[go: up one dir, main page]

WO2021248260A1 - 一种金属材料及其制备方法与应用 - Google Patents

一种金属材料及其制备方法与应用 Download PDF

Info

Publication number
WO2021248260A1
WO2021248260A1 PCT/CN2020/094850 CN2020094850W WO2021248260A1 WO 2021248260 A1 WO2021248260 A1 WO 2021248260A1 CN 2020094850 W CN2020094850 W CN 2020094850W WO 2021248260 A1 WO2021248260 A1 WO 2021248260A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
metal material
mixed powder
niobium
tantalum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2020/094850
Other languages
English (en)
French (fr)
Inventor
徐春娟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Jiangdong Industry And Trade Co Ltd
Original Assignee
Nanjing Jiangdong Industry And Trade Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Jiangdong Industry And Trade Co Ltd filed Critical Nanjing Jiangdong Industry And Trade Co Ltd
Priority to PCT/CN2020/094850 priority Critical patent/WO2021248260A1/zh
Priority to CN202080005302.1A priority patent/CN113166854A/zh
Publication of WO2021248260A1 publication Critical patent/WO2021248260A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C19/00—Alloys based on nickel or cobalt
    • C22C19/03—Alloys based on nickel or cobalt based on nickel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/04—Making non-ferrous alloys by powder metallurgy
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/04—Making non-ferrous alloys by powder metallurgy
    • C22C1/0433—Nickel- or cobalt-based alloys
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C30/00—Alloys containing less than 50% by weight of each constituent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Definitions

