WO2017101713A1

WO2017101713A1 - Continuous body temperature monitor

Info

Publication number: WO2017101713A1
Application number: PCT/CN2016/108724
Authority: WO
Inventors: Hong KANG
Original assignee: Well Diagnostics Technology (international) Corp
Current assignee: Well Diagnostics Technology (international) Corp
Priority date: 2015-12-18
Filing date: 2016-12-06
Publication date: 2017-06-22
Anticipated expiration: 2018-06-18
Also published as: CN206080497U; CN105662361A; CN205988282U

Abstract

A continuous body temperature monitor is disclosed. The continuous body temperature monitor comprises a stickup measuring apparatus of body surface physiological parameters, the apparatus comprising a flexible substrate(101), a sensor(102) for measuring human body parameters including temperature, and a stickup layer(103). The material and shape of the stickup layer(103) are improved by selecting a hydrogel layer with a hollow shape as the stickup layer(103), so that the measuring apparatus may be closely attached to a measurement part, which solves the problem of hysteresis change and inaccuracy of measurement caused by the thermal capacity of the material of the stickup layer(103) per se and thus improves the continuous measurement capability of the measuring apparatus. The continuous body temperature monitor having the measuring apparatus of body surface physiological parameters may be continuously attached to human body skin so as to serve as a continuous body temperature monitor to detect abnormal temperatures produced by abnormal metabolisms of cancer cells.

Description

CONTINUOUS BODY TEMPERATURE MONITOR

FIELD OF THE INVENTION

The present invention relates to the technical field of measuring parameters of a human body, and particularly to a stickup measuring apparatus for human body parameters.

BACKGROUND OF THE INVENTION

With constant progress and development of wearable technologies, more and more wearable apparatus products are emerging. Therefore, a demand arises as to how to leverage wearable technologies to monitor human body parameters such as temperature, humidity of a human body so as to provide data for health assessment.

SUMMARY OF THE INVENTION

To measure parameters of a human body, a stickup measuring apparatus disclosed in the present invention may, as an electronic device, be directly attached to human body surface in combination with a common wearable product such as an earphone, a sock, an insole so as to monitor human body parameters such as temperature and humidity of a human body continuously in a long term to provide data for medical diagnosis or health assessment.

With temperature measurement as an example, measurement precision of temperature is an important performance indicator for a stickup temperature measurement apparatus, while the measurement precision of temperature is affected by a plurality of factors. During research, the Inventors improved closeness degree of attachment between the temperature measurement apparatus and a part of a human body subjected to temperature measurement by providing an adhesive layer.

During using the temperature measurement apparatus with the stickup layer, the applicant found that measurement of temperature may be affected due to a relatively large footprint and consequent more adhesive material of the adhesive layer in use As the stickup layer has a relatively large thermal capacity and it will absorb a certain amount of heat from body surface, temperature environment around a temperature sensor may deviate from an actual condition. For example, when the temperature rises or drops abruptly, as an effect of absorbing or releasing heat produced by the human body may be affected by the stickup layer, temperature changes measured by the temperature sensor lags behind actual body temperature changes.

The applicant also found that under different temperature conditions, amounts of sweat precipitating from the body surface are different, which will lead to different humidities in microenvironments of the body surface. In other words, if the temperature of the body surface rises while the body surface is sweating, the temperature and the humidity of the body surface will be associated with each other. It becomes an important study orientation for monitoring human body parameters to monitor the humidity of the body surface with a humidity sensor to establish a standalone assessment system, or to combine the humidity and the temperature of the body surface to implement a comprehensive assessment. In view of the association between the temperature and the humidity of the body surface, it is useful to monitor only the temperature or the humidity of the body surface, which may still address the problems of measuring and monitoring the human body parameters and will be embodied in the invention. Of course, in measuring a human body parameter of sweat, a specific sensing device such as a sweat sensor may also be used in addition to the humidity sensor. The sweat sensor may detect biomarkers such as protein, sodium, lactic acid of a biological body surface.

Now, it becomes an imminent problem to be solved as to how to reduce or eliminate measurement deviations caused by thermal capacity of the stickup layer.

