WO2018203668A1 - External-use skin preparation composition for alleviating atopic skin, and cosmetic containing same - Google Patents

Abstract

The present invention relates to an external-use preparation composition for alleviating atopic skin, containing a Sophora Flavescens extract, a Dictamnus dasycarpus Turcz. extract, and a Phellodendron amurense extract so as to have an excellent ability to alleviate atopic skin, and being derived from a natural product so as to cause little skin irritation.

Description

Atopic dermatological composition for skin improvement and cosmetic comprising same

The present invention relates to a topical skin composition for improving atopic skin and a cosmetic comprising the same.

Skin has many opportunities for direct contact with external stimuli, such as ultraviolet light, or various pathogens, and is strongly affected by the body. In addition, due to genetic changes, inflammation, benign and malignant tumors, hormonal changes, trauma and degenerative pathological changes such as skin diseases can be caused by a variety of causes.

Inflammatory skin disease is a condition in which a series of clinical signs and symptoms, such as itching, swelling, erythema, peeling, etc., are caused by various stimulating factors that cause a series of inflammatory reactions in the skin epithelium. Atopic dermatitis, Contact dermatitis, seborrhea and acne are known. Until now, mainly antihistamines, vitamin ointments or corticosteroids have been used to treat such inflammatory skin diseases. However, these drugs are often temporary and often have severe side effects.

<Preceding technical literature>

(Patent Document 1) Korean Registered Patent No. 1036677

An object of the present invention is to provide a topical skin composition for improving atopic dermatitis using natural ingredients and having excellent efficacy with little skin irritation.

An object of the present invention is to provide a cosmetic comprising the composition.

1. Skin external preparation composition for improving atopic skin, comprising ginseng extract, ringworm skin extract and baekbaek extract.

2. according to the above 1, ginseng extract 50 to 200 parts by weight, 100 parts by weight of ginseng extract, skin whitening composition comprising 50 to 200 parts by weight of baekbaek extract.

3. according to the above 1, the composition for external application to the skin further comprising the extract and jinryul extract.

4. In the above 3, 50 to 200 parts by weight of the extract Mt. Ginseng compared to 100 parts by weight of ginseng extract, skin external composition comprising 50 to 200 parts by weight rhubarb extract.

5. Cosmetics made of the composition of any one of the above 1 to 4.

The external preparation composition of the present invention is excellent in the ability to improve atopic skin due to inflammation and sedation. Thus, it can be preferably used as a cosmetic, pharmaceutical composition.

The medicinal composition of the present invention contains a natural product-derived component, which has less skin irritation and is less likely to cause allergy.

Hereinafter, the present invention will be described in detail.

Atopic dermatitis composition for external skin improvement of the present invention comprises a ginseng extract, ringworm skin extract and yellow white extract.

The inventors of the present invention have found that when the ginseng extract, ringworm skin extract, and baekbaek extract are used together, they have remarkably superior atopy improvement effects compared to other medicinal extracts.

Each extract may be a solvent extraction of the respective medicines individually or mixed.

The solvent may be, for example, water, an alcohol having 1 to 4 carbon atoms, or the like. These can be used individually or in mixture of 2 or more types.

The extraction method is not particularly limited, and for example, hot water extraction, cold water extraction, ultrasonic extraction, reflux extraction, and the like may be used.

The extraction temperature can be, for example, 80 to 120 ° C., specifically 90 to 110 ° C., and the time can be, for example, 10 minutes to 12 hours, specifically 30 minutes to 3 hours, more specifically 1 hour to 2 hours. However, it is not limited thereto.

If necessary, the extract may be subjected to a process such as filtration and drying.

The content ratio of the extract according to the present invention is not particularly limited, and may be included, for example, in a ratio of 100 to 100 parts by weight of ginseng extract, 50 to 200 parts by weight, and 50 to 200 parts by weight of baekbaek extract. If the content ratio is within the above range, the atopy improvement effect can be maximized. Preferably, 100 to 100 parts by weight of ginseng extract 75 to 125 parts by weight, extract may be included in a ratio of 75 to 125 parts by weight of baekbaek extract.