  • the invention relates to the field of metal composite material preparation, in particular, to a composite metal material preparation and a preparation method and application thereof.
  • Titanium-based alloy materials are mainly used in aerospace and biomedical fields due to their unique chemical and mechanical properties and good biocompatibility. They are alloy materials commonly used in technology, but titanium alloys have poor oxidation resistance at high temperatures. , The forming atmosphere needs to be strictly controlled; at the same time, the thermal conductivity of titanium alloy is poor, and there are strict requirements for energy input during the forming process.
  • the biological materials used in the orthopedics field include metal materials, polymer materials, bioceramics and composite materials.
  • Metal materials are widely used in joint, spine and trauma diseases due to their high mechanical strength and fatigue resistance. Treatment has played a huge role in the reconstruction of bone stability and the replacement of joint function.
  • the most commonly used metal materials in clinical practice include stainless steel, cobalt-based alloys and titanium-based alloys. Others such as shape memory alloys and stable metals (tantalum, niobium, ho, etc.) have also been used more and more widely.
  • the present invention provides a metal material.
  • the alloy material has a relatively high Good fatigue resistance and strong corrosion resistance increase its comprehensive mechanical properties.
  • appropriate amount of silver is added to ensure its basic mechanical properties At the same time of performance, it has a certain broad-spectrum sterilization or antibacterial effect, effectively solves the bacterial infection problem of titanium alloy surgical implants, and can be widely used in medical fields such as joints, spine and trauma.
  • the technical solution of the present invention includes a metal material comprising the following components in parts by weight: 35-42 parts of nickel, 15-20 parts of cobalt, 1-3 parts of silver, 25-30 parts of titanium, 0.5-3 parts of tantalum, 0.1-0.3 parts of niobium.
  • niobium contains the following components in parts by weight: 38 parts of nickel, 17 parts of cobalt, 1.8 parts of silver, 26.5 parts of titanium, 0.8 parts of tantalum, and 0.1 parts of niobium.
  • the technical scheme of the present invention also includes a method for preparing a metal material, including the following steps:
  • Step 1 The ingredients are prepared according to the following parts by weight: 35-42 parts of nickel, 15-20 parts of cobalt, 1-3 parts of silver, 25-30 parts of titanium, 0.5-3 parts of tantalum, and 0.1-0.3 parts of niobium. Place the mixed powder in a stainless steel ball mill tank, fill it with absolute ethanol, and seal it. Use argon gas to protect and mix in a planetary ball mill for 4 hours. Take out the ball-milled mixed powder and place it on filter paper for 6-8 minutes to obtain mixed powder. ;
  • Step 2 Put a certain amount of polyvinyl alcohol into deionized distilled water and heat it until it dissolves. After cooling, add a certain proportion of polyvinyl alcohol solution to the mixed powder, and stir thoroughly to make it have a proper degree The slurry is naturally air-dried and cooled, then dried in a vacuum drying oven at a temperature of 70-80°C, and finally taken out for natural cooling.
  • Step 3 Keep the vacuum always below 8 ⁇ 10 -2 Pa for sintering, first heat to 200°C-300°C for debinding and decomposition; heat to sintering temperature 1400-1500°C°, keep for 2-4h, then heat to Keep the temperature at 1700°C-1800°C for 1-2h, cool to room temperature along with the furnace, take the sintered body out of the furnace, clean it in an ultrasonic water bath for 15-20min, and then dry it.
  • the ball-to-material ratio used in the ball milling in the step 1 is 10:1.
  • the rotation speed of the ball mill in the step 1 is 400-500 r/min.
  • the ratio of the mixed powder to the polyvinyl alcohol solution in step 2 is: each 100 g of the mixed powder is mixed with 20 ml of the polyvinyl alcohol solution.
  • heating is performed to a sintering temperature of 1400-1500°C° at a rate of 5-10°C/min.
  • step 3 heating to 1700°C-1800°C at a rate of 10-15°C/min.
  • the technical solution of the present invention also includes a metal material product, which is characterized in that it is made of the metal material described in any one of the above solutions, and is used in medical fields such as oral restorations, joints, spine, and trauma.
