WO2020044515A1 - 試料プレート供給制御装置、試料プレート供給制御システム、試料プレート供給制御方法および試料プレート供給制御プログラム - Google Patents
試料プレート供給制御装置、試料プレート供給制御システム、試料プレート供給制御方法および試料プレート供給制御プログラム Download PDFInfo
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- WO2020044515A1 WO2020044515A1 PCT/JP2018/032223 JP2018032223W WO2020044515A1 WO 2020044515 A1 WO2020044515 A1 WO 2020044515A1 JP 2018032223 W JP2018032223 W JP 2018032223W WO 2020044515 A1 WO2020044515 A1 WO 2020044515A1
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- Prior art keywords
- sample plate
- identification information
- unit
- sample
- target
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00752—Type of codes bar codes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/046—General conveyor features
- G01N2035/0465—Loading or unloading the conveyor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
Definitions
- the present invention relates to a sample plate supply control device and a sample plate supply control system provided with a sample plate holding unit for holding a sample plate supplied to an autosampler.
- the present invention also relates to a sample plate supply control method and a sample plate supply control program.
- the analysis system includes a plurality of functional units, a control device, and a computer.
- the control device controls the plurality of functional units.
- the computer analyzes the chromatogram data.
- the plurality of functional units include a pump, an oven, a detector, and the like included in the liquid chromatograph.
- the plurality of functional units include an autosampler for injecting a sample to be analyzed into the liquid chromatograph, a plate changer for supplying a sample plate containing the sample to the autosampler, and the like.
- the computer that analyzes the chromatogram data functions as a CDS (chromatography @ data @ system) by installing a program for controlling the analysis system and analyzing the chromatogram data.
- the user stores the sample plate containing the sample bottle in the plate changer in advance to start the analysis process.
- the user operates the computer functioning as the CDS, and selects a sample plate for starting the analysis process.
- the target sample plate is taken out of the plate changer, and the sample plate is supplied to the autosampler.
- the autosampler injects the sample into the liquid chromatograph, and the analysis process is started.
- Plate changers can accommodate multiple sample plates. For example, when 30 sample plates can be accommodated in the plate changer, the plate changer has the No. corresponding to the sample plate accommodation section. 1 to No. Numbers up to 30 are displayed.
- the computer specifies the number of the sample plate storage unit in the computer. For example, if the user is No. When the sample plate is accommodated in the sample plate accommodating section of No. 10, the user makes No. 10 on the computer. An instruction to start the analysis process is given to the ten sample plate storage units.
- Patent Literature 1 discloses an analysis system including a rack standby place (plate changer) capable of accommodating a plurality of racks (sample plates). JP 2006-189362 A
- a plate changer capable of accommodating a plurality of sample plates may be attached to the autosampler.
- the plate changer can accommodate a plurality of sample plates at the same time. For this reason, the user may make a mistake in the position for accommodating the sample plate in the plate changer. Alternatively, the user may mistakenly designate the position where the sample plate is stored in the operation of the computer.
- the user may specify the position where the sample plate is to be accommodated in advance by an analysis instruction or the like. Even in such a case, in an environment where a plurality of users share and use the analysis system, another user has already placed another sample plate in the storage position of the sample plate specified in the analysis instruction sheet. May be contained. In such a situation, the user must perform the work of replacing the sample plate.
- the user may store the sample plate in another unused sample plate storage unit. is there. In this case, the user has to operate the computer to change the set plate position.
- a sample plate supply control device is a sample plate supply control device that controls supply of a sample plate from a sample plate holding unit having a plurality of sample plate storage units to an autosampler.
- An identification information recognizing unit for recognizing identification information of the accommodated sample plate when a sample plate is accommodated in one of the sample plate accommodation units, and identification information of a target sample plate to be analyzed
- a supply instruction unit for instructing the sample plate holding unit to supply the sample plate stored in the one sample plate storage unit to the autosampler when the identification information recognized by the identification information recognition unit matches the identification information.
- This sample plate supply control device recognizes the identification information of the sample plate stored in one of the plurality of sample plate storage units. Then, when the identification information of the target sample plate matches the identification information of the recognized sample plate, the sample plate supply control device supplies the sample plate accommodated in one sample plate accommodation section to the autosampler. Thus, the target sample plate is supplied to the autosampler regardless of which sample plate storage unit stores the sample plate.
- the user does not have to be conscious of which sample plate storage section the sample plate should be stored in the sample plate holding section.
- the user only has to store the sample plate in the empty sample plate storage unit.
- the analysis process is not started for different sample plates due to an incorrect operation. Even when a plurality of users share the sample plate holding unit, each user can freely use the vacant sample plate storage unit.
- the supply instruction unit notifies the autosampler of the processing information, and stores the one sample plate. It may be instructed to execute processing on the sample plate stored in the unit based on the processing information.
- the sample plate supply control device supplies the sample plate stored in one sample plate storage unit to the autosampler. At this time, the sample plate supply control device notifies the autosampler of processing information for the target plate. Thus, no matter which sample plate storage unit stores the sample plate, the processing is started for the target sample plate based on the processing information.
- the sample plate holding unit may be instructed to supply the sample plate housed in one sample plate housing unit to the autosampler.
- the sample plate supply control device determines whether or not the autosampler is executing a process for another sample plate.
