ZA200600895B - 4-(Methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and pharmaceutical compositions comprising the same - Google Patents
4-(Methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and pharmaceutical compositions comprising the sameInfo
- Publication number
- ZA200600895B ZA200600895B ZA200600895A ZA200600895A ZA200600895B ZA 200600895 B ZA200600895 B ZA 200600895B ZA 200600895 A ZA200600895 A ZA 200600895A ZA 200600895 A ZA200600895 A ZA 200600895A ZA 200600895 B ZA200600895 B ZA 200600895B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical compositions
- same
- analgesic activity
- methyl sulfonyl
- showing excellent
- Prior art date
Links
- -1 4-(Methyl sulfonyl amino) phenyl Chemical class 0.000 title 1
- 229940122629 Vanilloid antagonist Drugs 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/14—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20030044552 | 2003-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200600895B true ZA200600895B (en) | 2009-07-29 |
Family
ID=36141774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200600895A ZA200600895B (en) | 2003-07-02 | 2004-07-02 | 4-(Methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and pharmaceutical compositions comprising the same |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8642657B2 (is) |
| EP (1) | EP1658265A4 (is) |
| JP (1) | JP4850702B2 (is) |
| KR (1) | KR100707123B1 (is) |
| CN (1) | CN100537528C (is) |
| AU (1) | AU2004253808B2 (is) |
| BR (1) | BRPI0412229A (is) |
| CA (1) | CA2533547C (is) |
| EC (1) | ECSP066321A (is) |
| IL (1) | IL172671A (is) |
| IS (1) | IS8216A (is) |
| NO (1) | NO332602B1 (is) |
| NZ (1) | NZ544943A (is) |
| RU (1) | RU2362768C2 (is) |
| WO (1) | WO2005003084A1 (is) |
| ZA (1) | ZA200600895B (is) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101087771A (zh) | 2004-11-10 | 2007-12-12 | 辉瑞大药厂 | 经取代n-磺酰基氨基苄基-2-苯氧基乙酰胺化合物 |
| ATE404546T1 (de) * | 2004-11-10 | 2008-08-15 | Pfizer | Substituierte n-sulfonylaminobenzyl-2- phenoxyacetamidverbindungen |
| JP4906839B2 (ja) | 2005-03-10 | 2012-03-28 | ファイザー株式会社 | 置換n−スルホニルアミノフェニルエチル−2−フェノキシアセトアミド化合物 |
| WO2006098554A1 (en) * | 2005-03-16 | 2006-09-21 | Amorepacific Corporation | Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same |
| EA200701745A1 (ru) | 2005-03-17 | 2008-06-30 | Пфайзер, Инк. | Циклопропанкарбоксамидные производные |
| WO2006101318A1 (en) * | 2005-03-19 | 2006-09-28 | Amorepacific Corporation | Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same |
| DE102005023943A1 (de) | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005050408A1 (de) * | 2005-10-19 | 2007-04-26 | Grünenthal GmbH | Neue Vanilloidrezeptor-Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| CA2625189A1 (en) * | 2005-10-19 | 2007-04-26 | Gruenenthal Gmbh | Novel vanilloid receptor ligands and their use for producing medicaments |
| JP2009536657A (ja) * | 2006-05-10 | 2009-10-15 | レノビス, インコーポレイテッド | イオンチャンネルリガンドとしてのアミド誘導体およびそれを用いる医薬組成物および方法 |
| ES2433095T3 (es) * | 2006-05-18 | 2013-12-09 | Dompe' S.P.A. | (2R)-2[(4-Sulfonil)aminofenil]propanamidas y composiciones farmacéuticas que las contienen |