The present invention provides a stickup measuring apparatus of body surface physiological parameters so as to improve measurement precision by improving the stickup layer. The stickup measuring apparatus includes:

a substrate provided with a conductive part, wherein the substrate is made of a semi-rigid or rigid material and preferably is a flexible substrate；

at least one body surface physiological parameter sensor fixed to a first side of the flexible substrate and electrically connected to the conductive part； and

a stickup layer with a hollow shape distributed around the body surface physiological parameter sensor.

Preferably, the body surface physiological parameter sensor is at least one of a temperature sensor, a humidity sensor, a temperature-humidity sensor, and a sweat sensor.

Preferably, the hollow shape includes a closed pattern surrounding the at least one body surface physiological parameter sensor.

Preferably, the body surface physiological parameter sensor includes a temperature sensor and/or a humidity sensor and/or a sweat sensor, which are electrically connected to the conductive part and are at least partially surrounded by the closed pattern, respectively.

Preferably, the closed pattern is a circular ring, an elliptical ring, a square ring, a triangular ring, or an irregular ring shape.

Preferably, the hollow shape includes a multi-segment discrete pattern surrounding the at least one body surface physiological parameter sensor.

Preferably, the body surface physiological parameter sensor includes a temperature sensor and/or a humidity sensor and/or a sweat sensor, which are electrically connected to the conductive part and at least partially surrounded by the multi-segment discrete pattern, respectively.

Preferably, the multi-segment discrete pattern is a circular ring, an elliptical ring, a square ring, a triangular ring, or an irregular and discontinuous ring shape consisted of arc line segments and/or line segments.

Preferably, the hollow shape includes patterns interlaced with the sensors.

Preferably, the hollow shape divides the sensors into multiple areas.

Preferably, each of the multiple areas includes at least one of the sensors.

Preferably, the substrate is made of breathable material.

Preferably, the stickup layer includes hydrogel.

Preferably, areas corresponding to the sensors on the stickup layer are hollowed out.

Preferably, a thermal conductive layer overlays the temperature sensor and has a height no lower than the stickup layer.

Preferably, the thermal conductive layer is thermal conductive glue.

Preferably, the thermal conductive glue is one or a combination of organosilicon thermal conductive glue, epoxy resin, polyurethane glue, or thermal conductive silicone grease.

Preferably, the thermal conductive glue includes metal filler.

Preferably, an anti-stick layer is provided on the stickup layer.

Preferably, the temperature sensor is a thermistor and the conductive part is a printed circuit.

Preferably, the flexible substrate is provided with a through-hole where the stickup layer and the temperature sensor are not provided.

Preferably, the flexible substrate is an X shape, four branches of which are radially distributed about the through-hole, the sensors being provided on the four branches.

Preferably, the flexible substrate is a cup and the sensors are provided on the cup.

Preferably, the hydrogel is temperature-sensitive hydrogel, photo-sensitive hydrogel or electricity-sensitive hydrogel.

Preferably, the hollow shape is an array shape.

Preferably, units in the array shape are rectangular rings or circular rings.

Preferably, the hollow shape is an irregular shape matching a human body temperature measurement surface.

Preferably, the apparatus is used for measuring breast surface physiological parameters.

Preferably, the hollow shape is used for reducing the material volume of the stickup layer, and/or the hollow shape is used for reducing the attachment area between the stickup layer and the temperature measurement surface.

In other words, the apparatus may reduce heat absorbed by the stickup layer from the body surface and thus prevent the stickup layer from affecting an actual measurement environment as much as possible by providing the hollow shape of the stickup layer. This helps to alleviate negative impacts of inaccurate measurement results of heat generated by the human body by relevant sensors due to the effect of absorbing or releasing heat of the stickup layer, and thus may improve the precision of human body parameters such as temperature, humidity or temperature-humidity that are acquired by the sensors.

More importantly, the stickup measuring apparatus of body surface physiological parameters may be applied to a continuous body temperature monitor. In the above and some other application scenarios, the continuous body temperature monitor having the above apparatus may be continuously attached to skin so as to detect abnormal temperatures produced by abnormal metabolisms of cancer cells.

BRIEF DESCRIPTION OF THE ACCOMPANYING DRAWINGS

In order to illustrate the technical solutions in the embodiments of the present invention or the prior art, the accompanying drawings to be used in describing the embodiments or the prior art will be described briefly below. Apparently, the accompanying drawings herein are only some embodiments of the present invention. For those skilled in the art, other accompanying drawings may also be obtained based on these accompanying drawings without any creative work.