  • the beneficial effects of the present invention are: by adding cobalt, tantalum and niobium, the alloy material has good fatigue resistance and strong corrosion resistance, and its comprehensive mechanical properties are increased. At the same time, it has good biocompatibility. Performance, high mechanical strength and fatigue resistance; the method of combining colloidal dipping and powder metallurgy can be used to prepare porous materials, through the design and construction of the porous structure, the connection between the implant and the bone is obtained, thereby providing a good Biologically fixed, the porous structure can improve the compatibility of the implant and bone tissue on the one hand, and on the other hand can promote the deposition of vitronectin and fibronectin on the surface and inside of the alloy, thereby increasing the adhesion of osteoblasts, Proliferation and differentiation; can be widely used in medical fields such as joints, spine and trauma.
  • adding a proper amount of silver to the titanium alloy can make the titanium alloy have a certain broad-spectrum bactericidal or antibacterial effect while ensuring its basic mechanical properties, effectively solving the bacterial infection problem of titanium alloy surgical implants.
  • a metal material comprising the following components in parts by weight: 35 parts of nickel, 15 parts of cobalt, 1 part of silver, 30 parts of titanium, 0.5 part of tantalum, and 0.1 part of niobium.
  • a metal material comprising the following components in parts by weight: 38 parts of nickel, 17 parts of cobalt, 1.8 parts of silver, 26.5 parts of titanium, 0.8 parts of tantalum, and 0.1 parts of niobium.
  • a metal material comprising the following components in parts by weight: 42 parts of nickel, 20 parts of cobalt, 3 parts of silver, 25 parts of titanium, 3 parts of tantalum, and 0.3 parts of niobium.
  • the metal material in Example 1 was prepared according to the following steps:
  • Step 1 The ingredients are prepared according to the following parts by weight: 35 parts of nickel, 15 parts of cobalt, 1 part of silver, 30 parts of titanium, 0.5 part of tantalum, and 0.1 part of niobium. Put the mixed powder in a stainless steel ball mill tank, fill it with absolute ethanol, and seal it. Use argon gas to protect and mix in the planetary ball mill for 4 hours. The speed of the ball mill is 400r/min. Take out the ball milled mixed powder and place it on the filter paper. 6 minutes to get mixed powder;
  • Step 2 Put a certain amount of polyvinyl alcohol into deionized distilled water and heat it until it dissolves. After cooling, add a certain proportion of polyvinyl alcohol solution to the mixed powder, and stir thoroughly to make it have a proper degree The slurry is naturally air-dried and cooled, then dried in a vacuum drying oven at a temperature of 80 °C, and finally taken out to be naturally cooled.
  • Step 3 Keep the vacuum always below 8 ⁇ 10 -2 Pa for sintering, first heat to 200°C for debinding and decomposition; heat to sintering temperature 1400°C for 2h, then heat to 1700°C for 2h, then The furnace is cooled to room temperature, and the sintered body is taken out of the furnace, cleaned in an ultrasonic water bath for 15 minutes, and then dried to obtain it.
  • the metal material in Example 3 was prepared according to the following steps:
  • Step 1 The ingredients are prepared according to the following parts by weight: 42 parts of nickel, 20 parts of cobalt, 3 parts of silver, 25 parts of titanium, 3 parts of tantalum, and 0.3 parts of niobium.
  • the planetary ball mill uses argon gas to protect and mix for 4 hours.
  • the ball-to-material ratio used in the ball mill is 10:1, and the speed of the ball mill is 500r/min. .
  • Step 2 Put a certain amount of polyvinyl alcohol into deionized distilled water and heat it to dissolve. After cooling, mix 100g of the mixed powder with 20ml polyvinyl alcohol solution and stir thoroughly to make it have a proper degree of consistency The slurry is naturally air-dried and cooled, then dried in a vacuum drying oven at a temperature of 70°C, and finally taken out for natural cooling.
  • Step 3 Keep the vacuum always below 8 ⁇ 10 -2 Pa for sintering, first heat to 300°C for debinding and decomposition; heat it to the sintering temperature of 1460°C at a rate of 5-10°C/min, and hold for 2 hours. Heat to 1780°C at a rate of 10-15°C/min, keep it for 2h, cool to room temperature along with the furnace, take the sintered body out of the furnace, clean it in an ultrasonic water bath for 20 minutes, and dry it to get it.
  • An artificial joint made of composite metal materials prepared in Examples 1-5 can be applied to joint replacement surgery.
  • a dental implant made of composite metal materials prepared in Examples 1-5 can be applied to denture implant surgery.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Powder Metallurgy (AREA)
  • Materials For Medical Uses (AREA)

