WO2017128170A1 - Reservoir-type dry powder inhaler - Google Patents

Abstract

Disclosed is a reservoir-type dry powder inhaler, comprising a base (1), a main body (2), a counting part (4), an air channel part (5) and a suction nozzle part (6). The base (1) is located at the lower part of the main body (2); the counting part (4) comprises a gear part (41) and a unidirectional control device (42); an upper cover (21) is mounted on the upper part of the main body (2), and a drug cover plate (22) is mounted on the middle part; the space between the drug cover plate (22) and a top cover (24) in the main body (2) is longitudinally divided into a drug storage chamber (25) and a drug inhalation channel (27); and a drug supply cabin (221) is arranged on an upper surface of the drug cover plate (22), and the drug supply cabin (221) shifts between the drug storage chamber (25) and the drug inhalation channel (27) during the rotation of the main body (2). The dry powder inhaler facilitates the storage and taking of a drug. With the air channel part (5) being in a double circular arc shape, a reasonable pressure gas flow rate can be guaranteed inside the inhalation channel during inhalation, thereby obviously improving the dispersion of a powdered drug. With the vertical column configuration of the drug cover plate (22), the dose of each administration is more accurate.

Description

Depot dry powder inhaler Technical field

The invention relates to the field of medical equipment, in particular to a reservoir type dry powder inhaler.

Background technique

Dry powder inhaler refers to the filling of a drug powder in a drug reservoir. The patient inhales through the inhaler, disperses the powder into a mist, and then inhales into the trachea or the lungs to exert a therapeutic effect. Current dry powder inhalers are respiratory-sensitive, and the source of drug dispersion and powder is derived from the patient's inhalation. Since the drug is filled in a powder form, the drug loading amount can be high; as a solid state, the stability of the drug is favorable. In particular, the respiratory touch is administered, and the patient's degree of cooperation is high. Therefore, in the past 10 years, the dry powder inhaler has developed rapidly. Not only short-term dry powder inhalers are most attractive as a topical medication for the treatment of the trachea or lungs, but in the long run, they have a more important potential advantage in systemic transport of biomolecules, antibiotics and genetic engineering drugs.

Certain conditions must be met before the drug powder is delivered to the lungs through the dry powder inhalation device. First, the particle size distribution of the drug powder in the special airflow environment of the respiratory tract should be within a certain range. It is generally believed that a particle size of 3 to 7 μm can be deposited well in the bronchus, and a thickness of 1 to 3 μm can be deposited in a deep region of the lung. Particles larger than 7 μm are easily trapped by the upper respiratory tract, and too small particles are easily exhaled from the patient's breathing after entering the terminal bronchus. The fine drug powder has a large surface tension, is easy to agglomerate, and has poor fluidity, making it difficult to fill and dispense. Therefore, a larger particle size of lactose (80 to 300 μm) is usually added as a carrier in the dry powder formulation. The drug powder is dispersed and attached to the surface of the carrier, the fluidity is greatly improved, and the dose accuracy is improved, so that it is widely used.

Summary of the invention

The object of the present invention is to solve the problems existing in the prior art, and in particular to provide a reservoir type dry powder inhaler which has long storage time, high safety, simple and effective inhalation mode, and simple and reliable counting method. The invention provides a reservoir type dry powder inhaler, a reservoir type dry powder inhaler, comprising a base, a main body, a one-way control device, a counting component, a medicine cover plate, an air passage component and a nozzle component, wherein The base is located at a lower portion of the main body, the counting member is disposed in the base, and the nozzle member is located at an upper portion of the main body; the counting member includes a gear member and a one-way control device; and the one-way control device ensures that only one direction of rotation of the main body is transmitted to the gear member; The upper part of the main body is mounted with a top cover, and the middle part is provided with a medicine cover plate, and the medicine cover plate is fixed in the main body through the bracket; the bracket is disposed on the one-way control device; the medicine cover plate and the top cover in the main body are longitudinally separated from each other For the drug storage chamber and the drug absorption channel, the upper surface of the medicine cover is provided with a drug storage chamber, and the drug storage chamber is cut between the drug storage chamber and the drug absorption channel during the rotation of the body. In other words, the nozzle member is located above the main body, the air passage member is located in the nozzle member, and one end is connected to the suction passage on the main body. Preferably, the base and the body are cylindrical.

Preferably, the airway component is a double arcuate structure.

Preferably, a main body cover is added to the main body, and the main body cover protects the nozzle component.

Preferably, a spring device is arranged between the bracket and the medicine cover, and the spring ensures that the medicine cover is tightly coupled with the lower wall of the main body.

