ZA200800681B - Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments - Google Patents

Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments

Info

Publication number: ZA200800681B
Authority: ZA; South Africa
Prior art keywords: glucopyranos; ethynyl; chloro; benzyl; benzene
Prior art date: 2005-09-08

Application number

ZA200800681A

Other languages

English (en)

Inventor

Eckhardt Matthias

Himmelsbach Frank

Butz Tanja

Schuehle Martin

Martin Hans-Juergen

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-08

Filing date

2008-01-23

Publication date

2009-03-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37478909&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200800681(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-01-23 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2009-03-25 Publication of ZA200800681B publication Critical patent/ZA200800681B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Obesity (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)
Pyrrole Compounds (AREA)

ZA200800681A 2005-09-08 2008-01-23 Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments ZA200800681B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05019527		2005-09-08

Publications (1)

Publication Number	Publication Date
ZA200800681B true ZA200800681B (en)	2009-03-25

Family

ID=37478909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200800681A ZA200800681B (en)	2005-09-08	2008-01-23	Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments

Country Status (19)

Country	Link
US (1)	US8507450B2 (xx)
EP (1)	EP1926720B1 (xx)
JP (1)	JP5345846B2 (xx)
KR (1)	KR20080053369A (xx)
CN (1)	CN101238112A (xx)
AR (1)	AR056055A1 (xx)
AT (1)	ATE491700T1 (xx)
AU (1)	AU2006289093A1 (xx)
BR (1)	BRPI0615882A2 (xx)
CA (1)	CA2621314A1 (xx)
DE (1)	DE602006018961D1 (xx)
ES (1)	ES2358051T3 (xx)
IL (1)	IL189950A0 (xx)
MX (1)	MX2008002457A (xx)
NZ (1)	NZ566787A (xx)
RU (1)	RU2008113050A (xx)
TW (1)	TW200745075A (xx)
WO (1)	WO2007028814A1 (xx)
ZA (1)	ZA200800681B (xx)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2360165A3 (de) *	2004-03-16	2012-01-04	Boehringer Ingelheim International GmbH	Glucopyranosyl-substituierte Benzol-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP2008524162A (ja) *	2004-12-16	2008-07-10	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	グルコピラノシル置換ベンゼン誘導体、該化合物を含む薬物、その使用及びその製造方法
DE602006009772D1 (de) *	2005-02-23	2009-11-26	Boehringer Ingelheim Int	Glucopyranosylsubstituierte ((hetero)arylethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters typ 2 (sglt2)
CA2605245A1 (en) *	2005-04-15	2006-10-19	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors
UA91546C2 (xx) *	2005-05-03	2010-08-10	Бьорінгер Інгельхайм Інтернаціональ Гмбх	КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-$4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ$КРИСТАЛЛИЧЕСКАЯ ФОРМА 1-ХЛОР-4-(b-D-ГЛЮКОПИРАНОЗ-1- ИЛ)-2-$4-((S)- ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ЕЕ ПРИМЕНЕНИЕ ПРИ ПРИГОТАВЛЕНИИ ЛЕКАРСТВЕННЫХ СРЕДСТВ
US7723309B2 (en)	2005-05-03	2010-05-25	Boehringer Ingelheim International Gmbh	Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
US7772191B2 (en)	2005-05-10	2010-08-10	Boehringer Ingelheim International Gmbh	Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
TW200733966A (en) *	2005-07-27	2007-09-16	Boehringer Ingelheim Int	Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
CA2620566A1 (en) *	2005-08-30	2007-03-08	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
RU2008113050A (ru)	2005-09-08	2009-10-20	БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE)	КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-(4-ЭТИНИЛБЕНЗИН)-БЕНЗОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО ПРИМЕНЕНИЕ ДЛЯ ПРИГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ
AR056195A1 (es) *	2005-09-15	2007-09-26	Boehringer Ingelheim Int	Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
