YU81800A - POSTUPAK ZA DOBIJANJE INHIBITORA HMG-CoA REDUKTAZE VISOKE ČISTOĆE - Google Patents
POSTUPAK ZA DOBIJANJE INHIBITORA HMG-CoA REDUKTAZE VISOKE ČISTOĆEInfo
- Publication number
- YU81800A YU81800A YU81800A YU81800A YU81800A YU 81800 A YU81800 A YU 81800A YU 81800 A YU81800 A YU 81800A YU 81800 A YU81800 A YU 81800A YU 81800 A YU81800 A YU 81800A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- coa reductase
- reductase inhibitors
- hmg
- purity
- chemical synthesis
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 4
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 4
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 241000894007 species Species 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 241000187643 Amycolatopsis Species 0.000 abstract 1
- 241000228212 Aspergillus Species 0.000 abstract 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 241000235395 Mucor Species 0.000 abstract 1
- 241000187654 Nocardia Species 0.000 abstract 1
- 241000228143 Penicillium Species 0.000 abstract 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 abstract 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
- AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 229960005370 atorvastatin Drugs 0.000 abstract 1
- 238000002086 displacement chromatography Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229960004844 lovastatin Drugs 0.000 abstract 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
- 229950009116 mevastatin Drugs 0.000 abstract 1
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract 1
- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 229960002965 pravastatin Drugs 0.000 abstract 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229960002855 simvastatin Drugs 0.000 abstract 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/422—Displacement mode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin i njihovi derivati i analozi su poznati kao inhibitori HMG-CoA reduktaze i upotrebljavaju se kao antihiperholesterolemijski agensi. Najveci deo njih se proizvodi fermentacijom, upotrebom mikroorganizama razlicitih vrsta, odredjenih kao vrste koje pripadaju Aspergillus, Monascus, Nocardia, Amicolatopsis, Mucor ili Penicillium genus, neki se dobijaju tretmanom proizvoda fermentacije koriscenjem metoda hemijske sinteze ili su proizvodi totalne hemijske sinteze. Cistoca aktivnog sastojka je vazan faktor u proizvodnji bezbednog i delotvornog farmaceutskog preparata narocito, ukoliko se farmaceutski proizvod mora koristiti tokom lecenja ili prevencije visokog plazmatskog holesterola, zasnovanih na duzem vremenskom periodu. Akumulacija necistoca iz farmaceutskih preparata nize cistoce moze prouzrokovati brojne sporedne efekte u toku lecenja. Ovaj pronalazak se odnosi na novi industrijski postupak za izolovanje inhibitora HMG-CoA reduktaze upotrebom takozvane, hromatografije istiskivanjem. Upotreba pronalaska omogucuje dobijanje inhibitora HMG-CoA reduktaze visoke cistoce, u visokim prinosima, sa niskim troskovima proizvodnje i pogodnim ekoloskim balansom.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9800241A SI20072A (sl) | 1998-09-18 | 1998-09-18 | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU81800A true YU81800A (sh) | 2003-02-28 |
| RS49996B RS49996B (sr) | 2008-09-29 |
Family
ID=20432332
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6695969B1 (sh) |
| EP (1) | EP1114040B1 (sh) |
| JP (1) | JP3795755B2 (sh) |
| KR (1) | KR100607608B1 (sh) |
| CN (1) | CN1186335C (sh) |
| AT (1) | ATE284396T1 (sh) |
| AU (1) | AU766630B2 (sh) |
| BG (1) | BG64676B1 (sh) |
| CA (1) | CA2343645A1 (sh) |
| DE (1) | DE69922519T2 (sh) |
