ZA200007222B - Glycopeptide derivatives and pharmaceutical compositions containing the same. - Google Patents

Glycopeptide derivatives and pharmaceutical compositions containing the same.

Info

Publication number: ZA200007222B
Authority: ZA; South Africa
Prior art keywords: pharmaceutical compositions; compositions containing; same; derivatives; glycopeptide derivatives
Prior art date: 1998-12-23

Application number

ZA200007222A

Other languages

English (en)

Inventor

J Kevin Judice

Bernice Lam

Martin Sheringham Linsell

Sean Gary Trapp

Gaung Yang

Paul Ross Fatheree

Michael Leadbetter

Yongqi Mu

Yan Zhu

Original Assignee

Advanced Medicine Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-23

Filing date

2000-12-06

Publication date

2002-03-06

2000-12-06 Application filed by Advanced Medicine Inc filed Critical Advanced Medicine Inc

2002-03-06 Publication of ZA200007222B publication Critical patent/ZA200007222B/xx

Links

DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title abstract 4
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200007222A 1998-12-23 2000-12-06 Glycopeptide derivatives and pharmaceutical compositions containing the same. ZA200007222B (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US11372898P	1998-12-23	1998-12-23
US12931399P	1999-04-14	1999-04-14
US16402499P	1999-11-04	1999-11-04
US16997899P	1999-12-10	1999-12-10
PCT/US1999/030543 WO2000039156A1 (en)	1998-12-23	1999-12-22	Glycopeptide derivatives and pharmaceutical compositions containing the same

Publications (1)

Publication Number	Publication Date
ZA200007222B true ZA200007222B (en)	2002-03-06

Family

ID=27493926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200007222A ZA200007222B (en)	1998-12-23	2000-12-06	Glycopeptide derivatives and pharmaceutical compositions containing the same.

Country Status (23)