Preferably, the upper surface of the medicine cover is provided with a column structure, and the column structure is located in the drug storage chamber when the body rotates.

Preferably, the gear component comprises a main gear, a driven gear, a pinion gear, a digital rack and a limiting device, wherein the main gear is installed in a middle portion of the base, and when the main gear rotates, the driven gear that meshes with the main gear rotates, The other end of the moving gear is pinched, and the pinion meshes with the digital rack mounted on the inner periphery of the base at the same time, and the main gear rotates once, which drives the digital rack to move in one direction.

Preferably, the one-way control device is mounted on the gear member and includes a one-way shaft and a one-way cover.

Preferably, a display window is arranged on the base, and the result of the rotation of the counting device once is displayed by digital in the display window.

Preferably, the drug delivery chamber is a trapezoidal concave structure or a circular concave structure, the volume of which is the dose required for one administration.

Preferably, the dry type inhaler of the depot type according to claim 1, wherein a longitudinal direction between the medicine cover and the top cover is further separated by a desiccant storage chamber, and a desiccant is placed in the desiccant storage chamber. Keep the inside of the device dry.

Preferably, the upper cover is divided into two parts, a first upper cover and a second upper cover respectively, the first upper cover is a storage compartment upper cover, and the second upper cover is a main component upper cover.

Preferably, the drug reservoir can be filled with one or more drugs.

Preferably, the drug is selected from the group consisting of a β2 agonist, one or more of formoterol, salbutamol, and salmeterol.

Preferably, the drug is selected from the group consisting of glucocorticoids, one or more of budesonide, fluticasone, and ciclesonide.

Preferably, the drug is selected from the group consisting of an anticholinergic drug, one or more selected from the group consisting of adiponium bromide and ipratropium bromide.

The invention provides a reservoir type dry powder inhaler, which has the advantages of:

1. The main body is vertically divided into a drug storage chamber, a drug absorption channel and a drying chamber, and has a simple structure and is convenient for drug storage and retrieval.

2, double arc-shaped airway components and ensure a reasonable pressure gas flow rate of the inhalation channel during inhalation, which significantly enhances the dispersibility of the powdered drug. .

3, mechanical technical components are safe and reliable, convenient for users to visually observe the progress of medication, and low cost.

4. The drug delivery bin has a simple structure, flexible setting method, reliable use and low cost, and if not inhaled after filling the drug storage bin, The filling drug can also be switched to the storage chamber again to prevent powder leakage and deliquescence.

5. Adding a column to the medicine cover plate can stir the powder to make the filling amount more balanced, increase the dispersibility and fluidity of the powder, and help the dosage of each dose to be more accurate.

6, dry powder inhaler overall structure is simple, smart design, safe and reliable, to meet the needs of users.

DRAWINGS

Other features, objects, and advantages of the present invention will become more apparent from the Detailed Description of Description

1 is a schematic view of the overall assembly of an embodiment of the present invention;

Figure 2 is a cross-sectional view showing an embodiment of the present invention.

detailed description

The invention is further described in detail below with reference to the accompanying drawings.

First, the basic structure of the present invention

As shown in FIGS. 1-8, an embodiment of the present invention is a reservoir type dry powder inhaler comprising a base 1, a main body 2, a unidirectional control device 3, a counting member 4, an air passage member 5, and a nozzle member. 6. The base 1 is located at a lower portion of the main body 2, the counting member 4 is disposed in the base 1 and the main body 2, and the nozzle member 6 is located at an upper portion of the main body 2. The counting member 4 includes a gear member 41 and a one-way control device 42. The gear member 41 includes The main gear 411 installed in the middle of the base 1 rotates when the main gear 411 rotates, and the driven gear 412 that meshes with the main gear 411 rotates. The other end pinion 413 of the driven gear 412 is kneaded, and the pinion 413 is simultaneously mounted with the number mounted on the inner periphery of the base. The rack 414 is engaged, and the main gear is rotated once, and the digital rack is driven once in one direction.

