TW201842928A - Skin external composition for improving atopic dermatitis and cosmetic composition including the same - Google Patents

Abstract

The present invention relates to an atopic dermatitis improving composition for external skin application, comprising a sophora root extract, a dictamnus root bark extract, and a phellodendron bark extract. The composition according to the invention is excellent in the ability to improve atopic dermatitis, and less likely to cause skin irritation since it is a nature-derived composition.

Description

Skin external composition for improving atopic dermatitis and cosmetic composition containing same

FIELD OF THE INVENTION The present invention relates to an atopic dermatitis improving composition for external application to the skin and a cosmetic comprising the same.

BACKGROUND OF THE INVENTION The skin has many opportunities for direct contact with external stimuli such as ultraviolet rays and various pathogens, and is strongly affected by the body. It is also affected by heredity, inflammation, benign and malignant tumors, hormones, trauma, and pathological changes such as retroplasia, so various causes can cause skin diseases.

Inflammatory skin diseases refer to diseases attributed to a variety of clinical signs and symptoms such as pruritus, edema, erythema, and peeling due to various stimulating factors that cause a series of inflammatory responses in skin epithelial cells, including atopic dermatitis, Contact dermatitis, seborrhea, acne and the like. To date, antihistamines, vitamin ointments, or corticosteroids have been used primarily to treat these inflammatory skin diseases. However, most of these drugs have temporary effects and their side effects are often severe.

SUMMARY OF THE INVENTION An object of the present invention is to provide an atopic dermatitis improving composition for external skin application, which uses natural ingredients and exhibits excellent efficacy and less skin irritation.

Another object of the present invention is to provide a cosmetic comprising the above composition.

A representative configuration of the present invention that achieves the above-mentioned objects is described below.

(i) An atopic dermatitis improving composition for external application to the skin, which comprises a bitter extract, a white fresh skin extract, and a scutellaria baicalensis extract.

(ii) The composition for external skin application according to (i), which comprises 50 to 200 parts by weight of white fresh skin extract and 50 to 200 parts by weight of scutellaria baicalensis with respect to 100 parts by weight of bitter extract. Extracts.

(iii) The composition for external skin application according to (i), further comprising a liriope tuber extract and a coptis rhizome extract.

(iv) The composition for external skin application as described in (iii), which comprises 50 to 200 parts by weight of the Oleifera extract and 50 to 200 parts by weight of Coptis chinensis relative to 100 parts by weight of the Melissa extract. Extracts.

(v) A cosmetic made of the composition as in any one of (i) to (iv).

The composition for external application according to the present invention is excellent in the ability to improve atopic dermatitis due to the alleviating and soothing effects of inflammation. Therefore, it can be preferably used as a cosmetic composition, a pharmaceutical composition, and the like.

The composition for external application according to the present invention contains natural ingredients and is less likely to cause skin irritation and allergies.

Detailed Description of the Preferred Embodiments Hereinafter, the present invention will be described in detail.

An atopic dermatitis improving composition for external application to the skin according to the present invention comprises a bitter extract, a white fresh skin extract, and a scutellaria baicalensis extract.

The inventors of the present invention have found that when a bitter sassafras extract, a white fresh skin extract, and a scutellaria baicalensis extract are used together, its atopic dermatitis improvement effect is significantly better than other medicinal extracts or A combination of classes.

These extracts may be obtained by solvent extraction of each corresponding medicinal substance or mixture thereof.

The solvent may be, for example, water, alcohols having 1 to 4 carbon atoms, and the like. One of these or a mixture of two or more of these may be used.

The extraction method is not particularly limited, and methods such as hot water extraction, cold water extraction, ultrasonic extraction, and reflux extraction may be used.

The extraction temperature may be, for example, 80 to 120 ° C, and specifically 90 to 110 ° C. The extraction time may be, for example, 10 minutes to 12 hours, specifically 30 minutes to 3 hours, and more specifically 1 hour to 2 hours. However, the extraction temperature and time are not limited to this.