EP1989191B1 (en) *	2006-02-15	2011-07-20	Boehringer Ingelheim International GmbH	Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
PE20080697A1 (es) *	2006-05-03	2008-08-05	Boehringer Ingelheim Int	Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
EP2054426A1 (en) *	2006-08-15	2009-05-06	Boehringer Ingelheim International GmbH	Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as sglt inhibitors and process for their manufacture
CA2664095A1 (en) *	2006-09-21	2008-03-27	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted difluorobenzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
EP2086991A1 (en)	2006-10-27	2009-08-12	Boehringer Ingelheim International GmbH	CRYSTALLINE FORM OF 4-(ß-D-GLUCOPYRANOS-1-YL)-1-METHYL-2-[4-((S)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS
EP2079753A1 (en)	2006-11-06	2009-07-22	Boehringer Ingelheim International GmbH	Glucopyranosyl-substituted benzyl-benzonitrile derivatives, medicaments containing such compounds, their use and process for their manufacture
JP2010519273A (ja)	2007-02-21	2010-06-03	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	四置換グルコピラノシル化ベンゼン誘導体、このような化合物を含む薬物、それらの使用及びそれらの製造方法
CL2008002427A1 (es)	2007-08-16	2009-09-11	Boehringer Ingelheim Int	Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
UA99924C2 (xx)	2007-08-23	2012-10-25	Теракос, Инк.	Похідні бензилбензолу та їх застосування$производные бензилбензола и их применение
UA101004C2 (xx)	2007-12-13	2013-02-25	Теракос, Инк.	Похідні бензилфенілциклогексану та їх застосування$производные бензилфенилциклогексана и их применение
NZ604897A (en)	2008-08-22	2014-03-28	Theracos Sub Llc	Processes for the preparation of sglt2 inhibitors
WO2010023594A1 (en) *	2008-08-28	2010-03-04	Pfizer Inc.	Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
UY32427A (es)	2009-02-13	2010-09-30	Boheringer Ingelheim Internat Gmbh	Composicion farmaceutica, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma
CN102307577A (zh)	2009-02-13	2012-01-04	贝林格尔.英格海姆国际有限公司	包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途
WO2010092126A1 (en)	2009-02-13	2010-08-19	Boehringer Ingelheim International Gmbh	Pharmaceutical composition comprising glucopyranosyl diphenylmethane derivatives, pharmaceutical dosage form thereof, process for their preparation and uses thereof for improved glycemic control in a patient
BRPI1013640A2 (pt)	2009-02-13	2019-09-24	Boehringer Ingelheim International Gmbh	composicao farmaceutica, metodos para o tratamento e usos dos mesmos
PT2486029E (pt)	2009-09-30	2015-10-14	Boehringer Ingelheim Int	Processos para a preparação de derivados de benzil-benzeno substituídos com glucopiranosilo
JP5736377B2 (ja)	2009-09-30	2015-06-17	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	１−クロロ−４−（β−Ｄ−グルコピラノス−１−イル）−２−［４−（（Ｓ）−テトラヒドロフラン−３−イルオキシ）ベンジル］ベンゼンの結晶形の調製方法
UY32919A (es)	2009-10-02	2011-04-29	Boehringer Ingelheim Int	Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos
CA2777857C (en)	2009-11-02	2014-12-02	Pfizer Inc.	Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
EP2552442A1 (en)	2010-03-30	2013-02-06	Boehringer Ingelheim International GmbH	Pharmaceutical composition comprising an sglt2 inhibitor and a ppar- gamma agonist and uses thereof
WO2011153712A1 (en)	2010-06-12	2011-12-15	Theracos, Inc.	Crystalline form of benzylbenzene sglt2 inhibitor
WO2012041898A1 (en)	2010-09-29	2012-04-05	Celon Pharma Sp. Z O.O.	Combination of sglt2 inhibitor and a sugar compound for the treatment of diabetes
US20120283169A1 (en)	2010-11-08	2012-11-08	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
US20130035281A1 (en)	2011-02-09	2013-02-07	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
UY33937A (es)	2011-03-07	2012-09-28	Boehringer Ingelheim Int	Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina
CA2837627A1 (en)	2011-06-03	2012-12-06	Boehringer Ingelheim International Gmbh	Sglt-2 inhibitors for treating metabolic disorders in patients treated with neuroleptic agents
US20130035298A1 (en)	2011-07-08	2013-02-07	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
