ZA200703579B - Potentiators of glutamate receptors - Google Patents
Potentiators of glutamate receptorsInfo
- Publication number
- ZA200703579B ZA200703579B ZA200703579A ZA200703579A ZA200703579B ZA 200703579 B ZA200703579 B ZA 200703579B ZA 200703579 A ZA200703579 A ZA 200703579A ZA 200703579 A ZA200703579 A ZA 200703579A ZA 200703579 B ZA200703579 B ZA 200703579B
- Authority
- ZA
- South Africa
- Prior art keywords
- potentiators
- glutamate receptors
- same
- intermediates
- preparing
- Prior art date
Links
- 102000018899 Glutamate Receptors Human genes 0.000 title 1
- 108010027915 Glutamate Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/63—One oxygen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Psychology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63006004P | 2004-11-22 | 2004-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200703579B true ZA200703579B (en) | 2009-04-29 |
Family
ID=35929650
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200703579A ZA200703579B (en) | 2004-11-22 | 2007-05-03 | Potentiators of glutamate receptors |
| ZA200704001A ZA200704001B (en) | 2004-11-22 | 2007-05-17 | Potentiators of glutamate receptors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200704001A ZA200704001B (en) | 2004-11-22 | 2007-05-17 | Potentiators of glutamate receptors |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US7858646B2 (xx) |
| EP (4) | EP2441762A1 (xx) |
| JP (2) | JP5175551B2 (xx) |
| KR (3) | KR20090006237A (xx) |
| CN (3) | CN101061105B (xx) |
| AT (3) | ATE461188T1 (xx) |
| AU (2) | AU2005309855B2 (xx) |
| BR (2) | BRPI0518360A2 (xx) |
| CA (2) | CA2588881C (xx) |
| CY (2) | CY1109998T1 (xx) |
| DE (2) | DE602005017510D1 (xx) |
| DK (2) | DK1817300T3 (xx) |
| EA (2) | EA200701122A1 (xx) |
| ES (3) | ES2333979T3 (xx) |
| HR (1) | HRP20120137T1 (xx) |
| IL (2) | IL182957A (xx) |
| MA (2) | MA29136B1 (xx) |
| MX (2) | MX2007006146A (xx) |
| NO (2) | NO20072971L (xx) |
| NZ (1) | NZ554399A (xx) |
| PL (2) | PL1817301T3 (xx) |
| PT (2) | PT1817300E (xx) |
| RS (1) | RS52268B (xx) |
| SI (2) | SI1817300T1 (xx) |
| TN (2) | TNSN07196A1 (xx) |
| UA (1) | UA90695C2 (xx) |
| WO (3) | WO2006057869A1 (xx) |
| ZA (2) | ZA200703579B (xx) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1817300E (pt) | 2004-11-22 | 2010-05-28 | Lilly Co Eli | Potenciadores de receptores de glutamato |
| KR100789242B1 (ko) | 2005-07-08 | 2008-01-02 | 주식회사 엘지화학 | 전이금속 화합물, 이를 포함하는 촉매 조성물 및 이를이용한 올레핀 중합 |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TWI443090B (zh) | 2007-05-25 | 2014-07-01 | Abbvie Deutschland | 作為代謝性麩胺酸受體2(mglu2 受體)之正向調節劑之雜環化合物 |
| DE602008004794D1 (de) | 2007-09-14 | 2011-03-10 | Addex Pharmaceuticals Sa | 1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyridinyl-2'-one |
| AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
| TW201006801A (en) * | 2008-07-18 | 2010-02-16 | Lilly Co Eli | Imidazole carboxamides |
| EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| CN102186477B (zh) | 2008-10-16 | 2013-07-17 | 奥梅-杨森制药有限公司 | 作为代谢型谷氨酸受体调节剂的吲哚和苯并吗啉衍生物 |
| CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
| AR076861A1 (es) | 2009-05-12 | 2011-07-13 | Addex Pharma Sa | Derivados de 1,2,4-triazolo (4,3-a)piridina y su uso como moduladores alostericos positivos de los receptores de mglur2 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| WO2010130422A1 (en) | 2009-05-12 | 2010-11-18 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| US8748632B2 (en) | 2010-03-19 | 2014-06-10 | Sanford-Burnham Medical Research Institute | Positive allosteric modulators of group II mGluRs |
| US8664214B2 (en) | 2010-03-30 | 2014-03-04 | AbbVie Deutschland GmbH & Co. KG | Small molecule potentiators of metabotropic glutamate receptors I |