The one-way control device 3 includes a one-way shaft 31 mounted on a main gear, and a one-way shaft 32 that ensures that only one direction of rotation of the main body 2 is transmitted to the gear member 41; 2, the upper part is mounted on the upper cover 21, the middle part is mounted with the medicine cover 22, and the upper cover 21 is divided into two parts, a first upper cover 211 and a second upper cover 212, respectively, and the first upper cover 211 is a storage compartment upper cover, The upper cover 212 is a cover for other components of the main body. The medicine cover 22 is fixed in the main body 2 by the bracket 23, and the bracket 23 is disposed on the one-way shaft 32; the medicine cover 22 and the top cover 24 in the main body 2 are longitudinally separated into a medicine storage chamber 25, A desiccant storage chamber 26 and a drug suction channel 27; a spring 28 is disposed between the stent 23 and the drug cover 22 to press the drug cover 22 against the lower edge of the drug storage chamber or the drug suction channel. The upper surface of the medicine cover 22 is provided with a drug delivery chamber 221, and the drug delivery chamber 221 is switched between the drug storage chamber 25 and the drug suction channel 27 during the rotation of the body 2. In this embodiment, the drug delivery chamber 221 has a trapezoidal concave structure and in other cases may have a circular concave structure or other shape structure, but the volume of the drug delivery chamber 221 is generally The dose required for one administration. The upper surface of the medicine cover 22 is further provided with a column 222 which is located in the drug storage chamber 25 when the body 2 is rotated. A spring device 231 is disposed between the bracket 23 and the medicine cover 22, and the spring device 231 presses the medicine cover against the lower edge of the suction passage. A desiccant is placed in the desiccant storage chamber 26 to keep the inside of the device dry. The nozzle member 6 is located above the main body, and the air passage member 7 has a double arc-shaped structure, which is located in the nozzle member, and one end is connected to the suction passage 27 on the main body. A main body cover 7 is attached to the main body 2, and the main body cover 7 protects the nozzle member. A display window 11 may be disposed on the base 1, and the result of the rotation of the counting member 4 once is numerically displayed in the display window 11.

Second, the working principle of the invention:

The dry powder inhaler can be divided into single dose and multiple dose according to the dosage. The multi-dose type can be divided into the manufacturer pre-dispensing type (blister type) and the reservoir type. The inhaler according to the present invention is a reservoir type, and is composed of a counter, a reservoir, a trough, an air passage, a powder dispersing member, and a desiccant storage chamber.

The working principle and process of the invention include:

1. When the user operates the depot dry powder inhaler shown in the embodiment of the present invention, the base portion can be held by the left hand, and the main body portion can be held by the right hand and rotated counterclockwise until the limit angle cannot be rotated. In this embodiment, the limit angle is achieved by providing two square pillars in the lower part of the main body. When the main body rotates, the square pillars collide with the bracket blocks fixed on the base, and the brackets are restricted to continue to rotate. In order to achieve the limit effect, the limit modes of the forward and reverse rotation are the same; when the main body rotates counterclockwise, the one-way shaft rotation in the one-way control device is driven, and the one-way shaft drives the driving gear to rotate, the driving gear The rotation will drive the driven gear and the pinion to rotate, the main body rotates once, and the digital rack moves a unit, and the number can be displayed through the counting display window associated with the digital rack.

At the same time, due to the rotation of the main body, the drug storage compartment on the medicine cover is switched from below the drug storage chamber to below the drug suction channel, and the dry powder inhaler enters the drug absorption state. At this time, the user can use the mouth to contain the nozzle, inhale hard, and a negative pressure will be generated in the channel, and the powder will flow with the airflow to reach the lungs of the patient, and the effect of the drug treatment can be achieved.

2, after taking the medicine, the main body rotates clockwise, until it can not be rotated, this is a reset. When the main body rotates clockwise, the one-way shaft does not transmit the rotation to the main gear of the counting device due to the action of the one-way control device, so the number displayed on the counting display window associated with the counting device does not change over the entire cycle. During the process, the counting device will move once, and the number will change by one unit, so as to accurately count the purpose of the patient's drug taking times. Regardless of whether the user inhales the drug, or whether the drug is completely inhaled, after the main body is reset, the drug delivery chamber on the medicine cover is switched from below the drug suction channel to the lower side of the drug storage chamber, and the dosage of one unit dose is maintained, and Prevent leakage or deliquescence in the inhalation channel. In this embodiment, the drug absorption amount is constant every time, and the effective statistical drug absorption frequency is 60 times; at the same time, the medicine cover plate of the embodiment is provided with a column mechanism, and the column mechanism is stored during the cycle of the body rotation. The drug room movement can effectively stir the powder in the drug storage chamber to make the drug add-on More uniform, strengthen the dispersion of the powder, stir the powder back and forth to achieve the powder flow, to ensure that the powder can enter the medicine silo on the medicine board. At the same time, in order to maintain the dryness of the powder, the present embodiment provides a desiccant storage chamber, and a desiccant is added thereto to maintain the dryness of the inside of the dry powder inhaler.

6. Counter: The digital rack in this embodiment will be printed with numbers. After each inhalation, the number of times that the remaining medicine can be taken can be read. The final number is fed back to the patient from the digital rack.