EP2597090A1 (en)	2011-11-28	2013-05-29	Sandoz AG	Crystalline dapagliflozin hydrate
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
US9192617B2 (en)	2012-03-20	2015-11-24	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
US9193751B2 (en)	2012-04-10	2015-11-24	Theracos, Inc.	Process for the preparation of benzylbenzene SGLT2 inhibitors
US9145434B2 (en) *	2012-07-26	2015-09-29	Boehringer Ingelheim International Gmbh	Crystalline complex of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(ss-d-glucopyranos-1-yl)-benzene, methods for its preparation and the use thereof for preparing medicaments
CN103910719B (zh) *	2012-12-31	2018-05-01	上海璎黎药业有限公司	葡萄糖衍生物与苯丙氨酸复合物、晶体、制备方法及应用
CN103910769B (zh) *	2012-12-31	2018-10-02	上海璎黎药业有限公司	葡萄糖衍生物和脯氨酸的复合物、晶体、制备方法及应用
WO2014161836A1 (en)	2013-04-04	2014-10-09	Boehringer Ingelheim Vetmedica Gmbh	Treatment of metabolic disorders in equine animals
HK1213818A1 (zh)	2013-04-05	2016-07-15	勃林格殷格翰国际有限公司	依帕列净的治疗用途
CA2812519A1 (en)	2013-04-05	2014-10-05	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
US20140303098A1 (en)	2013-04-05	2014-10-09	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
US11813275B2 (en)	2013-04-05	2023-11-14	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
HUE058731T2 (hu)	2013-04-18	2022-09-28	Boehringer Ingelheim Int	Gyógyászati készítmények, kezelési eljárások és ezek alkalmazásai
CN105611920B (zh)	2013-10-12	2021-07-16	泰拉科斯萨普有限责任公司	羟基-二苯甲烷衍生物的制备
PL3082829T3 (pl)	2013-12-17	2021-09-06	Boehringer Ingelheim Vetmedica Gmbh	Inhibitory sglt2 do leczenia zaburzeń metabolicznych u zwierząt kotowatych
US10603300B2 (en) *	2014-01-23	2020-03-31	Boehringer Ingelheim Vetmedica Gmbh	Treatment of metabolic disorders in canine animals
HUE068880T2 (hu)	2014-04-01	2025-02-28	Boehringer Ingelheim Vetmedica Gmbh	Hipofízis pars intermedia diszfunkció kezelése lófélékben
KR102539788B1 (ko)	2014-09-25	2023-06-07	베링거잉겔하임베트메디카게엠베하	말과 동물의 대사 장애를 예방하기 위한 sglt2 억제제와 도파민 작용제의 병용 치료
WO2016144862A1 (en)	2015-03-09	2016-09-15	Intekrin Therapeutics, Inc.	Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
LT3341024T (lt)	2015-08-27	2025-01-10	Boehringer Ingelheim Vetmedica Gmbh	Skystos farmacinės kompozicijos, apimančios sglt-2 inhibitorius
WO2017064193A1 (en)	2015-10-15	2017-04-20	Boehringer Ingelheim International Gmbh	Sglt-2 inhibitor for use in the treatment of a metabolic myopathy
US20190076395A1 (en)	2016-03-11	2019-03-14	Merck Sharp & Dohme Corp.	Methods of treating or reducing the risk of cardiovascular events and related diseases using sglt-2 inhibitors
WO2017206827A1 (zh) *	2016-05-28	2017-12-07	山东轩竹医药科技有限公司	钠-葡萄糖协同转运蛋白2抑制剂的晶型
CN109922813A (zh)	2016-11-10	2019-06-21	勃林格殷格翰国际有限公司	药物组合物、治疗方法及其用途
JP2020515639A (ja)	2017-04-03	2020-05-28	コヒラス・バイオサイエンシズ・インコーポレイテッド	進行性核上性麻痺の処置のためのＰＰＡＲγアゴニスト
KR102204439B1 (ko)	2018-05-14	2021-01-18	에이치케이이노엔 주식회사	Sglt-2 억제제 및 dpp-iv 억제제를 포함하는 약제학적 조성물
WO2020039394A1 (en)	2018-08-24	2020-02-27	Novartis Ag	New drug combinations
AU2020394498A1 (en)	2019-11-28	2022-06-09	Boehringer Ingelheim Vetmedica Gmbh	Use of SGLT-2 inhibitors in the drying-off of non-human mammals
US20220369685A1 (en) *	2020-02-03	2022-11-24	Societe Des Produits Nestle S.A.	Compositions and methods for the improvement and maintenance of glucose metabolism in childhood and adolescence
AU2021222297B2 (en)	2020-02-17	2026-01-22	Boehringer Ingelheim Vetmedica Gmbh	Use of SGLT-2 inhibitors for the prevention and/or treatment of cardiac diseases in felines
EP4114385A1 (en)	2020-03-06	2023-01-11	Vertex Pharmaceuticals Incorporated	Methods of treating apol-1 dependent focal segmental glomerulosclerosis
WO2022051316A1 (en)	2020-09-03	2022-03-10	Coherus Biosciences, Inc.	Fixed dose combinations of chs-131 and a sglt-2 inhibitor
CN119110722A (zh)	2022-05-25	2024-12-10	勃林格殷格翰动物保健有限公司	包含sglt-2抑制剂的水性医药组合物
AU2024233233A1 (en)	2023-03-06	2025-09-11	Boehringer Ingelheim Vetmedica Gmbh	Systems for delivery of liquid pharmaceutical compositions in particular comprising one or more sglt-2 inhibitor(s)