| EP1862454A1 (en) * | 2006-06-02 | 2007-12-05 | Amorepacific Corporation | Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same |
| JP2009542798A (ja) * | 2006-07-11 | 2009-12-03 | ファイザー株式会社 | 置換n−二環式アルキル二環式カルボキシアミド化合物 |
| CA2658925C (en) | 2006-07-27 | 2015-07-14 | Amorepacific Corporation | Novel sulfonylamino acrylamide derivatives, isomer thereof,or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same |
| EP2069302B1 (en) | 2006-09-15 | 2010-08-25 | Pfizer Inc. | Substituted pyridylmethyl bicyclocarboxyamide compounds |
| DE102007018150A1 (de) * | 2007-04-16 | 2008-10-23 | Grünenthal GmbH | VR1-Rezeptor-Liganden und µ-Opioid-Rezeptor-Liganden zur Behandlung von Schmerz |
| ES2368460T3 (es) | 2006-10-23 | 2011-11-17 | Pfizer Inc. | Compuestos de fenilmetil biciclocarboxiamida sustituidos. |
| EP2091944B1 (en) | 2006-11-17 | 2011-05-18 | Pfizer Inc. | Substituted bicyclocarboxyamide compounds |
| US20080207136A1 (en) * | 2007-02-20 | 2008-08-28 | Haiyun Tang | High Dynamic Range Tranceiver for Cognitive Radio |
| WO2008121859A1 (en) * | 2007-03-30 | 2008-10-09 | Xenon Pharmaceuticals Inc. | Methods of using tricyclic compounds in treating sodium channel-mediated diseases or conditions |
| DE102007017884A1 (de) | 2007-04-13 | 2008-10-16 | Grünethal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| EP2150531A2 (de) * | 2007-04-13 | 2010-02-10 | Grünenthal GmbH | Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln |
| DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| DE102007018149A1 (de) | 2007-04-16 | 2008-10-23 | Grünenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| EP1992228A1 (en) * | 2007-05-14 | 2008-11-19 | Bayer CropScience AG | Insecticidal substituted thiourea derivatives |
| JP5365509B2 (ja) * | 2007-10-25 | 2013-12-11 | 東レ株式会社 | 膜ろ過予測方法、予測装置、及び膜ろ過予測プログラム |
| JP2011503072A (ja) * | 2007-11-13 | 2011-01-27 | レノビス, インコーポレイテッド | イオンチャネルのリガンドとしてのアミド誘導体ならびにそれを使用する薬学的組成物および方法 |
| KR101619341B1 (ko) * | 2008-01-28 | 2016-05-11 | (주)아모레퍼시픽 | 바닐로이드 수용체 길항체로서의 신규 화합물, 이의 이성질체 또는 약제학적으로 허용가능한 염, 및 이를 함유하는 약학 조성물 |
| WO2010002209A2 (en) | 2008-07-02 | 2010-01-07 | Amorepacific Corporation | Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same |
| WO2010021882A2 (en) * | 2008-08-19 | 2010-02-25 | Janssen Pharmaceutica Nv | Cold menthol receptor antagonists |
| KR101367057B1 (ko) | 2009-03-17 | 2014-02-25 | (주)아모레퍼시픽 | 피부 자극 완화용 조성물 |
| WO2010056044A2 (ko) * | 2008-11-11 | 2010-05-20 | (주)아모레퍼시픽 | 바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염 및 이를 포함하는 약학 조성물 |
| EP2316820A1 (en) * | 2009-10-28 | 2011-05-04 | Dompe S.p.A. | 2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them |
| CN105820069A (zh) * | 2015-01-05 | 2016-08-03 | 齐鲁工业大学 | 一种n-{4-[3-(3-溴-苯基)-脲基甲基]-2,5-二丁氧基-苯基}-甲磺酰胺新化合物、制备方法及用途 |
| CN105820087A (zh) * | 2015-01-05 | 2016-08-03 | 齐鲁工业大学 | 一种5-[3-(2,5-二乙氧基-4-甲磺酰基-苄基)-脲基]-2-乙氧基-n-对甲苯基-苯甲酰胺新化合物、制备方法及用途 |
| CN105820076A (zh) * | 2015-01-05 | 2016-08-03 | 齐鲁工业大学 | 一种n-[2,5-二乙氧基-4-(3-对-甲苯基-脲基甲基)-苯基]-甲磺酰胺新化合物、制备方法及用途 |
| CN105820073A (zh) * | 2015-01-05 | 2016-08-03 | 齐鲁工业大学 | 一种n-{[2,5-二乙氧基-4-[3-(3-甲氧基-苯基)-脲基甲基]-苯基}-甲磺酰胺新化合物、制备方法及用途 |
| CN105820088A (zh) * | 2015-01-05 | 2016-08-03 | 齐鲁工业大学 | 一种n-(4-溴-苯基)-5-[3-(2,5-二乙氧基-4-甲磺酰基-苄基)-脲基]-2-乙氧基苯甲酰胺新化合物、制备方法及用途 |
