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YU46697B - Postupak za dobijanje novih supstituisanih pirimidina - Google Patents

Postupak za dobijanje novih supstituisanih pirimidina

Info

Publication number
YU46697B
YU46697B YU144288A YU144288A YU46697B YU 46697 B YU46697 B YU 46697B YU 144288 A YU144288 A YU 144288A YU 144288 A YU144288 A YU 144288A YU 46697 B YU46697 B YU 46697B
Authority
YU
Yugoslavia
Prior art keywords
mono
4alkyl
substituted pyrimidines
formula
procedure
Prior art date
Application number
YU144288A
Other languages
English (en)
Other versions
YU144288A (en
Inventor
M.S. Daluge
P.M. Skonezny
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Priority to YU144288A priority Critical patent/YU46697B/sh
Publication of YU144288A publication Critical patent/YU144288A/xx
Publication of YU46697B publication Critical patent/YU46697B/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • C07D239/49Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/40Nitrogen atoms attached in position 8
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH SUPSTITUISANIH PIRIMIDINA, opšte formule (I) ili njihovih soli, N-oksida ili acid derivata, u kojoj je (X) šestočlani prsten koji sadrži tri dvostruke veze, u kom slučaju je X -N= ili -C=, R1 i R2 su isti ili različiti i svaki je vodonik, C1-C4 alkil ili C1-C4alkoksi, R3 je vodonik, halogen. C2-4alkenil, hidroksi, C1-C4alkil ili C1-C4alkoksi, a R4 je C1-4alkoksi, mono-C1-C4alkilamino ili di-C1-4alkilamino, naznačen time, što obuhvata reakciju jedinjenja formule u kojoj je R4A hidroksi, amino ili mono-C1-4alkil amino a R1, R2 i R3 su definisani kao gore, sa sredstvom za alkilovanje koje služi za uvodjenje C1-4alkil grupe, kao što je C1-4alkil halogenid, poželjno jodid, ili C1-4 dialkilsulfat, u prisustvu baze kao što je alkoksid alkalnog metala sa 1-4 C-atoma, bikarbonat ili fosfat alkalnog metala, da bi se dobilo jedinjenje formule (I) u kojoj je R4 C1-4 alkoksi, C1-4mono-alkilamino ili C1-4 dialkilamino grupa.
YU144288A 1980-11-11 1988-07-26 Postupak za dobijanje novih supstituisanih pirimidina YU46697B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU144288A YU46697B (sh) 1980-11-11 1988-07-26 Postupak za dobijanje novih supstituisanih pirimidina

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8036135 1980-11-11
YU1983/83A YU43551B (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU144288A YU46697B (sh) 1980-11-11 1988-07-26 Postupak za dobijanje novih supstituisanih pirimidina

Publications (2)

Publication Number Publication Date
YU144288A YU144288A (en) 1990-04-30
YU46697B true YU46697B (sh) 1994-04-05

Family

ID=10517217

Family Applications (5)

Application Number Title Priority Date Filing Date
YU2663/81A YU42444B (en) 1980-11-11 1981-11-10 Process for obtaining new substituted pyrimidines
YU01982/83A YU198283A (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU01981/83A YU198183A (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU1983/83A YU43551B (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU144288A YU46697B (sh) 1980-11-11 1988-07-26 Postupak za dobijanje novih supstituisanih pirimidina

Family Applications Before (4)

Application Number Title Priority Date Filing Date
YU2663/81A YU42444B (en) 1980-11-11 1981-11-10 Process for obtaining new substituted pyrimidines
YU01982/83A YU198283A (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU01981/83A YU198183A (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU1983/83A YU43551B (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines

Country Status (35)