Fig. 1A is a section structure diagram of a stickup temperature measurement apparatus according to an embodiment of the present invention；

Fig. 1B is a section structure diagram of a stickup temperature measurement apparatus according to another embodiment of the present invention；

Fig. 2 is a section structure diagram of a stickup temperature measurement apparatus according to a further embodiment of the present invention；

Fig. 3 is a structure diagram of a stickup temperature measurement apparatus according to a still further embodiment of the present invention；

Fig. 4 is a diagram showing a measurement result of hysteresis effect of temperature change caused by the material of a stickup layer according to the present invention；

Fig. 5 is a diagram of a stickup temperature measurement apparatus having a hollowed stickup layer according to an embodiment of the present invention；

Fig. 6 is a diagram of a stickup temperature measurement apparatus having a hollowed stickup layer according to another embodiment of the present invention；

Fig. 7 is a local view of a hollowed stickup layer having a one-segment closed shape according to an embodiment of the present invention；

Fig. 8 is a local view of a hollowed stickup layer having a multi-segment discrete pattern according to another embodiment of the present invention；

Fig. 9 is a local view of a hollowed stickup layer having a rectangular-ring array pattern according to an embodiment of the present invention；

Fig. 10 is a local view of a hollowed stickup layer having an elliptical-ring array pattern according to another embodiment of the present invention；

Fig. 11 is a local view of a hollowed stickup layer having an irregular pattern according to an embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

To enable those skilled in the art to better understand the technical solutions in the embodiments of the present invention, the technical solutions in the embodiments of the present invention will be described clearly and comprehensively in combination with the accompanying drawings. It is apparent that the embodiments as described are only part of embodiments of the present invention. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without any creative work all fall within the scopes as claimed by the present invention.

As discussed above, in view of the association between temperature and humidity of a body surface, it is useful to monitor only the temperature or the humidity of the body surface, which may still address the problem of measuring and monitoring human body parameters. At the ease of description, respective technical solutions of the present invention will be illustrated by taking temperature as a human body parameter to be measured in the following embodiments. As the present invention utilizes association between body surface temperature and body surface sweating, embodiments of humidity measurement will be omitted.

In an embodiment, the present invention provides a stickup temperature measurement apparatus including a flexible substrate 101, a temperature sensor 102, and a stickup layer 103.

There may be one or more sensors, as long as basic measurement requirements are satisfied. The flexible substrate 101 may be made of soft material, and may also be made of semi-rigid or rigid material when the substrate requires a specific shape. As an example, the flexible substrate may be implemented as a flexible circuit board including at least the following components:

(1) A substrate, the material of which may be polyimide. To ensure that the substrate is comfortable to the human body, a 25μm-thickness substrate may be selected. If a stiff circuit board is required, the thickness of the substrate may be increased. For example, a 50μm-thickness substrate may be selected. On the contrary, if a soft circuit board is required, a 13μm-thickness substrate may be selected.

(2) Transparent glue on the substrate, which may be made of epoxy resin or polythene. The thicker the substrate and the transparent glue thereon are, the stiffer the circuit board is. If there is an area with a relatively large bend on the circuit board, thinner substrate and transparent glue may be selected to reduce stress on a surface of a copper foil, so that the chance of occurring small cracks on the copper foil is slim. A single-layer sheet should be used for such an area as much as possible.

(3) The copper foil, which may be made of rolled annealed copper or electrolytic copper. The rolled annealed copper has high strength and bend-resistance, but is expensive. The electrolytic copper is much cheaper, but has low strength and is easily broken, so it is generally applied in a place with little bend. The thickness of the copper foil is selected according to minimum width and minimum spacing of lead wires. The thinner the copper foil is, the smaller the achievable minimum width and spacing are. In embodiments of the present invention, the rolled annealed copper is selected, and it is necessary to ensure that the rolled and annealed direction of the copper foil is consistent with a main bend direction of the circuit board.

(4) A protective film and its transparent glue. In the technical solutions of the present application, because the circuit board has a relatively large bend, a 13μm-thickness protective film is selected. The material of the transparent glue may be one of epoxy resin and polyurethane. The thickness of the transparent glue is 13μm.