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58164502A (ja)	1982-03-26	1983-09-29	Chugai Pharmaceut Co Ltd	除草用組成物
US4786755A (en)	1985-06-03	1988-11-22	Warner-Lambert Company	Diphenic acid monoamides
US4602023A (en)	1985-06-03	1986-07-22	Warner-Lambert Company	Diphenic acid monoamides
US4786023A (en) *	1987-08-19	1988-11-22	Harris Leverett D	Drafting implement holder
US6515117B2 (en)	1999-10-12	2003-02-04	Bristol-Myers Squibb Company	C-aryl glucoside SGLT2 inhibitors and method
PH12000002657B1 (en)	1999-10-12	2006-02-21	Bristol Myers Squibb Co	C-aryl glucoside SGLT2 inhibitors
JP4456768B2 (ja)	2000-02-02	2010-04-28	壽製薬株式会社	Ｃ−配糖体を含有する薬剤
US6627611B2 (en)	2000-02-02	2003-09-30	Kotobuki Pharmaceutical Co Ltd	C-glycosides and preparation of thereof as antidiabetic agents
US6683056B2 (en)	2000-03-30	2004-01-27	Bristol-Myers Squibb Company	O-aryl glucoside SGLT2 inhibitors and method
IL155071A0 (en)	2000-09-29	2003-10-31	Kissei Pharmaceutical	Glucopyranosyloxybenzylbenzene derivatives and medical compositions containing the same
AU2002223127A1 (en)	2000-11-30	2002-06-11	Kissei Pharmaceutical Co., Ltd. Intellectual Property	Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
TWI255817B (en)	2001-02-14	2006-06-01	Kissei Pharmaceutical	Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
US6936590B2 (en) *	2001-03-13	2005-08-30	Bristol Myers Squibb Company	C-aryl glucoside SGLT2 inhibitors and method
US6774112B2 (en)	2001-04-11	2004-08-10	Bristol-Myers Squibb Company	Amino acid complexes of C-aryl glucosides for treatment of diabetes and method
US20020151874A1 (en)	2001-04-12	2002-10-17	Kolster Alwin H.	Liposuction cannula device and method
DE10227566B4 (de)	2002-06-20	2007-09-27	Dentsply Detrey Gmbh	Heizmuffel für einen Brennofen zur Herstellung eines Titan enthaltenden Dentalkeramikerzeugnisses, Verfahren zu seiner Herstellung und Verwendung, sowie Brennofen enthaltend die Heizmuffel
TWI254635B (en)	2002-08-05	2006-05-11	Yamanouchi Pharma Co Ltd	Azulene derivative and salt thereof
DE10258008B4 (de)	2002-12-12	2006-02-02	Sanofi-Aventis Deutschland Gmbh	Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10258007B4 (de)	2002-12-12	2006-02-09	Sanofi-Aventis Deutschland Gmbh	Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
MXPA05007052A (es)	2003-01-03	2005-08-18	Squibb Bristol Myers Co	Metodos para producir c-aril-glucosidos como inhibidores de sglt2.
EP1597266A4 (en)	2003-02-27	2008-02-20	Bristol Myers Squibb Co	NON-CRYOGENIC PROCESS FOR THE PRODUCTION OF GLYCOSIDES
TWI309980B (en)	2003-03-14	2009-05-21	Yamanouchi Pharma Co Ltd	C-glycoside derivatives or salts thereof
JP2004359630A (ja)	2003-06-06	2004-12-24	Yamanouchi Pharmaceut Co Ltd	ジフルオロジフェニルメタン誘導体及びその塩
TW200521131A (en)	2003-08-01	2005-07-01	Janssen Pharmaceutica Nv	Substituted fused heterocyclic c-glycosides
PL1651658T5 (pl)	2003-08-01	2020-11-30	Mitsubishi Tanabe Pharma Corporation	Nowe związki o działaniu inhibitującym transporter zależny od sodu
US7375090B2 (en)	2003-08-26	2008-05-20	Boehringer Ingelheim International Gmbh	Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof
US7371732B2 (en)	2003-12-22	2008-05-13	Boehringer Ingelheim International Gmbh	Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture
CN1934103B (zh)	2004-03-04	2011-06-01	橘生药品工业株式会社	稠杂环衍生物，包含稠杂环衍生物的药物组合物及其医药用途
ZA200606792B (en)	2004-03-04	2007-12-27	Kissei Pharmaceutical	Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
EP2360165A3 (de)	2004-03-16	2012-01-04	Boehringer Ingelheim International GmbH	Glucopyranosyl-substituierte Benzol-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7393836B2 (en)	2004-07-06	2008-07-01	Boehringer Ingelheim International Gmbh	D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
DE102004034690A1 (de)	2004-07-17	2006-02-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
TW200606129A (en)	2004-07-26	2006-02-16	Chugai Pharmaceutical Co Ltd	Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
CA2574451A1 (en)	2004-07-27	2006-02-02	Boehringer Ingelheim International Gmbh	D-glucopyranosyl phenyl-substituted cyclene, medicaments containing these compounds, their use, and method for the production thereof
WO2006018150A1 (de)	2004-08-11	2006-02-23	Boehringer Ingelheim International Gmbh	D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
AR051446A1 (es)	2004-09-23	2007-01-17	Bristol Myers Squibb Co	Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
DE102004048388A1 (de)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP2008524162A (ja)	2004-12-16	2008-07-10	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	グルコピラノシル置換ベンゼン誘導体、該化合物を含む薬物、その使用及びその製造方法
