YU137083A - Process for preparing alkylesters of 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylic acid - Google Patents
Process for preparing alkylesters of 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylic acidInfo
- Publication number
- YU137083A YU137083A YU01370/83A YU137083A YU137083A YU 137083 A YU137083 A YU 137083A YU 01370/83 A YU01370/83 A YU 01370/83A YU 137083 A YU137083 A YU 137083A YU 137083 A YU137083 A YU 137083A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- bromo
- chloro
- pyrrolo
- dihydro
- alkylesters
- Prior art date
Links
- YZHUGKQYWSIWIA-UHFFFAOYSA-N 6-bromo-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid Chemical compound C1=C(Br)C=C2C(C(=O)O)CCN21 YZHUGKQYWSIWIA-UHFFFAOYSA-N 0.000 title 1
- 125000005907 alkyl ester group Chemical group 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- XWQXHYYQCCZBSH-UHFFFAOYSA-N 2-bromo-6,7-dihydro-5h-pyrrolizine-1-carboxylic acid Chemical class C1CCC2=C(C(=O)O)C(Br)=CN21 XWQXHYYQCCZBSH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 229940125716 antipyretic agent Drugs 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000050 smooth muscle relaxant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/157,719 US4344943A (en) | 1980-06-09 | 1980-06-09 | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU137083A true YU137083A (en) | 1983-12-31 |
Family
ID=22564979
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU1423/81A YU43235B (en) | 1980-06-09 | 1981-06-05 | Process for preparing 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylic acid and alkyl esthers thereoff |
| YU01370/83A YU137083A (en) | 1980-06-09 | 1983-06-22 | Process for preparing alkylesters of 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylic acid |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU1423/81A YU43235B (en) | 1980-06-09 | 1981-06-05 | Process for preparing 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylic acid and alkyl esthers thereoff |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4344943A (xx) |
| EP (1) | EP0041711B1 (xx) |
| JP (1) | JPS5714591A (xx) |
| KR (1) | KR850000609B1 (xx) |
| AT (1) | ATE12771T1 (xx) |
| AU (1) | AU546012B2 (xx) |
| CA (1) | CA1178277A (xx) |
| DE (1) | DE3169956D1 (xx) |
| DK (1) | DK249781A (xx) |
| ES (1) | ES8203376A1 (xx) |
| GR (1) | GR74615B (xx) |
| HU (1) | HU185430B (xx) |
| IE (1) | IE51523B1 (xx) |
| IL (1) | IL63047A (xx) |
| NZ (1) | NZ197331A (xx) |
| PT (1) | PT73154B (xx) |
| SU (1) | SU1217260A3 (xx) |
| YU (2) | YU43235B (xx) |
| ZA (1) | ZA813829B (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4457941A (en) * | 1982-03-22 | 1984-07-03 | Syntex (U.S.A.) Inc. | Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes |
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4612325A (en) * | 1982-06-08 | 1986-09-16 | Syntex (U.S.A) Inc. | 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories |
| US4511724A (en) * | 1982-06-10 | 1985-04-16 | Merck & Co., Inc. | 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents |
| US4874872A (en) * | 1987-01-14 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates |
| US4835288A (en) * | 1987-01-14 | 1989-05-30 | Syntex Inc. | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates |
| HU198927B (en) * | 1987-01-14 | 1989-12-28 | Richter Gedeon Vegyeszet | Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same |
| US4849526A (en) * | 1987-01-14 | 1989-07-18 | Syntex (U.S.A.) Inc. | Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates |
| US4874871A (en) * | 1987-03-25 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
| JP2649168B2 (ja) * | 1988-02-25 | 1997-09-03 | 久光製薬株式会社 | 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体 |