7. When not in use, the dry powder inhaler in this embodiment may be covered with a main body cover to protect the cleaning of the nozzle member.

8. This embodiment uses aerodynamic principles to design a double circular arc-shaped airway. The drug and carrier powder can generate sufficient turbulence when passing through the airway, disperse the aggregated mass and make the drug and carrier. Separate sufficiently to produce the largest proportion of particles of optimal particle size. The contradiction between drug powder dispersion and airflow resistance is well solved, and the best effect is obtained.

It is apparent to those skilled in the art that the present invention is not limited to the details of the above-described exemplary embodiments, and the present invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the invention is defined by the appended claims instead All changes in the meaning and scope of equivalent elements are included in the present invention. Any reference signs in the claims should not be construed as limiting the claim. In addition, it is to be understood that the word "comprising" does not exclude other elements or steps. A plurality of units or devices recited in the device claims may also be implemented by a unit or device by software or hardware. The first, second, etc. words are used to denote names and do not denote any particular order.

Claims (16)

A reservoir type dry powder inhaler comprises a base, a main body, a one-way control device, a counting component, a medicine cover plate, an air passage component and a nozzle component, wherein the base is located at a lower part of the main body, and the counting component is placed on the base The nozzle member is located at an upper portion of the main body; the counting member includes a gear member and a one-way control device; the one-way control device ensures that only one direction of rotation of the main body is transmitted to the gear member; the upper portion of the main body is mounted with a cover, and the middle portion is provided with a medicine cover a medicine plate cover is fixed in the main body by a bracket; the bracket is disposed on the one-way control device; the medicine cover plate and the top cover in the main body are longitudinally separated into a drug storage chamber and a drug absorption channel, The upper surface of the medicine cover is provided with a drug delivery chamber. During the rotation of the main body, the drug delivery chamber is switched between the drug storage chamber and the drug absorption channel, the nozzle member is located above the main body, and the airway component is located in the nozzle component, and one end is The drug absorption channels on the main body are connected. A depot dry powder inhaler according to claim 1 wherein said base and body are cylindrical. A depot dry powder inhaler according to claim 1, wherein said air passage member has a double arcuate configuration. A depot dry powder inhaler according to claim 1, wherein a main body cover is attached to said main body, and said main body cover protects said nozzle member. The depot type dry powder inhaler according to claim 1, wherein a spring device is disposed between the bracket and the medicine cover, and the spring ensures that the medicine cover is tightly coupled with the lower wall of the main body. The depot type dry powder inhaler according to claim 1, wherein the upper surface of the medicine cover is provided with a column structure, and the column structure is located in the drug storage chamber when the body rotates. The depot type dry powder inhaler according to claim 1, wherein the gear member comprises a main gear, a driven gear, a pinion gear, a digital rack and a limiting device, and the main gear is installed in a middle portion of the base. When the main gear rotates, the driven gear that meshes with it rotates, and the other end of the driven gear is pinched. The pinion meshes with the digital rack mounted on the inner periphery of the base at the same time, and the main gear rotates once to drive the digital rack. Exercise once. A depot dry powder inhaler according to claim 1 wherein said one-way control means is mounted on the gear member and includes a one-way shaft and a one-way cover. The depot type dry powder inhaler according to claim 1, wherein a display window is provided on the base, and a result of the rotation of the counting device once is digitally displayed in the display window. A depot type dry powder inhaler according to claim 1, wherein said drug delivery chamber is a trapezoidal recessed structure or a circular recessed structure, the volume of which is a dose required for one administration. The depot type dry powder inhaler according to claim 1, wherein a desiccant storage chamber is further partitioned between the medicine cover and the top cover in the main body, and a desiccant is placed in the desiccant storage chamber, and the holding device is Dry inside. A depot type dry powder inhaler according to claim 1, wherein said upper cover is divided into two parts respectively The first upper cover and the second upper cover, the first upper cover is a storage compartment upper cover, and the second upper cover is a cover of other parts of the main body. A depot dry powder inhaler according to claim 1 wherein said reservoir is filled with one or more drugs. The depot dry powder inhaler according to claim 1, wherein the drug is selected from the group consisting of a β2 agonist, and one or more of formoterol, salbutamol, and salmeterol may be selected. A depot dry powder inhaler according to claim 1, wherein said drug is selected from the group consisting of glucocorticoids, one or more of budesonide, fluticasone, and ciclesonide. A depot dry powder inhaler according to claim 1, wherein said drug is selected from the group consisting of an anticholinergic drug, one or more selected from the group consisting of adiponium bromide and ipratropium bromide.

Images