DE602006009772D1 (de)	2005-02-23	2009-11-26	Boehringer Ingelheim Int	Glucopyranosylsubstituierte ((hetero)arylethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters typ 2 (sglt2)
CA2605245A1 (en)	2005-04-15	2006-10-19	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors
US7723309B2 (en)	2005-05-03	2010-05-25	Boehringer Ingelheim International Gmbh	Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
UA91546C2 (xx)	2005-05-03	2010-08-10	Бьорінгер Інгельхайм Інтернаціональ Гмбх	КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-$4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ$КРИСТАЛЛИЧЕСКАЯ ФОРМА 1-ХЛОР-4-(b-D-ГЛЮКОПИРАНОЗ-1- ИЛ)-2-$4-((S)- ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ЕЕ ПРИМЕНЕНИЕ ПРИ ПРИГОТАВЛЕНИИ ЛЕКАРСТВЕННЫХ СРЕДСТВ
US7772191B2 (en)	2005-05-10	2010-08-10	Boehringer Ingelheim International Gmbh	Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
WO2007000445A1 (en)	2005-06-29	2007-01-04	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
TW200733966A (en)	2005-07-27	2007-09-16	Boehringer Ingelheim Int	Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
CA2620566A1 (en)	2005-08-30	2007-03-08	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
RU2008113050A (ru)	2005-09-08	2009-10-20	БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE)	КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-(4-ЭТИНИЛБЕНЗИН)-БЕНЗОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО ПРИМЕНЕНИЕ ДЛЯ ПРИГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ
AR056195A1 (es)	2005-09-15	2007-09-26	Boehringer Ingelheim Int	Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
EP1989191B1 (en)	2006-02-15	2011-07-20	Boehringer Ingelheim International GmbH	Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
PE20080697A1 (es)	2006-05-03	2008-08-05	Boehringer Ingelheim Int	Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
EP2054426A1 (en)	2006-08-15	2009-05-06	Boehringer Ingelheim International GmbH	Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as sglt inhibitors and process for their manufacture
CA2664095A1 (en)	2006-09-21	2008-03-27	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted difluorobenzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
EP2086991A1 (en)	2006-10-27	2009-08-12	Boehringer Ingelheim International GmbH	CRYSTALLINE FORM OF 4-(ß-D-GLUCOPYRANOS-1-YL)-1-METHYL-2-[4-((S)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS
EP2079753A1 (en)	2006-11-06	2009-07-22	Boehringer Ingelheim International GmbH	Glucopyranosyl-substituted benzyl-benzonitrile derivatives, medicaments containing such compounds, their use and process for their manufacture
MX2009004104A (es)	2006-11-09	2009-06-16	Boehringer Ingelheim Int	Terapia combinada con inhibidores de sglt-2 y sus composiciones farmaceuticas.
AR065033A1 (es)	2007-01-26	2009-05-13	Boehringer Ingelheim Int	Metodos para prevenir y tratar trastornos neurodegenerativos
JP2010519273A (ja)	2007-02-21	2010-06-03	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	四置換グルコピラノシル化ベンゼン誘導体、このような化合物を含む薬物、それらの使用及びそれらの製造方法
PE20090603A1 (es)	2007-08-16	2009-06-11	Boehringer Ingelheim Int	Composicion farmaceutica que comprende un inhibidor de sglt2 y un inhibidor de dpp iv
CL2008002427A1 (es)	2007-08-16	2009-09-11	Boehringer Ingelheim Int	Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
WO2010092126A1 (en)	2009-02-13	2010-08-19	Boehringer Ingelheim International Gmbh	Pharmaceutical composition comprising glucopyranosyl diphenylmethane derivatives, pharmaceutical dosage form thereof, process for their preparation and uses thereof for improved glycemic control in a patient
UY32427A (es)	2009-02-13	2010-09-30	Boheringer Ingelheim Internat Gmbh	Composicion farmaceutica, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma
CN102307577A (zh)	2009-02-13	2012-01-04	贝林格尔.英格海姆国际有限公司	包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途
BRPI1013640A2 (pt)	2009-02-13	2019-09-24	Boehringer Ingelheim International Gmbh	composicao farmaceutica, metodos para o tratamento e usos dos mesmos
PT2486029E (pt)	2009-09-30	2015-10-14	Boehringer Ingelheim Int	Processos para a preparação de derivados de benzil-benzeno substituídos com glucopiranosilo
JP5736377B2 (ja)	2009-09-30	2015-06-17	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	１−クロロ−４−（β−Ｄ−グルコピラノス−１−イル）−２−［４−（（Ｓ）−テトラヒドロフラン−３−イルオキシ）ベンジル］ベンゼンの結晶形の調製方法
UY32919A (es)	2009-10-02	2011-04-29	Boehringer Ingelheim Int	Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos

2006
- 2006-09-07 RU RU2008113050/04A patent/RU2008113050A/ru not_active Application Discontinuation
- 2006-09-07 ES ES06793305T patent/ES2358051T3/es active Active
- 2006-09-07 AU AU2006289093A patent/AU2006289093A1/en not_active Abandoned
- 2006-09-07 WO PCT/EP2006/066107 patent/WO2007028814A1/en not_active Ceased
- 2006-09-07 NZ NZ566787A patent/NZ566787A/en unknown
- 2006-09-07 BR BRPI0615882-0A patent/BRPI0615882A2/pt not_active IP Right Cessation
- 2006-09-07 AT AT06793305T patent/ATE491700T1/de active
- 2006-09-07 TW TW095133001A patent/TW200745075A/zh unknown
- 2006-09-07 CN CNA2006800287058A patent/CN101238112A/zh active Pending
- 2006-09-07 US US11/470,684 patent/US8507450B2/en active Active
- 2006-09-07 MX MX2008002457A patent/MX2008002457A/es not_active Application Discontinuation
- 2006-09-07 KR KR1020087008490A patent/KR20080053369A/ko not_active Withdrawn
- 2006-09-07 EP EP06793305A patent/EP1926720B1/en active Active
- 2006-09-07 JP JP2008529633A patent/JP5345846B2/ja active Active
- 2006-09-07 DE DE602006018961T patent/DE602006018961D1/de active Active
- 2006-09-07 CA CA002621314A patent/CA2621314A1/en not_active Withdrawn
- 2006-09-08 AR ARP060103906A patent/AR056055A1/es unknown
2008
- 2008-01-23 ZA ZA200800681A patent/ZA200800681B/xx unknown
- 2008-03-05 IL IL189950A patent/IL189950A0/en unknown