Abstract

一种金属材料及其制备方法、金属材料制品，该金属材料包含按重量份计的组分：镍35-42份、钴15-20份、银1-3份、钛25-30份、钽0.5-3份、铌0.1-0.3份。该金属材料的制备方法采用胶体浸渍法与粉末冶金法相结合，改善了钛合金在高温下抗氧化能力差，导热性差，成形过程中对能量的输入有严格要求的缺点，通过添加钴、钽和铌，使该金属材料具有较好的耐疲劳性、抗腐烛性和综合力学性能，同时由于其具有良好的生物相容性、较高的机械强度和抗疲劳性能，加入适量银元素，保证其基本力学性能的同时，具有一定的广谱杀菌或抑菌功效，有效解决了钛合金外科植入器械细菌感染问题，由该金属材料制成的金属材料制品可以广泛应用于口腔修复体、关节、脊柱及创伤等医疗领域。

Description

一种金属材料及其制备方法与应用 技术领域
本发明涉及金属复合材料制备领域，具体地，涉及一种复合金属材料制备及其制备方法与应用。
背景技术
随着科学技术的不断进步，单一材料已经很难满足现代工业对材料综合性能的需求，复合材料由于其性能可设计性，越来越受到业界的关注。
钛基合金材料因其独特的化学、机械性能及良好的生物相容性，主要应用于航空航天和生物医学领域，是技术中较常采用的合金材料，但钛合金在高温下抗氧化能力差，需要严格控制成形气氛；同时，钛合金的导热性差，成形过程中对能量的输入也有严格的要求。
目前，在骨科领域应用的生物材料包括金属材料、高分子材料、生物陶瓷及复合材料，其中金属材料因具有较高的机械强度和抗疲劳性能而广泛应用于关节、脊柱及创伤等领域疾病的治疗，在骨骼稳定性重建及关节功能替代方面发挥了巨大的作用。目前，临床上最为常用的金属材料包括不锈钢、钴基合金与钛基合金，其他如形状记忆合金、稳定金属(钽、铌、浩等)也得到了越来越广泛的应用。但作为生物医用材料，传统的金属材料仍在以下方面存在不可回避的不足，金属假体-骨界面结合问题，假体表面光滑，远期固定效果不佳；大多数表面改性层一般比表面涂层厚且性能呈梯度逐渐改变，具有高于表面涂层的载荷承载能力。但改性层的孔隙率、覆盖厚度还不能尽如人意，表面改性后的假体-骨界面也并非理想的骨整合，合金与纯金属相比往往具有制备工艺简单、力学性能及延展性好的特点，这一点从钛合金的广泛应用可以得到验证，从这个角度出发，我们选择了钛钴镍与钽铌一起制备合金，以期获得具有良好的生物相容性，并且耐 疲劳性好、抗腐烛性强、综合力学性能高和抗氧化能力强，流动性好的金属材料。并通过加入适量银元素，使其具有一定的广谱杀菌或抑菌功效，有效解决钛合金外科植入器械细菌感染问题。
发明内容
为解决钛合金在高温下抗氧化能力差，导热性差，及其用于医疗材料存在不可回避的不足，本发明提供了一种金属材料，通过添加钴、钽和铌，使该合金材料具有较好的耐疲劳性和抗腐烛性强，使其综合力学性能增加高，同时由于其具有良好的生物相容性、较高的机械强度和抗疲劳性能，加入适量银元素，保证其基本力学性能的同时，具有一定的广谱杀菌或抑菌功效，有效解决钛合金外科植入器械细菌感染问题，可以广泛应用于关节、脊柱及创伤等医疗领域。
为实现上述目的，本发明技术方案为：
本发明技术方案包括一种金属材料，包含按重量份计的下列组分：镍35-42份、钴15-20份、银1-3份、钛25-30份、钽0.5-3份、铌0.1-0.3份。
具体的，包含按重量份计的下列组分：镍38份、钴17份、银1.8份、钛26.5份、钽0.8份、铌0.1份。
本发明技术方案还包括一种金属材料的制备方法，包括如下步骤：
步骤1：配料按照按以下重量份配制混合粉：镍35-42份、钴15-20份、银1-3份、钛25-30份、钽0.5-3份、铌0.1-0.3份。将混合粉置于不锈钢球磨罐中，注满无水乙醇后密封，在行星球磨机采用氩气保护混合4h，将球磨好的混合粉取出并置于滤纸上静置6-8分钟，得到混合粉；
步骤2：将一定量的聚乙稀醇放入去离子蒸饱水中加热至其溶解，冷却后，按一定比例取聚乙烯醇溶液加入混合粉中，充分搅拌均勾使之成为具有适当點度的浆状物，自然风干冷却，再放到温度为70-80℃的真空干燥箱里干燥，最后取出自然冷却。
步骤3：保持真空度始终在8×10 -2Pa以下进行烧结，先加热至200℃-300℃进行排胶和分解；加热至烧结温度1400-1500℃°，保温2-4h后，加热至1700℃-1800℃，保温1-2h，随炉冷却至室温，将烧结体从炉内取出，置于超声波水浴中清洗15-20min后烘干，即得。