Country	Link
US (9)	US6392012B1 (de)
EP (1)	EP1140993B1 (de)
JP (1)	JP4362017B2 (de)
KR (1)	KR100665204B1 (de)
CN (1)	CN1249081C (de)
AT (1)	ATE242783T1 (de)
AU (1)	AU768204B2 (de)
BR (1)	BRPI9914221B8 (de)
CA (1)	CA2336445C (de)
CZ (1)	CZ301184B6 (de)
DE (1)	DE69908819T2 (de)
DK (1)	DK1140993T3 (de)
ES (1)	ES2201825T3 (de)
HK (1)	HK1040721B (de)
HU (1)	HU230190B1 (de)
IL (2)	IL140093A0 (de)
NO (1)	NO326066B1 (de)
NZ (1)	NZ508594A (de)
PL (1)	PL198311B1 (de)
PT (1)	PT1140993E (de)
SI (1)	SI1140993T1 (de)
WO (1)	WO2000039156A1 (de)
ZA (1)	ZA200007222B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1140993E (pt) *	1998-12-23	2003-10-31	Theravance Inc	Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
US6699836B2 (en) *	1999-04-02	2004-03-02	The Trustees Of Princeton University	Vancomycin analogs
WO2000059528A1 (en) *	1999-04-02	2000-10-12	The Trustees Of Princeton University	Desleucyl glycopeptide antibiotics and methods of making same
WO2001057071A2 (en) *	2000-02-04	2001-08-09	Advanced Medicine, Inc.	Glycopeptide derivatives having antibiotic activity
WO2001083520A2 (en)	2000-05-02	2001-11-08	Theravance,Inc	Polyacid glycopeptide derivatives
AU2001257464A1 (en)	2000-05-02	2001-11-12	Theravance, Inc.	Reductive alkylation process on glycopeptides
BR0110530A (pt)	2000-05-02	2003-04-08	Theravance Inc	Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina
AU2001259816A1 (en)	2000-06-22	2002-01-02	Advanced Medecine, Inc.	Polyhydroxy glycopeptide derivatives
UA75083C2 (uk) *	2000-06-22	2006-03-15	Тераванс, Інк.	Похідні глікопептидфосфонатів
US6872804B2 (en)	2000-06-22	2005-03-29	Theravance, Inc.	Glycopeptide disulfide and thioester derivatives
AU2001259303A1 (en) *	2000-06-22	2002-01-02	Advanced Medicine, Inc.	Glycopeptide carboxy-saccharide derivatives
US6905669B2 (en) *	2001-04-24	2005-06-14	Supergen, Inc.	Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
TWI312785B (en)	2001-08-24	2009-08-01	Theravance Inc	Process for preparing vancomycin derivatives
TWI275594B (en)	2001-08-24	2007-03-11	Theravance Inc	Process for preparing vancomycin phosphonate derivatives
EP1295711B1 (de)	2001-09-19	2006-04-12	The Procter & Gamble Company	Farbbedruckte Mehrschichtstruktur, ein damit hergestellter absorbierender Artikel und Verfahren zu deren Herstellung
TWI335332B (en) *	2001-10-12	2011-01-01	Theravance Inc	Cross-linked vancomycin-cephalosporin antibiotics
CN101404986B (zh)	2002-05-17	2011-09-28	赛奎拉公司	用于诊断和治疗感染性疾病的组合物和制药方法
US20040033986A1 (en) *	2002-05-17	2004-02-19	Protopopova Marina Nikolaevna	Anti tubercular drug: compositions and methods
US6878686B2 (en)	2002-05-24	2005-04-12	Theravance, Inc.	Cross-linked glycopeptide-cephalosporin antibiotics
US6951963B2 (en)	2002-06-17	2005-10-04	Theravance, Inc.	Process for preparing N-protected β-amino aldehyde compounds
WO2004004712A1 (en) *	2002-07-09	2004-01-15	Fasgen, Llc	Methods of treating microbial infections in humans and animals
US20060074014A1 (en) *	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
AU2003299561A1 (en) *	2002-11-18	2004-06-15	Vicuron Pharmaceuticals Inc.	Compositions and methods for treating bacterial infections with protein-dalbavancin complexes
WO2004113350A1 (en)	2003-05-23	2004-12-29	Theravance, Inc.	Cross-linked glycopeptide - cephalosporin antibiotics
ATE388153T1 (de)	2003-07-11	2008-03-15	Theravance Inc	Quervernetzte glycopeptid-cephalosporin- antibiotika
DE102004055582A1 (de) *	2004-11-18	2006-05-24	Bayer Cropscience Ag	N-Heterocyclyl-phthalsäurediamide
