (1)	NZ566313A (ru)
PL (1)	PL1926476T3 (ru)
PT (1)	PT1926476E (ru)
RS (1)	RS52914B (ru)
SI (1)	SI1926476T1 (ru)
TN (1)	TNSN08069A1 (ru)
TW (1)	TWI398250B (ru)
UA (1)	UA93517C2 (ru)
WO (1)	WO2007027494A2 (ru)
ZA (1)	ZA200801893B (ru)

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EP2007756B1 (en)	2006-04-07	2015-08-26	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
CN101702878B (zh) *	2007-05-11	2012-11-28	弗·哈夫曼-拉罗切有限公司	可溶性差的药物的药物组合物
KR20100124710A (ko) *	2008-03-11	2010-11-29	닥터 레디스 레보러터리즈 리미티드	레날리도미드의 제조
WO2010021905A1 (en) *	2008-08-18	2010-02-25	Sanofi-Aventis U.S. Llc	Process for preparing polymorph of 7-chloro-n, n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4h-pyridazin0[4,5-b]indole-1-acetamide
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
CN102892764B (zh) *	2010-03-25	2016-07-06	弗特克斯药品有限公司	(r)-1(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(1-(2,3-二羟基丙基)-6-氟-2-(1-羟基-2-甲基丙-2-基)-1h-吲哚-5-基)环丙烷甲酰胺的固体形式
WO2013132457A2 (en)	2012-03-07	2013-09-12	National Institute Of Pharmaceutical Education And Research (Niper)	Nanocrystalline solid dispersion compositions and process of preparation thereof
KR101986683B1 (ko) *	2012-12-13	2019-06-10	한미약품 주식회사	테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체
WO2015030788A1 (en) *	2013-08-30	2015-03-05	Hewlett-Packard Development Company, L.P.	Comparing real-time movements to pattern profile background
EP3120871B1 (en) *	2014-03-18	2023-06-28	Takeda Pharmaceutical Company Limited	Solid dispersion
JP6543268B2 (ja)	2014-04-15	2019-07-10	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物
CN108367005B (zh)	2016-02-29	2022-01-07	豪夫迈·罗氏有限公司	包含酪氨酸蛋白激酶抑制剂的剂型组合物
US11304945B2 (en) *	2017-07-04	2022-04-19	Jiangsu Hengrui Medicine Co., Ltd.	Pharmaceutical composition and method for preparing same

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US5091381A (en) *	1991-04-12	1992-02-25	Biomeasure, Inc.	2H-1,3,4-benzotriazepin-2-ones
TW487582B (en) *	1995-08-11	2002-05-21	Nissan Chemical Ind Ltd	Method for converting sparingly water-soluble medical substance to amorphous state
FR2766823B1 (fr)	1997-07-30	1999-10-08	Synthelabo	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
EP0901786B1 (en) *	1997-08-11	2007-06-13	Pfizer Products Inc.	Solid pharmaceutical dispersions with enhanced bioavailability
AUPP278498A0 (en) *	1998-04-03	1998-04-30	Australian Nuclear Science & Technology Organisation	Peripheral benzodiazepine receptor binding agents
FR2788696B1 (fr) *	1999-01-26	2004-03-05	Synthelabo	Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
ATE400251T1 (de)	1999-02-09	2008-07-15	Pfizer Prod Inc	Zusammensetzungen basischer arzneistoffe mit verbesserter bioverfügbarkeit
DE60039802D1 (de) *	1999-02-10	2008-09-25	Pfizer Prod Inc	Vorrichtung mit matrixgesteuerter Wirkstofffreisetzung
DE60039379D1 (de)	1999-02-10	2008-08-21	Pfizer Prod Inc	Pharmazeutische feste Dispersionen
EP1120109A3 (en) *	2000-01-24	2002-07-10	Pfizer Products Inc.	Rapidly disintegrating and fast dissolving solid dosage form
FR2829939B3 (fr) *	2001-09-21	2003-11-28	Sanofi Synthelabo	Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide
CL2004001884A1 (es)	2003-08-04	2005-06-03	Pfizer Prod Inc	Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
US20050220881A1 (en) *	2003-10-10	2005-10-06	Bvm Holding Co.	Pharmaceutical composition