Also Published As

Publication number	Publication date
JP2009507809A (ja)	2009-02-26
MX2008002457A (es)	2008-04-07
US8507450B2 (en)	2013-08-13
EP1926720B1 (en)	2010-12-15
RU2008113050A (ru)	2009-10-20
NZ566787A (en)	2010-02-26
BRPI0615882A2 (pt)	2011-05-31
DE602006018961D1 (de)	2011-01-27
WO2007028814A1 (en)	2007-03-15
US20070054867A1 (en)	2007-03-08
AU2006289093A1 (en)	2007-03-15
TW200745075A (en)	2007-12-16
AR056055A1 (es)	2007-09-12
CN101238112A (zh)	2008-08-06
JP5345846B2 (ja)	2013-11-20
AU2006289093A8 (en)	2008-05-08
IL189950A0 (en)	2008-08-07
KR20080053369A (ko)	2008-06-12
EP1926720A1 (en)	2008-06-04
ATE491700T1 (de)	2011-01-15
ES2358051T3 (es)	2011-05-05
CA2621314A1 (en)	2007-03-15

Publication	Publication Date	Title
ZA200800681B (en)	2009-03-25	Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments
SI1888552T1 (sl)	2010-04-30	KristaliniŽŤna oblika 1-kloro-4-(beta-D-glukopiranoz-1-il)-2-(4-((S)-tetrahidrofuran-3-iloksi) -benzil)-benzena, postopek za njeno pripravo in njena uporaba za pripravo zdravil
IL177450A0 (en)	2006-12-10	Substituted pyrazoline compounds, their preparation and use as medicaments
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IL220816A0 (en)	2012-08-30	Process for preparing cell-binding agent-cytotoxic agent
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IL193339A0 (en)	2009-05-04	Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
IL206197A (en)	2015-03-31	Crystalline forms of the compound (r1, r2) –3– (3– dimethylamino – 1 – ethyl – 2 – methyl-profile) –phenol processes for their preparation, pharmaceutical compositions containing them, and their use in the preparation of pain treatment compositions
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PL1940840T3 (pl)	2010-12-31	Pochodne 6-heteroarylopirydoindolonu, ich wytwarzanie i ich zastosowanie w lecznictwie
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