| CN106344552B (zh) * | 2015-07-15 | 2021-04-30 | 齐鲁工业大学 | 新型磺酰胺类化合物、制备方法及其作为蛋白酪氨酸磷酸酯酶1b抑制剂的用途 |
| WO2021064189A2 (en) * | 2019-10-02 | 2021-04-08 | Domain Therapeutics | Prostaglandin e2 (pge2) ep4 receptor antagonists |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2076098C1 (ru) * | 1990-02-07 | 1997-03-27 | Ниппон синяку компани лимитед | 3'-(2-амино-1-гидроксиэтил)-4'-фторметансульфонанилид и средство для лечения недержания мочи |
| ES2253208T3 (es) * | 1999-02-22 | 2006-06-01 | Pacific Corporation | Analogos de vaniloide que contienen farmacoforos de resiniferatoxina como ponentes agonistas del receptor de vaniloide y analgesicos, composiciones y utilizaciones de los mismos. |
| JP5001505B2 (ja) * | 2000-08-21 | 2012-08-15 | 株式會社アモーレパシフィック | 新規チオウレア誘導体およびこれを含有する薬学的組成物 |
| KR100453078B1 (ko) * | 2000-08-21 | 2004-10-15 | 주식회사 태평양 | 신규 티오우레아 화합물 및 이를 함유하는 약제학적 조성물 |
| GB0110901D0 (en) * | 2001-05-02 | 2001-06-27 | Smithkline Beecham Plc | Novel Compounds |
-
2004
- 2004-06-22 KR KR1020040046508A patent/KR100707123B1/ko not_active Expired - Fee Related
- 2004-07-02 WO PCT/KR2004/001641 patent/WO2005003084A1/en not_active Ceased
- 2004-07-02 ZA ZA200600895A patent/ZA200600895B/xx unknown
- 2004-07-02 JP JP2006518539A patent/JP4850702B2/ja not_active Expired - Fee Related
- 2004-07-02 CA CA2533547A patent/CA2533547C/en not_active Expired - Fee Related
- 2004-07-02 AU AU2004253808A patent/AU2004253808B2/en not_active Ceased
- 2004-07-02 US US10/562,698 patent/US8642657B2/en not_active Expired - Fee Related
- 2004-07-02 IL IL172671A patent/IL172671A/en not_active IP Right Cessation
- 2004-07-02 BR BRPI0412229-1A patent/BRPI0412229A/pt not_active IP Right Cessation
- 2004-07-02 RU RU2006102868/04A patent/RU2362768C2/ru not_active IP Right Cessation
- 2004-07-02 NZ NZ544943A patent/NZ544943A/en not_active IP Right Cessation
- 2004-07-02 CN CNB2004800245997A patent/CN100537528C/zh not_active Expired - Fee Related
- 2004-07-02 EP EP04748386A patent/EP1658265A4/en not_active Withdrawn
-
2005
- 2005-12-30 IS IS8216A patent/IS8216A/is unknown
-
2006
- 2006-01-09 NO NO20060122A patent/NO332602B1/no not_active IP Right Cessation
- 2006-01-26 EC EC2006006321A patent/ECSP066321A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20060122L (no) | 2006-01-09 |
| EP1658265A4 (en) | 2006-11-29 |
| CA2533547C (en) | 2013-09-10 |
| EP1658265A1 (en) | 2006-05-24 |
| CA2533547A1 (en) | 2005-01-13 |
| CN1852891A (zh) | 2006-10-25 |
| US8642657B2 (en) | 2014-02-04 |
| IS8216A (is) | 2005-12-30 |
| RU2006102868A (ru) | 2007-08-10 |
| WO2005003084A1 (en) | 2005-01-13 |
| US20060258884A1 (en) | 2006-11-16 |
| RU2362768C2 (ru) | 2009-07-27 |
| KR100707123B1 (ko) | 2007-04-16 |
| AU2004253808A1 (en) | 2005-01-13 |
| AU2004253808B2 (en) | 2011-02-03 |
| KR20050004006A (ko) | 2005-01-12 |
| IL172671A0 (en) | 2006-04-10 |
| BRPI0412229A (pt) | 2006-08-22 |
| NO332602B1 (no) | 2012-11-12 |
| IL172671A (en) | 2013-08-29 |
| JP2007521288A (ja) | 2007-08-02 |
| NZ544943A (en) | 2009-07-31 |
| CN100537528C (zh) | 2009-09-09 |
| ECSP066321A (es) | 2006-07-28 |
| JP4850702B2 (ja) | 2012-01-11 |
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