(5) A bonding pad coating, which is consisted of an electroplating nickel layer and a chemical gold plating layer. The thickness of the electroplating nickel layer is in a range of 0.5-2μm, while the thickness of the chemical gold plating layer is in a range of 0.05-0.1μm.

A conductive part 106 is provided within the flexible substrate 101 (as shown in Fig. 3) . The conductive part is at least one printed circuit, which may be made of metal material having good electrical conductivity and bend-resistance, such as the copper foil. The printed circuit may be freely bent, wound, or folded； may be arranged arbitrarily according to requirements of spatial layout； may also be moved, stretched out or drawn back freely in a three-dimensional space, so as to realize integration of component assemblies (e.g., the temperature sensor) with wire connections.

In order to acquire temperature data from the human body, it is necessary to provide temperature sensors 102 in the stickup temperature measurement apparatus. The temperature sensors 102 continuously acquire temperature data from a surface of an object to be measured with a preset time interval, for example, once every five minutes in a certain period (e.g., 10 hours) . All of the acquired temperature data are stored in a portable storage device. The sensors 102 are fixed to one side of the flexible substrate and connected to a circuit within the flexible substrate. Apparently, continuous acquisition facilitates motoring relevant data within a certain period.

The temperature sensor 102 may be implemented as a variety of sensors. For example, the temperature sensor 102 may be implemented by a thermistor. Dependent on the material of the thermistor, the thermistor may be a semiconductor thermistor, a metal thermistor, or an alloy thermistor.

Besides, the stickup temperature measurement apparatus further includes the stickup layer 103. The stickup layer 103 is mainly used to fix the temperature sensor to the human body. As shown in Fig. 1A and Fig. 1B, the stickup layer may be provided on the flexible substrate in various ways. Presence of the stickup layer and the stickup measurement apparatus, especially adoption of the flexible substrate also facilitate monitoring relevant data within a certain period.

As shown in Fig. 1A, the stickup layer is directly overlaid on the temperature sensor 302 and the flexible substrate, the implementation of which is convenient and thus facilitates cutting and batch production of the stickup layer in preparation.

Besides the above implementation, as shown in Fig. 1B, the stickup layer 103 may also be provided on other areas in addition to the temperature sensor 102. There is a through-hole, through which the temperature sensor is mounted, on the stickup layer 103, such that the temperature sensor may be mounted within the through-hole. In other areas except the through-hole, the stickup layer 103 is directly attached onto the flexible substrate 101.

The stickup layer may be made of a plurality of adhesive materials. For example, the stickup layer may be made of hydrogel that is strongly adhesive to skin and may be separated painlessly.

The adoption of a hydrogel layer in place of traditional fixation means like adhesive tape makes the temperature sensor of the temperature measurement apparatus attached to the body surface of the human body more conveniently and more tightly, so that the temperature sensor may sufficiently contact with the area to be measured on the body surface and thus heat transfer between them may be efficiently implemented, which improves measurement precision of the temperature measurement apparatus.

The above structure design of the stickup temperature measurement apparatus may achieve advantageous effects. Taking the measurement of breast temperature as an example, the following three kinds of temperature measurement apparatuses are used: (1) a common electronic thermometer, for example MC-246 thermometer of some company； (2) the temperature measurement apparatus in the present embodiment； (3) an invasive blood temperature measuring instrument.

Through multiple measurements, the measurement results of the above three kinds of temperature measurement apparatuses with respect to the body temperature of a study object are: 1) 36.77℃, 2) 36.86℃, 3) 36.90℃.

The body temperature data measured by the invasive blood temperature measuring instrument is taken as standard reference data. According to statistics on axillary temperature measurement results of 100 study objects, the data measured by the common electronic thermometer are within an error range of [-0.97％, +0.31％] over the body temperature data measured by the invasive blood temperature measuring instrument； a distribution center of the data measured by the common electronic thermometer relative to the standard reference data is substantially at -0.57％. In contrast, the data measured by the temperature measurement apparatus in the present embodiment are within an error range of [-0.19％, +0.06％] over the body temperature data measured by the invasive blood temperature measuring instrument, and the distribution center of the data measured by the temperature measurement apparatus in the present embodiment relative to the standard reference data is substantially at -0.08％. The precision of the data measured by the temperature measurement apparatus in the present invention is apparently superior to that of the data measured by the common electronic thermometer.

