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WO2018077311A1 - Composition pour soulager la fatigue oculaire et son procédé de préparation - Google Patents

Composition pour soulager la fatigue oculaire et son procédé de préparation Download PDF

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Publication number
WO2018077311A1
WO2018077311A1 PCT/CN2017/114288 CN2017114288W WO2018077311A1 WO 2018077311 A1 WO2018077311 A1 WO 2018077311A1 CN 2017114288 W CN2017114288 W CN 2017114288W WO 2018077311 A1 WO2018077311 A1 WO 2018077311A1
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WO
WIPO (PCT)
Prior art keywords
parts
extract
composition
visual fatigue
flower tea
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Ceased
Application number
PCT/CN2017/114288
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English (en)
Chinese (zh)
Inventor
黄爱强
钟文
黄爱毅
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Guangxi Sanpotel Health Industry Co Ltd
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Guangxi Sanpotel Health Industry Co Ltd
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Publication of WO2018077311A1 publication Critical patent/WO2018077311A1/fr
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Definitions

  • the invention belongs to the field of medicines, health foods and foods, and relates to a composition preparation and a preparation method thereof, in particular to a composition for relieving visual fatigue and a preparation method thereof.
  • Vitamin C is a commonly used drug or nutritional supplement in the clinic. It is one of the antioxidant vitamins. It is involved in the hydroxylation reaction in the body and is necessary for the formation of bone, tooth, connective tissue and non-epithelial cells. The normal function of bones and blood vessels, increase the resistance to disease, and is one of the essential nutrients for the human body. It is widely used in the prevention and treatment of various diseases. Vitamin C sodium is the sodium salt of vitamin C. The pH of the aqueous solution is close to neutral. It has the same effect as vitamin C, but because it is sodium salt, the performance is more stable. At the same time, there is no longer strong acidity of vitamin C. The drug is taken at the same time, which is better than vitamin C.
  • Effervescent tablets are a novel tablet developed and applied abroad in recent years. The difference between it and ordinary tablets is that it also contains an effervescent disintegrant.
  • effervescent tablet When the effervescent tablet is placed in drinking water, under the action of the effervescent disintegrant, a large amount of air bubbles are generated immediately, so that the tablet is quickly formed. Disintegration and melting, sometimes the bubbles generated by disintegration also cause the tablets to roll up and down in the water, accelerating their disintegration and melting. The gas generated when the tablet disintegrates is partially dissolved in the drinking water, so that the drinking water has a soda-like beauty when it is drunk in the mouth.
  • Effervescent tablets have the following advantages: easy to store and carry; rapid disintegration, convenient taking, rapid onset; high bioavailability, can improve clinical efficacy; especially suitable for children, the elderly and patients who have difficulty swallowing pills; Effervescent tablets after seasoning, taste better, good medicine is not It is hard to make consumers or patients more willing to accept.
  • the invention has the advantages of relatively simple action for relieving visual fatigue products and high acidity after dissolution of vitamin C-containing effervescent tablets, great stimulation to oral cavity, throat esophagus and gastric mucosa, unsuitable for long-term administration, and easy to oxidize vitamin C during storage.
  • the effervescent tablet is easy to absorb moisture and damp, and provides a composition for relieving visual fatigue and improving immunity, lowering blood sugar, blood pressure, blood fat, clearing heat, eyesight, whitening and beauty, and a preparation method thereof, and solving the product on the market.
  • the effect is relatively simple, and the clinical application of vitamin C is unstable in quality and difficult to take for a long time.
  • the composition for relieving visual fatigue of the invention has the advantages of safe, non-toxic side effects, and can be used for improving symptoms such as blurred vision, dry eyes, eye swelling, eye pain and photophobia for a long time; or long-term use as a nutritional supplement.
  • a composition for relieving visual fatigue comprising the following components by weight: 50-100 parts of vitamin C sodium, 10-20 parts of taurine, 10-20 parts of zinc gluconate, and 10-20 parts of flower tea fruit extract.