- the sample plate supply control device may set the autosampler to store the sample plate stored in one sample plate storage unit after the process on another sample plate is completed. To supply.
- the execution of the target sample plate is reserved. The user can set the target sample plate regardless of whether or not the autosampler is executing a process for another sample plate.
- the supply instructing unit notifies the sample plate holding unit. It may be instructed to supply the sample plate stored in one sample plate storage unit to the autosampler.
- the sample plate supply control device supplies the sample plate stored in one sample plate storage unit to the auto sampler when any of the identification information of the plurality of target sample plates matches the identification information of the recognized sample plate. I do. Thereby, even if any of the sample plate storage units stores the sample plate, any one of the plurality of target sample plates is supplied to the autosampler. The user can make a reservation for the analysis process for a plurality of target sample plates at the same time.
- a printing unit for printing identification information of the target sample plate to be attached to the target sample plate may be further provided.
- Identification information to be attached to the target sample plate is printed.
- the user can set the target sample plate and print the identification information to be attached to the target sample plate.
- the identification information of the target sample plate may be attached to the target sample plate as a barcode image.
- Identification information is affixed to the target sample plate as a barcode image. Using the barcode reading function, the identification information of the target sample plate can be read.
- a sample plate supply control system includes an autosampler that injects a sample to be analyzed into an analyzer, a sample plate holding unit having a plurality of sample plate storage units, and a sample plate.
- the sample plate holding unit includes an identification information recognition unit that recognizes identification information of the accommodated sample plate when the sample plate is accommodated in one of the plurality of sample plate accommodation units, and is accommodated.
- An identification information presenting unit that provides the identification information of the sample plate to the terminal device.
- the identification information acquisition unit that acquires the identification information of the sample plate accommodated from the sample plate holding unit matches the identification information of the target sample plate to be analyzed with the identification information acquired by the identification information acquisition unit.
- a supply instruction unit for instructing the sample plate holding unit to supply the sample plate stored in one sample plate storage unit to the autosampler.
- This sample plate supply system recognizes the identification information of the sample plate stored in one of the plurality of sample plate storage units. Then, when the identification information of the target sample plate matches the identification information of the recognized sample plate, the sample plate supply control system supplies the sample plate accommodated in one sample plate accommodation section to the autosampler. Thus, the target sample plate is supplied to the autosampler regardless of which sample plate storage unit stores the sample plate.
- the sample plate holding unit may include a plurality of indicators provided corresponding to the plurality of sample plate storage units. Each display may display a processing state for each sample plate stored in each sample plate storage unit.
- the display displays the processing status of the sample plate in each sample plate storage unit.
- the user can identify available sample plate receptacles.
- a sample plate supply control method is a sample plate supply control method for controlling supply of a sample plate from a sample plate holding unit having a plurality of sample plate storage units to an autosampler. Acquiring the identification information of the accommodated sample plate from the sample plate holding unit when the sample plate is housed in one of the plurality of sample plate housing units; and When the identification information of the plate and the identification information obtained from the sample plate holding unit match, instructing the sample plate holding unit to supply the sample plate housed in one sample plate housing unit to the autosampler; and Is provided.
- a sample plate supply control program is a sample plate supply control program for controlling supply of a sample plate from a sample plate holding unit having a plurality of sample plate storage units to an autosampler.
- An object of the present invention is to provide a sample plate supply control device and a sample plate supply control system having a sample plate holding unit capable of accommodating a plurality of sample plates, thereby improving the efficiency of sample plate accommodation operations and sample plate supply instructions. it can.
- FIG. 1 is an overall view of an analysis system according to the present embodiment.
- 2A is a plan view of the sample plate
- FIG. 2B is a rear view of the sample template.
- FIG. 3 is a diagram showing a plate changer and an autosampler according to the present embodiment.
- FIG. 4 is a functional block diagram of the sample plate supply control system according to the present embodiment.
- FIG. 5 is a view showing a plate setting screen displayed on the monitor of the computer according to the present embodiment.
- FIG. 6 is a flowchart executed by the computer according to the present embodiment.
- FIG. 7 is a flowchart executed by the computer according to the present embodiment.
- FIG. 8 is a flowchart executed by the computer according to the present embodiment.
- FIG. 1 is an overall view of an analysis system 10 according to the present embodiment.
- the analysis system 10 shown in FIG. 1 includes a computer 1, a network 2, a server 3, a control device 4, a plurality of functional units 5, and a printer 9.
- a liquid chromatograph 50 is constituted by a plurality of functional units 5.
- the liquid chromatograph 50 is, for example, a high-performance liquid chromatograph.
- the computer 1 is, for example, a general personal computer.
- the computer 1 executes a control process of the analysis system 10, a process of analyzing chromatogram data, and the like.
- the network 2 is a computer network such as a LAN (local area network).
- the computer 1 and the server 3 are connected via the network 2.
- the server 3 is, for example, a general computer server.
- the storage unit of the server 3 stores a batch table database 30 (hereinafter, abbreviated as a batch table DB 30).
- the batch table DB 30 stores a plurality of batch tables.
- the batch table is data in which the execution order and execution conditions of the analysis processing executed in the analysis system 10 are described.
- the batch table is set for a sample plate 8 (see FIG. 3) that contains a plurality of sample bins (vials).
- the batch table contains multiple records.
- One record is a record corresponding to one sample bin stored in the sample plate.