US8778874B2 (en)	2004-11-29	2014-07-15	National University Corporation Nagoya University	Glycopeptide antibiotic monomer derivatives
US8304597B2 (en)	2004-12-15	2012-11-06	The Procter And Gamble Company	Method of using an absorbent article having a functional enhancement indicator
US7368422B2 (en) *	2005-02-28	2008-05-06	Novartis Vaccines And Diagnostics Inc.	Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) *	2005-02-28	2009-12-15	Novartis Vaccines And Diagnostics, Inc.	Semi-synthetic glycopeptides with antibiotic activity
US20070185015A1 (en) *	2005-02-28	2007-08-09	Chiron Corporation and North China Pharmaceutical Corporation	Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
EP1933881B1 (de)	2005-09-22	2019-03-13	Medivas, LLC	Feste polymer-abgabezusammensetzungen und anwendungsverfahren dafür
CA2623198C (en)	2005-09-22	2014-08-05	Medivas, Llc	Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
WO2007084507A2 (en) *	2006-01-13	2007-07-26	The Scripps Research Institute	[ψ[CH2NH]PG4] GLYCOPEPTIDE ANTIBIOTIC ANALOGS
TW200808818A (en)	2006-05-26	2008-02-16	Shionogi & Co	Glycopeptide antibiotic derivatives
AU2008343502A1 (en) *	2007-12-26	2009-07-09	Biomarin Pharmaceutical Inc.	Novel semi-synthetic glycopeptides as antibacterial agents
BRPI0821947A2 (pt)	2007-12-26	2015-09-22	Shionogi & Co	derivados de antibiótico de glicopetídeo glicosilatado
CN102083862A (zh)	2008-04-01	2011-06-01	康奈尔大学	有机-可溶性壳聚糖盐和由其制备的壳聚糖衍生生物材料
GB2465863A (en) *	2008-12-05	2010-06-09	Lead Therapeutics Inc	Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) *	2009-06-26	2013-10-16	上海来益生物药物研究开发中心有限责任公司	一种新的化合物及其应用
WO2012129493A1 (en) *	2011-03-24	2012-09-27	Seachaid Pharmaceuticals, Inc.	Vancomycin derivatives
KR102237887B1 (ko)	2013-03-15	2021-04-07	멜린타 서브시디어리 코프.	항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
AU2014322817A1 (en) *	2013-09-23	2016-04-21	Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)	Vancomycin-sugar conjugates and uses thereof
WO2016103284A1 (en) *	2014-12-25	2016-06-30	Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)	Glycopeptides and uses thereof
KR20210094657A (ko) *	2016-01-15	2021-07-29	함부르크대학교	람노실화된 플라보노이드의 제조 방법
JP2019511561A (ja) *	2016-01-28	2019-04-25	アカテコール・インコーポレイテッドＡＣａｔｅｃｈｏｌ，Ｉｎｃ．	光開裂性プライマー組成物および使用方法
CN107325159A (zh)	2016-04-29	2017-11-07	中国科学院上海药物研究所	一类万古霉素衍生物、其制备方法、药物组合物和用途
AU2018271873B2 (en)	2017-05-22	2023-11-02	Insmed Incorporated	Glycopeptide derivative compounds and uses thereof
CN107987131B (zh) *	2017-11-16	2021-03-09	上海来益生物药物研究开发中心有限责任公司	一组具有抗耐药性细菌活性的化合物、其制备方法和应用
CN108409837B (zh)	2018-03-06	2021-09-24	上海来益生物药物研究开发中心有限责任公司	一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
NL2023883B1 (en) *	2019-09-24	2021-04-26	Univ Leiden	Antibiotic compounds
CN111620931B (zh) *	2020-06-12	2021-12-17	苏州博源医疗科技有限公司	万古霉素衍生物及其制备方法和应用
CN114213284B (zh) *	2022-01-04	2023-08-01	丽珠集团福州福兴医药有限公司	(9h-芴-9-基)-癸基(2-氧代乙基)氨基甲酸甲酯及其合成方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4497802A (en)	1983-10-21	1985-02-05	Eli Lilly And Company	N-Acyl glycopeptide derivatives
US4914187A (en)	1984-11-13	1990-04-03	Gruppo Lepetit S.P.A	Ester derivatives of antibiotic L 17046
GB8428619D0 (en)	1984-11-13	1984-12-19	Lepetit Spa	Derivatives of antibiotic l 17046
US4698327A (en)	1985-04-25	1987-10-06	Eli Lilly And Company	Novel glycopeptide derivatives
US4643987A (en)	1985-08-14	1987-02-17	Eli Lilly And Company	Modified glycopeptides
US4639433A (en)	1985-08-14	1987-01-27	Eli Lilly And Company	Glycopeptide derivatives
GB8704847D0 (en)	1987-03-02	1987-04-08	Lepetit Spa	Substituted alkylamides of teicoplanin compounds