  • the extract of the flower tea fruit described above is prepared from the following raw materials by weight: 40-60 parts of medlar flower, 20-40 parts of golden flower tea, and 5-10 parts of fresh lemon.
  • the preparation method of the above-mentioned flower tea fruit extract is as follows:
  • the extraction method under the step S2 is preferably heated reflux extraction and ultrasonic extraction.
  • the drying method under the step S4 is preferably oven heating drying and spray drying.
  • composition for relieving visual fatigue as described above preferably further comprises the following components by weight: 50-100 parts of tartaric acid, 60-150 parts of sodium hydrogencarbonate, and 20-40 parts of aspartame.
  • composition for relieving visual fatigue further preferably further comprises 0.5 to 1.0% of trehalose and 0.3 to 0.5% of lactose based on the total weight of the above components.
  • composition for relieving visual fatigue preferably comprises the following components by weight: 80 parts of vitamin C sodium, 15 parts of taurine, 15 parts of zinc gluconate, 15 parts of flower tea fruit extract, 70 parts of tartaric acid. There are 100 parts of sodium hydrogencarbonate and 30 parts of aspartame, and further comprises trehalose in an amount of 0.8% by weight based on the total weight of the above components and lactose in an amount of 0.4% by weight based on the total weight of the above components.
  • the above-mentioned flower tea fruit extract is preferably preferably made of the following raw materials by weight: 50 parts of medlar, 30 parts of golden tea, and 8 parts of fresh lemon.
  • the preparation method of the composition for relieving visual fatigue mentioned above comprises the following steps:
  • T1 Preparation of flower tea fruit extract: Weigh the following raw materials by weight: 40-60 parts of dense flower, 20-40 parts of golden flower tea, 5-10 parts of fresh lemon; take densely weighed flower, golden flower tea Add 6-10 times of water, soak for 30 minutes, extract 2-3 times, each time 30-40 minutes, filter, get the tea fruit extract; take the fresh lemon, wash, peel, squeeze The juice is filtered, and the lemon juice is obtained; the flower tea extract is mixed with the lemon juice, and concentrated under reduced pressure at 80 ° C or lower to obtain a flow extract having a relative density of 1.18-1.22 at 60 ° C, and the flow extract is dried to control drying. The temperature is 65-80 ° C, and the tea fruit extract is obtained;
  • T2 Weigh the following components by weight: 50-100 parts of vitamin C sodium, 10-20 parts of taurine, 10-20 parts of zinc gluconate, 10-20 parts of flower tea fruit extract, 50-100 parts of tartaric acid, 60-150 parts of sodium hydrogencarbonate, 20-40 parts of aspartame; further weigh 0.5-1.0% of the total weight of the component of trehalose and 0.3-0.5% of the total weight of the component;
  • T3 Take 1/2 of the total weight of tartaric acid, flower tea fruit extract, 1/2 of the total weight of trehalose, aspartame, mix, spray 50-60% ethanol solution, mix, granulate, sieve , dry, whole grain, acidifier;
  • T4 Take 1/2 of the total weight of sodium bicarbonate and flower tea extract, 1/2 of the total weight of trehalose, mix, spray 50-60% ethanol solution, mix, granulate, sieve, dry, Whole grain, alkali agent;
  • T5 Take vitamin C sodium, taurine, zinc gluconate, acid, alkali, lactose, mix, tablet, that is.
  • the drying temperature in the step T3, T4 is preferably 80 ° C or less, so that the obtained particles have a moderate hardness, which is more favorable for tableting, and utilizes disintegration; and the screening step described in the steps T3 and T4 is used.
  • the screen is preferably 14-30 mesh.
  • the invention overcomes the problem that the existing vitamin C-containing effervescent tablet has high acidity after dissolution, is irritating to the oral cavity, throat esophagus and gastric mucosa, and is not suitable for long-term use, and the vitamin C is easily oxidized and failed during storage, and the effervescent tablet It is easy to absorb moisture and damp, so that the product has better stability and more effective curative effect. It is suitable for long-term use by consumers or patients without side effects.
  • the raw materials of the tea fruit extract of the present invention are all "medicine and food homologous" varieties, wherein the dense Mongolian flower has the effects of hurricane, cooling blood, moistening the liver and improving eyesight, and is used for treating redness and swelling of the eye. More tears and shame, blue-blind dysfunction, windy string and eye, special medicine for ophthalmology; Golden Camellia is a plant with high medicinal value and high health value. It is unique to Guangxi, non-toxic and contains more than 400 kinds of nutrients. Studies have shown that Jinhuacha has obvious effects on regulating human blood lipids, blood sugar, cholesterol and enhancing immunity.