- One record describes the identification information of the sample plate 8, the sample bin number, the sample type, and the method file name.
- the method file is a data file in which the execution order and execution conditions of the analysis processing are described. That is, in the batch table, a method file in which the content of the analysis processing is described is set for each sample bin. Since the sample plate 8 contains a plurality of sample bins, the batch table includes records for all the sample bins contained in the sample plate 8.
- the control device 4 is connected to the computer 1 via a communication cable.
- the control device 4 is also connected to a plurality of functional units 5 via a communication cable.
- the analysis system 10 includes a plurality of functional units 5.
- the plurality of functional units 5 include a pump, an oven, a detector, and the like included in the liquid chromatograph 50.
- an autosampler 7 (see FIG. 2) for injecting a sample to be analyzed into the liquid chromatograph 50 and a sample plate containing the sample are supplied to the plurality of functional units 5 to the autosampler 7.
- the plate changer 6 (see FIG. 2) and the like are included.
- FIG. 2A is a plan view of the sample plate 8.
- FIG. 2B shows a rear view of the sample plate 8.
- FIG. 3 is a diagram showing a configuration of the plate changer 6. First, the sample plate 8 will be described with reference to FIGS.
- the sample plate 8 is provided with a plurality of holes 81 for accommodating the sample bottles.
- a bar code 91 is attached to the back surface of the sample plate 8 of the present embodiment.
- information for identifying the sample plate 8 is written as identification information.
- the stored sample plate 8 is specified by reading the barcode 91.
- the plate changer 6 is provided on a side of the autosampler 7 as a device attached to the autosampler 7.
- the plate changer 6 can hold a plurality of sample plates 8.
- the sample plate 8 can accommodate a plurality of sample bins each containing a sample to be analyzed.
- each of the three changers 6A, 6B, and 6C can store a plurality of sample plates 8 (in this example, each can store 14 sample plates 8).
- the changer 6A is No. 3 to No. It is provided with up to 16 sample plate storage units 61.
- the changer 6B is No. 17-No. Up to 30 sample plate storage units 61 are provided.
- the changer 6C is No. 31-No. Up to 44 sample plate storage units 61 are provided.
- the autosampler 7 has No. 1 and No. No. 2 is provided, so that the number of the sample plate storage portion 61 of the changer 6A is No. It starts with 3.
- a display 62 is provided on the side of each sample plate housing 61.
- an LED is used as the display 62.
- the display 62 displays the processing state of the sample plate 8 stored in the sample plate storage unit 61.
- the display 62 turns on red light.
- the user may, for example, select No.
- the indicator 62 on the side of the sample plate storage part 61 of No. 25 is lit in red, It can be determined that the sample plates 8 stored in the 25 sample plate storage units 61 have not been processed. That is, the user is assigned the No. It can be determined that the sample plates 8 stored in the 25 sample plate storage units 61 are in the standby state.
- the display 62 illuminates red light when the unprocessed sample plate 8 is stored, but other processing states of the sample plate 8 may be identified.
- the adjacent display 62 may turn on green light with respect to the sample plate storage unit 61 in which the sample plate 8 on which the analysis processing has been completed is stored.
- the adjacent display 62 emits orange light. It may be turned on.
- FIG. 4 is a functional block diagram of the sample plate supply control system 20.
- the plate changer 6 includes a reading unit 63, a plate transport device 64, an identification information recognition unit 65, and an identification information presentation unit 66.
- the plate changer 6 includes a control unit 60 including a CPU (Central Processing Unit), a RAM (Random Access Memory), a ROM (Read Only Memory), and the like.
- the ROM stores a computer program such as a first control program.
- the CPU executes the first control program stored in the ROM on the RAM, the functions of the identification information recognition unit 65 and the identification information presentation unit 66 are realized.
- part or all of the identification information recognition unit 65 and the identification information presentation unit 66 may be realized by hardware such as an electronic circuit.
- the reading unit 63 obtains the information written in the barcode 91 by reading the barcode 91 attached to the sample plate 8 stored in each sample plate storage unit 61, and the obtained information and the sample plate 8 The number of the accommodated sample plate accommodation section 61 is given to the identification information recognition section 65.
- the plate transport device 64 takes out the sample plate 8 housed in any one of the plurality of sample plate housing sections 61 and supplies the taken out sample plate 8 to the autosampler 7. After the analysis process is completed, the plate transport device 64 receives the sample plate 8 from the autosampler 7, and stores the received sample plate 8 in the original sample plate storage unit 61.
- the sample plate 8 stored in each sample plate storage unit 61 is once taken out of the sample plate storage unit 61 by the plate transport device 64 for reading of the barcode 91 by the reading unit 63. .
- the plate transport device 64 moves the sample plate 8 taken out of the sample plate storage section 61 to a position where the reading section 63 can read the barcode 91.
- the plate transport device 64 transports the sample plate 8 to the original sample plate storage unit 61.
- a reading unit 63 may be individually provided for each sample plate storage unit 61.
- the identification information recognition unit 65 recognizes the identification information of the sample plate 8 stored in the sample plate storage unit 61. Specifically, the identification information recognition unit 65 acquires the identification information of the accommodated sample plate 8 from the information received from the reading unit 63. Then, the identification information recognition unit 65 gives the identification information of the sample plate 8 and the number of the sample plate storage unit 61 in which the sample plate 8 is stored to the identification information presentation unit 66.