FR2632185B1 (fr) *	1988-06-01	1992-05-22	Rhone Poulenc Chimie	Silice pour compositions dentifrices compatible notamment avec le zinc
GB8817397D0 (en)	1988-07-21	1988-08-24	Lepetit Spa	N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
US5534420A (en)	1988-07-28	1996-07-09	Eli Lilly And Company	Biotransformation of glycopeptide antibiotics
ES2083374T3 (es) *	1988-12-27	1996-04-16	Lepetit Spa	Derivados amidicos en posicion c63 de 34-des(acetilglucosaminil)-34-desoxi-teicoplaninas.
IE64155B1 (en) *	1989-03-29	1995-07-12	Lepetit Spa	New substituted alkylamide derivatives of teicoplanin
ZA909847B (en)	1989-12-13	1992-08-26	Lilly Co Eli	Glycopeptide derivatives
AU647122B2 (en)	1990-05-28	1994-03-17	Gruppo Lepetit S.P.A.	C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy- teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
WO1992017456A1 (fr)	1991-03-26	1992-10-15	Fujisawa Pharmaceutical Co., Ltd.	Derive d'acide amine et sel dudit derive
US5750509A (en)	1991-07-29	1998-05-12	Gruppo Lepetit S.P.A.	Amide derivatives of antibiotic A 40926
EP0596929B1 (de)	1991-07-29	1995-07-26	GRUPPO LEPETIT S.p.A.	Amidderivate vom Antibiotikum A 40926
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
TW457248B (en)	1994-01-28	2001-10-01	Lilly Co Eli	Glycopeptide antibiotic derivatives
IT1282586B1 (it)	1996-02-08	1998-03-31	Chemical And Biolog Ind	Composizioni farmaceutiche per il trattamento biologico delle infezioni dovute a ceppi di enterococcus faecium resistenti agli
WO1997034623A1 (en)	1996-03-21	1997-09-25	Transcell Technologies, Inc.	Solid phase lipoglycopeptide library, compositions and methods
AU2609297A (en)	1996-04-12	1997-11-07	Eli Lilly And Company	Glycopeptide compounds
WO1997038702A1 (en)	1996-04-12	1997-10-23	Eli Lilly And Company	Covalently-linked glycopeptide dimers
US6218505B1 (en)	1996-04-23	2001-04-17	Biosearch Italia S.P.A.	Chemical process for preparing amide derivatives of antibiotic A 40926
US5919756A (en)	1996-06-28	1999-07-06	Eli Lilly And Company	Amides
US5952466A (en)	1997-11-12	1999-09-14	Eli Lilly And Company	Reductive alkylation of glycopeptide antibiotics
US5939382A (en)	1996-11-21	1999-08-17	Eli Lilly And Company	Reducing agent for reductive alkylation of glycopeptide antibiotics
US5916873A (en)	1997-04-17	1999-06-29	Eli Lilly And Company	Teicoplanin derivatives
US5952310A (en)	1997-05-20	1999-09-14	Eli Lilly And Company	Glycopeptide hexapeptides
US5977063A (en)	1997-05-20	1999-11-02	Eli Lilly And Company	Alkylated hexapeptides
US5919771A (en)	1997-05-20	1999-07-06	Eli Lilly And Company	Urea and thiourea derivatives of glycopeptides
US6518242B1 (en) *	1998-02-20	2003-02-11	Theravance, Inc.	Derivatives of glycopeptide antibacterial agents
FR2778184A1 (fr)	1998-02-20	1999-11-05	Advanced Medicine Inc	Composes a liaisons multiples antibacteriens nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
EP1073447B1 (de)	1998-05-01	2007-05-09	Eli Lilly And Company	N1 modifizierte glycopeptide
WO2000004044A1 (en)	1998-07-14	2000-01-27	Princeton University	Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
PT1140993E (pt)	1998-12-23	2003-10-31	Theravance Inc	Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
UA75083C2 (uk) *	2000-06-22	2006-03-15	Тераванс, Інк.	Похідні глікопептидфосфонатів
US6878686B2 (en) *	2002-05-24	2005-04-12	Theravance, Inc.	Cross-linked glycopeptide-cephalosporin antibiotics
ATE388153T1 (de) *	2003-07-11	2008-03-15	Theravance Inc	Quervernetzte glycopeptid-cephalosporin- antibiotika

