ZA200005797B - Imidazo pyridine derivatives which inhibit gastric acid secretion. - Google Patents

Imidazo pyridine derivatives which inhibit gastric acid secretion. Download PDF

Info

Publication number: ZA200005797B
Authority: ZA; South Africa
Prior art keywords: compound; formula; carboxamide; pyridine; dimethyl
Prior art date: 1998-04-29

Application number

ZA200005797A

Other languages

English (en)

Inventor

Kosrat Amin

Michael Dahlstroem

Peter Nordberg

Ingemar Starke

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-29

Filing date

2000-10-18

Publication date

2002-01-18

2000-10-18 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-01-18 Publication of ZA200005797B publication Critical patent/ZA200005797B/en

Links

230000027119 gastric acid secretion Effects 0.000 title claims description 10
125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 137
125000000217 alkyl group Chemical group 0.000 claims description 34
238000000034 method Methods 0.000 claims description 28
239000000203 mixture Substances 0.000 claims description 26
239000012442 inert solvent Substances 0.000 claims description 23
238000002360 preparation method Methods 0.000 claims description 21
238000011282 treatment Methods 0.000 claims description 18
150000003839 salts Chemical class 0.000 claims description 16
230000008569 process Effects 0.000 claims description 14
239000002253 acid Substances 0.000 claims description 11
125000004185 ester group Chemical group 0.000 claims description 10
239000008194 pharmaceutical composition Substances 0.000 claims description 10
208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims description 9
241000282414 Homo sapiens Species 0.000 claims description 9
239000004480 active ingredient Substances 0.000 claims description 9
229910052736 halogen Inorganic materials 0.000 claims description 9
150000002367 halogens Chemical class 0.000 claims description 9
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QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 8
241000124008 Mammalia Species 0.000 claims description 6
239000004599 antimicrobial Substances 0.000 claims description 6
-1 carboxamide mesylate Chemical class 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 6
238000011321 prophylaxis Methods 0.000 claims description 6
241000590002 Helicobacter pylori Species 0.000 claims description 5
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210000001156 gastric mucosa Anatomy 0.000 claims description 5
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MUDJXGVFMYNBMY-UHFFFAOYSA-N 8-[(2,6-dimethylphenyl)methylamino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide Chemical compound C=1C(C(N)=O)=CN2C(C)=C(C)N=C2C=1NCC1=C(C)C=CC=C1C MUDJXGVFMYNBMY-UHFFFAOYSA-N 0.000 claims description 4
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229940040944 tetracyclines Drugs 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA200005797A 1998-04-29 2000-10-18 Imidazo pyridine derivatives which inhibit gastric acid secretion. ZA200005797B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9801526A SE9801526D0 (sv)	1998-04-29	1998-04-29	New compounds

Publications (1)

Publication Number	Publication Date
ZA200005797B true ZA200005797B (en)	2002-01-18

Family

ID=20411154

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ZA200005797A ZA200005797B (en)	1998-04-29	2000-10-18	Imidazo pyridine derivatives which inhibit gastric acid secretion.
ZA200005796A ZA200005796B (en)	1998-04-29	2000-10-18	Imidazo pyridine derivatives which inhibit gastric acid secretion.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ZA200005796A ZA200005796B (en)	1998-04-29	2000-10-18	Imidazo pyridine derivatives which inhibit gastric acid secretion.

Country Status (33)

Country	Link
US (2)	US6313136B1 (is)
EP (4)	EP1491542B1 (is)
JP (2)	JP3692034B2 (is)
KR (3)	KR100595805B1 (is)
CN (2)	CN1165535C (is)
AR (2)	AR015768A1 (is)
AT (4)	ATE372339T1 (is)
AU (2)	AU769190B2 (is)
BR (2)	BR9909996B1 (is)
CA (2)	CA2329922C (is)
CZ (2)	CZ292567B6 (is)
DE (4)	DE69937076T2 (is)
DK (2)	DK1073656T3 (is)
EE (2)	EE04916B1 (is)
ES (2)	ES2249913T3 (is)
HU (2)	HUP0102425A3 (is)
ID (2)	ID26819A (is)
IL (4)	IL139200A0 (is)
IS (2)	IS5683A (is)
MY (2)	MY121379A (is)
NO (2)	NO318203B1 (is)
NZ (2)	NZ507639A (is)
PL (2)	PL343797A1 (is)
RU (2)	RU2238271C2 (is)
SA (2)	SA99200065B1 (is)
SE (1)	SE9801526D0 (is)
SI (1)	SI1073656T1 (is)
SK (2)	SK285768B6 (is)
TR (4)	TR200102612T2 (is)
TW (2)	TWI250159B (is)
UA (2)	UA67769C2 (is)
WO (2)	WO1999055706A1 (is)
ZA (2)	ZA200005797B (is)

