WO2017128170A1 - 一种储库型干粉吸入器 - Google Patents
一种储库型干粉吸入器 Download PDFInfo
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- WO2017128170A1 WO2017128170A1 PCT/CN2016/072472 CN2016072472W WO2017128170A1 WO 2017128170 A1 WO2017128170 A1 WO 2017128170A1 CN 2016072472 W CN2016072472 W CN 2016072472W WO 2017128170 A1 WO2017128170 A1 WO 2017128170A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
Definitions
- the invention relates to the field of medical equipment, in particular to a reservoir type dry powder inhaler.
- Dry powder inhaler refers to the filling of a drug powder in a drug reservoir. The patient inhales through the inhaler, disperses the powder into a mist, and then inhales into the trachea or the lungs to exert a therapeutic effect.
- Current dry powder inhalers are respiratory-sensitive, and the source of drug dispersion and powder is derived from the patient's inhalation. Since the drug is filled in a powder form, the drug loading amount can be high; as a solid state, the stability of the drug is favorable. In particular, the respiratory touch is administered, and the patient's degree of cooperation is high. Therefore, in the past 10 years, the dry powder inhaler has developed rapidly. Not only short-term dry powder inhalers are most attractive as a topical medication for the treatment of the trachea or lungs, but in the long run, they have a more important potential advantage in systemic transport of biomolecules, antibiotics and genetic engineering drugs.
- the particle size distribution of the drug powder in the special airflow environment of the respiratory tract should be within a certain range. It is generally believed that a particle size of 3 to 7 ⁇ m can be deposited well in the bronchus, and a thickness of 1 to 3 ⁇ m can be deposited in a deep region of the lung. Particles larger than 7 ⁇ m are easily trapped by the upper respiratory tract, and too small particles are easily exhaled from the patient's breathing after entering the terminal bronchus.
- the fine drug powder has a large surface tension, is easy to agglomerate, and has poor fluidity, making it difficult to fill and dispense.
- lactose 80 to 300 ⁇ m
- the drug powder is dispersed and attached to the surface of the carrier, the fluidity is greatly improved, and the dose accuracy is improved, so that it is widely used.
- the object of the present invention is to solve the problems existing in the prior art, and in particular to provide a reservoir type dry powder inhaler which has long storage time, high safety, simple and effective inhalation mode, and simple and reliable counting method.
- the invention provides a reservoir type dry powder inhaler, a reservoir type dry powder inhaler, comprising a base, a main body, a one-way control device, a counting component, a medicine cover plate, an air passage component and a nozzle component, wherein
- the base is located at a lower portion of the main body, the counting member is disposed in the base, and the nozzle member is located at an upper portion of the main body;
- the counting member includes a gear member and a one-way control device; and the one-way control device ensures that only one direction of rotation of the main body is transmitted to the gear member;
- the upper part of the main body is mounted with a top cover, and the middle part is provided with a medicine cover plate, and the medicine cover plate is fixed in the main body through the bracket
- the airway component is a double arcuate structure.
- a main body cover is added to the main body, and the main body cover protects the nozzle component.
- a spring device is arranged between the bracket and the medicine cover, and the spring ensures that the medicine cover is tightly coupled with the lower wall of the main body.
- the upper surface of the medicine cover is provided with a column structure, and the column structure is located in the drug storage chamber when the body rotates.
- the gear component comprises a main gear, a driven gear, a pinion gear, a digital rack and a limiting device, wherein the main gear is installed in a middle portion of the base, and when the main gear rotates, the driven gear that meshes with the main gear rotates, The other end of the moving gear is pinched, and the pinion meshes with the digital rack mounted on the inner periphery of the base at the same time, and the main gear rotates once, which drives the digital rack to move in one direction.
- the one-way control device is mounted on the gear member and includes a one-way shaft and a one-way cover.
- a display window is arranged on the base, and the result of the rotation of the counting device once is displayed by digital in the display window.
- the drug delivery chamber is a trapezoidal concave structure or a circular concave structure, the volume of which is the dose required for one administration.
- the dry type inhaler of the depot type according to claim 1 wherein a longitudinal direction between the medicine cover and the top cover is further separated by a desiccant storage chamber, and a desiccant is placed in the desiccant storage chamber. Keep the inside of the device dry.