1999
- 1999-12-22 PT PT99965331T patent/PT1140993E/pt unknown
- 1999-12-22 ES ES99965331T patent/ES2201825T3/es not_active Expired - Lifetime
- 1999-12-22 EP EP99965331A patent/EP1140993B1/de not_active Expired - Lifetime
- 1999-12-22 PL PL348451A patent/PL198311B1/pl unknown
- 1999-12-22 NZ NZ508594A patent/NZ508594A/en not_active IP Right Cessation
- 1999-12-22 BR BRPI9914221A patent/BRPI9914221B8/pt not_active IP Right Cessation
- 1999-12-22 HU HU0400887A patent/HU230190B1/hu unknown
- 1999-12-22 CN CNB99809434XA patent/CN1249081C/zh not_active Expired - Lifetime
- 1999-12-22 AU AU31273/00A patent/AU768204B2/en not_active Expired
- 1999-12-22 IL IL14009399A patent/IL140093A0/xx active IP Right Grant
- 1999-12-22 US US09/470,209 patent/US6392012B1/en not_active Expired - Lifetime
- 1999-12-22 SI SI9930389T patent/SI1140993T1/xx unknown
- 1999-12-22 CZ CZ20010022A patent/CZ301184B6/cs not_active IP Right Cessation
- 1999-12-22 JP JP2000591067A patent/JP4362017B2/ja not_active Expired - Fee Related
- 1999-12-22 WO PCT/US1999/030543 patent/WO2000039156A1/en not_active Ceased
- 1999-12-22 HK HK02102171.5A patent/HK1040721B/en unknown
- 1999-12-22 CA CA2336445A patent/CA2336445C/en not_active Expired - Lifetime
- 1999-12-22 DK DK99965331T patent/DK1140993T3/da active
- 1999-12-22 DE DE69908819T patent/DE69908819T2/de not_active Expired - Lifetime
- 1999-12-22 KR KR1020017003918A patent/KR100665204B1/ko not_active Expired - Lifetime
- 1999-12-22 AT AT99965331T patent/ATE242783T1/de active
2000
- 2000-09-06 US US09/656,473 patent/US6444786B1/en not_active Expired - Lifetime
- 2000-11-01 US US09/674,456 patent/US6455669B1/en not_active Expired - Lifetime
- 2000-12-05 IL IL140093A patent/IL140093A/en not_active IP Right Cessation
- 2000-12-06 ZA ZA200007222A patent/ZA200007222B/xx unknown
- 2000-12-12 NO NO20006323A patent/NO326066B1/no not_active IP Right Cessation
2002
- 2002-03-06 US US10/092,088 patent/US6962970B2/en not_active Expired - Lifetime
2004
- 2004-04-15 US US10/825,038 patent/US6949681B2/en not_active Expired - Lifetime
2005
- 2005-05-13 US US11/128,901 patent/US7101964B2/en not_active Expired - Lifetime
2006
- 2006-04-17 US US11/405,234 patent/US7351791B2/en not_active Expired - Fee Related
2007
- 2007-10-24 US US11/977,377 patent/US7723470B2/en not_active Expired - Fee Related
2009
- 2009-05-08 US US12/437,778 patent/US8030445B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20050239690A1 (en)	2005-10-27
HK1040721B (en)	2003-10-17
CZ200122A3 (en)	2001-06-13
NO20006323D0 (no)	2000-12-12
CA2336445C (en)	2011-07-19
JP4362017B2 (ja)	2009-11-11
US6962970B2 (en)	2005-11-08
CA2336445A1 (en)	2000-07-06
PT1140993E (pt)	2003-10-31
DE69908819D1 (de)	2003-07-17
CN1249081C (zh)	2006-04-05
AU3127300A (en)	2000-07-31
US20060241024A1 (en)	2006-10-26
PL198311B1 (pl)	2008-06-30
US20030060598A1 (en)	2003-03-27
US6444786B1 (en)	2002-09-03
PL348451A1 (en)	2002-05-20
US20090215982A1 (en)	2009-08-27
HK1040721A1 (en)	2002-06-21
US7351791B2 (en)	2008-04-01
EP1140993B1 (de)	2003-06-11
IL140093A (en)	2006-06-11
CN1315961A (zh)	2001-10-03
HU230190B1 (hu)	2015-09-28
US8030445B2 (en)	2011-10-04
BRPI9914221B8 (pt)	2021-05-25
KR20010085857A (ko)	2001-09-07
AU768204B2 (en)	2003-12-04
EP1140993A1 (de)	2001-10-10
DE69908819T2 (de)	2004-05-06
NO326066B1 (no)	2008-09-08
IL140093A0 (en)	2002-02-10
SI1140993T1 (en)	2003-12-31
KR100665204B1 (ko)	2007-01-04
BR9914221A (pt)	2001-06-26
NO20006323L (no)	2001-02-12
DK1140993T3 (da)	2003-10-06
ES2201825T3 (es)	2004-03-16
CZ301184B6 (cs)	2009-12-02
NZ508594A (en)	2003-05-30
US20080103292A1 (en)	2008-05-01
ATE242783T1 (de)	2003-06-15
US6455669B1 (en)	2002-09-24
JP2002533472A (ja)	2002-10-08
HUP0400887A2 (hu)	2004-08-30
US7101964B2 (en)	2006-09-05
US7723470B2 (en)	2010-05-25
US6392012B1 (en)	2002-05-21
US6949681B2 (en)	2005-09-27
US20040204346A1 (en)	2004-10-14
BR9914221B1 (pt)	2013-12-31
HUP0400887A3 (en)	2012-09-28
WO2000039156A1 (en)	2000-07-06

