ZA200301319B - Hard capsule. - Google Patents

Hard capsule. Download PDF

Info

Publication number: ZA200301319B
Authority: ZA; South Africa
Prior art keywords: hard capsule; capsule; capsule according; hard; polymerizable vinyl
Prior art date: 2000-08-29

Application number

ZA200301319A

Other languages

English (en)

Inventor

Noboru Hoshi

Shigeru Sugiyama

Toshio Shimamoto

Original Assignee

Nisshin Kasei Co Ltd

Daido Chemical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-29

Filing date

2003-02-18

Publication date

2004-02-10

2003-02-18 Application filed by Nisshin Kasei Co Ltd, Daido Chemical Corp filed Critical Nisshin Kasei Co Ltd

2004-02-10 Publication of ZA200301319B publication Critical patent/ZA200301319B/en

Links

239000007902 hard capsule Substances 0.000 title claims description 113
239000002775 capsule Substances 0.000 claims description 50
-1 alkylamine salts Chemical class 0.000 claims description 35
239000004372 Polyvinyl alcohol Substances 0.000 claims description 33
229920002451 polyvinyl alcohol Polymers 0.000 claims description 33
235000019422 polyvinyl alcohol Nutrition 0.000 claims description 33
239000000178 monomer Substances 0.000 claims description 26
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 26
229920002554 vinyl polymer Polymers 0.000 claims description 26
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 23
235000014113 dietary fatty acids Nutrition 0.000 claims description 21
239000000194 fatty acid Substances 0.000 claims description 21
229930195729 fatty acid Natural products 0.000 claims description 21
229920000642 polymer Polymers 0.000 claims description 21
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 19
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 19
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 19
239000002202 Polyethylene glycol Substances 0.000 claims description 17
229920001223 polyethylene glycol Polymers 0.000 claims description 17
238000006116 polymerization reaction Methods 0.000 claims description 14
150000001875 compounds Chemical class 0.000 claims description 12
150000002148 esters Chemical class 0.000 claims description 12
239000003795 chemical substances by application Substances 0.000 claims description 11
229920001214 Polysorbate 60 Polymers 0.000 claims description 8
MTHSVFCYNBDYFN-UHFFFAOYSA-N anhydrous diethylene glycol Natural products OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 8
229920001577 copolymer Polymers 0.000 claims description 8
125000004432 carbon atom Chemical group C* 0.000 claims description 7
230000000379 polymerizing effect Effects 0.000 claims description 7
JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims description 6
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims description 6
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 6
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 6
229920001451 polypropylene glycol Polymers 0.000 claims description 6
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 6
239000004359 castor oil Substances 0.000 claims description 5
235000019438 castor oil Nutrition 0.000 claims description 5
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 5
125000003396 thiol group Chemical group [H]S* 0.000 claims description 5
229910052799 carbon Inorganic materials 0.000 claims description 4
239000002562 thickening agent Substances 0.000 claims description 4
229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 3
XLPJNCYCZORXHG-UHFFFAOYSA-N 1-morpholin-4-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCOCC1 XLPJNCYCZORXHG-UHFFFAOYSA-N 0.000 claims description 3
GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 claims description 3
WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 claims description 3
OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 3
RUMACXVDVNRZJZ-UHFFFAOYSA-N 2-methylpropyl 2-methylprop-2-enoate Chemical compound CC(C)COC(=O)C(C)=C RUMACXVDVNRZJZ-UHFFFAOYSA-N 0.000 claims description 3
CFVWNXQPGQOHRJ-UHFFFAOYSA-N 2-methylpropyl prop-2-enoate Chemical compound CC(C)COC(=O)C=C CFVWNXQPGQOHRJ-UHFFFAOYSA-N 0.000 claims description 3
WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 claims description 3
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 3
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 3
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 3
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 3
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims description 3
150000003863 ammonium salts Chemical class 0.000 claims description 3
CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 3
OIWOHHBRDFKZNC-UHFFFAOYSA-N cyclohexyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1CCCCC1 OIWOHHBRDFKZNC-UHFFFAOYSA-N 0.000 claims description 3
KBLWLMPSVYBVDK-UHFFFAOYSA-N cyclohexyl prop-2-enoate Chemical compound C=CC(=O)OC1CCCCC1 KBLWLMPSVYBVDK-UHFFFAOYSA-N 0.000 claims description 3
150000002170 ethers Chemical class 0.000 claims description 3
SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims description 3
150000004665 fatty acids Chemical class 0.000 claims description 3
239000001530 fumaric acid Substances 0.000 claims description 3
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
239000011976 maleic acid Substances 0.000 claims description 3
LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 3
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 3
159000000001 potassium salts Chemical class 0.000 claims description 3
159000000000 sodium salts Chemical class 0.000 claims description 3
230000008859 change Effects 0.000 description 48
238000012360 testing method Methods 0.000 description 31
238000000034 method Methods 0.000 description 27
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
238000005452 bending Methods 0.000 description 17