- the identification information presentation unit 66 transmits to the control device 4 the identification information of the sample plate 8 received from the identification information recognition unit 65 and the number of the sample plate storage unit 61 in which the sample plate 8 is stored.
- the control device 4 transmits the identification information of the sample plate 8 received from the identification information presentation unit 66 and the number of the sample plate storage unit 61 in which the sample plate 8 is stored to the computer 1 via the control device 4.
- the computer 1 includes a target plate setting unit 11, a target plate storage unit 12, an identification information acquisition unit 13, a supply instruction unit 14, a printing unit 15, a monitor 18, and an operation unit 19.
- the supply instruction unit 14 includes a processing instruction unit 141.
- the computer 1 includes a storage device such as a CPU (Central Processing Unit), a RAM (Random Access Memory), a ROM (Read Only Memory), and a hard disk.
- a computer program such as a second control program is stored in the ROM.
- the CPU executes the second control program stored in the ROM or the storage device on the RAM, the functions of the target plate setting unit 11, the identification information acquisition unit 13, the supply instruction unit 14, and the printing unit 15 are realized. .
- Some or all of these functional units may be realized by hardware such as an electronic circuit.
- an analysis program for analyzing the chromatogram data is installed in the computer 1.
- the computer 1 functions as a CDS (chromatography ⁇ data ⁇ system) by the second control program and the analysis program.
- the target plate storage unit 12 is configured by a storage device such as a RAM or a hard disk.
- the target plate setting unit 11 sets analysis processing for the sample plate 8 to be analyzed.
- the sample plate 8 to be analyzed is appropriately referred to as a target sample plate 8T in the following description.
- the target plate setting unit 11 sets the plate identification information of the target sample plate 8T, the sample bin number, the sample type, and the method file name in association with each other as one record.
- the target plate setting unit 11 can set a plurality of records for the correspondence between the plate identification information of the target sample plate 8T, the sample bin number, the sample type, and the method file name.
- the target plate setting unit 11 collectively sets a plurality of records having the same plate identification information of the target sample plate 8T as a batch table.
- the target plate storage unit 12 stores the batch table set for the target sample plate 8T in the target plate setting unit 11.
- the identification information acquisition unit 13 receives the identification information of the sample plate 8 transmitted by the identification information presentation unit 66 via the control device 4 and the number of the sample plate storage unit 61 in which the sample plate 8 is stored.
- the supply instruction unit 14 compares the identification information of the target sample plate 8T stored in the target plate storage unit 12 with the identification information of the sample plate 8 acquired by the identification information acquisition unit 13. When the identification information of the target sample plate 8T stored in the target plate storage unit 12 matches the identification information of the sample plate 8 acquired by the identification information acquisition unit 13, the supply instruction unit 14 sends the identification information to the sample plate storage unit 61. It is determined that the accommodated sample plate 8 is the target sample plate 8T to be processed. When the supply instruction unit 14 determines that the target sample plate 8T is stored in the sample plate storage unit 61, the supply instruction unit 14 instructs the sample plate supply control system 20 to supply a sample plate. The processing content of the sample plate supply instruction will be described later in detail.
- the printing unit 15 generates a barcode 91 to be attached to the target sample plate 8T and gives an instruction to print.
- the printing unit 15 issues a print instruction for the barcode 91 to the printer 9.
- FIG. 5 is a diagram showing a plate setting screen 100 displayed on the monitor 18 of the computer 1 when the target plate setting unit 11 is executed.
- the plate setting screen 100 includes a plate identification information field 101 for inputting identification information of the target sample plate 8T, a batch table name field 102 for specifying a batch table name, a barcode print instruction button 103, and a standby instruction button 104.
- identification information for specifying the target sample plate 8T is input by the user.
- the user operates the operation unit 19 of the computer 1 and inputs identification information for specifying the target sample plate 8T using characters, numbers, symbols, or a combination thereof.
- the identification information to be input may be arbitrarily set by the user. Alternatively, the input identification information is set according to an analysis procedure manual or the like.
- the target plate setting unit 11 acquires a batch table from the batch table DB 30 stored in the server 3 shown in FIG.
- the user can display the batch table list screen by operating the operation unit 19 and moving the pointer to the batch table name field 102.
- the target plate setting unit 11 accesses the batch table DB 30 of the server 3, acquires a list of a plurality of batch tables prepared in advance, and displays the list on the monitor 18 as a list screen.
- the user can set a batch table by the target plate setting unit 11 accessing the batch table DB 30 of the server 3. That is, the user can select a batch table prepared in advance.
- the user may be able to create a batch table on the plate setting screen 100.
- the user may be able to edit the batch table acquired from the server 3 on the plate setting screen 100.
- the barcode print instruction button 103 is for generating a barcode 91 and instructing printing.
- the printing unit 15 When the user operates the operation unit 19 and selects the barcode print instruction button 103, the printing unit 15 generates image data of the barcode 91.
- the printing unit 15 converts the identification information input to the plate identification information field 101 into a barcode, and generates barcode 91 image data.
- the printing unit 15 transmits a print instruction for the generated image data of the barcode 91 to the printer 9.
- the printer 9 prints the sticker on which the image of the barcode 91 is printed.
- the user attaches the printed barcode 91 sticker to a predetermined position on the back surface of the sample plate 8 as shown in FIG.