| HR (1) | HRP20010045B1 (sh) |
| HU (1) | HUP0102997A2 (sh) |
| IL (2) | IL142056A0 (sh) |
| IS (1) | IS2149B (sh) |
| NZ (1) | NZ509582A (sh) |
| PL (1) | PL200336B1 (sh) |
| RO (1) | RO121116B1 (sh) |
| RS (1) | RS49996B (sh) |
| RU (1) | RU2235098C2 (sh) |
| SI (1) | SI20072A (sh) |
| SK (1) | SK285868B6 (sh) |
| WO (1) | WO2000017182A1 (sh) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
| US7141602B2 (en) * | 1998-09-18 | 2006-11-28 | Lek Pharmaceuticals D.D. | Process for obtaining HMG-CoA reductase inhibitors of high purity |
| HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| DE04010770T1 (de) * | 1999-11-30 | 2005-10-20 | Biogal Gyogyszergyar | Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe |
| SK8312002A3 (en) * | 1999-12-14 | 2003-05-02 | Biogal Gyogyszergyar | Novel forms of pravastatin sodium |
| US6521762B2 (en) | 2000-03-03 | 2003-02-18 | BIOGAL Gyógyszergyar RT. | Process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
| US20050215636A1 (en) * | 2000-10-05 | 2005-09-29 | Vilmos Keri | Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same |
| JP3737801B2 (ja) * | 2000-10-05 | 2006-01-25 | テバ ジョジセルジャール レースベニュタールシャシャーグ | プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物 |
| US6936731B2 (en) | 2000-10-05 | 2005-08-30 | TEVA Gyógyszergyár Részvénytársaság | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
| JP3236282B1 (ja) | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
| JP3463875B2 (ja) | 2001-08-06 | 2003-11-05 | 三共株式会社 | プラバスタチンを精製する方法 |
| KR100407758B1 (ko) * | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | 스타틴의 제조에 있어서 락톤화 방법 |
| JP2003093045A (ja) * | 2001-09-26 | 2003-04-02 | Godo Shusei Co Ltd | 有用変換微生物 |
| KR100435078B1 (ko) * | 2002-02-08 | 2004-06-09 | 종근당바이오 주식회사 | 심바스타틴의 정제방법 |
| JP3463881B2 (ja) | 2002-08-06 | 2003-11-05 | 三共株式会社 | プラバスタチン又はその薬理上許容される塩の単離・精製方法 |
| WO2004087935A2 (en) * | 2003-04-01 | 2004-10-14 | Ranbaxy Laboratories Limited | Fermentation process for the preparation of pravastatin |
| US6978908B2 (en) * | 2003-09-15 | 2005-12-27 | Gerber Products Company | Drinking vessel with adjustable handles |
| DE202004020671U1 (de) * | 2003-11-24 | 2005-12-08 | Teva Gyogyszergyar Reszvenytarsasag | Pravastatin |
| ES2239533B1 (es) * | 2004-03-01 | 2006-12-16 | Ercros Industrial, S.A. | Procedimiento para la obtencion de compactina. |
| TW200825092A (en) * | 2004-09-28 | 2008-06-16 | Teva Pharma | A method for reducing the level of AED in atorvastatin calcium sample |
| CN102043030A (zh) * | 2009-10-22 | 2011-05-04 | 北京万全阳光医学技术有限公司 | 一种用高效液相色谱法测定烟酸辛伐他汀缓释片有关物质的方法 |
| CN102621238A (zh) * | 2011-02-01 | 2012-08-01 | 北京北大维信生物科技有限公司 | 一种测定HMG-CoA还原酶抑制剂浓度的方法 |
| CN105985244A (zh) * | 2015-02-04 | 2016-10-05 | 北京北大维信生物科技有限公司 | 化合物、其分离方法、合成方法及用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| SU1319352A1 (ru) * | 1985-01-07 | 1995-09-10 | Ленинградский государственный университет им.А.А.Жданова | Способ очистки препарата гистона н4 из ткани тимуса |
| IT1232311B (it) * | 1989-09-04 | 1992-01-28 | Sclavo Spa | Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare. |
| US5202029A (en) * | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
| CA2106098C (en) * | 1991-03-14 | 1996-07-02 | Shigeru Handa | Article control system |
| US5420024A (en) * | 1993-05-11 | 1995-05-30 | Merck & Co., Inc. | Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea |
| US5427686A (en) * | 1994-04-05 | 1995-06-27 | Sri International | Process for separating material from mixture using displacement chromatography |
| EP0877089A1 (en) * | 1997-05-07 | 1998-11-11 | Gist-Brocades B.V. | HMG-CoA reductase inhibitor preparation process |
-
1998