| US5082950A (en) * | 1990-10-12 | 1992-01-21 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor |
| EP0707465A4 (en) * | 1993-07-08 | 1997-04-16 | Cygnus Therapeutic Systems | MONOLITHIC MATRIX TRANSDERMAL DELIVERY SYSTEM |
| US5621115A (en) * | 1996-02-21 | 1997-04-15 | Ohmeda Pharmaceutical Products Division Inc. | Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids |
| US6191285B1 (en) | 1997-07-03 | 2001-02-20 | Abbott Laboratories | Process for the preparation of ketorolac tromethamine |
| OA12162A (en) * | 2000-01-19 | 2006-05-08 | Cadila Healthcare Ltd | Novel compounds having hypolipedemic, hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them. |
| WO2002062341A1 (en) * | 2001-02-07 | 2002-08-15 | University Of Florida | Method and composition for the control of hair growth |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087539A (en) * | 1976-07-14 | 1978-05-02 | Syntex (U.S.A.) Inc. | 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| JPS539788A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative |
| US4097579A (en) * | 1977-03-31 | 1978-06-27 | Syntex (U.S.A.) Inc. | 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US4140698A (en) * | 1977-07-25 | 1979-02-20 | Syntex (Usa) Inc. | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles |
| US4232038A (en) * | 1979-08-31 | 1980-11-04 | Syntex (U.S.A.) Inc. | 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids |
-
1980
- 1980-06-09 US US06/157,719 patent/US4344943A/en not_active Expired - Lifetime
-
1981
- 1981-04-02 JP JP4999181A patent/JPS5714591A/ja active Pending
- 1981-06-03 KR KR1019810001987A patent/KR850000609B1/ko not_active Expired
- 1981-06-04 DK DK249781A patent/DK249781A/da not_active Application Discontinuation
- 1981-06-05 AT AT81104368T patent/ATE12771T1/de not_active IP Right Cessation
- 1981-06-05 YU YU1423/81A patent/YU43235B/xx unknown
- 1981-06-05 DE DE8181104368T patent/DE3169956D1/de not_active Expired
- 1981-06-05 EP EP81104368A patent/EP0041711B1/en not_active Expired
- 1981-06-05 IL IL63047A patent/IL63047A/xx unknown
- 1981-06-08 IE IE1269/81A patent/IE51523B1/en unknown
- 1981-06-08 ZA ZA00813829A patent/ZA813829B/xx unknown
- 1981-06-08 GR GR65174A patent/GR74615B/el unknown
- 1981-06-08 HU HU811700A patent/HU185430B/hu not_active IP Right Cessation
- 1981-06-08 PT PT73154A patent/PT73154B/pt unknown
- 1981-06-08 NZ NZ197331A patent/NZ197331A/en unknown
- 1981-06-08 CA CA000379266A patent/CA1178277A/en not_active Expired
- 1981-06-08 SU SU813300100A patent/SU1217260A3/ru active
- 1981-06-08 ES ES502855A patent/ES8203376A1/es not_active Expired
- 1981-06-09 AU AU71438/81A patent/AU546012B2/en not_active Ceased
-
1983
- 1983-06-22 YU YU01370/83A patent/YU137083A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE811269L (en) | 1981-12-09 |
| DE3169956D1 (en) | 1985-05-23 |
| KR830006289A (ko) | 1983-09-20 |
| ZA813829B (en) | 1983-01-26 |
| PT73154B (en) | 1982-07-16 |
| PT73154A (en) | 1981-07-01 |
| ATE12771T1 (de) | 1985-05-15 |
| AU546012B2 (en) | 1985-08-08 |
| YU43235B (en) | 1989-06-30 |
| SU1217260A3 (ru) | 1986-03-07 |
| US4344943A (en) | 1982-08-17 |
| GR74615B (xx) | 1984-06-29 |
| JPS5714591A (en) | 1982-01-25 |
| EP0041711A1 (en) | 1981-12-16 |
| EP0041711B1 (en) | 1985-04-17 |
| ES502855A0 (es) | 1982-04-01 |
| IL63047A (en) | 1984-07-31 |
| ES8203376A1 (es) | 1982-04-01 |
| HU185430B (en) | 1985-02-28 |
| CA1178277A (en) | 1984-11-20 |
| YU142381A (en) | 1983-12-31 |
| AU7143881A (en) | 1981-12-17 |
| IE51523B1 (en) | 1987-01-07 |
| NZ197331A (en) | 1985-05-31 |
| KR850000609B1 (ko) | 1985-05-01 |
| IL63047A0 (en) | 1981-09-13 |
| DK249781A (da) | 1981-12-10 |
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