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RU2403904C1 (ru) *	2009-02-26	2010-11-20	Федеральное государственное учреждение "Научно-исследовательский институт по изучению лепры Федерального агентства по здравоохранению и социальному развитию Росздрава"	Способ профилактики острых гастродуоденальных язв у больных колоректальным раком в раннем послеоперационном периоде
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CN106279151A (zh) *	2015-06-26	2017-01-04	江苏太瑞生诺生物医药科技有限公司	5-(2-(8-((2,6-二甲基苄基)氨基)-2,3-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺基)乙氧基)-5-氧代戊酸的固体形式及其制备方法
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CN111683976B (zh)	2018-02-05	2022-11-18	生物辐射实验室股份有限公司	具有阴离子交换-疏水混合模式配体的色谱树脂
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1998
- 1998-04-29 SE SE9801526A patent/SE9801526D0/xx unknown
1999
- 1999-04-16 AR ARP990101776A patent/AR015768A1/es active IP Right Grant
- 1999-04-16 TW TW088106128A patent/TWI250159B/zh not_active IP Right Cessation
- 1999-04-16 TW TW088106129A patent/TW490466B/zh not_active IP Right Cessation
- 1999-04-16 AR ARP990101777A patent/AR015769A1/es active IP Right Grant
- 1999-04-23 PL PL99343797A patent/PL343797A1/xx unknown
- 1999-04-23 TR TR2001/02612T patent/TR200102612T2/xx unknown
- 1999-04-23 AU AU43007/99A patent/AU769190B2/en not_active Ceased
- 1999-04-23 SK SK1492-2000A patent/SK285768B6/sk not_active IP Right Cessation
- 1999-04-23 DE DE69937076T patent/DE69937076T2/de not_active Expired - Lifetime
- 1999-04-23 RU RU2000127019/04A patent/RU2238271C2/ru active
- 1999-04-23 WO PCT/SE1999/000663 patent/WO1999055706A1/en not_active Ceased
- 1999-04-23 US US09/319,890 patent/US6313136B1/en not_active Expired - Fee Related
- 1999-04-23 PL PL343801A patent/PL195000B1/pl not_active IP Right Cessation
- 1999-04-23 AT AT04023090T patent/ATE372339T1/de not_active IP Right Cessation
- 1999-04-23 DE DE69928792T patent/DE69928792T2/de not_active Expired - Lifetime
- 1999-04-23 CN CNB998078026A patent/CN1165535C/zh not_active Expired - Fee Related
- 1999-04-23 KR KR1020057022787A patent/KR100595805B1/ko not_active Expired - Fee Related
- 1999-04-23 KR KR1020007012028A patent/KR100650472B1/ko not_active Expired - Fee Related
- 1999-04-23 DE DE69937077T patent/DE69937077T2/de not_active Expired - Lifetime
- 1999-04-23 EE EEP200000664A patent/EE04916B1/xx not_active IP Right Cessation
- 1999-04-23 NZ NZ507639A patent/NZ507639A/en unknown
- 1999-04-23 CA CA002329922A patent/CA2329922C/en not_active Expired - Fee Related
- 1999-04-23 CZ CZ20003982A patent/CZ292567B6/cs not_active IP Right Cessation
- 1999-04-23 ES ES99947037T patent/ES2249913T3/es not_active Expired - Lifetime
- 1999-04-23 ES ES99947038T patent/ES2252975T3/es not_active Expired - Lifetime
- 1999-04-23 NZ NZ507638A patent/NZ507638A/en unknown
- 1999-04-23 EE EEP200000626A patent/EE04676B1/xx not_active IP Right Cessation
- 1999-04-23 CN CNB998077992A patent/CN1174980C/zh not_active Expired - Fee Related
- 1999-04-23 SK SK1491-2000A patent/SK14912000A3/sk unknown
- 1999-04-23 DE DE69927803T patent/DE69927803T2/de not_active Expired - Lifetime
- 1999-04-23 RU RU2000127020/04A patent/RU2235725C2/ru active
- 1999-04-23 AT AT04023091T patent/ATE372340T1/de not_active IP Right Cessation
- 1999-04-23 WO PCT/SE1999/000662 patent/WO1999055705A1/en not_active Ceased
- 1999-04-23 UA UA2000106033A patent/UA67769C2/uk unknown