125000000914 phenoxymethylpenicillanyl group Chemical group CC1(S[C@H]2N([C@H]1C(=O)*)C([C@H]2NC(COC2=CC=CC=C2)=O)=O)C 0.000 description 17
238000011156 evaluation Methods 0.000 description 16
229940114077 acrylic acid Drugs 0.000 description 14
229940063559 methacrylic acid Drugs 0.000 description 14
230000015572 biosynthetic process Effects 0.000 description 13
238000004519 manufacturing process Methods 0.000 description 13
238000003786 synthesis reaction Methods 0.000 description 13
239000002904 solvent Substances 0.000 description 12
239000007903 gelatin capsule Substances 0.000 description 11
JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 11
230000001225 therapeutic effect Effects 0.000 description 11
239000012530 fluid Substances 0.000 description 10
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 10
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 10
239000002994 raw material Substances 0.000 description 10
239000004615 ingredient Substances 0.000 description 9
238000005259 measurement Methods 0.000 description 8
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
239000000825 pharmaceutical preparation Substances 0.000 description 8
239000007864 aqueous solution Substances 0.000 description 7
239000000203 mixture Substances 0.000 description 7
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 7
229920000053 polysorbate 80 Polymers 0.000 description 7
239000000126 substance Substances 0.000 description 7
108010010803 Gelatin Proteins 0.000 description 6
235000019417 choline salt Nutrition 0.000 description 6
GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 6
229920000159 gelatin Polymers 0.000 description 6
239000008273 gelatin Substances 0.000 description 6
235000019322 gelatine Nutrition 0.000 description 6
235000011852 gelatine desserts Nutrition 0.000 description 6
238000003860 storage Methods 0.000 description 6
230000006835 compression Effects 0.000 description 5
238000007906 compression Methods 0.000 description 5
229940079593 drug Drugs 0.000 description 5
239000003814 drug Substances 0.000 description 5
238000011049 filling Methods 0.000 description 5
CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
235000010418 carrageenan Nutrition 0.000 description 4
239000000679 carrageenan Substances 0.000 description 4
229920001525 carrageenan Polymers 0.000 description 4
229940113118 carrageenan Drugs 0.000 description 4
238000005266 casting Methods 0.000 description 4
229920002678 cellulose Polymers 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
238000004090 dissolution Methods 0.000 description 4
238000001879 gelation Methods 0.000 description 4
230000007062 hydrolysis Effects 0.000 description 4
238000006460 hydrolysis reaction Methods 0.000 description 4
238000005342 ion exchange Methods 0.000 description 4
239000000463 material Substances 0.000 description 4
238000002156 mixing Methods 0.000 description 4
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 4
239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000000654 additive Substances 0.000 description 3
239000007765 cera alba Substances 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 3
238000000465 moulding Methods 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 3
235000012239 silicon dioxide Nutrition 0.000 description 3
238000006467 substitution reaction Methods 0.000 description 3
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 description 2
239000013543 active substance Substances 0.000 description 2
ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
229910001424 calcium ion Inorganic materials 0.000 description 2
238000007334 copolymerization reaction Methods 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
238000007598 dipping method Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
229960002598 fumaric acid Drugs 0.000 description 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
229940098895 maleic acid Drugs 0.000 description 2
229940102838 methylmethacrylate Drugs 0.000 description 2
239000003505 polymerization initiator Substances 0.000 description 2
239000001103 potassium chloride Substances 0.000 description 2
235000011164 potassium chloride Nutrition 0.000 description 2
238000003756 stirring Methods 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
WHRZCXAVMTUTDD-UHFFFAOYSA-N 1h-furo[2,3-d]pyrimidin-2-one Chemical compound N1C(=O)N=C2OC=CC2=C1 WHRZCXAVMTUTDD-UHFFFAOYSA-N 0.000 description 1
LRRBNLHPFPHVCW-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;hydrogen peroxide Chemical compound OO.OC(=O)C(O)C(O)C(O)=O LRRBNLHPFPHVCW-UHFFFAOYSA-N 0.000 description 1
LCPVQAHEFVXVKT-UHFFFAOYSA-N 2-(2,4-difluorophenoxy)pyridin-3-amine Chemical compound NC1=CC=CN=C1OC1=CC=C(F)C=C1F LCPVQAHEFVXVKT-UHFFFAOYSA-N 0.000 description 1
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239000008101 lactose Substances 0.000 description 1
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210000003205 muscle Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
150000001451 organic peroxides Chemical class 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000012466 permeate Substances 0.000 description 1
JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920000223 polyglycerol Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229910001414 potassium ion Inorganic materials 0.000 description 1
USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
238000010926 purge Methods 0.000 description 1
239000012966 redox initiator Substances 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
230000035900 sweating Effects 0.000 description 1
238000010998 test method Methods 0.000 description 1
239000000814 tuberculostatic agent Substances 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Polymerisation Methods In General (AREA)
Graft Or Block Polymers (AREA)