- the upper cover is divided into two parts, a first upper cover and a second upper cover respectively, the first upper cover is a storage compartment upper cover, and the second upper cover is a main component upper cover.
- the drug reservoir can be filled with one or more drugs.
- the drug is selected from the group consisting of a ⁇ 2 agonist, one or more of formoterol, salbutamol, and salmeterol.
- the drug is selected from the group consisting of glucocorticoids, one or more of budesonide, fluticasone, and ciclesonide.
- the drug is selected from the group consisting of an anticholinergic drug, one or more selected from the group consisting of adiponium bromide and ipratropium bromide.
- the invention provides a reservoir type dry powder inhaler, which has the advantages of:
- the main body is vertically divided into a drug storage chamber, a drug absorption channel and a drying chamber, and has a simple structure and is convenient for drug storage and retrieval.
- the drug delivery bin has a simple structure, flexible setting method, reliable use and low cost, and if not inhaled after filling the drug storage bin, The filling drug can also be switched to the storage chamber again to prevent powder leakage and deliquescence.
- Adding a column to the medicine cover plate can stir the powder to make the filling amount more balanced, increase the dispersibility and fluidity of the powder, and help the dosage of each dose to be more accurate.
- dry powder inhaler overall structure is simple, smart design, safe and reliable, to meet the needs of users.
- FIG. 1 is a schematic view of the overall assembly of an embodiment of the present invention
- Figure 2 is a cross-sectional view showing an embodiment of the present invention.
- an embodiment of the present invention is a reservoir type dry powder inhaler comprising a base 1, a main body 2, a unidirectional control device 3, a counting member 4, an air passage member 5, and a nozzle member. 6.
- the base 1 is located at a lower portion of the main body 2
- the counting member 4 is disposed in the base 1 and the main body 2
- the nozzle member 6 is located at an upper portion of the main body 2.
- the counting member 4 includes a gear member 41 and a one-way control device 42.
- the gear member 41 includes The main gear 411 installed in the middle of the base 1 rotates when the main gear 411 rotates, and the driven gear 412 that meshes with the main gear 411 rotates.
- the other end pinion 413 of the driven gear 412 is kneaded, and the pinion 413 is simultaneously mounted with the number mounted on the inner periphery of the base.
- the rack 414 is engaged, and the main gear is rotated once, and the digital rack is driven once in one direction.
- the one-way control device 3 includes a one-way shaft 31 mounted on a main gear, and a one-way shaft 32 that ensures that only one direction of rotation of the main body 2 is transmitted to the gear member 41; 2, the upper part is mounted on the upper cover 21, the middle part is mounted with the medicine cover 22, and the upper cover 21 is divided into two parts, a first upper cover 211 and a second upper cover 212, respectively, and the first upper cover 211 is a storage compartment upper cover, The upper cover 212 is a cover for other components of the main body.
- the medicine cover 22 is fixed in the main body 2 by the bracket 23, and the bracket 23 is disposed on the one-way shaft 32; the medicine cover 22 and the top cover 24 in the main body 2 are longitudinally separated into a medicine storage chamber 25, A desiccant storage chamber 26 and a drug suction channel 27; a spring 28 is disposed between the stent 23 and the drug cover 22 to press the drug cover 22 against the lower edge of the drug storage chamber or the drug suction channel.
- the upper surface of the medicine cover 22 is provided with a drug delivery chamber 221, and the drug delivery chamber 221 is switched between the drug storage chamber 25 and the drug suction channel 27 during the rotation of the body 2.
- the drug delivery chamber 221 has a trapezoidal concave structure and in other cases may have a circular concave structure or other shape structure, but the volume of the drug delivery chamber 221 is generally The dose required for one administration.
- the upper surface of the medicine cover 22 is further provided with a column 222 which is located in the drug storage chamber 25 when the body 2 is rotated.
- a spring device 231 is disposed between the bracket 23 and the medicine cover 22, and the spring device 231 presses the medicine cover against the lower edge of the suction passage.
- a desiccant is placed in the desiccant storage chamber 26 to keep the inside of the device dry.
- the nozzle member 6 is located above the main body, and the air passage member 7 has a double arc-shaped structure, which is located in the nozzle member, and one end is connected to the suction passage 27 on the main body.
- a main body cover 7 is attached to the main body 2, and the main body cover 7 protects the nozzle member.