Country Link
US (4) US4438267A (sh)
EP (1) EP0051879B1 (sh)
JP (1) JPS57114581A (sh)
KR (1) KR880001736B1 (sh)
AR (1) AR245447A1 (sh)
AU (1) AU549449B2 (sh)
CA (1) CA1186310A (sh)
CS (1) CS273153B2 (sh)
CY (1) CY1419A (sh)
DD (1) DD201896A5 (sh)
DE (1) DE3173752D1 (sh)
DK (1) DK172884B1 (sh)
EG (1) EG16107A (sh)
ES (5) ES506969A0 (sh)
FI (1) FI76333C (sh)
GB (1) GB2087881B (sh)
GR (1) GR81317B (sh)
HK (1) HK23388A (sh)
HU (1) HU188762B (sh)
IE (1) IE52128B1 (sh)
IL (1) IL64256A (sh)
IT (1) IT1210589B (sh)
MC (1) MC1418A1 (sh)
MY (1) MY8600678A (sh)
NO (2) NO160137C (sh)
NZ (1) NZ198932A (sh)
PH (2) PH22654A (sh)
PL (4) PL139523B1 (sh)
PT (1) PT73960B (sh)
RU (1) RU1819264C (sh)
SG (1) SG62686G (sh)
SU (4) SU1424732A3 (sh)
YU (5) YU42444B (sh)
ZA (1) ZA817780B (sh)
ZM (1) ZM9481A1 (sh)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
DK190983A (da) * 1982-05-01 1983-11-02 Wellcome Found 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
ZA833067B (en) * 1982-05-01 1984-12-24 Wellcome Found Antibacterial compounds
US4590271A (en) * 1982-05-01 1986-05-20 Burroughs Wellcome Co. 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
US4587341A (en) * 1982-05-07 1986-05-06 Burroughs Wellcome Co. 2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
GB8603964D0 (en) * 1986-02-18 1986-03-26 Cooper Animal Health Ltd Compositions
GB8603962D0 (en) * 1986-02-18 1986-03-26 Wellcome Found Chemical compositions
LU86703A1 (fr) * 1986-12-08 1988-07-14 Oreal Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
GB8903978D0 (en) * 1989-02-22 1989-04-05 Coopers Animal Health Chemical compositions
GB9000241D0 (en) * 1990-01-05 1990-03-07 Coopers Animal Health Pharmaceutical use
RU95113597A (ru) * 1992-12-02 1997-06-10 ФМК Корпорейшн (US) Инсектицидная композиция, способы борьбы с насекомыми
KR100224135B1 (ko) * 1993-01-28 1999-10-15 다께다 구니오 퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
US5707996A (en) * 1995-11-06 1998-01-13 Macleod Pharmaceuticals, Inc. Pharmaceutical solution and methods for preparation thereof
JP3309340B2 (ja) * 1995-12-04 2002-07-29 アルピダ・アーゲー ジアミノピリミジン、それらを含む医薬組成物及びそれらの抗菌剤としての用途
RU2141322C1 (ru) * 1997-08-12 1999-11-20 Голощапов Николай Михайлович Иммуномодулятор с антимикобактериальной активностью "изофон", способ его получения и применения
GB0016877D0 (en) * 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
US7678805B2 (en) 2001-06-29 2010-03-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)
EP1401415B1 (en) * 2001-06-29 2006-06-21 AB Science Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases
US7727731B2 (en) * 2001-06-29 2010-06-01 Ab Science Potent, selective and non toxic c-kit inhibitors
CA2452371A1 (en) * 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitors for treating allergic diseases
ATE401078T1 (de) * 2001-09-20 2008-08-15 Ab Science Die verwendung von c-kithemmern zur förderung des haarwuchses
US20040242601A1 (en) * 2001-09-20 2004-12-02 Alain Moussy Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
DE60225590T2 (de) * 2001-09-20 2008-09-25 Ab Science C-kithemmer zur behandlung von bakteriellen infektionen
EP1651639B1 (en) * 2003-07-11 2010-05-26 Arpida AG, Benzofuran derivatives and their use in the treatment of microbial infections
HUP0700605A3 (en) * 2005-02-18 2008-02-28 Arpida Ag Novel processes for the preparation of a benzofuran
EP1924565B1 (en) * 2005-09-01 2016-09-14 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p3x2/3 modulators
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US20120122819A1 (en) * 2009-06-12 2012-05-17 Socpra - Sciences Et Genie S.E.C. Guanine riboswitch binding compounds and their use as antibiotics
CN102649786B (zh) * 2011-02-28 2014-08-27 郑州福源动物药业有限公司 一种2,4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2,4-(1h,3h)嘧啶的制备方法
CN103755684B (zh) * 2014-02-10 2015-09-09 青岛蔚蓝生物股份有限公司 一种巴喹普林的制备方法
JP7538153B2 (ja) * 2019-06-06 2024-08-21 ベイジン タイド ファーマシューティカル カンパニー リミテッド P2x3及び/又はp2x2/3受容体アンタゴニスト、それを含む医薬組成物及びその使用
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
US20240226100A1 (en) * 2021-04-09 2024-07-11 The Trustees Of The University Of Pennsylvania Control of protein expression with tmp-protac compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1303727B (de) 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
US3956327A (en) * 1969-03-06 1976-05-11 Burroughs Wellcome Co. Method of preparing 2,4-diamino-5-benzyl pyrimidines
BE792096A (fr) * 1971-12-01 1973-05-30 Hoffmann La Roche Nouvelles benzylpyrimidines
GB1468374A (en) 1974-03-06 1977-03-23 Wellcome Found Process for preparing a pyrimidine derivative
US4039543A (en) 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
GB1582245A (en) * 1976-06-09 1981-01-07 Wellcome Found Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
DE2730467A1 (de) * 1977-07-06 1979-01-18 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use