Publication	Publication Date	Title
ZA200007222B (en)	2002-03-06	Glycopeptide derivatives and pharmaceutical compositions containing the same.
AU2002239344A1 (en)	2002-06-24	Pyrazolopyridines
DE60204452D1 (de)	2005-07-07	Pyrazolo[1,5]pyridinderivate
CA2274464A1 (en)	1998-06-18	Ketobenzamides as calpain inhibitors
WO2001098328A3 (en)	2002-04-11	Glycopeptide phosphonate derivatives
PL337329A1 (en)	2000-08-14	Oxazolydinone based antibacterial agents comprising a thiocarbonyl functional group
HRP20020330B1 (de)	2013-01-31
CA2243504A1 (en)	1997-07-31	New 19-nor-pregnene derivatives
DE60112330D1 (en)	2005-09-01	Pyrazolopyridinderivate
GB0011203D0 (en)	2000-06-28	Chemical compounds
IL140070A0 (en)	2002-02-10	Benzamide derivatives and pharmaceutical compositions containing the same
CA2152771A1 (en)	1996-01-29	7-o-ethers of taxane derivatives
BG104575A (en)	2001-02-28	Matrix metalloprotease inhibitors
AU2002357740A1 (en)	2003-06-23	Pyrazolo-pyridine derivatives as antiherpes agents
AU2002248531A1 (en)	2002-09-24	Pyrazolopyriadine derivatives
EP1073447A4 (de)	2001-10-04	N1 modifizierte glycopeptide
SE9904128D0 (sv)	1999-11-15	Novel compounds
MY133195A (en)	2007-10-31	Polycyclic thiazole systems, processes for their preparation and pharmaceuticals comprising these compounds
WO2001057071A3 (en)	2003-10-30	Glycopeptide derivatives having antibiotic activity
MY123217A (en)	2006-05-31	Glycopeptide derivatives and pharmaceutical compositions containing the same
TR200103169T2 (tr)	2002-04-22	1,5-Benzodiazepin türevleri
CA2420056A1 (en)	2002-03-28	1-amino-alkylcyclohexanes as trypanocidal agents
AU1783700A (en)	2000-07-12	1,8-benzonaphthyridine derivatives
BR9915898A (pt)	2001-08-21	Compostos, composição farmacêutica, e, utilização de um composto