If necessary, the topical skin composition for improving atopic dermatitis of the present invention may further comprise the extract of Macmundong and rhubarb extract. In such a case, the effect of improving atopy can be further increased.

Macmundong extract and rhubarb extract may also be solvent extraction of each medicine individually or mixed.

Extraction methods and conditions may be in the above range, but is not limited thereto.

The content of the medicinal extracts and the medicinal extracts of the ginmundong is not particularly limited, and for example, 50-200 parts by weight of ganmundong extracts and 50-200 parts by weight of rhubarb extracts may be included relative to 100 parts by weight of red ginseng extract. If the content ratio is within the above range, the atopy improvement effect can be maximized. Preferably it may be included in a ratio of 75 to 125 parts by weight, 75 to 125 parts by weight of rhubarb extract, relative to 100 parts by weight of ginseng extract.

The external preparation composition for skin of the present invention may be a cosmetic composition or a pharmaceutical composition. When used as a cosmetic composition has an excellent atopic skin improvement ability, when used as a pharmaceutical composition can exhibit a prophylactic or therapeutic effect of atopic dermatitis.

The appearance of the cosmetic composition according to the present invention may contain a cosmetically or dermatologically acceptable medium or base. These are all formulations suitable for topical application, for example, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) obtained by dispersing the oil phase in solutions, gels, solids, pasty anhydrous products, aqueous phases, and It may be provided in the form of a nonionic vesicle dispersant or in the form of a cream, skin, lotion, powder, ointment, spray or cone stick. These compositions can be prepared according to conventional methods in the art. The composition according to the invention can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition of the present invention is a fatty substance, an organic solvent, a dissolving agent, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant, water, an ionic or nonionic type. Cosmetics such as emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredient commonly used in cosmetics Or an adjuvant commonly used in the field of dermatology. Such adjuvants are introduced in amounts generally used in the cosmetic or dermatological arts.

The cosmetic composition of the present invention is not particularly limited in the formulation, for example, supple cosmetics, astringent cosmetics, nourishing cosmetics, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing It can be formulated into cosmetics such as water, packs, powders, body lotions, body creams, body oils and body essences.

The external preparation composition for skin of the present invention may be a pharmaceutical composition. The pharmaceutical composition may further contain pharmaceutical aids such as preservatives, stabilizers, hydrating or emulsifiers, salts and / or buffers for controlling osmotic pressure and other therapeutically useful substances. The pharmaceutical composition may be formulated as a lotion, cream, ointment or gel.

It is preferable that the said pharmaceutical composition is administered transdermally.

The dosage of the extract, which is an active ingredient of the pharmaceutical composition, will vary depending on the age, sex, and weight of the subject to be treated, the specific disease or pathology to be treated, the severity of the disease or pathology, the route of administration, and the judgment of the prescriber. Dosage determination based on these factors is within the level of skill in the art. Generally dosages range from 0.0001 mg / kg / day to approximately 2000 g / kg / day.

Hereinafter, the present invention will be described in detail with reference to Examples.

Example

1. Preparation of Extract

Each extract was put into 10 times the weight of each medicine, extracted at 95 ℃, 1 hour 30 minutes, filtered under reduced pressure. The filtered extract was refrigerated at 4 ° C. for 24 hours and then filtered again to obtain an extract, which was refrigerated at 4 ° C.

2. Preparation of Composition

To prepare a composition by mixing the components shown in Table 1 to the corresponding content (parts by weight).

division Gosam Ringworm Yellow white Macmundong goldthread Gold licorice Eoseongcho Donkey Example 1 100 50 50 - - - - - - Example 2 100 100 100 - - - - - - Example 3 100 200 200 - - - - - - Example 4 100 100 100 100 100 - - - - Example 5 100 100 100 100 100 100 - - - Example 6 100 100 100 100 100 - 100 - - Example 7 100 100 100 - - - - 100 100 Example 8 100 100 100 50 50 - - - - Example 9 100 100 100 200 200 - - - - Comparative Example 1 - 100 100 100 - 100 - - - Comparative Example 2 100 - 100 - - - 100 100 - Comparative Example 3 100 100 - 100 100 - - - - Comparative Example 4 - 100 100 100 100 - - - 100 Comparative Example 5 100 100 - - - 100 - 100 100