Besides the stickup layer, some fixing means may also be provided so as to fix the temperature measurement apparatus. As shown in Fig. 3, taking the measurement of breast temperature of the human body as an example, a through-hole 105 may be provided on the flexible substrate. The stickup layer and the temperature sensor are not provided at the through-hole 105. The through-hole 105 is used for cup jointing a nipple or another protruding part of the human body so as to fix the apparatus to the human body. The flexible substrate is provided as an X shape, which facilitates attachment of the apparatus to a breast of the human body and occupies a small space. Of course, besides the X shape, the flexible substrate may also be provided as other common shapes, e.g., Y shape.

To ensure accuracy and effectiveness of temperature measurement, as shown in Fig. 2, the temperature sensor 102 is overlaid by a thermal conductive part 104 that is made higher than the stickup layer 103, which may ensure that when the temperature measurement apparatus is attached to the human body, the thermal conductive part is sufficiently attached to skin so that heat conduction effect and body temperature sensing precision of the sensor is enhanced. Specifically, the thermal conductive part may be made of a plurality of thermal conductive materials. For example, the thermal conductive part may be thermal conductive glue for transferring heat. The thermal conductive glue may be one or more of epoxy resin, organosilicon thermally conductive glue, polyurethane glue, and thermally conductive silicone grease. Preferably, the thermal conductive glue may be mixed with metal powder such as aluminum powder, copper powder, ferrous powder, which may improve thermal conductivity thereof.

For the temperature measurement apparatus of the above structure, the measurement precision of temperature is further improved. With temperature measurement at the breast area as an example, the following three different kinds of temperature measurement apparatuses are used, respectively: (1) a common electronic thermometer, for example MC-246 thermometer of some company) ； (2) the temperature measurement apparatus in the present embodiment； (3) an invasive blood temperature measuring instrument.

The body temperature data measured by the invasive blood temperature measuring instrument is taken as standard reference data. According to statistics on axillary temperature measurement results of 100 study objects, the data measured by the common electronic thermometer are within an error range of [-0.97％, +0.31％] over the body temperature data measured by the invasive blood temperature measuring instrument； a distribution center of the data measured by the common electronic thermometer relative to the standard reference data is substantially at -0.57％. In contrast, the data measured by the temperature measurement apparatus in the present embodiment are within an error range of [-0.10％, +0.02％] over the body temperature data measured by the invasive blood temperature measuring instrument, and the distribution center of the data measured by the temperature measurement apparatus in the present embodiment relative to the standard reference data is substantially at -0.04％. The precision of data measured by the temperature measurement apparatus in the present embodiment is apparently superior to that of the data measured by the common electronic thermometer.

In order to prevent the stickup layer from being contaminated with dust, which will reduce the stickiness of the stickup layer, an anti-stick layer is overlaid on the stickup layer. Specifically, the anti-stick layer may be a piece of plastic paper.

As a specific embodiment, the stickup layer 103 is made of hydrogel material. The hydrogel material may contact with tissues of the human body directly, and thus may prevent infection from in-vitro microorganisms, suppresses loss of body fluid, and transfer oxygen to a wound, which generally may facilitate healing of the wound.

When the hydrogel is transplanted or injected into a biological body, the hydrogel may maintain or controlled release the medicine imbedded within the hydrogel to body fluid. Generally, there are the following two kinds of controlled release ways: one is to release small molecules, like a gel coating； the other is to gradually decompose a polymer base material containing medicine, in which case the medicine is diffused into a surrounding environment, controlled by a biological decomposition rate of the material. Sometimes, the hydrogel serves as a micelle to load the medicine, and the release rate of the medicine is adjusted by adjusting a crosslinking degree and chemical composition of the hydrogel. Particularly, the hydrogel is becoming more and more widely used with emergence of smart hydrogel.

Specifically, the hydrogel may be temperature-sensitive hydrogel. Common temperature-sensitive hydrogel includes ionized polyacrylamide hydrogel, poly (M, N –dihexyl) acrylamide hydrogel, and poly (N-isopropyl) acrylamide hydrogel, and so on.

Besides, the hydrogel may be photo-sensitive hydrogel or electro-sensitive hydrogel.