- the sticker of the barcode 91 is attached to the back surface of the sample plate 8.
- a sticker of the barcode 91 may be attached to the side surface or the upper surface of the sample plate 8.
- the batch table for the target sample plate 8T is set. Further, the identification information of the target sample plate 8T is converted into a barcode, and a sticker of the barcode 91 is printed. The user attaches the seal of the barcode 91 to a predetermined position on the back surface of the target sample plate 8T as shown in FIG. 2B.
- the user operates the operation unit 19 to select the standby instruction button 104.
- the target plate setting unit 11 stores information set on the plate setting screen 100 in the target plate storage unit 12.
- the target plate storage unit 12 stores identification information of the target sample plate 8T and a batch table.
- the user After selecting the standby instruction button 104, the user moves to the place of the plate changer 6.
- the user accommodates the target sample plate 8T in any one of the sample plate accommodation portions 61 of the plate changer 6. At this time, the user may store the target sample plate 8T in any of the sample plate storage units 61.
- the user may store the target sample plate 8T in any of the sample plate storage units 61.
- a large number of sample plate storage units 61 are prepared, but the user may store the target sample plate 8T in any of the sample plate storage units 61.
- Preparations for analysis processing are completed by the above operations and processing. That is, the user inputs the identification information of the target sample plate 8T on the plate setting screen 100. The user sets a batch table on the plate setting screen 100. The user prints the sticker of the barcode 91 and affixes it to the target sample plate 8T.
- the target plate storage unit 12 stores the identification information of the target sample plate 8T and the batch table. Then, the user stores the target sample plate to which the barcode 91 seal is attached in one of the sample plate storage units 61. Next, the supply process of the sample plate 8 is started.
- the reading unit 63 reads the barcode 91 in the plate changer 6. You.
- the reading section 63 gives the information of the barcode 91 and the number of the sample plate storage section 61 in which the sample plate 8 has been stored to the identification information recognition section 65.
- the sample plate 8 is simply referred to as the sample plate 8 instead of the target sample plate 8T because it is a stage before it is determined whether or not the sample plate 8 is the target sample plate 8T.
- the identification information recognition unit 65 recognizes the identification information of the accommodated sample plate 8 from the received information of the barcode 91. Then, the identification information recognition unit 65 gives the identification information of the sample plate 8 and the number of the sample plate storage unit 61 in which the sample plate 8 is stored to the identification information presentation unit 66.
- the identification information presentation unit 66 transmits the identification information of the sample plate 8 and the number of the sample plate storage unit 61 to the control device 4.
- the control device 4 transmits the identification information of the sample plate 8 and the number of the sample plate storage section 61 to the computer 1.
- FIG. 6 is a flowchart showing processing executed by the identification information acquisition unit 13 and the supply instruction unit 14 of the computer 1.
- the identification information acquisition unit 13 of the computer 1 checks whether or not the identification information of the sample plate 8 and the number of the sample plate storage unit 61 have been acquired (Step S101).
- the supply instruction unit 14 refers to the target plate storage unit 12 (Step S102). If the identification information acquisition unit 13 does not acquire the identification information of the sample plate 8 and the number of the sample plate storage unit 61, the process ends.
- the supply instruction unit 14 determines whether the identification information of the target sample plate 8T stored in the target plate storage unit 12 matches the identification information of the sample plate 8 acquired by the identification information acquisition unit 13. Is determined (step S103). When the identification information of the target sample plate 8T stored in the target plate storage unit 12 matches the identification information of the sample plate 8 acquired by the identification information acquisition unit 13, the supply instruction unit 14 sends the identification information to the sample plate storage unit 61. It is determined that the accommodated sample plate 8 is the target sample plate 8T to be processed. When determining that the target sample plate 8T has been stored in the sample plate storage unit 61, the supply instruction unit 14 instructs the plate changer 6 to supply the target sample plate 8T.
- the supply instruction unit 14 instructs the plate changer 6 to supply the sample plate 8 having the identification information acquired by the identification information acquisition unit 13 to the autosampler 7 (Step S104).
- the supply instruction unit 14 instructs the plate changer 6 to supply the sample plate 8 stored in the sample plate storage unit 61 having the number acquired by the identification information acquisition unit 13 to the autosampler 7.
- the supply instruction unit 14 ends the process.
- the processing instruction unit 141 refers to the target plate storage unit 12 and acquires a batch table associated with the target sample plate 8T. Then, the processing instruction unit 141 notifies the autosampler 7 of information on the analysis processing based on the batch table (Step S105). Through the above processing, the plate changer 6 supplies the target sample plate 8T to the autosampler 7. Then, a sample is collected from the sample bin accommodated in the target sample plate 8T by the autosampler 7, and the sample is injected into the analyzer.
- the sample plate supply control system 20 of the present embodiment acquires the identification information of the sample plate 8 stored in any one of the sample plate storage units 61 among the plurality of sample plate storage units 61. I do. Then, when the identification information of the target sample plate 8T matches the identification information of the sample plate 8 acquired by the identification information acquisition unit 13, the sample plate supply control system 20 converts the sample plate 8 from which the identification information has been acquired into an autosampler. 7 Accordingly, the target sample plate 8T stored in the target plate storage unit 12 is supplied to the autosampler 7 regardless of which sample plate storage unit 61 stores the sample plate 8.