If necessary, these extracts may be obtained through processes such as filtration and drying.

The content ratio of the extracts according to the present invention is not particularly limited. For example, it may contain 50 to 200 parts by weight of white fresh skin extract and 50 to 200 parts by weight of scutellaria baicalensis extract with respect to 100 parts by weight of bitter extract. When the content ratio falls within the above range, the improvement effect of atopic dermatitis may be maximized. Preferably, it may contain 75 to 125 parts by weight of white fresh skin extract and 75 to 125 parts by weight of scutellaria baicalensis extract with respect to 100 parts by weight of bitter extract.

If necessary, the atopic dermatitis improving composition for external skin application according to the present invention may further comprise an asparagus extract and a Coptis chinensis extract. In this case, the improvement effect of atopic dermatitis may be further enhanced.

The asparagus extract and the Coptis chinensis extract may also be obtained by solvent extraction of each corresponding medicinal substance or a mixture thereof.

The extraction methods and conditions may fall into the above description, but are not limited thereto. The content ratio of the asparagus extract to the berberine extract is not particularly limited. For example, it may contain 50 to 200 parts by weight of the asparagus extract and 50 to 200 parts by weight of the pistacia extract relative to 100 parts by weight of the bitter extract. When the content ratio falls within the above range, the improvement effect of atopic dermatitis may be maximized. Preferably, it may contain 75 to 125 parts by weight of the asparagus extract and 75 to 125 parts by weight of the pistacia extract relative to 100 parts by weight of the bitter tea extract.

The composition for external skin application according to the present invention may be a cosmetic composition or a pharmaceutical composition. When this is used as a cosmetic composition, it has excellent ability to improve atopic dermatitis. When this is used as a pharmaceutical composition, it can exhibit the effect of preventing or treating atopic dermatitis.

The cosmetic composition according to the present invention may contain a cosmetically or dermatologically acceptable medium or base. The person may be provided in any form suitable for topical application. For example, it may be in solution, gel, solid, pasty anhydrous product, emulsion, suspension, microemulsion, microcapsule, microparticle, or ion (lipid) obtained by dispersing the oil phase in the water phase. Body) or non-ionic vesicle dispersant, or may be provided in the form of a cream, lotion, lotion, powder, ointment, spray or conical stick. These compositions may be prepared according to a conventional method in the art. The composition according to the invention may also be used in the form of a foam, or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition according to the present invention may contain a lipid, an organic solvent, a co-solvent, a thickener, a gelling agent, a softener, an antioxidant, a suspending agent, a stabilizer, and a foaming agent. , An air freshener, a surfactant, water, an ionic or non-ionic emulsifier, a filler, a sequestering agent, a chelating agent, a preservative, a vitamin, a blocking agent ( blocking agent), a wetting agent, an essential oil, a dye, a pigment, a hydrophilic or lipophilic active agent, a lipid vesicle, or any other ingredient commonly used in cosmetics, or conventionally used in the field of beauty or dermatology Any adjuvant. These adjuvants are introduced in amounts commonly used in the fields of beauty or dermatology.

The formulation of the cosmetic composition according to the present invention is not particularly limited. For example, the person may be formulated such as emollients, astringents, nourishing lotions, nourishing creams, massage creams, serums, eye creams, eye serums, cleansing creams, cleansing foams, cleansing water ), Mask, powder, body lotion, body cream, body oil and body essence.

The composition for the external skin application according to the present invention may be a pharmaceutical composition. The pharmaceutical composition may further contain a preservative, a stabilizer, a wetting agent or an emulsifier, a medical adjuvant such as a salt and / or a buffer for controlling osmotic pressure, and other medically useful substances . The pharmaceutical composition may be formulated as an emulsion, a cream, an ointment, a gel, or the like.

Preferably, the pharmaceutical composition is administered transdermally.