  • the composition for relieving visual fatigue of the invention has the advantages of simple preparation, good fluidity of the particles, no sticking of the tablet, and the prepared tablet has a smooth surface, is not easy to absorb moisture, has uniform effervescent gas, and has short disintegration time and disintegration. After the solution is transparent and clear, the taste is sweet, the quality is stable, and the carrying is convenient. It has the characteristics of solid preparation and liquid preparation, and is especially suitable for children, the elderly and patients who cannot swallow solid preparations, has high bioavailability and is safer and more effective to use. Can be taken as a nutritional supplement for a long time.
  • the word "preferred" and variants refers to embodiments of the invention that are capable of providing a particular benefit in a particular environment. However, other embodiments may be preferred under the same or other circumstances. In addition, the detailed description of one or more preferred embodiments does not indicate that other embodiments are useless and are not intended to exclude other embodiments from the scope of the invention.
  • the acid sources commonly used in effervescent tablets are tartaric acid, citric acid, fumaric acid, adipic acid, malic acid, etc.; alkali sources include sodium hydrogencarbonate, potassium carbonate, potassium hydrogencarbonate, calcium carbonate and the like.
  • the effervescent tablet prepared by using sodium hydrogencarbonate as an alkali source can rapidly disintegrate in water, and the pH of the effervescent solution is suitable for the stabilization of vitamin C sodium, so the alkali source of the present invention selects sodium hydrogencarbonate.
  • the formulation in Table 1 is followed by tartaric acid, Citric acid, fumaric acid, malic acid, and adipic acid were selected to determine the best source of acid in the effervescent tablet.
  • the present invention uses tartaric acid mixed with vitamin C sodium, sodium hydrogencarbonate and aspartame, and is good for granulation, the lapse of disintegration time is short, the solution is clear, the mouthfeel is good, but it is sticky when tableting.
  • the rushing phenomenon is better than other acid sources, so the acid source of the present invention selects tartaric acid, and the alkali source selects sodium hydrogencarbonate.
  • the invention compares the dry pressing tablet, the wet granulation and the re-pulling, the dry pressing tablet adopts the ordinary tableting machine has a poor effect and has high requirements on the equipment, so the invention adopts the wet granulation and the tableting.
  • 30% starch slurry, 40% sucrose syrup, 5% hypromellose aqueous solution, and 55% ethanol were used as binders. The results are shown in Table 2.
  • Vitamin C sodium is the sodium salt of vitamin C. Its performance is more stable than vitamin C, but it is prepared into effervescent tablets. In the acid, alkali, other auxiliary materials and the influence of moisture and oxidation in the air, it is necessary to guarantee the product during the shelf life. The quality is stable and it is still necessary to add stabilizers. In the test, 0.02% EDTA disodium, 1% trehalose, and 0.2% sodium sulfite were compared. The samples prepared by the above stabilizers were respectively packaged with aluminum-plastic composite film, and the stability was accelerated in the test chamber: temperature: 40 ⁇ 2°C, relative humidity: 75 ⁇ 5%, accelerated test for 3 months, the test results are shown in Table 4.
  • the material before the tableting of the invention has acid agent, sodium vitamin C, sweetener and alkali agent, and the particle size and texture of the material are uneven. When the tablet is pressed, the particle flowability is poor, and the tablet is easy to stick and punch.
  • the formulas except the lubricant are the same, and after the preliminary test is used to determine the available ratio, the different amounts of the dodecyl magnesium sulfate, lactose, mannitol, and the samples prepared by using the above lubricants are specifically compared. They are packaged with aluminum-plastic composite film respectively, and the stability test is accelerated in the test chamber: temperature: 40 ⁇ 2°C, relative humidity: 75 ⁇ 5%, accelerated test for 3 months, and the results are shown in Table 6.
  • a method for preparing a composition for relieving visual fatigue comprising the steps of:
  • T1 Preparation of flower tea fruit extract: Weigh the following raw materials by weight: 40 parts of densely scented flowers, 40 parts of golden scented tea, and 5 parts of fresh lemon; take a good amount of densely scented flowers, golden scented tea, and add 6 times of water Soak for 30 minutes, heat and reflux for 3 times, each time for 30 minutes, filter, get the tea extract; take the fresh lemon, wash, peel, extract the juice, filter, get lemon juice; The flower tea extract is mixed with lemon juice, concentrated under reduced pressure at 80 ° C or lower, and a flow extract having a relative density of 1.20 at 60 ° C is obtained, and the flow extract is spray-dried to control the drying temperature to 70 ° C to obtain a flower tea fruit extract;