- a display window 11 may be disposed on the base 1, and the result of the rotation of the counting member 4 once is numerically displayed in the display window 11.
- the dry powder inhaler can be divided into single dose and multiple dose according to the dosage.
- the multi-dose type can be divided into the manufacturer pre-dispensing type (blister type) and the reservoir type.
- the inhaler according to the present invention is a reservoir type, and is composed of a counter, a reservoir, a trough, an air passage, a powder dispersing member, and a desiccant storage chamber.
- the working principle and process of the invention include:
- the base portion can be held by the left hand, and the main body portion can be held by the right hand and rotated counterclockwise until the limit angle cannot be rotated.
- the limit angle is achieved by providing two square pillars in the lower part of the main body. When the main body rotates, the square pillars collide with the bracket blocks fixed on the base, and the brackets are restricted to continue to rotate.
- the limit modes of the forward and reverse rotation are the same; when the main body rotates counterclockwise, the one-way shaft rotation in the one-way control device is driven, and the one-way shaft drives the driving gear to rotate, the driving gear The rotation will drive the driven gear and the pinion to rotate, the main body rotates once, and the digital rack moves a unit, and the number can be displayed through the counting display window associated with the digital rack.
- the drug storage compartment on the medicine cover is switched from below the drug storage chamber to below the drug suction channel, and the dry powder inhaler enters the drug absorption state.
- the user can use the mouth to contain the nozzle, inhale hard, and a negative pressure will be generated in the channel, and the powder will flow with the airflow to reach the lungs of the patient, and the effect of the drug treatment can be achieved.
- the main body rotates clockwise, until it can not be rotated, this is a reset.
- the one-way shaft does not transmit the rotation to the main gear of the counting device due to the action of the one-way control device, so the number displayed on the counting display window associated with the counting device does not change over the entire cycle.
- the counting device will move once, and the number will change by one unit, so as to accurately count the purpose of the patient's drug taking times.
- the drug delivery chamber on the medicine cover is switched from below the drug suction channel to the lower side of the drug storage chamber, and the dosage of one unit dose is maintained, and Prevent leakage or deliquescence in the inhalation channel.
- the drug absorption amount is constant every time, and the effective statistical drug absorption frequency is 60 times; at the same time, the medicine cover plate of the embodiment is provided with a column mechanism, and the column mechanism is stored during the cycle of the body rotation.
- the drug room movement can effectively stir the powder in the drug storage chamber to make the drug add-on More uniform, strengthen the dispersion of the powder, stir the powder back and forth to achieve the powder flow, to ensure that the powder can enter the medicine silo on the medicine board.
- the present embodiment provides a desiccant storage chamber, and a desiccant is added thereto to maintain the dryness of the inside of the dry powder inhaler.
- Counter The digital rack in this embodiment will be printed with numbers. After each inhalation, the number of times that the remaining medicine can be taken can be read. The final number is fed back to the patient from the digital rack.
- the dry powder inhaler in this embodiment may be covered with a main body cover to protect the cleaning of the nozzle member.
- This embodiment uses aerodynamic principles to design a double circular arc-shaped airway.
- the drug and carrier powder can generate sufficient turbulence when passing through the airway, disperse the aggregated mass and make the drug and carrier. Separate sufficiently to produce the largest proportion of particles of optimal particle size. The contradiction between drug powder dispersion and airflow resistance is well solved, and the best effect is obtained.