ZA200301319A 2000-08-29 2003-02-18 Hard capsule. ZA200301319B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000259830		2000-08-29

Publications (1)

Publication Number	Publication Date
ZA200301319B true ZA200301319B (en)	2004-02-10

Family

ID=18747950

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200301319A ZA200301319B (en)	2000-08-29	2003-02-18	Hard capsule.

Country Status (15)

Country	Link
US (2)	US6967026B2 (fr)
EP (1)	EP1323404B1 (fr)
JP (1)	JP4596732B2 (fr)
KR (1)	KR100829474B1 (fr)
CN (1)	CN1209091C (fr)
AU (2)	AU8013801A (fr)
BR (1)	BR0113570A (fr)
CA (1)	CA2419825C (fr)
ES (1)	ES2437791T3 (fr)
HU (1)	HUP0300853A3 (fr)
MX (1)	MXPA03001854A (fr)
RU (1)	RU2003108732A (fr)
TW (1)	TWI249411B (fr)
WO (1)	WO2002017848A1 (fr)
ZA (1)	ZA200301319B (fr)

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IT1393524B1 (it) *	2009-01-30	2012-04-27	Altergon Sa	Contenitore per uso farmaceutico atto al rilascio quantitativo di una monodose per somministrazione orale di ormoni tiroidei t3 e t4 in soluzione
JPWO2010093020A1 (ja) *	2009-02-13	2012-08-16	日新化成株式会社	硬カプセル
WO2010114134A1 (fr)	2009-04-03	2010-10-07	日新化成株式会社	Capsule dure
US20120157580A1 (en) *	2009-08-31	2012-06-21	Hiroyuki Yoshino	Coating composition
JP5705206B2 (ja) *	2010-02-26	2015-04-22	日新化成株式会社	硬カプセルおよびその製造方法
RS60087B1 (sr)	2010-03-29	2020-05-29	Opko Ireland Global Holdings Ltd	Postupci i kompozicije za snižavanje nivoa paratireoidnog hormona
KR101847947B1 (ko)	2013-03-15	2018-05-28	옵코 아이피 홀딩스 Ⅱ 인코포레이티드	안정화되고 변형된 비타민 ｄ 방출 제형
ES2793530T3 (es) *	2014-05-19	2020-11-16	Tillotts Pharma Ag	Cápsulas revestidas de liberación modificada
CA2910865C (fr)	2014-07-15	2016-11-29	Isa Odidi	Compositions et methodes destines a reduire les surdoses
US10220047B2 (en)	2014-08-07	2019-03-05	Opko Ireland Global Holdings, Ltd.	Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
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KR102296142B1 (ko)	2016-07-06	2021-08-31	쿠오리카프스 가부시키가이샤	경도가 개선된 경질 캡슐 및 그 제조 방법
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2001
- 2001-08-24 EP EP01958454.9A patent/EP1323404B1/fr not_active Expired - Lifetime
- 2001-08-24 CN CNB018147372A patent/CN1209091C/zh not_active Expired - Fee Related
- 2001-08-24 HU HU0300853A patent/HUP0300853A3/hu unknown
- 2001-08-24 ES ES01958454.9T patent/ES2437791T3/es not_active Expired - Lifetime
- 2001-08-24 CA CA2419825A patent/CA2419825C/fr not_active Expired - Fee Related
- 2001-08-24 AU AU8013801A patent/AU8013801A/xx active Pending
- 2001-08-24 RU RU2003108732/15A patent/RU2003108732A/ru not_active Application Discontinuation
- 2001-08-24 KR KR1020037002968A patent/KR100829474B1/ko not_active Expired - Fee Related
- 2001-08-24 JP JP2002522823A patent/JP4596732B2/ja not_active Expired - Fee Related
- 2001-08-24 AU AU2001280138A patent/AU2001280138B2/en not_active Ceased