  • T2 Weigh the following components by weight: 50 parts of vitamin C sodium, 10 parts of taurine, 10 parts of zinc gluconate, 10 parts of flower tea fruit extract, 50 parts of tartaric acid, 60 parts of sodium hydrogencarbonate, aspartame 20 parts; further weigh 0.5% of the total weight of the components of trehalose and 0.3% of the total weight of the components of lactose;
  • T3 Take 1/2 of the total weight of tartaric acid, flower tea fruit extract, 1/2 of the total weight of trehalose, aspartame, mix, spray 50% ethanol solution, mix, granulate, pass 20 mesh sieve Dry at 80 ° C, whole grain, acidifier;
  • T4 Take 1/2 of the total weight of sodium bicarbonate and flower tea extract, 1/2 of the total weight of trehalose, mix, spray 50% ethanol solution, mix, granulate, pass 20 mesh sieve, 80 ° C Drying, granules, alkali agent;
  • T5 Take vitamin C sodium, taurine, zinc gluconate, acid, alkali, lactose, mix, tablet, that is.
  • a method for preparing a composition for relieving visual fatigue comprising the steps of:
  • T1 Preparation of flower tea fruit extract: Weigh the following raw materials by weight: 50 parts of densely scented flowers, 30 parts of golden scented tea, and 7 parts of fresh lemon; take a good amount of densely scented flowers, golden scented tea, and add 8 times of water Soak for 30 minutes, heat and reflux for 2 times, each time for 40 minutes, filter, get the tea extract; take the fresh lemon, wash, peel, squeeze the juice, filter, get lemon juice; The flower tea extract is mixed with lemon juice, concentrated under reduced pressure at 80 ° C or lower, and a flow extract having a relative density of 1.18 at 60 ° C is obtained, and the flow extract is spray-dried to control the drying temperature to 80 ° C to obtain a flower tea fruit extract;
  • T2 Weigh the following components by weight: 80 parts of vitamin C sodium, 15 parts of taurine, 15 parts of zinc gluconate, 15 parts of flower tea fruit extract, 70 parts of tartaric acid, 100 parts of sodium hydrogencarbonate, aspartame 30 parts; further weigh 0.8% of the total weight of the components of trehalose and 0.4% of the total weight of the components of lactose;
  • T3 Take 1/2 of the total weight of tartaric acid, flower tea fruit extract, 1/2 of the total weight of trehalose, aspartame, mix, spray 55% ethanol solution, mix, granulate, pass 30 mesh sieve Dry at 80 ° C, whole grain, acidifier;
  • T4 Take 1/2 of the total weight of sodium bicarbonate and flower tea extract, 1/2 of the total weight of trehalose, mix, spray 55% ethanol solution, mix, granulate, pass 30 mesh sieve, 80 ° C Drying, granules, alkali agent;
  • T5 Take vitamin C sodium, taurine, zinc gluconate, acid, alkali, lactose, mix, tablet, that is.
  • a method for preparing a composition for relieving visual fatigue comprising the steps of:
  • T1 Preparation of flower tea fruit extract: Weigh the following raw materials by weight: 60 parts of densely scented flowers, 40 parts of golden scented tea, and 10 parts of fresh lemon; take a good amount of medlar flower, golden flower tea, add 10 times of water Soak for 30 minutes, ultrasonic extraction 3 times, 40 minutes each time, filter, get the tea extract; take the fresh lemon, wash, peel, extract the juice, filter, get lemon juice; The extract is mixed with lemon juice, concentrated under reduced pressure at 80 ° C to obtain a flow extract having a relative density of 1.22 at 60 ° C, and the flow extract is placed in an oven for heating and drying, and the drying temperature is controlled to 65 ° C to obtain a tea fruit extract. ;
  • T2 Weigh the following components by weight: 100 parts of vitamin C sodium, 20 parts of taurine, 20 parts of zinc gluconate, 20 parts of flower tea fruit extract, 100 parts of tartaric acid, 150 parts of sodium hydrogencarbonate, aspartame 40 parts; further weigh 1.0% of the total weight of the component of trehalose and 0.5% of the total weight of the component of lactose;
  • T3 Take 1/2 of the total weight of tartaric acid, flower tea fruit extract, 1/2 of the total weight of trehalose, aspartame, mix, spray 60% ethanol solution, mix, granulate, pass 14 mesh sieve Dry at 80 ° C, whole grain, acidifier;
  • T4 Take 1/2 of the total weight of sodium bicarbonate and flower tea extract, 1/2 of the total weight of trehalose, mix, spray 60% ethanol solution, mix, granulate, pass 14 mesh sieve, 80 ° C Drying, granules, alkali agent;
  • T5 Take vitamin C sodium, taurine, zinc gluconate, acid, alkali, lactose, mix, tablet, that is.