具体的，所述步骤1中球磨中采用的球料比为10:1。
具体的，所述步骤1中球磨机的转速为400-500r/min。
具体的，所述步骤2中混合粉与聚乙稀醇溶液比例为：每100g混合粉与20ml聚乙稀醇溶液混合。
具体的，所述步骤3中以5-10℃/min的速率加热至烧结温度1400-1500℃°。
具体的，所述步骤3中以10-15℃/min的速率加热至1700℃-1800℃。
本发明技术方案还包括一种金属材料制品，其特征在于，利用上述方案中任一项所述的金属材料制成，应用于口腔修复体、关节、脊柱及创伤等医疗领域。
本发明的有益效果是：通过添加钴、钽和铌，使该合金材料具有较好的耐疲劳性和抗腐烛性强，使其综合力学性能增加高，同时由于其具有良好的生物相容性、较高的机械强度和抗疲劳性能；通过胶体浸渍法与粉末冶金法相结合的方法可制备得到多孔材料，通过多孔结构的设计和构建，获得植入物和骨的连接，从而提供良好的生物学固定，多孔结构一方面可以改善植入物和骨组织的相容性，另一方面能促进玻连蛋白和纤连蛋白在合金表面及内部的沉积，从而增加成骨细胞的粘附、增殖和分化；可以广泛应用于关节、脊柱及创伤等医疗领域。
尤其是在钛合金中适量加入银元素，可使钛合金在保证其基本力学 性能的同时，具有一定的广谱杀菌或抑菌功效，有效解决钛合金外科植入器械细菌感染问题。
具体实施方式
实施例1
一种金属材料，包含按重量份计的下列组分：镍35份、钴15份、银1份、钛30份、钽0.5份、铌0.1份。
实施例2
一种金属材料，包含按重量份计的下列组分：镍38份、钴17份、银1.8份、钛26.5份、钽0.8份、铌0.1份。
实施例3
一种金属材料，包含按重量份计的下列组分：镍42份、钴20份、银3份、钛25份、钽3份、铌0.3份。
实施例4
实施例1中的金属材料，按照以下步骤进行制备：
步骤1：配料按照按以下重量份配制混合粉：镍35份、钴15份、银1份、钛30份、钽0.5份、铌0.1份。将混合粉置于不锈钢球磨罐中，注满无水乙醇后密封，在行星球磨机采用氩气保护混合4h，球磨机的转速为400r/min，将球磨好的混合粉取出并置于滤纸上静置6分钟，得到混合粉；
步骤2：将一定量的聚乙稀醇放入去离子蒸饱水中加热至其溶解，冷却后，按一定比例取聚乙烯醇溶液加入混合粉中，充分搅拌均勾使之成为具有适当點度的浆状物，自然风干冷却，再放到温度为80℃的真空干燥箱里干燥，最后取出自然冷却。
步骤3：保持真空度始终在8×10 -2Pa以下进行烧结，先加热至200℃进行排胶和分解；加热至烧结温度1400℃°，保温2h后，加热至1700℃，保温2h，随炉冷却至室温，将烧结体从炉内取出，置于超声波水浴中清洗15min后烘干，即得。
实施例5
实施例3中的金属材料，按照以下步骤进行制备：
步骤1：配料按照按以下重量份配制混合粉：镍42份、钴20份、银3份、钛25份、钽3份、铌0.3份。将混合粉置于不锈钢球磨罐中，注满无水乙醇后密封，在行星球磨机采用氩气保护混合4h，球磨中采用的球料比为10:1，球磨机的转速为500r/min。。将球磨好的混合粉取出并置于滤纸上静置8分钟，得到混合粉；
步骤2：将一定量的聚乙稀醇放入去离子蒸饱水中加热至其溶解，冷却后，每100g混合粉与20ml聚乙稀醇溶液混合，充分搅拌均勾使之成为具有适当點度的浆状物，自然风干冷却，再放到温度为70℃的真空干燥箱里干燥，最后取出自然冷却。
步骤3：保持真空度始终在8×10 -2Pa以下进行烧结，先加热至300℃进行排胶和分解；以5-10℃/min的速率加热至烧结温度1460℃°，保温2h后，以10-15℃/min的速率加热至1780℃，保温2h，随炉冷却至室温，将烧结体从炉内取出，置于超声波水浴中清洗20min后烘干，即得。
实施例6
一种利用实施例1-5所制备得到复合金属材料制成的人工关节，可应用于关节置换手术。
实施例7
一种利用实施例1-5所制备得到复合金属材料制成的牙种植体，可应用于义齿种植手术。
以上所述仅是本发明的优选实施方式，应当指出：对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。