- 2001-08-24 MX MXPA03001854A patent/MXPA03001854A/es unknown
- 2001-08-24 WO PCT/JP2001/007244 patent/WO2002017848A1/fr not_active Ceased
- 2001-08-24 US US10/362,114 patent/US6967026B2/en not_active Expired - Fee Related
- 2001-08-24 BR BR0113570-8A patent/BR0113570A/pt not_active Application Discontinuation
- 2001-08-28 TW TW090121157A patent/TWI249411B/zh not_active IP Right Cessation
2003
- 2003-02-18 ZA ZA200301319A patent/ZA200301319B/en unknown
2005
- 2005-04-20 US US11/110,428 patent/US20050186268A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1323404B1 (fr)	2013-10-16
RU2003108732A (ru)	2004-07-27
EP1323404A8 (fr)	2004-02-25
US6967026B2 (en)	2005-11-22
JP4596732B2 (ja)	2010-12-15
KR100829474B1 (ko)	2008-05-16
US20050186268A1 (en)	2005-08-25
AU2001280138B2 (en)	2006-03-16
KR20030026358A (ko)	2003-03-31
HUP0300853A3 (en)	2006-07-28
EP1323404A4 (fr)	2005-06-22
EP1323404A1 (fr)	2003-07-02
BR0113570A (pt)	2004-07-06
CN1209091C (zh)	2005-07-06
MXPA03001854A (es)	2004-12-03
US20030166763A1 (en)	2003-09-04
CA2419825A1 (fr)	2003-02-18
HUP0300853A2 (hu)	2003-10-28
AU8013801A (en)	2002-03-13
TWI249411B (en)	2006-02-21
WO2002017848A1 (fr)	2002-03-07
ES2437791T3 (es)	2014-01-14
CN1449272A (zh)	2003-10-15
CA2419825C (fr)	2010-05-25

Publication	Publication Date	Title
CA2419825C (fr)	2010-05-25	Gelule dure faite d'un polymere ou d'un copolymere obtenu par polymerisation d'au moins un monomere du vinyle en presence de poly(alcool vinylique) ou d'un derive de ce dernier
JPWO2002017848A1 (ja)	2003-10-14	硬カプセル
AU682827B2 (en)	1997-10-23	Sustained-release hydrogel preparation
US6974591B2 (en)	2005-12-13	Method for producing a controlled-release preparation
CN1202812C (zh)	2005-05-25	直接压缩聚合物片剂核
US20080008750A1 (en)	2008-01-10	Band-Seals For Hard Capsules
US6436440B1 (en)	2002-08-20	Use of N-vinyllactam-or-N-vinylamine-containing copolymers as matrix for producing solid pharmaceutical and cosmetic presentations
EP2415485A1 (fr)	2012-02-08	Capsule dure
US3520970A (en)	1970-07-21	Solid oral drug medicament coated for rapid or gradual release with copolymers of polymerizable quaternary ammonium monomers and water-insoluble homopolymer-forming monomers
EP2397160A1 (fr)	2011-12-21	Gélule
US8900628B2 (en)	2014-12-02	Hard capsule and method for producing same
Park et al.	1994	Polymers in pharmaceutical products
ES2204036T3 (es)	2004-04-16	Empleo de copolimeros que contienen n-vinilpirrolidona y acetato de vinilo como matriz para la obtencion de preparados farmaceuticos y cosmeticos solidos, orales.
JP2007091670A (ja)	2007-04-12	退色が抑制された着色カプセル
CA3060026A1 (fr)	2018-10-25	Formulation a base de polymere pour la liberation de medicaments et de produits bioactifs au niveau de sites specifiques du git
WO2002018494A1 (fr)	2002-03-07	Composition de resine
Kostova et al.	2007	New co-polymer zwitterionic matrices for sustained release of verapamil hydrochloride