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WO2021248260A1 - Matériau métallique, son procédé de préparation et application associée - Google Patents

Matériau métallique, son procédé de préparation et application associée Download PDF

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Publication number
WO2021248260A1
WO2021248260A1 PCT/CN2020/094850 CN2020094850W WO2021248260A1 WO 2021248260 A1 WO2021248260 A1 WO 2021248260A1 CN 2020094850 W CN2020094850 W CN 2020094850W WO 2021248260 A1 WO2021248260 A1 WO 2021248260A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
metal material
mixed powder
niobium
tantalum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2020/094850
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English (en)
Chinese (zh)
Inventor
徐春娟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Jiangdong Industry And Trade Co Ltd
Original Assignee
Nanjing Jiangdong Industry And Trade Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Jiangdong Industry And Trade Co Ltd filed Critical Nanjing Jiangdong Industry And Trade Co Ltd
Priority to PCT/CN2020/094850 priority Critical patent/WO2021248260A1/fr
Priority to CN202080005302.1A priority patent/CN113166854A/zh
Publication of WO2021248260A1 publication Critical patent/WO2021248260A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C19/00—Alloys based on nickel or cobalt
    • C22C19/03—Alloys based on nickel or cobalt based on nickel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/04—Making non-ferrous alloys by powder metallurgy
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/04—Making non-ferrous alloys by powder metallurgy
    • C22C1/0433—Nickel- or cobalt-based alloys
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C30/00—Alloys containing less than 50% by weight of each constituent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Definitions