Claims (9)

  1. 一种金属材料，其特征在于，包含其组分按重量份计的下列组分：镍35-42份、钴15-20份、银1-3份、钛25-30份、钽0.5-3份、铌0.1-0.3份。
  2. 根据权利要求1所述的一种金属材料，其特征在于，包含其组分按重量份计的下列组分：镍38份、钴17份、银1.8份、钛26.5份、钽0.8份、铌0.1份。
  3. 一种金属材料的制备方法，其特征在于，包括如下步骤：
    步骤1：配料按照按以下重量份配制混合粉：镍35-42份、钴15-20份、银1-3份、钛25-30份、钽0.5-3份、铌0.1-0.3份。将混合粉置于不锈钢球磨罐中，注满无水乙醇后密封，在行星球磨机采用氩气保护混合4h，将球磨好的混合粉取出并置于滤纸上静置6-8分钟，得到混合粉；
    步骤2：将一定量的聚乙稀醇放入去离子蒸饱水中加热至其溶解，冷却后，按一定比例取聚乙烯醇溶液加入混合粉中，充分搅拌均勾使之成为具有适当點度的浆状物，自然风干冷却，再放到温度为70-80℃的真空干燥箱里干燥，最后取出自然冷却。
    步骤3：保持真空度始终在8×10 -2Pa以下进行烧结，先加热至200℃-300℃进行排胶和分解；加热至烧结温度1400-1500℃°，保温2-4h后，加热至1700℃-1800℃，保温1-2h，随炉冷却至室温，将烧结体从炉内取出，置于超声波水浴中清洗15-20min后烘干，即得。
  4. 根据权利要求3所述的一种金属材料的制备方法，其特征在于，所述步骤1中球磨中采用的球料比为10:1。
  5. 根据权利要求3所述的一种金属材料的制备方法，其特征在于，所述步骤1中球磨机的转速为400-500r/min。
  6. 根据权利要求3所述的一种金属材料的制备方法，其特征在于，所述步骤2中混合粉与聚乙稀醇溶液比例为：每100g混合粉与20ml 聚乙稀醇溶液混合。
  7. 根据权利要求3所述的一种金属材料的制备方法，其特征在于，所述步骤3中以5-10℃/min的速率加热至烧结温度1400-1500℃°。
  8. 根据权利要求3所述的一种金属材料的制备方法，其特征在于，所述步骤3中以10-15℃/min的速率加热至1700℃-1800℃。
  9. 一种金属材料制品，其特征在于，利用权利要求1-8任一项所述的金属材料制成，应用于口腔修复体、关节、脊柱及创伤等医疗领域。
PCT/CN2020/094850 2020-06-08 2020-06-08 一种金属材料及其制备方法与应用 Ceased WO2021248260A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2020/094850 WO2021248260A1 (zh) 2020-06-08 2020-06-08 一种金属材料及其制备方法与应用
CN202080005302.1A CN113166854A (zh) 2020-06-08 2020-06-08 一种金属材料及其制备方法与应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2020/094850 WO2021248260A1 (zh) 2020-06-08 2020-06-08 一种金属材料及其制备方法与应用

Publications (1)

Publication Number Publication Date
WO2021248260A1 true WO2021248260A1 (zh) 2021-12-16