In an experiment process, the applicant found that if the stickup layer 103 has a continuous shape with an even thickness, because the stickup layer in use is attached to skin surface, when the body temperature changes, the stickup layer will dissipate or absorb heat along with fall or rise of the body temperature and thus hampers temperature change surrounding the temperature sensor； consequently, the temperature change of the human body sensed by the temperature sensor lags behind an actual change and thus affects the sensitivity of temperature sensing. Test results show that the volume (weight) of the stickup layer and the contact area between the stickup layer and the temperature measurement surface are most important factors that affect the hysteresis of temperature change. According to the contrast between curves of the actual temperature change and the measured temperature change shown in Fig. 4, the hysteresis of temperature change will increase with enlargement of the volume (weight) of the stickup layer. In the case that the stickup layer having a same volume and a different thickness is utilized, it is found that the hysteresis of temperature change increases with the enlargement of the contact area between the stickup layer and the temperature measurement surface (skin) .

In order to solve the above problem, as the hysteresis of temperature change is caused by the thermal capacity of the stickup layer per se, on the premise of not affecting adhesion fastness, reduction of the material volume (weight) of the stickup layer may significantly reduce the thermal capacity of the stickup layer. Besides, the larger the contact area between the stickup layer and the temperature measurement surface is, the larger the area of heat transfer is. Therefore, reduction of the contact area between the stickup layer and the temperature measurement surface may also improve the hysteresis of temperature change. At least one of the above two ways is utilized to improve the hysteresis effect of temperature change.

In an embodiment, while ensuring adhesion fastness, the stickup layer is hollowed to reduce the material of the stickup layer and the contact area of the stickup layer and the temperature measurement surface. A local area of the hollowed stickup layer is a continuous one-segment closed shape, which forms a locally enclosed space with the temperature measurement surface and the flexible substrate 101. As the closed shape has a small thermal capacity and a small contact area with the temperature measurement surface, a local microclimate will be formed in the enclosed space, and the temperature sensor may acquire temperature information of the local area without being affected.

In an embodiment, the apparatus may also include a humidity sensor, and a local area of the hollowed stickup layer is a multi-segment discrete pattern. The multi-segment discrete pattern surrounds the temperature sensor and the humidity sensor, which may increase openness of the local area where the temperature-humidity sensor array is located, such that the temperature-humidity sensor array can acquire temperature and humidity parameters in a body surface microenvironment closest to natural state.

In an embodiment, the apparatus may also include a sweat sensor instead of the humidity sensor. The sweat sensor may analyze constituents in the sweat to help collect richer data for provision of professional recommendations. By integrating the sweat sensor into a small patch and tightly attaching the patch to skin, biological marks that may indicate your physical conditions, such as water, electrolyte, sodium, lactic acid, and protein, in the sweat, may be detected. The collected biological marks may be analyzed through a preset algorithm. In one aspect, biological conditions may be assessed separately and thus it may be known when to supplement water, how much water to be drunk, or whether purified water or sports drinking to be drunk. It may even alarm a risk of heat stroke or hyperkinesia. In addition to electrolytic balance detection and water content detection, the sensor technology may also monitor muscle fatigue, physical exhaustion level, breath, and PH value of skin, so as to effectively reduce occurrences of cramps in exercise. On the other hand, human body conditions may be monitored powerfully by an assessment system consisted of temperature sensors and sweat sensors in combination with body temperature conditions obtained by the temperature sensors.

In some other embodiments, the hollowed stickup layer may be interlaced with the temperature sensors and the humidity sensors.

In the above embodiments, the temperature sensor, the humidity sensor, the sweat sensor, and the temperature-humidity sensor form electrical connections with the conductive part, respectively, which ensures independent transmission of signals acquired by the sensors.

In a measurement process, different measurement modes may be used. In the embodiment corresponding to Fig. 5, the flexible substrate is made into a bra shape for measuring the breast temperature. The hollowed stickup layer includes a local continuous one-segment closed shape and a local multi-segment discrete pattern. The temperature sensor array and the humidity sensor are surrounded in temperature-humidity patterns of different shapes. The hollow shape may significantly reduce the influence of the thermal capacity of the stickup layer to local temperatures； the local closed shape may also form a local microclimate in an enclosed space, such that the temperature sensor may acquire temperature information of a local area without being affected； the local multi-segment discrete pattern enables the temperature-humidity sensor array to acquire temperature and humidity parameters in a body surface micro environment closest to the natural state. The hysteresis effect of temperature caused by the stickup layer may be further corrected through the acquired temperature data of the two local areas.