The dosage of these extracts (the active ingredients of the pharmaceutical composition) may vary with the age, sex, and weight of the subject being treated, the specific disease or pathological condition being treated, the severity of the disease or pathological condition, and the The route of medication and the judgment of the prescriber vary. Those skilled in the art may decide the dose based on these factors. Generally, dosages range from 0.0001 mg / kg / day to about 2000 g / kg / day.

Hereinafter, the embodiments of the present invention will be described in detail. Example 1. Preparation of these extracts

The medicinal substance corresponding to each of these extracts was put into 10 times the weight of the substance in the water, extracted at 95 ° C for 1 hour and 30 minutes, and then filtered under reduced pressure with a filter paper. The filtered extract was refrigerated at 4 ° C for 24 hours, and then filtered again to obtain the extract. The extract was refrigerated at 4 ° C. 2. Preparation of the composition

The composition was prepared by mixing the ingredients listed in Table 1 below at the corresponding contents (parts by weight). Table 1 Test example 1. Mouse model of atopic dermatitis

For each of the five groups, namely an untreated (normal) group, a DNCB group, a tacrolimus group, an example treatment group, and a trial example treatment group, 5 NC / Nga cells were used. Rats perform the assessment. A 0.1 g depilatory cream was applied to the back and neck of each NC / Nga mouse, and hair was removed using a soft paper towel to prevent scratches. After the mice were left for 5 days to allow fine scratches to heal, 200 μl of 1% DNCB (acetone: olive oil = 3: 1) was applied three times a week to the back and ears of the mice for 2 weeks to induce Atopic dermatitis. After inducing atopic dermatitis, the extracts of Examples and Comparative Examples were applied to the affected area at 100 mg / kg twice a week for four weeks. For comparison, tacrolimus is used as a treatment for atopic dermatitis. Tacrolimus is applied to the area of atopic dermatitis at 100 mg / kg twice a week for four weeks. 2. Ability to improve atopic dermatitis in a mouse model of atopic dermatitis (1) Inhibitory effect on serum IgE

After completion of the test substance treatment, control mice induced by DNCB with atopic dermatitis, mice treated with examples and comparative examples, and mice treated with tacrolimus were sacrificed. Blood was then collected from their hearts and serum was separated from it to measure IgE. Specifically, the antibody was diluted in a buffer solution using an IgE ELISA kit (BD Biosciences, San Diego, California) and attached to a 96-well plate. The plate was left overnight at 4 ° C and tested according to the manual. The amount of IgE protein was measured by measuring the absorbance at 450 nm with a microwell disk analyzer.

The serum isolated from the blood collected from the heart was measured using an IgE ELISA kit to transmit the IgE amount of allergic diseases. The results are shown in Table 2. Table 2

Referring to Table 2 above, it can be seen that compared to NC / Nga mice with atopic dermatitis induced by DNCB, NC / Nga mice treated with tacrolimus and mice treated with these examples, IgE Department lowered. (2) Measurement of skin moisture content

The water content (%) in the back skin of mice in each group was measured with a skin moisturizer (Corneometer CM820, Courage & Khazaka, Cologne, Germany) and a transdermal water loss tester (tewameter TM210, Courage & Khazaka, Cologne, Germany). , Once a week for three weeks. table 3

Referring to Table 3 above, it can be seen that the water content in the skin of the NC / Nga mice of the example treatment group was higher.

Claims (5)

An atopic dermatitis improving composition for external skin application, comprising: a sophora root extract; a dictamnus root bark extract; and a phellodendron bark extract . The composition for external skin application according to claim 1, wherein the composition comprises 50 to 200 parts by weight of white fresh skin extract and 50 to 200 parts by weight of scutellaria baicalensis extract with respect to 100 parts by weight of bitter extract. The composition for external skin application according to claim 1, further comprising: a liriope tuber extract; and a coptis rhizome extract. The composition for external skin application as claimed in claim 3, which contains 50 to 200 parts by weight of the Oleifera extract and 50 to 200 parts by weight of the Coptis chinensis extract with respect to 100 parts by weight of the Melia extract. A cosmetic made from a composition according to any one of claims 1-4.