Family

ID=76879192

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/094850 Ceased WO2021248260A1 (zh) 2020-06-08 2020-06-08 一种金属材料及其制备方法与应用

Country Status (2)

Country Link
CN (1) CN113166854A (zh)
WO (1) WO2021248260A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114990457A (zh) * 2021-12-31 2022-09-02 苏州市博旺金属工艺制品有限公司 一种铁基复合材料及其制备方法
CN115927912A (zh) * 2023-01-09 2023-04-07 广西农业职业技术大学 一种耐热型钛合金及其制备方法
KR20240066921A (ko) 2022-11-08 2024-05-16 한국생산기술연구원 고내식성 타이타늄 합금의 제조방법

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115305384A (zh) * 2022-01-20 2022-11-08 昆明医科大学第一附属医院 一种具有形状记忆功能的抑菌合金的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1659302A (zh) * 2002-05-30 2005-08-24 德累斯顿协会莱布尼茨固体材料研究所 由钛合金构成的高强度的、可塑变形的成型体
CN101212990A (zh) * 2005-07-01 2008-07-02 金文申有限公司 包含网状复合材料的医疗器械
WO2008122595A2 (en) * 2007-04-05 2008-10-16 Cinvention Ag Biodegradable therapeutic implant for bone or cartilage repair
CN103540784A (zh) * 2013-10-29 2014-01-29 昆明理工大学 一种生物医用多孔钛合金的制备方法
CN103906850A (zh) * 2011-10-21 2014-07-02 利默里克大学 形成烧结的镍-钛-稀土（Ni-Ti-RE）合金的方法
CN106029931A (zh) * 2013-10-09 2016-10-12 怡康医疗股份有限公司 用于医疗装置的改善的金属合金
US20170151053A1 (en) * 2000-05-12 2017-06-01 Vactronix Scientific, Inc. Monolithic biocompatible implantable laminated materials
CN109261968A (zh) * 2018-11-16 2019-01-25 攀枝花学院 多孔钛及钛合金的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048369B2 (en) * 2003-09-05 2011-11-01 Ati Properties, Inc. Cobalt-nickel-chromium-molybdenum alloys with reduced level of titanium nitride inclusions
EP2496724B1 (en) * 2009-11-02 2016-09-28 SAES Smart Materials Ni-Ti SEMI-FINISHED PRODUCTS AND RELATED METHODS
CN103805798A (zh) * 2014-02-20 2014-05-21 中南大学 多孔钽铌合金及其制备方法
CN104152738B (zh) * 2014-08-14 2016-12-07 昆明理工大学 一种生物医用多孔镍钛合金的制备方法
CN109310493A (zh) * 2016-04-20 2019-02-05 韦恩堡金属研究产品公司 具有减少的氧化物夹杂物的镍-钛-钇合金
CN106119794A (zh) * 2016-07-08 2016-11-16 苏州市皎朝纳米科技有限公司 一种含铌镍钛系形状记忆合金及其制备方法和应用
CN107794426B (zh) * 2017-04-10 2019-05-07 中南大学 一种孔隙可控的多孔铌钽钛合金材料及其制备方法
CN108504901A (zh) * 2018-04-02 2018-09-07 苏州诺弘添恒材料科技有限公司 一种钛镍钴记忆合金体的制备方法
WO2020039658A1 (ja) * 2018-08-22 2020-02-27 株式会社ジャロック 超弾性シームレスチューブの製造方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170151053A1 (en) * 2000-05-12 2017-06-01 Vactronix Scientific, Inc. Monolithic biocompatible implantable laminated materials
CN1659302A (zh) * 2002-05-30 2005-08-24 德累斯顿协会莱布尼茨固体材料研究所 由钛合金构成的高强度的、可塑变形的成型体
CN101212990A (zh) * 2005-07-01 2008-07-02 金文申有限公司 包含网状复合材料的医疗器械
WO2008122595A2 (en) * 2007-04-05 2008-10-16 Cinvention Ag Biodegradable therapeutic implant for bone or cartilage repair
CN103906850A (zh) * 2011-10-21 2014-07-02 利默里克大学 形成烧结的镍-钛-稀土（Ni-Ti-RE）合金的方法
CN106029931A (zh) * 2013-10-09 2016-10-12 怡康医疗股份有限公司 用于医疗装置的改善的金属合金
CN103540784A (zh) * 2013-10-29 2014-01-29 昆明理工大学 一种生物医用多孔钛合金的制备方法
CN109261968A (zh) * 2018-11-16 2019-01-25 攀枝花学院 多孔钛及钛合金的制备方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114990457A (zh) * 2021-12-31 2022-09-02 苏州市博旺金属工艺制品有限公司 一种铁基复合材料及其制备方法
KR20240066921A (ko) 2022-11-08 2024-05-16 한국생산기술연구원 고내식성 타이타늄 합금의 제조방법
CN115927912A (zh) * 2023-01-09 2023-04-07 广西农业职业技术大学 一种耐热型钛合金及其制备方法
CN115927912B (zh) * 2023-01-09 2024-03-15 广西农业职业技术大学 一种耐热型钛合金及其制备方法