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Abstract
一种储库型干粉吸入器,包括底座(1)、主体(2)、计数部件(4)、气道部件(5)及吸嘴部件(6)。底座(1)位于主体(2)下部,计数部件(4)包括齿轮部件(41)及单向控制装置(42),主体(2)上部安装上盖(21),中部安装药盖板(22),主体(2)内的药盖板(22)与顶盖(24)间纵向分隔为储药室(25)和吸药通道(27),药盖板(22)上表面设有给药仓(221),主体(2)旋转过程中给药仓(221)在储药室(25)和吸药通道(27)之间切换。该干粉吸入器有利于药物储存和取用,双圆弧形气道部件(5)保证吸气时吸气通道内合理的压力气体流速,能明显增强粉末状药物的分散性,药盖板(22)立柱的设置使每次给药的剂量更准确。
Description
本发明涉及医疗设备领域,尤其涉及一种储库型干粉吸入器。
干粉吸入剂是指将药物粉末装填于一药物储库中,患者通过吸入器吸气,将粉末分散成雾状后吸入气管或肺部发挥疗效。当前的干粉吸入剂是呼吸触动型,药物分散和粉雾的产生源动力来自患者的吸气。因为药物以粉末状填装,因而载药量可以很高;作为固态,有利药物的稳定性。特别是呼吸触动给药,病人的配合度高,因而近10年来,干粉吸入剂得到了突飞猛进的发展。不仅短期内干粉吸入剂作为治疗气管或肺部的局部用药是最具吸引力的,而且从长期来看,其在全身性转运生物分子、抗生素及基因工程药物方面具有更重要的潜在优势。
药物粉末通过干粉吸入装置传递至肺部前需要满足一定的条件。首先药物粉末在呼吸道这种特殊的气流环境中表现出来的粒径分布应在一定范围之内。一般认为3~7μm粒径可在支气管较好地沉积,而1~3μm则可沉积到肺深部区域。大于7μm的微粒易被上呼吸道截留,过小的微粒在进入末端支气管后又易随着患者的呼吸而呼出体外。细微的药物粉末由于表面张力大,易团聚,流动性差,很难进行填充和分剂量。因此干粉处方中通常加入较大粒径的乳糖(80~300μm)作为载体。药物粉末分散附着在载体表面,流动性得到很大提高,剂量准确性提高,因而得以广泛应用。
发明内容
本发明的目的是解决现有技术存在的问题,特别是提供一种储存时间长,安全性高,吸入方式简单有效,计数方式简便可靠的储库型干粉吸入器。本发明提供的一种储库型干粉吸入器,储库型干粉吸入器,包括底座、主体、单向控制装置、计数部件、药盖板、气道部件及吸嘴部件,其特征在于,所述底座位于主体下部,计数部件置于底座内,吸嘴部件位于主体上部;计数部件包括齿轮部件及单向控制装置;单向控制装置确保只将主体一个方向的旋转传动到齿轮部件上;所述主体上部安装上盖,中部安装药盖板,所述药盖板通过支架固定在主体内;所述支架安置在单向控制装置上;所述主体内的药盖板与顶盖间纵向分隔为储药室和吸药通道,所述药盖板上表面设有给药仓,主体旋转过程中所述给药仓在储药室和吸药通道之间切
换,吸嘴部件位于主体上方,气道部件位于吸嘴部件内,一端与主体上的吸药通道相连。优选地,所述底座及主体为圆柱形。
优选地,所述气道部件为双圆弧形结构。
优选地,所述主体上加设主体盖,主体盖对吸嘴部件产生保护。
优选地,所述支架与药盖板之间设有弹簧装置,弹簧保证药盖板与主体下壁紧密结合。
优选地,所述药盖板上表面设有立柱结构,在主体旋转时,该立柱结构位于储药室内。
优选地,所述齿轮部件包括主齿轮、从动齿轮、小齿轮、数字齿条及限位装置,所述主齿轮安装在底座内中部,主齿轮转动时带动与其啮合的从动齿轮转动,从动齿轮的另一端小齿轮捏合,小齿轮同时与安装在底座内周边的数字齿条啮合,主齿轮定向旋转一次,带动数字齿条单向运动一次。
优选地,所述单向控制装置安装在齿轮部件上,包括单向轴和单向盖。
优选地,所述底座上设置显示窗,计数装置转动一次后的结果在显示窗中通过数字显示。
优选地,所述给药仓为梯形凹陷结构或圆形凹陷结构,其容积为一次给药所需的剂量。
优选地,根据权利要求1所述的储库型干粉吸入器,其特征在于所述主体内的药盖板与顶盖间纵向还分隔有干燥剂储存室,所述干燥剂储存室内放置干燥剂,保持装置内部干燥。
优选地,所述上盖分为两部分分别为第一上盖和第二上盖,所述第一上盖为储药室上盖,第二上盖为主体其他部件上盖。
优选地,所述储药室可填充一种或多种药物。
优选地,所述药物选自β2激动剂,可选择福莫特罗,沙丁胺醇,沙美特罗中的一种或多种。
优选地,所述药物选自糖皮质激素,可选择布地奈德,氟替卡松,环索奈德中的一种或多种。
优选地,所述药物选自抗胆碱能药物,可选择阿地溴铵,异丙托溴铵中的一种或多种。
本发明提供的储库型干粉吸入器,其优点在于:
1,主体纵向分割为储药室、吸药通道和干燥室,结构简单,且有利于药物储存和取用。