  • the invention relates to the field of metal composite material preparation, in particular, to a composite metal material preparation and a preparation method and application thereof.
  • Titanium-based alloy materials are mainly used in aerospace and biomedical fields due to their unique chemical and mechanical properties and good biocompatibility. They are alloy materials commonly used in technology, but titanium alloys have poor oxidation resistance at high temperatures. , The forming atmosphere needs to be strictly controlled; at the same time, the thermal conductivity of titanium alloy is poor, and there are strict requirements for energy input during the forming process.
  • the biological materials used in the orthopedics field include metal materials, polymer materials, bioceramics and composite materials.
  • Metal materials are widely used in joint, spine and trauma diseases due to their high mechanical strength and fatigue resistance. Treatment has played a huge role in the reconstruction of bone stability and the replacement of joint function.
  • the most commonly used metal materials in clinical practice include stainless steel, cobalt-based alloys and titanium-based alloys. Others such as shape memory alloys and stable metals (tantalum, niobium, ho, etc.) have also been used more and more widely.
  • the present invention provides a metal material.
  • the alloy material has a relatively high Good fatigue resistance and strong corrosion resistance increase its comprehensive mechanical properties.
  • appropriate amount of silver is added to ensure its basic mechanical properties At the same time of performance, it has a certain broad-spectrum sterilization or antibacterial effect, effectively solves the bacterial infection problem of titanium alloy surgical implants, and can be widely used in medical fields such as joints, spine and trauma.
  • the technical solution of the present invention includes a metal material comprising the following components in parts by weight: 35-42 parts of nickel, 15-20 parts of cobalt, 1-3 parts of silver, 25-30 parts of titanium, 0.5-3 parts of tantalum, 0.1-0.3 parts of niobium.
  • niobium contains the following components in parts by weight: 38 parts of nickel, 17 parts of cobalt, 1.8 parts of silver, 26.5 parts of titanium, 0.8 parts of tantalum, and 0.1 parts of niobium.
  • the technical scheme of the present invention also includes a method for preparing a metal material, including the following steps:
  • Step 1 The ingredients are prepared according to the following parts by weight: 35-42 parts of nickel, 15-20 parts of cobalt, 1-3 parts of silver, 25-30 parts of titanium, 0.5-3 parts of tantalum, and 0.1-0.3 parts of niobium. Place the mixed powder in a stainless steel ball mill tank, fill it with absolute ethanol, and seal it. Use argon gas to protect and mix in a planetary ball mill for 4 hours. Take out the ball-milled mixed powder and place it on filter paper for 6-8 minutes to obtain mixed powder. ;
  • Step 2 Put a certain amount of polyvinyl alcohol into deionized distilled water and heat it until it dissolves. After cooling, add a certain proportion of polyvinyl alcohol solution to the mixed powder, and stir thoroughly to make it have a proper degree The slurry is naturally air-dried and cooled, then dried in a vacuum drying oven at a temperature of 70-80°C, and finally taken out for natural cooling.
  • Step 3 Keep the vacuum always below 8 ⁇ 10 -2 Pa for sintering, first heat to 200°C-300°C for debinding and decomposition; heat to sintering temperature 1400-1500°C°, keep for 2-4h, then heat to Keep the temperature at 1700°C-1800°C for 1-2h, cool to room temperature along with the furnace, take the sintered body out of the furnace, clean it in an ultrasonic water bath for 15-20min, and then dry it.
  • the ball-to-material ratio used in the ball milling in the step 1 is 10:1.
  • the rotation speed of the ball mill in the step 1 is 400-500 r/min.
  • the ratio of the mixed powder to the polyvinyl alcohol solution in step 2 is: each 100 g of the mixed powder is mixed with 20 ml of the polyvinyl alcohol solution.
  • heating is performed to a sintering temperature of 1400-1500°C° at a rate of 5-10°C/min.
  • step 3 heating to 1700°C-1800°C at a rate of 10-15°C/min.
  • the technical solution of the present invention also includes a metal material product, which is characterized in that it is made of the metal material described in any one of the above solutions, and is used in medical fields such as oral restorations, joints, spine, and trauma.
  • the beneficial effects of the present invention are: by adding cobalt, tantalum and niobium, the alloy material has good fatigue resistance and strong corrosion resistance, and its comprehensive mechanical properties are increased. At the same time, it has good biocompatibility. Performance, high mechanical strength and fatigue resistance; the method of combining colloidal dipping and powder metallurgy can be used to prepare porous materials, through the design and construction of the porous structure, the connection between the implant and the bone is obtained, thereby providing a good Biologically fixed, the porous structure can improve the compatibility of the implant and bone tissue on the one hand, and on the other hand can promote the deposition of vitronectin and fibronectin on the surface and inside of the alloy, thereby increasing the adhesion of osteoblasts, Proliferation and differentiation; can be widely used in medical fields such as joints, spine and trauma.
  • adding a proper amount of silver to the titanium alloy can make the titanium alloy have a certain broad-spectrum bactericidal or antibacterial effect while ensuring its basic mechanical properties, effectively solving the bacterial infection problem of titanium alloy surgical implants.
  • a metal material comprising the following components in parts by weight: 35 parts of nickel, 15 parts of cobalt, 1 part of silver, 30 parts of titanium, 0.5 part of tantalum, and 0.1 part of niobium.
  • a metal material comprising the following components in parts by weight: 38 parts of nickel, 17 parts of cobalt, 1.8 parts of silver, 26.5 parts of titanium, 0.8 parts of tantalum, and 0.1 parts of niobium.
  • a metal material comprising the following components in parts by weight: 42 parts of nickel, 20 parts of cobalt, 3 parts of silver, 25 parts of titanium, 3 parts of tantalum, and 0.3 parts of niobium.
  • the metal material in Example 1 was prepared according to the following steps:
  • Step 1 The ingredients are prepared according to the following parts by weight: 35 parts of nickel, 15 parts of cobalt, 1 part of silver, 30 parts of titanium, 0.5 part of tantalum, and 0.1 part of niobium. Put the mixed powder in a stainless steel ball mill tank, fill it with absolute ethanol, and seal it. Use argon gas to protect and mix in the planetary ball mill for 4 hours. The speed of the ball mill is 400r/min. Take out the ball milled mixed powder and place it on the filter paper. 6 minutes to get mixed powder;
  • Step 2 Put a certain amount of polyvinyl alcohol into deionized distilled water and heat it until it dissolves. After cooling, add a certain proportion of polyvinyl alcohol solution to the mixed powder, and stir thoroughly to make it have a proper degree The slurry is naturally air-dried and cooled, then dried in a vacuum drying oven at a temperature of 80 °C, and finally taken out to be naturally cooled.
  • Step 3 Keep the vacuum always below 8 ⁇ 10 -2 Pa for sintering, first heat to 200°C for debinding and decomposition; heat to sintering temperature 1400°C for 2h, then heat to 1700°C for 2h, then The furnace is cooled to room temperature, and the sintered body is taken out of the furnace, cleaned in an ultrasonic water bath for 15 minutes, and then dried to obtain it.
  • the metal material in Example 3 was prepared according to the following steps:
  • Step 1 The ingredients are prepared according to the following parts by weight: 42 parts of nickel, 20 parts of cobalt, 3 parts of silver, 25 parts of titanium, 3 parts of tantalum, and 0.3 parts of niobium.
  • the planetary ball mill uses argon gas to protect and mix for 4 hours.
  • the ball-to-material ratio used in the ball mill is 10:1, and the speed of the ball mill is 500r/min. .
  • Step 2 Put a certain amount of polyvinyl alcohol into deionized distilled water and heat it to dissolve. After cooling, mix 100g of the mixed powder with 20ml polyvinyl alcohol solution and stir thoroughly to make it have a proper degree of consistency The slurry is naturally air-dried and cooled, then dried in a vacuum drying oven at a temperature of 70°C, and finally taken out for natural cooling.
  • Step 3 Keep the vacuum always below 8 ⁇ 10 -2 Pa for sintering, first heat to 300°C for debinding and decomposition; heat it to the sintering temperature of 1460°C at a rate of 5-10°C/min, and hold for 2 hours. Heat to 1780°C at a rate of 10-15°C/min, keep it for 2h, cool to room temperature along with the furnace, take the sintered body out of the furnace, clean it in an ultrasonic water bath for 20 minutes, and dry it to get it.
  • An artificial joint made of composite metal materials prepared in Examples 1-5 can be applied to joint replacement surgery.
  • a dental implant made of composite metal materials prepared in Examples 1-5 can be applied to denture implant surgery.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Powder Metallurgy (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un matériau métallique, son procédé de préparation et un produit de matériau métallique associé, le matériau métallique comprenant les composants suivants en parties en poids : de 35 à 42 parties de nickel, de 15 à 20 parties de cobalt, de 1 à 3 parties d'argent, de 25 à 30 parties de titanium, de 0,5 à 3 parties de tantale et de 0,1 à 0,3 parties de niobium. Le procédé de préparation du matériau métallique utilise une combinaison d'un procédé de trempage par colloïde et d'un procédé de métallurgie des poudres, ce qui permet d'améliorer les défauts dans lesquels un alliage de titane a une faible résistance à l'oxydation et une faible conductivité thermique à des températures élevées et a des exigences strictes en termes d'entrée d'énergie pendant un processus de formation ; en outre, en ajoutant du cobalt, du tantale et du niobium, le matériau métallique présente une résistance à la fatigue, une résistance à la corrosion et des propriétés mécaniques globales relativement bonnes. Entre temps, étant donné que le matériau métallique a une bonne biocompatibilité, une résistance mécanique et une résistance à la fatigue relativement élevées, l'ajout d'une quantité appropriée d'élément d'argent assure ses propriétés mécaniques de base et le matériau métallique a également un certain effet antibactérien ou de stérilisation à large spectre, ce qui permet de résoudre efficacement le problème d'infections bactériennes d'instruments d'implantation chirurgicale en alliage de titane. En outre, les produits en matériau métallique fabriqués à partir dudit matériau métallique peuvent être largement appliqués à des domaines médicaux tels que des prothèses buccales, des articulations, de la colonne vertébrale, des traumatismes et ainsi de suite.
PCT/CN2020/094850 2020-06-08 2020-06-08 Matériau métallique, son procédé de préparation et application associée Ceased WO2021248260A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2020/094850 WO2021248260A1 (fr) 2020-06-08 2020-06-08 Matériau métallique, son procédé de préparation et application associée
CN202080005302.1A CN113166854A (zh) 2020-06-08 2020-06-08 一种金属材料及其制备方法与应用