Also Published As

Publication number Publication date
CN113166854A (zh) 2021-07-23

Similar Documents

Publication Publication Date Title
Priyadarshini et al. Bioactive coating as a surface modification technique for biocompatible metallic implants: a review
WO2021248260A1 (zh) 一种金属材料及其制备方法与应用
Avila et al. Additive manufacturing of titanium and titanium alloys for biomedical applications
CN103599561B (zh) 一种镁合金/羟基磷灰石复合材料的制备方法
CN102312129B (zh) 一种利用放电等离子烧结制备钛铌锆锡生物医用钛合金的方法
Nasar Hydroxyapatite and its coatings in dental implants
CN104436301B (zh) 一种镁合金上植酸/羟基磷灰石杂化涂层的制备方法
CN107119260B (zh) 一种骨植入用镁-铜涂层及其制备方法
CN104857566B (zh) 一种钛铌锆基羟基磷灰石生物复合材料的制备方法
CN106420119A (zh) 一种高抗菌性钛合金人工髋关节的成形方法
Shah et al. Surface Modification on Titanium Alloy for Biomedical Application
CN104894420A (zh) 一种钛铌锆基焦磷酸钙生物复合材料的制备方法
CN107693848A (zh) 一种生物医用金属材料及其制备方法
CN101138649B (zh) 一种在植入物表面获得生物活性、开放式多孔钛涂层的方法
Albayrak et al. Ceramic coatings for biomedical applications
Xiaopeng et al. Electrochemical corrosion and bioactivity of Ti-Nb-Sn-hydroxyapatite composites fabricated by pulse current activated sintering
Sridhar Nanobioceramic coatings for biomedical applications
CN105671365A (zh) 一种钛钙铜生物材料的制备方法
CN112831703B (zh) 一种铌铜合金材料及其制备方法
CN112063886A (zh) 一种具有微/纳米孔隙的含镁生物β钛合金及其制备方法
Xu et al. Microstructure, degradation properties and cytocompatibility of micro-arc oxidation coatings on the microwave sintered Ti-15Mg metal-metal composite
CN108126245B (zh) 一种骨科钛合金植入材料及其制备方法
CN113046596B (zh) 一种骨修复钛钼基羟基磷灰石复合材料及其制备方法
CN116103553A (zh) 一种Mo-Mn系可降解钼合金及其制备方法与应用
Babu et al. Review on Emerging Applications of Nanobiomaterials in Dentistry and Orthopaedics.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20939962

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20939962

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 20939962

Country of ref document: EP

Kind code of ref document: A1

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 01/06/2023)

122 Ep: pct application non-entry in european phase

Ref document number: 20939962

Country of ref document: EP

Kind code of ref document: A1