| US8314120B2 (en) | 2010-03-30 | 2012-11-20 | Abbott Gmbh & Co. Kg | Small molecule potentiators of metabotropic glutamate receptors |
| US8993591B2 (en) | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| US9000044B2 (en) | 2012-02-28 | 2015-04-07 | Hoffmann-La Roche Inc. | Substituted naphthylacetic acids |
| CN102977040B (zh) * | 2012-11-20 | 2015-06-03 | 浙江工业大学 | 一种2-喹喔啉基二甲缩醛和2-喹喔啉基甲醛的合成方法 |
| EP2746259A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| EP2746260A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| PH12019500127B1 (en) | 2014-01-21 | 2022-05-04 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| SMT201900545T1 (it) | 2014-01-21 | 2019-11-13 | Janssen Pharmaceutica Nv | Combinazioni comprendenti modulatori allosterici positivi o agonisti ortosterici del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo |
| WO2015157187A1 (en) * | 2014-04-06 | 2015-10-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor positive allosteric modulators (pams) and uses thereof |
| CN104959070A (zh) * | 2015-06-19 | 2015-10-07 | 武汉工程大学 | 一种阳离子双子表面活性剂及其制备方法 |
| BR112019015721A2 (pt) * | 2017-01-30 | 2020-03-24 | Western New England University | Inibidores de tiol isomerases e uso dos mesmos |
| CN110467544A (zh) * | 2019-08-19 | 2019-11-19 | 武汉轻工大学 | 一种克立硼罗中间体的制备方法 |
| EP4073035B1 (en) * | 2019-12-11 | 2025-05-07 | Taro Pharmaceutical Industries Ltd. | Preparation of trifarotene and intermediates and polymorphs thereof |
| CN114702408B (zh) * | 2022-02-22 | 2024-01-16 | 南京康川济医药科技有限公司 | 一种克立硼罗杂质的制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3068213D1 (en) * | 1979-09-05 | 1984-07-19 | Glaxo Group Ltd | Phenol derivatives, processes for their preparation and pharmaceutical compositions containing them |
| GB2058785B (en) | 1979-09-05 | 1983-05-25 | Glaxo Group Ltd | Phenol derivatives |
| US4666928A (en) | 1984-08-30 | 1987-05-19 | Merck Frosst Canada, Ind. | Propylphenoxy pyridine carboxylates as leukotriene antagonists |
| JPS61130271A (ja) * | 1984-11-30 | 1986-06-18 | Tokyo Tanabe Co Ltd | 芳香族カルボン酸誘導体及びその塩 |
| US4853398A (en) | 1987-04-13 | 1989-08-01 | Eli Lilly And Company | Leukotriene antagonists and use thereas |
| JPH0768224B2 (ja) * | 1987-04-20 | 1995-07-26 | 杏林製薬株式会社 | ベンズイミダゾール誘導体およびその製造法 |
| TW204343B (xx) * | 1991-05-31 | 1993-04-21 | Sumitomo Pharmaceutics Co Ltd | |
| HU226462B1 (en) | 1995-02-17 | 2008-12-29 | Hoechst Ag | Substituted benzol-sulfonyl-ureas and -thioureas, process for producing them, pharmaceutical compositions containing them, and their use |
| US6194432B1 (en) | 1998-10-13 | 2001-02-27 | Fred D. Sheftell | Prevention and treatment of migraine, cluster and other recurrent headaches using leukotriene antagonist drugs |
| CN1414965A (zh) * | 1999-12-31 | 2003-04-30 | 德州生物科技公司 | 调整内皮肽活性的磺酰胺及其衍生物 |
| WO2001056990A2 (en) | 2000-02-03 | 2001-08-09 | Eli Lilly And Company | Pyridine derivates as potentiators of glutamate receptors |
| WO2004018386A2 (en) * | 2002-08-26 | 2004-03-04 | Merck & Co., Inc. | Acetophenone potentiators of metabotropic glutamate receptors |
| FR2871713B1 (fr) | 2004-06-21 | 2006-08-25 | Renault Sas | Installation d'application de peinture automobile et procede utilisant l'installation |
| AU2005269546A1 (en) * | 2004-07-30 | 2006-02-09 | Merck & Co., Inc. | Heterocyclic acetophenone potentiators of metabotropic glutamate receptors |
| JP2008508306A (ja) | 2004-07-30 | 2008-03-21 | メルク エンド カムパニー インコーポレーテッド | メタボトロピックグルタミン酸受容体のインダノン増強剤 |
| AU2005302608A1 (en) | 2004-10-28 | 2006-05-11 | Merck & Co., Inc. | Pyrimidine and quinoline potentiators of metabotropic glutamate receptors |
| PT1817300E (pt) | 2004-11-22 | 2010-05-28 | Lilly Co Eli | Potenciadores de receptores de glutamato |
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2005
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