2,双圆弧型气道部件并保证吸气时吸气通道合理的压力气体流速,明显增强粉末状药物的分散性。。
3,机械式的技术部件安全可靠,方便使用者可视化观察用药进度,且成本低廉。
4,给药仓结构简单,设置方式灵活,使用可靠且成本低廉,给药仓填装后如果不吸入,
填装药物还可以再次切换到储药室,防止药粉泄漏及潮解。
5,药盖板上加装立柱,可以可搅动药粉使得加装量更为均衡,增加药粉的分散性和流动性,帮助每次给药的剂量更为准确。
6,干粉吸入器整体结构简单,设计巧妙,安全可靠,满足使用者的使用需要。
通过阅读参照以下附图所作的对非限制性实施例所作的详细描述,本发明的其它特征、目的和优点将会变得更明显:
图1为本发明实施例的整体装配示意图;
图2为本发明实施例的剖视图。
下面结合附图对本发明作进一步详细描述。
一、本发明的基本构造
如图1-8所示,本发明的一种实施例为一种储库型干粉吸入器,包括底座1、主体2、单向控制装置3、计数部件4、气道部件5及吸嘴部件6,所述底座1位于主体2下部,计数部件4置于底座1和主体2内,吸嘴部件6位于主体2上部;计数部件4包括齿轮部件41及单向控制装置42;齿轮部件41包括安装在底座1内中部的主齿轮411,主齿轮411转动时带动与其啮合的从动齿轮412转动,从动齿轮412的另一端小齿轮413捏合,小齿轮413同时与安装在底座内周边的数字齿条414啮合,主齿轮定向旋转一次,带动数字齿条单向运动一次。
单向控制装置3包括单向轴31和单向轴32,单向轴31安装在主齿轮上,单向控制装置3确保只将主体2一个方向的旋转传动到齿轮部件41上;所述主体2上部安装上盖21,中部安装药盖板22,上盖21分为两部分分别为第一上盖211和第二上盖212,所述第一上盖211为储药室上盖,第二上盖212为主体其他部件上盖。所述药盖板22通过支架23固定在主体2内,所述支架23安置在单向轴32上;所述主体2内的药盖板22与顶盖24间纵向分隔为储药室25、干燥剂储存室26和吸药通道27;所述支架23和药盖板22之间装配弹簧28,将药盖板22压紧在储药室或吸药通道下沿。所述药盖板22上表面设有给药仓221,主体2旋转过程中所述给药仓221在储药室25和吸药通道27之间切换。本实施例中给药仓221为梯形凹陷结构而其他情况下也可以为为圆形凹陷结构或其他形状结构,但给药仓221的容积一般
为一次给药所需的剂量。药盖板22上表面还设有立柱222,在主体2旋转时,该立柱222位于储药室25内。所述支架23与药盖板22之间设置有弹簧装置231,弹簧装置231将将药盖板压紧在吸药通道下沿。所述干燥剂储存室26内放置干燥剂,保持装置内部干燥。吸嘴部件6位于主体上方,气道部件7为双圆弧形结构,其位于吸嘴部件内,一端与主体上的吸药通道27相连。主体2上加设主体盖7,主体盖7对吸嘴部件产生保护。所述底座1上可以设置显示窗11,计数部件4转动一次后的结果在显示窗11中通过数字显示。
二、本发明的工作原理:
干粉吸入器按剂量多少可分为单剂量和多剂量两种,其中多剂量型又可分为厂家预分剂量型(泡罩型)和储库型。本发明所涉及的吸入器为储库型,是由计数器,储库,料槽,气道,粉末分散部件以及干燥剂存放室等零件组成。
本发明的工作原理及流程包括:
1,使用者操作本发明实施例所示的储库型干粉吸入器时,可以左手握住底座部分,右手握住主体部分并进行逆时针旋转,直至到达限位角度无法旋转为止。本实施例中实现限位角度是通过在主体下部设两个方柱,主体旋转时方柱会和固定在底座上的支架块相碰,靠支架限制主体继续转动。以达到限位效果,正向和反向旋转的限位方式相同;当主体作逆时针旋转时会带动单向控制装置中的单向轴转动,而单向轴则带动主动齿轮旋转,主动齿轮旋转会带动从动齿轮及小齿轮旋转,主体旋转一次,带动数字齿条运动一个单元,并可以通过数字齿条关联的计数显示窗显示数字。
同时,由于主体旋转,药盖板上的给药仓从储药室下方切换到吸药通道下方,干粉吸入器进入吸药状态。使用者可以在此时用嘴含住吸嘴,用力吸气,通道内会产生负压,药粉会随气流流动,到达患者的肺部,达到给药治疗的效果。
2,吸药后,主体作顺时针旋转,到不能转动为止,此为复位。在主体顺时针旋转时,由于单向控制装置的作用,单向轴不将转动传动到计数装置的主齿轮上,因此计数装置关联的计数显示窗上显示的数字不发生变化,在整个一个循环过程中,计数装置会走动一次,数字会变动一个单元,从而准确统计患者吸药次数的目的。无论使用者是否吸入药物,或者是否完全将药物吸入,主体复位后,药盖板上的给药仓从吸药通道下方切换回储药室下方,保持盛载一个单位剂量的药量,并可防止在吸药通道中泄漏或潮解。本实施例中的吸药量每次为恒定,有效统计吸药次数为60次;同时本实施例的药盖板上加装一立柱机构,在主体转动的循环过程中,该立柱机构在储药室内运动,可以有效的搅动储药室内的药粉,使得药物加装