- the user does not need to be conscious of which sample plate storage section 61 the sample plate 8 should be stored in the plate changer 6.
- the user has only to accommodate the sample plate 8 in the empty sample plate accommodation section 61.
- the analysis process is not started for a different sample plate 8 due to an erroneous operation. Even when a plurality of users share the plate changer 6, each user can freely use the vacant sample plate storage unit 61.
- the sample plate supply control system 20 stores the information in the target plate storage unit 12 with respect to the autosampler 7. Specify the contents of the stored batch table. Thus, no matter which sample plate storage unit 61 stores the sample plate 8, the target sample plate 8 T stored in the target plate storage unit 12 is stored in the target plate storage unit 12. The analysis process is started based on the batch table.
- FIG. 7 is a flowchart illustrating processing executed by the identification information acquisition unit 13 and the supply instruction unit 14 of the computer 1 in the second embodiment.
- the identification information acquisition unit 13 of the computer 1 checks whether or not the identification information of the sample plate 8 and the number of the sample plate storage unit 61 have been acquired (Step S201).
- the supply instruction unit 14 refers to the target plate storage unit 12 (Step S202). If the identification information acquisition unit 13 does not acquire the identification information of the sample plate 8 and the number of the sample plate storage unit 61, the process ends.
- the supply instruction unit 14 determines whether the identification information of the target sample plate 8T stored in the target plate storage unit 12 matches the identification information of the sample plate 8 acquired by the identification information acquisition unit 13. Is determined (step S203). When the identification information of the target sample plate 8T stored in the target plate storage unit 12 matches the identification information of the sample plate 8 acquired by the identification information acquisition unit 13, the supply instruction unit 14 sends the identification information to the sample plate storage unit 61. It is determined that the accommodated sample plate 8 is the target sample plate 8T to be processed.
- the supply instruction unit 14 determines whether the target sample plate 8T is stored in the sample plate storage unit 61, it determines whether the autosampler 7 is executing a process for another sample plate 8 (step S204).
- the supply instruction unit 14 obtains the processing state of the autosampler 7 by making an inquiry to the control device 4.
- the supply instruction unit 14 obtains the processing state of the autosampler 7 by making an inquiry to the autosampler 7 via the control device 4.
- step S205 the supply instruction unit 14 waits for a predetermined time (step S205). If the predetermined time has elapsed, the supply instruction unit 14 returns to step S204, and determines whether the autosampler 7 is executing a process for another sample plate 8. If the autosampler 7 is executing a process for another sample plate 8, the processes of steps S204 and S205 are repeated.
- steps S206 and S207 are the same as steps S104 and S105 in FIG. 6 in the first embodiment, and thus description thereof will be omitted.
- the sample plate supply control system 20 of the present embodiment Is performing a process on another sample plate 8.
- the sample plate supply control system 20 supplies the sample plate 8 to the auto sampler 7 after the process for another sample plate 8 is completed when the auto sampler 7 is executing the process for another sample plate 8.
- execution of the target sample plate 8T is reserved. The user can set the target sample plate 8T regardless of whether or not the autosampler 7 is executing a process for another sample plate 8.
- the plurality of target sample plates 8T are in a standby state.
- identification information of a plurality of target sample plates 8T is stored in the target plate storage unit 12. That is, the user makes settings for a plurality of plate identification numbers on the plate setting screen 100 shown in FIG. 5, and selects the standby instruction button 104 for the plurality of settings. Thereby, the plurality of target sample plates 8T enter the standby state.
- FIG. 8 is a flowchart showing processing executed by the identification information acquisition unit 13 and the supply instruction unit 14 of the computer 1 in the third embodiment.
- the identification information acquisition unit 13 of the computer 1 checks whether the identification information of the sample plate 8 and the number of the sample plate storage unit 61 have been acquired (step S301).
- the supply instruction unit 14 refers to the target plate storage unit 12 (Step S302). If the identification information acquisition unit 13 does not acquire the identification information of the sample plate 8 and the number of the sample plate storage unit 61, the process ends.
- the supply instruction unit 14 determines a result obtained by referring to the target plate storage unit 12.
- the supply instructing unit 14 is configured to identify the identification information of any one of the target sample plates 8T among the identification information of the plurality of target sample plates 8T stored in the target plate storage unit 12 and the sample plate 8 acquired by the identification information acquisition unit 13. It is determined whether or not the identification information matches (step S303).
- the supply instruction unit 14 stores the sample plate. It is determined that the sample plate 8 accommodated in the unit 61 is the target sample plate 8T to be processed.
- the supply instruction unit 14 determines that the target sample plate 8T is stored in the sample plate storage unit 61, the supply instruction unit 14 instructs the plate changer 6 to supply the sample plate 8. Subsequent steps S304 and S305 are the same as steps S104 and S105 in FIG. 6 in the first embodiment, and thus description thereof will be omitted.
- the identification information of the target sample plate 8T stored in plurals matches the identification information of the sample plate 8 acquired by the identification information acquisition unit 13.
- the sample plate 8 is supplied to the autosampler 7. Accordingly, even when the sample plate 8 is stored in any of the sample plate storage units 61, any one of the target sample plates 8T among the plurality of target sample plates 8T stored in the target plate storage unit 12 is used. Is supplied to the autosampler 7. The user can make a reservation for the analysis process for a plurality of target sample plates 8T at the same time.
