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ZA200407244B - NK, antagonists. - Google Patents

NK, antagonists. Download PDF

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Publication number
ZA200407244B
ZA200407244B ZA200407244A ZA200407244A ZA200407244B ZA 200407244 B ZA200407244 B ZA 200407244B ZA 200407244 A ZA200407244 A ZA 200407244A ZA 200407244 A ZA200407244 A ZA 200407244A ZA 200407244 B ZA200407244 B ZA 200407244B
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ZA
South Africa
Prior art keywords
group
alkyl
disorder
compound
ring
Prior art date
Application number
ZA200407244A
Other languages
English (en)
Inventor
Michelle Laci Wrobleski
Neng-Yang Shih
Gregory A Reichard
Dong Xiao
Original Assignee
Schering Corp
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200407244B publication Critical patent/ZA200407244B/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
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    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
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ZA200407244A 2002-03-13 2004-09-09 NK, antagonists. ZA200407244B (en)

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US36376102P 2002-03-13 2002-03-13

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ZA200407244B true ZA200407244B (en) 2005-10-04

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US (1) US6878732B2 (zh)
EP (1) EP1483228B1 (zh)
JP (1) JP4458853B2 (zh)
KR (1) KR20040093123A (zh)
CN (1) CN100506776C (zh)
AR (1) AR039084A1 (zh)
AT (1) ATE469875T1 (zh)
AU (1) AU2003220215B2 (zh)
CA (1) CA2478211A1 (zh)
DE (1) DE60332816D1 (zh)
ES (1) ES2345437T3 (zh)
IL (1) IL163939A0 (zh)
MX (1) MXPA04008803A (zh)
NZ (1) NZ535121A (zh)
PE (1) PE20040682A1 (zh)
TW (1) TWI231756B (zh)
WO (1) WO2003078376A1 (zh)
ZA (1) ZA200407244B (zh)

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WO2002066453A1 (en) * 2001-02-22 2002-08-29 Natco Pharma Limited Process for the preparation of citalopram
SE0400850D0 (sv) * 2004-03-30 2004-03-31 Astrazeneca Ab Novel Compounds
EP1802601A1 (en) * 2004-09-20 2007-07-04 Targacept, Inc. Azaspiroalkene and azapiroalkane compounds with nicotinic cholinergic receptor activity
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