更加均匀,加强要药粉分散度,来回搅动药粉,以达到粉末流动,保证粉末能进入到药板上的药仓内。同时为了保持药粉的干燥性,本实施例设置了干燥剂储存室,并在其中添加干燥剂,保持干粉吸入器内部的干燥性。
6,计数器:本实施例中的数字齿条上会印有数字,每次吸药后能读到余下还可以吸药的次数,最终所见的数字就从数字齿条上反馈给患者。
7,闲置不使用时,本实施例中干粉吸入器可以盖上主体盖,以保护吸嘴部件的清洁。
8,本实施例利用空气动力学原理设计了一个双园弧形气道,药物及载体粉末在通过该气道时可产生足够大的湍流,将聚集的团块打散,并使药物与载体充分分离,以产生最大比例的最佳粒径微粒。很好的解决了药物粉末分散和气流阻力的矛盾,得到最佳效果。
对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化涵括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。此外,显然“包括”一词不排除其他单元或步骤,单数不排除复数。装置权利要求中陈述的多个单元或装置也可以由一个单元或装置通过软件或者硬件来实现。第一,第二等词语用来表示名称,而并不表示任何特定的顺序。
Claims (16)
- 一种储库型干粉吸入器,包括底座、主体、单向控制装置、计数部件、药盖板、气道部件及吸嘴部件,其特征在于,所述底座位于主体下部,计数部件置于底座内,吸嘴部件位于主体上部;计数部件包括齿轮部件及单向控制装置;单向控制装置确保只将主体一个方向的旋转传动到齿轮部件上;所述主体上部安装上盖,中部安装药盖板,所述药盖板通过支架固定在主体内;所述支架安置在单向控制装置上;所述主体内的药盖板与顶盖间纵向分隔为储药室和吸药通道,所述药盖板上表面设有给药仓,主体旋转过程中所述给药仓在储药室和吸药通道之间切换,吸嘴部件位于主体上方,气道部件位于吸嘴部件内,一端与主体上的吸药通道相连。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述底座及主体为圆柱形。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述气道部件为双圆弧形结构。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述主体上加设主体盖,主体盖对吸嘴部件产生保护。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述支架与药盖板之间设有弹簧装置,弹簧保证药盖板与主体下壁紧密结合。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述药盖板上表面设有立柱结构,在主体旋转时,该立柱结构位于储药室内。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述齿轮部件包括主齿轮、从动齿轮、小齿轮、数字齿条及限位装置,所述主齿轮安装在底座内中部,主齿轮转动时带动与其啮合的从动齿轮转动,从动齿轮的另一端小齿轮捏合,小齿轮同时与安装在底座内周边的数字齿条啮合,主齿轮定向旋转一次,带动数字齿条单向运动一次。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述单向控制装置安装在齿轮部件上,包括单向轴和单向盖。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述底座上设置显示窗,计数装置转动一次后的结果在显示窗中通过数字显示。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述给药仓为梯形凹陷结构或圆形凹陷结构,其容积为一次给药所需的剂量。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述主体内的药盖板与顶盖间纵向还分隔有干燥剂储存室,所述干燥剂储存室内放置干燥剂,保持装置内部干燥。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述上盖分为两部分分别为 第一上盖和第二上盖,所述第一上盖为储药室上盖,第二上盖为主体其他部件上盖。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述储药室可填充一种或多种药物。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述药物选自β2激动剂,可选择福莫特罗,沙丁胺醇,沙美特罗中的一种或多种。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述药物选自糖皮质激素,可选择布地奈德,氟替卡松,环索奈德中的一种或多种。