Applications Claiming Priority (1)

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PCT/CN2020/094850 WO2021248260A1 (fr) 2020-06-08 2020-06-08 Matériau métallique, son procédé de préparation et application associée

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CN114990457A (zh) * 2021-12-31 2022-09-02 苏州市博旺金属工艺制品有限公司 一种铁基复合材料及其制备方法
CN115927912A (zh) * 2023-01-09 2023-04-07 广西农业职业技术大学 一种耐热型钛合金及其制备方法
KR20240066921A (ko) 2022-11-08 2024-05-16 한국생산기술연구원 고내식성 타이타늄 합금의 제조방법

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CN1659302A (zh) * 2002-05-30 2005-08-24 德累斯顿协会莱布尼茨固体材料研究所 由钛合金构成的高强度的、可塑变形的成型体
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Publication number Priority date Publication date Assignee Title
CN114990457A (zh) * 2021-12-31 2022-09-02 苏州市博旺金属工艺制品有限公司 一种铁基复合材料及其制备方法
KR20240066921A (ko) 2022-11-08 2024-05-16 한국생산기술연구원 고내식성 타이타늄 합금의 제조방법
CN115927912A (zh) * 2023-01-09 2023-04-07 广西农业职业技术大学 一种耐热型钛合金及其制备方法
CN115927912B (zh) * 2023-01-09 2024-03-15 广西农业职业技术大学 一种耐热型钛合金及其制备方法

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