2006
- 2006-08-24 NZ NZ566313A patent/NZ566313A/en not_active IP Right Cessation
- 2006-08-24 RS RS20130288A patent/RS52914B/sr unknown
- 2006-08-24 JP JP2008529117A patent/JP5026426B2/ja not_active Expired - Fee Related
- 2006-08-24 PT PT68022151T patent/PT1926476E/pt unknown
- 2006-08-24 CN CN2006800317142A patent/CN101272767B/zh not_active Expired - Fee Related
- 2006-08-24 ES ES06802215T patent/ES2414434T3/es active Active
- 2006-08-24 KR KR1020087004952A patent/KR20080061354A/ko not_active Abandoned
- 2006-08-24 AU AU2006285111A patent/AU2006285111B8/en not_active Ceased
- 2006-08-24 UA UAA200803944A patent/UA93517C2/ru unknown
- 2006-08-24 ME MEP-2013-80A patent/ME01560B/me unknown
- 2006-08-24 EP EP06802215.1A patent/EP1926476B1/en active Active
- 2006-08-24 ZA ZA200801893A patent/ZA200801893B/xx unknown
- 2006-08-24 WO PCT/US2006/033022 patent/WO2007027494A2/en not_active Ceased
- 2006-08-24 SI SI200631605T patent/SI1926476T1/sl unknown
- 2006-08-24 PL PL06802215T patent/PL1926476T3/pl unknown
- 2006-08-24 CA CA002619438A patent/CA2619438A1/en not_active Abandoned
- 2006-08-24 BR BRPI0615609-6A patent/BRPI0615609A2/pt not_active IP Right Cessation
- 2006-08-24 HR HRP20130533TT patent/HRP20130533T1/hr unknown
- 2006-08-24 DK DK06802215.1T patent/DK1926476T3/da active
- 2006-08-24 EA EA200800713A patent/EA015715B1/ru not_active IP Right Cessation
- 2006-08-28 AR ARP060103739A patent/AR055615A1/es not_active Application Discontinuation
- 2006-08-29 TW TW095131682A patent/TWI398250B/zh not_active IP Right Cessation
2008
- 2008-02-12 US US12/029,691 patent/US7713548B2/en not_active Expired - Fee Related
- 2008-02-13 TN TNP2008000069A patent/TNSN08069A1/en unknown
- 2008-02-18 IL IL189587A patent/IL189587A/en not_active IP Right Cessation
- 2008-02-19 EC EC2008008203A patent/ECSP088203A/es unknown
- 2008-02-21 CR CR9750A patent/CR9750A/es unknown
- 2008-02-28 HN HN2008000360A patent/HN2008000360A/es unknown
- 2008-03-14 NO NO20081364A patent/NO20081364L/no not_active Application Discontinuation
- 2008-03-17 MA MA30752A patent/MA29783B1/fr unknown

Also Published As

Publication number	Publication date
EP1926476A2 (en)	2008-06-04
US20080160080A1 (en)	2008-07-03
ES2414434T3 (es)	2013-07-19
CR9750A (es)	2008-06-18
IL189587A (en)	2012-12-31
HRP20130533T1 (en)	2013-07-31
NZ566313A (en)	2011-04-29
AR055615A1 (es)	2007-08-29
NO20081364L (no)	2008-04-03
ZA200801893B (en)	2009-08-26
ECSP088203A (es)	2008-06-30
CA2619438A1 (en)	2007-03-08
TW200727902A (en)	2007-08-01
PT1926476E (pt)	2013-07-10
BRPI0615609A2 (pt)	2011-05-24
MA29783B1 (fr)	2008-09-01
KR20080061354A (ko)	2008-07-02
IL189587A0 (en)	2008-08-07
SI1926476T1 (sl)	2013-07-31
EA015715B1 (ru)	2011-10-31
WO2007027494A3 (en)	2007-08-02
RS52914B (sr)	2014-02-28
HK1124785A1 (en)	2009-07-24
JP5026426B2 (ja)	2012-09-12
TWI398250B (zh)	2013-06-11
PL1926476T3 (pl)	2013-08-30
EP1926476B1 (en)	2013-04-10
ME01560B (me)	2014-04-20
AU2006285111B2 (en)	2012-04-26
TNSN08069A1 (en)	2009-07-14
EA200800713A1 (ru)	2008-10-30
US7713548B2 (en)	2010-05-11
WO2007027494A2 (en)	2007-03-08
DK1926476T3 (da)	2013-07-01
AU2006285111B8 (en)	2012-05-17
CN101272767A (zh)	2008-09-24
AU2006285111A1 (en)	2007-03-08
CN101272767B (zh)	2012-08-29
HN2008000360A (es)	2011-05-31
JP2009506114A (ja)	2009-02-12

Publication	Publication Date	Title
TNSN08069A1 (en)	2009-07-14	Amorphous solid dispersions of 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5,-dihydro-4h-pyridazino[4,5 b] indole -1- acetamide
IL209494A (en)	2015-07-30	Formulations of insulin oligomeric monoconogues and their use
EP2223921B8 (en)	2013-02-20	2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents
SG153834A1 (en)	2009-07-29	1-aza-bicyclo[3.3.1]nonanes
WO2007011741A3 (en)	2008-01-17	Stable organic devices
WO2007076370A3 (en)	2008-07-24	Block copolymer particles
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