- 1999-04-23 ID IDW20002206A patent/ID26819A/id unknown
- 1999-04-23 EP EP04023090A patent/EP1491542B1/en not_active Expired - Lifetime
- 1999-04-23 TR TR2001/02728T patent/TR200102728T2/xx unknown
- 1999-04-23 AT AT99947037T patent/ATE307130T1/de not_active IP Right Cessation
- 1999-04-23 AU AU43006/99A patent/AU769108B2/en not_active Ceased
- 1999-04-23 EP EP99947038A patent/EP1073657B1/en not_active Expired - Lifetime
- 1999-04-23 AT AT99947038T patent/ATE312101T1/de not_active IP Right Cessation
- 1999-04-23 TR TR2000/03149T patent/TR200003149T2/xx unknown
- 1999-04-23 KR KR1020007012027A patent/KR100595806B1/ko not_active Expired - Fee Related
- 1999-04-23 JP JP2000545865A patent/JP3692034B2/ja not_active Expired - Fee Related
- 1999-04-23 SI SI9930850T patent/SI1073656T1/sl unknown
- 1999-04-23 HU HU0102425A patent/HUP0102425A3/hu unknown
- 1999-04-23 EP EP04023091A patent/EP1491543B1/en not_active Expired - Lifetime
- 1999-04-23 CA CA002329921A patent/CA2329921A1/en not_active Abandoned
- 1999-04-23 IL IL13920099A patent/IL139200A0/xx unknown
- 1999-04-23 DK DK99947037T patent/DK1073656T3/da active
- 1999-04-23 UA UA2000106034A patent/UA66846C2/uk unknown
- 1999-04-23 BR BRPI9909996-9A patent/BR9909996B1/pt not_active IP Right Cessation
- 1999-04-23 JP JP2000545864A patent/JP3883383B2/ja not_active Expired - Fee Related
- 1999-04-23 IL IL13929799A patent/IL139297A0/xx active IP Right Grant
- 1999-04-23 HU HU0102313A patent/HUP0102313A3/hu unknown
- 1999-04-23 CZ CZ20003981A patent/CZ293977B6/cs not_active IP Right Cessation
- 1999-04-23 DK DK99947038T patent/DK1073657T3/da active
- 1999-04-23 EP EP99947037A patent/EP1073656B1/en not_active Expired - Lifetime
- 1999-04-23 TR TR2000/03176T patent/TR200003176T2/xx unknown
- 1999-04-23 BR BRPI9909995-0A patent/BR9909995B1/pt not_active IP Right Cessation
- 1999-04-23 ID IDW20002205A patent/ID27530A/id unknown
- 1999-04-23 US US09/319,973 patent/US6313137B1/en not_active Expired - Fee Related
- 1999-04-27 MY MYPI99001650A patent/MY121379A/en unknown
- 1999-04-27 MY MYPI99001649A patent/MY121389A/en unknown
- 1999-05-01 SA SA99200065A patent/SA99200065B1/ar unknown
- 1999-05-01 SA SA99200064A patent/SA99200064B1/ar unknown
2000
- 2000-10-18 ZA ZA200005797A patent/ZA200005797B/en unknown
- 2000-10-18 ZA ZA200005796A patent/ZA200005796B/en unknown
- 2000-10-23 IL IL139200A patent/IL139200A/en not_active IP Right Cessation
- 2000-10-25 IS IS5683A patent/IS5683A/is unknown
- 2000-10-25 IS IS5684A patent/IS5684A/is unknown
- 2000-10-26 IL IL139297A patent/IL139297A/en not_active IP Right Cessation
- 2000-10-27 NO NO20005451A patent/NO318203B1/no not_active IP Right Cessation
- 2000-10-27 NO NO20005450A patent/NO317262B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1174980C (zh)	2004-11-10
KR100650472B1 (ko)	2006-11-28
JP2002513025A (ja)	2002-05-08
SA99200064B1 (ar)	2006-10-11
HK1033457A1 (en)	2001-08-31
EE200000664A (et)	2002-04-15
EP1491542B1 (en)	2007-09-05
TR200003149T2 (tr)	2001-03-21
TR200102612T2 (tr)	2002-06-21
AU4300799A (en)	1999-11-16
HK1033317A1 (en)	2001-08-24
HUP0102313A3 (en)	2002-10-28
HK1071139A1 (en)	2005-07-08
EP1491543B1 (en)	2007-09-05
JP3883383B2 (ja)	2007-02-21
HUP0102313A2 (hu)	2001-12-28
NO20005451L (no)	2000-12-27
DE69937076D1 (de)	2007-10-18
KR100595805B1 (ko)	2006-07-03
SA99200065B1 (ar)	2006-11-07
AU769190B2 (en)	2004-01-22
EE04676B1 (et)	2006-08-15