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Abstract

L'invention concerne une composition pour soulager la fatigue oculaire, ladite composition comprenant les composants suivants en parties en poids : de 50 à 100 parties de vitamine C sodique, 10 à 20 parties de taurine, 10 à 20 parties de gluconate de zinc, et 10 à 20 parties d'un extrait de fruit de thé parfumé. La présente invention vise à résoudre des problèmes tels que des comprimés effervescents contenant de la vitamine C existants ayant une acidité élevée après dissolution, irritant pour la bouche, la gorge, l'œsophage et la muqueuse gastrique, étant impropre à une utilisation à long terme, une perte d'efficacité pendant le stockage due à l'oxydation facile de la vitamine C, et la sensibilité à l'absorption d'humidité. La composition a des effets tels que l'amélioration de l'immunité, la réduction de la glycémie, de la pression artérielle et des lipides sanguins, l'élimination de la chaleur, l'amélioration de la vue, le blanchiment et l'embellissement, et améliore significativement les symptômes tels que la vision floue, les yeux secs, les yeux gonflés, la douleur oculaire et la photophobie.
PCT/CN2017/114288 2016-10-24 2017-12-01 Composition pour soulager la fatigue oculaire et son procédé de préparation Ceased WO2018077311A1 (fr)

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Application Number Priority Date Filing Date Title
CN201610936762.1 2016-10-24
CN201610936762.1A CN106491840A (zh) 2016-10-24 2016-10-24 一种缓解视疲劳的组合物及其制备方法

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WO2018077311A1 true WO2018077311A1 (fr) 2018-05-03

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CN113598249A (zh) * 2021-08-10 2021-11-05 山西中医药大学 一种黄芪明目袋泡茶的制备方法
CN115920009A (zh) * 2022-12-26 2023-04-07 成都普什制药有限公司 一种可缓解眼部疲劳的护理用洗眼液及其制备方法

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