- 根据权利要求1所述的储库型干粉吸入器,其特征在于所述药物选自抗胆碱能药物,可选择阿地溴铵,异丙托溴铵中的一种或多种。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908442A (zh) * | 2019-01-25 | 2019-06-21 | 苏州艾莱科劢德电子科技有限公司 | 一种基于声音的干粉吸入器的流速侦测装置 |
| CN110064110A (zh) * | 2019-05-29 | 2019-07-30 | 上海理工大学 | 一种容积旋钮式干粉储存吸入装置 |
| CN115970104A (zh) * | 2022-12-09 | 2023-04-18 | 中国药科大学 | 一种新型储库型干粉吸入器 |
| CN118831230A (zh) * | 2024-07-23 | 2024-10-25 | 华中科技大学 | 可吸入干粉制剂雾化设备 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1662270A (zh) * | 2002-05-14 | 2005-08-31 | 佩尔洛斯公司 | 吸入器及其制造方法 |
| CN1684731A (zh) * | 2002-09-21 | 2005-10-19 | 艾文蒂斯药品有限公司 | 吸入器 |
| US20090120436A1 (en) * | 2007-11-09 | 2009-05-14 | Hitachi, Ltd. | Powder medicine administering apparatus |
| CN104168940A (zh) * | 2012-01-23 | 2014-11-26 | 赛诺菲股份有限公司 | 吸入装置 |
| CN204521855U (zh) * | 2015-03-13 | 2015-08-05 | 丁要武 | 吸粉器及连接于该吸粉器的吸粉器本体上的药匣组件 |
| CN105031782A (zh) * | 2015-06-30 | 2015-11-11 | 上海臣邦医药科技有限公司 | 一种提高粉雾剂给药装置加药量计量准确性的方法 |
-
2016
- 2016-01-28 WO PCT/CN2016/072472 patent/WO2017128170A1/zh not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1662270A (zh) * | 2002-05-14 | 2005-08-31 | 佩尔洛斯公司 | 吸入器及其制造方法 |
| CN1684731A (zh) * | 2002-09-21 | 2005-10-19 | 艾文蒂斯药品有限公司 | 吸入器 |
| US20090120436A1 (en) * | 2007-11-09 | 2009-05-14 | Hitachi, Ltd. | Powder medicine administering apparatus |
| CN104168940A (zh) * | 2012-01-23 | 2014-11-26 | 赛诺菲股份有限公司 | 吸入装置 |
| CN204521855U (zh) * | 2015-03-13 | 2015-08-05 | 丁要武 | 吸粉器及连接于该吸粉器的吸粉器本体上的药匣组件 |
| CN105031782A (zh) * | 2015-06-30 | 2015-11-11 | 上海臣邦医药科技有限公司 | 一种提高粉雾剂给药装置加药量计量准确性的方法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908442A (zh) * | 2019-01-25 | 2019-06-21 | 苏州艾莱科劢德电子科技有限公司 | 一种基于声音的干粉吸入器的流速侦测装置 |
| CN110064110A (zh) * | 2019-05-29 | 2019-07-30 | 上海理工大学 | 一种容积旋钮式干粉储存吸入装置 |
| CN115970104A (zh) * | 2022-12-09 | 2023-04-18 | 中国药科大学 | 一种新型储库型干粉吸入器 |
| CN118831230A (zh) * | 2024-07-23 | 2024-10-25 | 华中科技大学 | 可吸入干粉制剂雾化设备 |
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