In the embodiment corresponding to Fig. 6, the flexible substrate is made into a bra shape so as to measure the temperature of breast, wherein there are provided three temperature-humidity sensor arrays； the hollowed stickup layer is discretely provided among the three temperature-humidity sensor arrays in a closed manner. When used, the stickup parts 1-4 are attached to skin at parts such as a breast, such that the three temperature-humidity sensor arrays may measure temperature and humidity information of corresponding parts, respectively. The flexible substrate is made of breathable material, such that it will not hamper heat dissipation and water content evaporation of the body surface in natural state. In such a way, the temperature-humidity sensor arrays may capture the temperature and humidity information in natural state.

In the embodiments corresponding to Figs. 5-8, a local area of the hollowed stickup layer is a circular ring, an elliptical ring, a rectangular ring, a triangular ring, or an irregular ring consisted of arc line segments and/or line segments. The stickup layer may also be arranged as a one-segment enclosed shape or a multi-segment discrete pattern. Different hollow patterns are arranged on flexible substrates of different shapes so as to adapt different parts for temperature measurement.

In the embodiments corresponding to Figs. 9-11, the stickup layer may also be arranged as an array of certain patterns. In Fig. 9, the stickup layer is hollowed into an array consisted of rectangular rings, each of which surrounds a group of temperature sensors and a humidity sensor inside. This kind of hollow structure is more suitable for a relatively flat temperature measuring surface, e.g., may be provided in a belly band, a wrist band, or a head band so as to measure temperatures at the belly, wrist or head.

In Fig. 10, the stickup layer is hollowed into an array consisted of elliptical rings, each of which surrounds a group of temperature sensors and a humidity sensor inside. This kind of hollow structure is also suitable for a relatively flat temperature measuring surface, e.g., may be provided in a belly band, a wrist band, or a head band so as to measure temperatures at the belly, wrist or head. Besides, more material may be hollowed out for the elliptical or circular shape than the square shape, and the adhesion effect of the circular ring to the temperature measurement surface is also slightly superior to that of the square shape.

In Fig. 11, the stickup layer is hollowed into a semi-open irregular shape, which may fit different temperature measurement surfaces of the human body better. The semi-open shape enables the temperature-humidity sensor array to sample the temperature and humidity parameters in the body surface microenvironment closest to a natural state.

In some other embodiments, the stickup layer may be an array consisted of hollow patterns of different shapes or a discrete shape.

In the figure, a “diamond” represents a humidity sensor, while a “square” represents a temperature sensor or a sweat sensor. The sensors are surrounded or semi-surrounded by hollow patterns or are interlaced with the hollow patterns. The sensors may be temperature sensors, humidity sensors, or a combination thereof； the sensors may also be temperature-humidity sensors integrating both temperature measurement function and humidity measurement function.

The temperature measurement apparatus in some embodiments above may also serve as a cancer cell thermometer for detecting and monitoring temperature abnormalities of the human body, particularly of the body surface, possibly produced by growth of cancer cells or cancerization, so as to facilitate disease (e.g., cancer) screening and health assessment based on variations of body temperature.

In particular, most of the above embodiments are described by taking temperature measurement as an example, and some of the above embodiments are described by combining humidity measurement with temperature measurement. As mentioned above, in various embodiments, the temperature measurement apparatus for measuring temperature is taken as an example to illustrate the human body parameter measurement apparatus of the present invention. As the present invention utilizes the association between body surface temperature and body surface sweating, corresponding embodiments of measuring humidity will not be redundantly described； correspondingly, embodiments of mainly measuring humidity in combination with measuring temperature will not be redundantly described.

More importantly, the above stickup measuring apparatus of body surface physiological parameters may be applied to the continuous body temperature monitor. In the above and some other application scenarios, the continuous body temperature monitor having the apparatus may be continuously attached onto skin so as to detect abnormal temperatures produced by abnormal metabolisms of cancer cells.

What have been described above are only specific embodiments of the present invention, and the protection scope of the present invention is not limited thereto. Changes or substitutions within the technical disclosure of the present invention which may be easily envisaged by the person skilled in the art should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be limited by the protection scopes of the claims.