- the plate changer 6 is an example of the plate holding unit
- the computer 1 is an example of the terminal device
- the batch table is an example of the processing information.
- an apparatus functionally including the identification information recognition unit 65 of the plate changer 6 and the supply instruction unit 14 of the computer 1 is an example of the sample plate supply apparatus.
- one apparatus that is functionally provided with the identification information recognition unit 65 of the plate changer 6 and the supply instruction unit 14 of the computer 1 is not illustrated. The device may be provided.
- the second control program is an example of the sample plate supply control program.
- the plate changer 6, which is an example of the sample plate holding unit, is another device attached to the autosampler 7.
- the sample plate holder may be a separate device attached to the autosampler 7, but the autosampler 7 may have the sample plate holder inside.
- the plate changer 6 is used as a device for supplying the sample plate 8 to the autosampler 7 for liquid chromatography. It can be used as a device for supplying the sample plate 8 to an autosampler used in the device.
- the analysis system 10 of the present invention is not limited to a liquid chromatograph, and can be used for other analytical devices such as other types of liquid chromatographs.
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Abstract
Description
(1)分析システムの全体構成
図1は、本実施の形態に係る分析システム10の全体図である。図1に示す分析システム10は、コンピュータ1、ネットワーク2、サーバ3、制御装置4、複数の機能ユニット5およびプリンタ9を備える。本実施の形態においては、複数の機能ユニット5によって液体クロマトグラフ50が構成される。液体クロマトグラフ50は、例えば、高速液体クロマトグラフである。
図2(A)は、試料プレート8の平面図を示す。図2(B)は試料プレート8の背面図を示す。図3は、プレートチェンジャー6の構成を示す図である。まず、図2(A),(B)を参照しつつ試料プレート8について説明する。
図4は、試料プレート供給制御システム20の機能ブロック図である。図4に示すように、プレートチェンジャー6は、読取部63、プレート搬送装置64、識別情報認識部65および識別情報提示部66を備えている。プレートチェンジャー6は、CPU(中央演算処理装置)、RAM(ランダムアクセスメモリ)およびROM(リードオンリメモリ)等から構成される制御部60を有する。ROMには、第1の制御プログラム等のコンピュータプログラムが記憶される。CPUがROMに記憶された第1の制御プログラムをRAM上で実行することにより、識別情報認識部65および識別情報提示部66の機能が実現される。なお、識別情報認識部65および識別情報提示部66の一部またはすべてが電子回路等のハードウェアにより実現されてもよい。
次に、対象試料プレート8Tを設定するプレート設定の操作が説明される。プレート設定の操作は、コンピュータ1が備える対象プレート設定部11により実行される。図5は、対象プレート設定部11が実行されることにより、コンピュータ1のモニタ18に表示されるプレート設定画面100を示す図である。
ユーザが対象試料プレート8Tをいずれかの試料プレート収容部61に収容すると、プレートチェンジャー6において、読取部63によるバーコード91の読取操作が実行される。読取部63は、バーコード91の情報と試料プレート8が収容されていた試料プレート収容部61の番号とを識別情報認識部65に与える。なお、以降の処理では、試料プレート8が対象試料プレート8Tであるか否かが識別される前の段階のため、試料プレート8は、対象試料プレート8Tではなく単に試料プレート8と呼ばれる。識別情報認識部65は、受け取ったバーコード91の情報から、収容された試料プレート8の識別情報を認識する。そして、識別情報認識部65は、認識した試料プレート8の識別情報と試料プレート8が収容されている試料プレート収容部61の番号とを識別情報提示部66に与える。
次に、本発明の第2の実施の形態が説明される。第2の実施の形態においては、オートサンプラ7が分析処理を実行しているとき、プレートチェンジャー6が待機状態となる。図7は、第2の実施の形態においてコンピュータ1の識別情報取得部13および供給指示部14により実行される処理を示すフローチャートである。まず、コンピュータ1の識別情報取得部13は、試料プレート8の識別情報と試料プレート収容部61の番号とを取得したか否かをチェックする(ステップS201)。識別情報取得部13が試料プレート8の識別情報と試料プレート収容部61の番号とを取得した場合、供給指示部14は、対象プレート記憶部12を参照する(ステップS202)。識別情報取得部13が試料プレート8の識別情報と試料プレート収容部61の番号とを取得しない場合、処理を終了する。
次に、本発明の第3の実施の形態が説明される。第3の実施の形態においては、複数の対象試料プレート8Tがスタンバイ状態となる。第3の実施の形態の前提として、対象プレート記憶部12には、複数の対象試料プレート8Tの識別情報が記憶される。つまり、ユーザは、図5で示したプレート設定画面100において、複数のプレート識別番号について設定を行い、複数の設定に対してスタンバイ指示ボタン104を選択している。これにより、複数の対象試料プレート8Tがスタンバイ状態となる。