EP1073657B1 (en)	2005-12-07
TR200003176T2 (tr)	2001-03-21
AR015768A1 (es)	2001-05-16
SA99200065A (ar)	2005-12-03
CZ292567B6 (cs)	2003-10-15
HUP0102425A2 (hu)	2001-11-28
BR9909996B1 (pt)	2010-08-24
CA2329922C (en)	2006-04-11
CA2329921A1 (en)	1999-11-04
SK14912000A3 (sk)	2001-06-11
KR20010043133A (ko)	2001-05-25
DK1073656T3 (da)	2006-01-16
DE69937077T2 (de)	2008-05-29
RU2235725C2 (ru)	2004-09-10
TWI250159B (en)	2006-03-01
ATE372339T1 (de)	2007-09-15
HK1036981A1 (en)	2002-01-25
EP1073656A1 (en)	2001-02-07
CN1306533A (zh)	2001-08-01
ID27530A (id)	2001-04-12
WO1999055705A1 (en)	1999-11-04
NO20005451D0 (no)	2000-10-27
IS5684A (is)	2000-10-25
SK14922000A3 (sk)	2001-06-11
CZ20003981A3 (cs)	2001-03-14
RU2238271C2 (ru)	2004-10-20
KR20010043134A (ko)	2001-05-25
US6313136B1 (en)	2001-11-06
MY121379A (en)	2006-01-28
WO1999055706A9 (en)	2000-03-16
DE69937076T2 (de)	2008-05-29
MY121389A (en)	2006-01-28
JP3692034B2 (ja)	2005-09-07
ATE372340T1 (de)	2007-09-15
DE69927803D1 (de)	2006-03-02
AU769108B2 (en)	2004-01-15
DE69927803T2 (de)	2006-07-06
NZ507639A (en)	2004-01-30
TR200102728T2 (tr)	2002-06-21
IL139297A0 (en)	2001-11-25
EP1073657A1 (en)	2001-02-07
DE69937077D1 (de)	2007-10-18
UA67769C2 (uk)	2004-07-15
CN1307577A (zh)	2001-08-08
BR9909995A (pt)	2000-12-26
HK1036984A1 (en)	2002-01-25
IL139200A (en)	2010-04-29
PL343797A1 (en)	2001-09-10
EE200000626A (et)	2002-04-15
SK285768B6 (sk)	2007-07-06
CZ293977B6 (cs)	2004-09-15
SI1073656T1 (sl)	2006-02-28
WO1999055706A1 (en)	1999-11-04
ES2249913T3 (es)	2006-04-01
KR20050121760A (ko)	2005-12-27
PL195000B1 (pl)	2007-07-31
EP1491542A2 (en)	2004-12-29
KR100595806B1 (ko)	2006-07-03
NO318203B1 (no)	2005-02-14
HUP0102425A3 (en)	2002-12-28
IS5683A (is)	2000-10-25
IL139200A0 (en)	2001-11-25
NO317262B1 (no)	2004-09-27
DE69928792D1 (de)	2006-01-12
ID26819A (id)	2001-02-15
EP1491543A1 (en)	2004-12-29
CN1165535C (zh)	2004-09-08
EE04916B1 (et)	2007-10-15
SE9801526D0 (sv)	1998-04-29
CA2329922A1 (en)	1999-11-04
ATE312101T1 (de)	2005-12-15
EP1073656B1 (en)	2005-10-19
DE69928792T2 (de)	2006-07-20
ES2252975T3 (es)	2006-05-16
DK1073657T3 (da)	2006-03-13
PL343801A1 (en)	2001-09-10
CZ20003982A3 (cs)	2001-02-14
US6313137B1 (en)	2001-11-06
NO20005450D0 (no)	2000-10-27
IL139297A (en)	2007-06-03
BR9909995B1 (pt)	2010-07-13
TW490466B (en)	2002-06-11
UA66846C2 (uk)	2004-06-15
BR9909996A (pt)	2000-12-26
NZ507638A (en)	2003-10-31
EP1491542A3 (en)	2005-01-05
AU4300699A (en)	1999-11-16
NO20005450L (no)	2000-12-22
JP2002513024A (ja)	2002-05-08
AR015769A1 (es)	2001-05-16
ZA200005796B (en)	2002-01-18
ATE307130T1 (de)	2005-11-15

Publication	Publication Date	Title
ZA200005797B (en)	2002-01-18	Imidazo pyridine derivatives which inhibit gastric acid secretion.
AU752187B2 (en)	2002-09-12	Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof
CZ301499A3 (cs)	2000-02-16	Sloučeniny pro inhibici sekrece žaludeční kyseliny
US6613775B1 (en)	2003-09-02	Imidazo[1,2-a]pyridine compounds
US20040220209A1 (en)	2004-11-04	Novel imidazopyridine compounds with therapeutic effect
HK1033457B (en)	2006-04-07	Imidazo pyridine derivatives which inhibit gastric acid secretion
HK1033317B (en)	2006-06-30	Imidazo pyridine derivatives which inhibit gastric acid secretion
HK1036274B (en)	2003-12-05	Imidazo (1,2-a) pyridine derivatives for the treatment of gastrointestinal diseases
AU2002324402A1 (en)	2003-03-10	Novel imidazopyridine compounds with therapeutic effect