Claims

A stickup measuring apparatus of body surface physiological parameters, comprising:

a substrate provided with a conductive part；

at least one body surface physiological parameter sensor fixed to a first side of the flexible substrate and electrically connected to the conductive part； and

a stickup layer with a hollow shape distributed around the body surface physiological parameter sensor.
The measuring apparatus according to claim 1, characterized in that the body surface physiological parameter sensor is at least one of a temperature sensor, a humidity sensor, a temperature-humidity sensor, and a sweat sensor.
The measuring apparatus according to claim 1, characterized in that the hollow shape comprises a closed pattern surrounding the at least one body surface physiological parameter sensor.
The measuring apparatus according to claim 3, characterized in that the body surface physiological parameter sensor comprises a temperature sensor and/or a humidity sensor and/or a sweat sensor, which are electrically connected to the conductive part and are at least partially surrounded by the closed pattern, respectively.
The measuring apparatus according to claim 3, characterized in that the closed pattern is a circular ring, an elliptical ring, a square ring, a triangular ring, or an irregular ring shape.
The measuring apparatus according to claim 1, characterized in that the hollow shape comprises a multi-segment discrete pattern surrounding the at least one body surface physiological parameter sensor.
The measuring apparatus according to claim 6, characterized in that the body surface physiological parameter sensor comprises a temperature sensor and/or a humidity sensor and/or a sweat sensor, which are electrically connected to the conductive part and at least partially surrounded by the multi-segment discrete pattern, respectively.
The measuring apparatus according to claim 6, characterized in that the multi-segment discrete pattern is a circular ring, an elliptical ring, a square ring, a triangular ring, or an irregular and discontinuous ring shape consisted of arc line segments and/or line segments.
The measuring apparatus according to claim 1, characterized in that the hollow shape comprises patterns interlaced with the sensors.
The measuring apparatus according to claim 1, characterized in that the hollow shape divides the sensors into multiple areas.
The measuring apparatus according to claim 10, characterized in that each of the multiple areas comprises at least one of the sensors.
The measuring apparatus according to any of claims 1-11, characterized in that the substrate is made of breathable material.
The measuring apparatus according to any of claims 1-11, characterized in that the stickup layer comprises hydrogel.
The measuring apparatus according to claim 1, characterized in that areas corresponding to the sensors on the stickup layer are hollowed out.
The measuring apparatus according to claim 2, characterized in further comprising:

a thermal conductive layer overlaying the temperature sensor and having a height no lower than the stickup layer.
The measuring apparatus according to claim 15, characterized in that the thermal conductive layer is thermal conductive glue.
The measuring apparatus according to claim 16, characterized in that the thermal conductive glue is one or a combination of organosilicon thermal conductive glue, epoxy resin, polyurethane glue, or thermal conductive silicone grease.
The measuring apparatus according to claim 16, characterized in that the thermal conductive glue comprises metal filler.
The measuring apparatus according to claim 1, characterized in further comprising:

an anti-stick layer provided on the stickup layer.
The measuring apparatus according to claim 2, characterized in that the temperature sensor is a thermistor and the conductive part is a printed circuit.
The measuring apparatus according to claim 1, characterized in that the flexible substrate is provided with a through-hole where the stickup layer and the temperature sensor are not provided.
The measuring apparatus according to claim 2, characterized in that the flexible substrate is an X shape, four branches of which are radially distributed about the through-hole, the sensors being provided on the four branches.
The measuring apparatus according to claim 1, characterized in that the flexible substrate is a cup and the sensors are provided on the cup.
The measuring apparatus according to claim 13, characterized in that the hydrogel is temperature-sensitive hydrogel, photo-sensitive hydrogel or electricity-sensitive hydrogel.
The measuring apparatus according to claim 1, characterized in that the hollow shape is an array shape.
The measuring apparatus according to claim 25, characterized in that units in the array shape are rectangular rings or circular rings.
The measuring apparatus according to claim 1, characterized in that the hollow shape is an irregular shape matching a human body temperature measurement surface.
The measuring apparatus according to claim 1, characterized in that the apparatus is used for measuring breast surface physiological parameters.
The measuring apparatus according to claim 1, characterized in that the hollow shape is used for reducing the material volume of the stickup layer, and/or the hollow shape is used for reducing the stickup area between the stickup layer and a temperature measurement surface.
A continuous body temperature monitor comprising the stickup measuring apparatus of body surface physiological parameters according to any one of claims 1-29.