Experimental Example

1. Atopic Induction Mouse Model

5 NC / Nga mice (5 for each example and 5 for each group) divided into a total of 5 groups of no treatment group (normal), DNCB group, tacrolimus group, example treatment group and comparative treatment group. Evaluated using. Epidermal cream 0.1g was applied to the back and neck of NC / Nga mice and hair was removed using a soft tissue so as not to be injured. After leaving for 5 days to heal the micro-wounds, atopy was induced by applying 200 μl of 1% DNCB (acetone: olive oil = 3: 1) to the back and ears three times a week for 2 weeks. After atopic induction was applied twice a week for 4 weeks, the extracts of Examples and Comparative Examples were applied to the affected area at 100 mg / kg. To compare the efficacy, tacrolimus was used as an atopic drug. Tacrolimus was applied twice a week at 100 mg / kg for atopic dermatitis for 4 weeks.

2. Atopic Improvement in Atopic Induced Mouse Model

(1) serum IgE inhibitory effect

After completion of the test material treatment, blood was collected from the heart at the expense of control mice induced with atopy with DNCB, mice treated with tacrolimus, and mice treated with Examples and Comparative Examples, from which serum was separated and measured for IgE. Specifically, using an IgE ELISA Kit (BD Biosciences, San Diego, Calif.), The antibody was diluted in a buffer solution, attached to a 96-well plate and allowed to stand overnight at 4 ° C., and the experiment was performed according to the manual. Protein content of IgE was measured at 450 nm with a microplate reader.

Table 2 shows the results of measuring the amount of IgE, which mediates allergic disease, from the serum obtained by separating blood from the heart using the IgE ELISA Kit.

division IgE (% of control) Example 1 43 Example 2 35 Example 3 39 Example 4 27 Example 5 33 Example 6 34 Example 7 43 Example 8 30 Example 9 32 Comparative Example 1 56 Comparative Example 2 53 Comparative Example 3 47 Comparative Example 4 57 Comparative Example 5 50 Normal 9 DNCB 100 tacrolimus 67

Referring to Table 2, IgE was reduced in tacrolimus and Example treatment group NC / Nga mice compared to atopically induced NC / Nga mice by DNCB.

(2) measuring the moisture content of the skin

The back skin moisture (%) of the mice in each group was measured by corneometer CM820 (Courage & Khazaka, Cologne, Germany) and tewameter TM210 (Courage & Khazaka, Cologne, Germany) once a week for three weeks.

division 1 week past 2 weeks past 3 weeks past Example 1 68 72 77 Example 2 70 75 84 Example 3 69 74 80 Example 4 70 77 87 Example 5 69 71 78 Example 6 70 77 77 Example 7 71 72 75 Example 8 69 75 85 Example 9 70 74 84 Comparative Example 1 64 68 66 Comparative Example 2 66 66 62 Comparative Example 3 67 72 72 Comparative Example 4 67 67 71 Comparative Example 5 68 66 69 Normal 67 67 67

Referring to Table 3, it can be confirmed that the skin moisture content in the Example treatment group NC / Nga mouse.

Claims (5)

A topical skin improvement composition for improving atopic skin, comprising ginseng extract, ringworm skin extract and baekbaek extract. The composition for applying the external of the skin according to claim 1, comprising 100-200 parts by weight of white ginseng extract, 50-200 parts by weight of baekbaek extracts. The composition for applying the external of the skin according to claim 1, further comprising the extract of Macmundong and rhubarb extract. The composition for applying the external of the skin according to claim 3, comprising 50 to 200 parts by weight of extract of Macmundong relative to 100 parts by weight of ginseng extract and 50 to 200 parts by weight of sulfur extract. Cosmetics prepared from the composition of any one of claims 1 to 4.