以下、請求項の各構成要素と実施の形態の各要素との対応の例について説明するが、本発明は下記の例に限定されない。上記の実施の形態では、プレートチェンジャー6がプレート保持部の例であり、コンピュータ1が端末装置の例であり、バッチテーブルが処理情報の例である。
上記の実施の形態においては、試料プレート保持部の例であるプレートチェンジャー6がオートサンプラ7に付属される別装置であった。試料プレート保持部は、オートサンプラ7に付属される別装置であってもよいが、オートサンプラ7が試料プレート保持部を内部に保有してもよい。
Claims (10)
- 複数の試料プレート収容部を有する試料プレート保持部からオートサンプラへの試料プレートの供給を制御する試料プレート供給制御装置であって、
前記複数の試料プレート収容部のうち一の試料プレート収容部に試料プレートが収容されたときに、前記収容された試料プレートの識別情報を認識する識別情報認識部と、
分析対象である対象試料プレートの識別情報と前記識別情報認識部により認識された識別情報とが一致した場合に、前記一の試料プレート収容部に収容された試料プレートを前記オートサンプラに供給するように前記試料プレート保持部に指示する供給指示部とを備えた、試料プレート供給制御装置。 - 前記供給指示部は、
前記対象試料プレートの識別情報と、前記識別情報認識部により認識された識別情報とが一致した場合に、前記オートサンプラに対して処理情報を通知して、前記一の試料プレート収容部に収容された試料プレートに対して前記処理情報に基づいて処理を実行するよう指示する処理指示部を有する、請求項1に記載の試料プレート供給制御装置。 - 前記供給指示部は、
前記対象試料プレートの識別情報と、前記識別情報認識部により認識された識別情報とが一致し、かつ、前記オートサンプラにおいて別の試料プレートに対する処理が実行されている場合に、前記別の試料プレートに対する処理が完了するのを待って前記試料プレート保持部に対して前記一の試料プレート収容部に収容された試料プレートを前記オートサンプラに供給するよう指示する、請求項1または請求項2に記載の試料プレート供給制御装置。 - 前記供給指示部は、
複数の対象試料プレートの中のいずれかの対象試料プレートの識別情報と、前記識別情報認識部が認識した識別情報とが一致する場合に、前記試料プレート保持部に対して前記一の試料プレート収容部に収容された試料プレートを前記オートサンプラに供給するよう指示する、請求項1~請求項3のいずれか一項に記載の試料プレート供給制御装置。 - 前記対象試料プレートに貼付するための前記対象試料プレートの識別情報を印刷する印刷部、
をさらに備える、請求項1~請求項4のいずれか一項に記載の試料プレート供給制御装置。 - 前記対象試料プレートの識別情報はバーコード画像として前記対象試料プレートに貼付される、請求項1~請求項5のいずれか一項に記載の試料プレート供給制御装置。
- 分析装置に対して分析対象である試料を注入するオートサンプラと、
複数の試料プレート収容部を有する試料プレート保持部と、
前記試料プレート保持部を制御する端末装置とを備え、
前記試料プレート保持部は、
前記複数の試料プレート収容部のうち一の試料プレート収容部に試料プレートが収容されたときに、前記収容された試料プレートの識別情報を認識する識別情報認識部と、
前記収容された試料プレートの識別情報を前記端末装置に与える識別情報提示部とを含み、
前記端末装置は、
前記試料プレート保持部から前記収容された試料プレートの識別情報を取得する識別情報取得部と、
分析対象である対象試料プレートの識別情報と前記識別情報取得部により取得された識別情報とが一致した場合に、前記一の試料プレート収容部に収容された試料プレートを前記オートサンプラに供給するように前記試料プレート保持部に指示する供給指示部とを備えた、試料プレート供給制御システム。 - 前記試料プレート保持部は、
前記複数の試料プレート収容部に対応して設けられた複数の表示器、
を有し、
各表示器は、各試料プレート収容部に収容された各試料プレートに対する処理状態を表示する、請求項7に記載の試料プレート供給制御システム。 - 複数の試料プレート収容部を有する試料プレート保持部からオートサンプラへの試料プレートの供給を制御する試料プレート供給制御方法であって、
前記複数の試料プレート収容部のうち一の試料プレート収容部に試料プレートが収容されたときに、前記試料プレート保持部から前記収容された試料プレートの識別情報を取得するステップと、
分析対象である対象試料プレートの識別情報と前記試料プレート保持部から取得した識別情報とが一致した場合に、前記一の試料プレート収容部に収容された試料プレートを前記オートサンプラに供給するように前記試料プレート保持部に指示するステップとを備えた、試料プレート供給制御方法。 - 複数の試料プレート収容部を有する試料プレート保持部からオートサンプラへの試料プレートの供給を制御する試料プレート供給制御プログラムであって、
前記複数の試料プレート収容部のうち一の試料プレート収容部に試料プレートが収容されたときに、前記試料プレート保持部から前記収容された試料プレートの識別情報を取得する処理と、
分析対象である対象試料プレートの識別情報と前記試料プレート保持部から取得した識別情報とが一致した場合に、前記一の試料プレート収容部に収容された試料プレートを前記オートサンプラに供給するように前記試料プレート保持部に指示する処理とを、コンピュータに実行させるための試料プレート供給制御プログラム。
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2018
- 2018-08-30 WO PCT/JP2018/032223 patent/WO2020044515A1/ja not_active Ceased
- 2018-08-30 JP JP2020539966A patent/JP7163963B2/ja active Active
- 2018-08-30 US US17/270,839 patent/US12399192B2/en active Active
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| Publication number | Publication date |
|---|---|
| JP7163963B2 (ja) | 2022-11-01 |
| US12399192B2 (en) | 2025-08-26 |
| US20210190807A1 (en) | 2021-06-24 |
| JPWO2020044515A1 (ja) | 2021-08-12 |
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