Also Published As

Publication number Publication date
GB2087881B (en) 1985-05-15
IL64256A (en) 1988-01-31
IL64256A0 (en) 1982-02-28
AU7733481A (en) 1982-05-20
CA1186310A (en) 1985-04-30
YU198383A (en) 1984-04-30
PL233754A1 (en) 1983-08-01
GR81317B (sh) 1984-12-11
ZA817780B (en) 1983-06-29
PT73960A (en) 1981-12-01
PL139827B1 (en) 1987-02-28
PH25053A (en) 1991-01-28
PL239280A1 (en) 1983-08-01
IT8149676A0 (it) 1981-11-10
YU266381A (en) 1984-04-30
NO160137B (no) 1988-12-05
CS273153B2 (en) 1991-03-12
SU1535379A3 (ru) 1990-01-07
AR245447A1 (es) 1994-01-31
US4587342A (en) 1986-05-06
KR830007628A (ko) 1983-11-04
YU43551B (en) 1989-08-31
YU42444B (en) 1988-08-31
DE3173752D1 (en) 1986-03-20
DK496681A (da) 1982-05-12
US4603136A (en) 1986-07-29
DD201896A5 (de) 1983-08-17
PL239279A1 (en) 1983-08-01
EG16107A (en) 1987-10-30
DK172884B1 (da) 1999-09-06
AU549449B2 (en) 1986-01-30
NO160137C (no) 1989-03-15
FI76333C (fi) 1988-10-10
ES8307759A1 (es) 1983-07-01
PL139523B1 (en) 1987-01-31
YU198283A (en) 1984-04-30
SU1318148A3 (ru) 1987-06-15
IE52128B1 (en) 1987-06-24
MY8600678A (en) 1986-12-31
GB2087881A (en) 1982-06-03
ES8405377A1 (es) 1984-06-01
FI76333B (fi) 1988-06-30
FI813546L (fi) 1982-05-12
IT1210589B (it) 1989-09-14
SU1306473A3 (ru) 1987-04-23
PL139427B1 (en) 1987-01-31
CS825781A2 (en) 1990-07-12
ES521201A0 (es) 1984-06-01
ES8405379A1 (es) 1984-06-01
SU1424732A3 (ru) 1988-09-15
ES521204A0 (es) 1984-06-01
ES8405378A1 (es) 1984-06-01
CY1419A (en) 1988-04-22
PT73960B (en) 1983-11-23
ES8405380A1 (es) 1984-06-01
ES521202A0 (es) 1984-06-01
SG62686G (en) 1987-03-27
NO1994029I1 (no) 1994-12-29
JPH0474351B2 (sh) 1992-11-26
ES521203A0 (es) 1984-06-01
IE812631L (en) 1982-05-11
EP0051879A3 (en) 1982-08-04
EP0051879B1 (en) 1986-02-05
PL139828B1 (en) 1987-02-28
KR880001736B1 (ko) 1988-09-10
MC1418A1 (fr) 1982-10-18
PL239278A1 (en) 1983-08-01
YU144288A (en) 1990-04-30
US4438267A (en) 1984-03-20
YU198183A (en) 1984-04-30
ES506969A0 (es) 1983-07-01
JPS57114581A (en) 1982-07-16
NZ198932A (en) 1985-05-31
HK23388A (en) 1988-04-08
PH22654A (en) 1988-10-28
NO813804L (no) 1982-05-12
HU188762B (en) 1986-05-28
US4761475A (en) 1988-08-02
RU1819264C (ru) 1993-05-30
ZM9481A1 (en) 1983-11-21
EP0051879A2 (en) 1982-05-19

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