- 1998-09-18 SI SI9800241A patent/SI20072A/sl not_active IP Right Cessation
-
1999
- 1999-09-17 DE DE69922519T patent/DE69922519T2/de not_active Expired - Lifetime
- 1999-09-17 IL IL14205699A patent/IL142056A0/xx active IP Right Grant
- 1999-09-17 US US09/720,952 patent/US6695969B1/en not_active Expired - Fee Related
- 1999-09-17 RO ROA200100289A patent/RO121116B1/ro unknown
- 1999-09-17 AU AU55284/99A patent/AU766630B2/en not_active Ceased
- 1999-09-17 PL PL345883A patent/PL200336B1/pl not_active IP Right Cessation
- 1999-09-17 HR HR20010045A patent/HRP20010045B1/xx not_active IP Right Cessation
- 1999-09-17 RU RU2001108381/04A patent/RU2235098C2/ru not_active IP Right Cessation
- 1999-09-17 EP EP99941797A patent/EP1114040B1/en not_active Expired - Lifetime
- 1999-09-17 KR KR1020017000044A patent/KR100607608B1/ko not_active Expired - Fee Related
- 1999-09-17 CN CNB998110760A patent/CN1186335C/zh not_active Expired - Fee Related
- 1999-09-17 JP JP2000574092A patent/JP3795755B2/ja not_active Expired - Fee Related
- 1999-09-17 SK SK2002-2000A patent/SK285868B6/sk not_active IP Right Cessation
- 1999-09-17 HU HU0102997A patent/HUP0102997A2/hu unknown
- 1999-09-17 NZ NZ509582A patent/NZ509582A/en not_active IP Right Cessation
- 1999-09-17 WO PCT/IB1999/001553 patent/WO2000017182A1/en not_active Ceased
- 1999-09-17 AT AT99941797T patent/ATE284396T1/de active
- 1999-09-17 CA CA002343645A patent/CA2343645A1/en not_active Abandoned
- 1999-09-17 RS YUP-818/00A patent/RS49996B/sr unknown
-
2001
- 2001-03-12 IS IS5886A patent/IS2149B/is unknown
- 2001-03-16 BG BG105348A patent/BG64676B1/bg unknown
- 2001-03-18 IL IL142056A patent/IL142056A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2235098C2 (ru) | 2004-08-27 |
| CN1318063A (zh) | 2001-10-17 |
| SK20022000A3 (sk) | 2001-08-06 |
| KR20010099584A (ko) | 2001-11-09 |
| ATE284396T1 (de) | 2004-12-15 |
| HRP20010045B1 (en) | 2005-08-31 |
| JP2002526486A (ja) | 2002-08-20 |
| IL142056A (en) | 2006-08-01 |
| AU766630B2 (en) | 2003-10-23 |
| PL200336B1 (pl) | 2008-12-31 |
| SK285868B6 (sk) | 2007-10-04 |
| EP1114040A1 (en) | 2001-07-11 |
| DE69922519D1 (de) | 2005-01-13 |
| US6695969B1 (en) | 2004-02-24 |
| DE69922519T2 (de) | 2005-12-08 |
| KR100607608B1 (ko) | 2006-08-02 |
| BG105348A (en) | 2001-11-30 |
| EP1114040B1 (en) | 2004-12-08 |
| HUP0102997A2 (hu) | 2001-12-28 |
| RS49996B (sr) | 2008-09-29 |
| IS2149B (is) | 2006-10-13 |
| CN1186335C (zh) | 2005-01-26 |
| RO121116B1 (ro) | 2006-12-29 |
| BG64676B1 (bg) | 2005-11-30 |
| HRP20010045A2 (en) | 2001-12-31 |
| IL142056A0 (en) | 2002-03-10 |
| PL345883A1 (en) | 2002-01-14 |
| WO2000017182A1 (en) | 2000-03-30 |
| JP3795755B2 (ja) | 2006-07-12 |
| SI20072A (sl) | 2000-04-30 |
| AU5528499A (en) | 2000-04-10 |
| CA2343645A1 (en) | 2000-03-30 |
| NZ509582A (en) | 2003-10-31 |
| IS5886A (is) | 2001-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU81800A (sh) | POSTUPAK ZA DOBIJANJE INHIBITORA HMG-CoA REDUKTAZE VISOKE ČISTOĆE | |
| IL187261A0 (en) | Crystals of the sodium salt of pravastatin | |
| IL142055A0 (en) | New salts of hmg-coa reductase inhibitors | |
| PL347686A1 (en) | Stable pharmaceutical formulation comprising a hmg-coa reductase inhibitor | |
| AU4943400A (en) | Stabilized pharmaceutically effective composition and pharmaceutical formulationcomprising the same | |
| AU1510800A (en) | Process for the preparation of simvastatin and analogs thereof | |
| HUP0301423A2 (hu) | Eljárás lovasztatin izolálására | |
| AU2000250960A1 (en) | Stable pharmaceutical product and formulation | |
| YU88602A (sh) | Stabilizovane farmaceutski efektivne smeše i farmaceutske formulacije koje ih sadrže |