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WO2017047791A9 - ピペラジン化合物の新規結晶 - Google Patents

ピペラジン化合物の新規結晶 Download PDF

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Publication number
WO2017047791A9
WO2017047791A9 PCT/JP2016/077547 JP2016077547W WO2017047791A9 WO 2017047791 A9 WO2017047791 A9 WO 2017047791A9 JP 2016077547 W JP2016077547 W JP 2016077547W WO 2017047791 A9 WO2017047791 A9 WO 2017047791A9
Authority
WO
WIPO (PCT)
Prior art keywords
new crystal
piperazine compound
crystal
present
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2016/077547
Other languages
English (en)
French (fr)
Other versions
WO2017047791A1 (ja
Inventor
青木　真一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2016324121A priority Critical patent/AU2016324121B2/en
Priority to RU2018113722A priority patent/RU2018113722A/ru
Priority to CA2999009A priority patent/CA2999009C/en
Priority to PL16846662T priority patent/PL3351542T3/pl
Priority to MYPI2018700802A priority patent/MY193595A/en
Priority to US15/760,366 priority patent/US20180258069A1/en
Priority to MX2018003320A priority patent/MX383936B/es
Priority to HK18107367.0A priority patent/HK1247921A1/zh
Priority to BR112018003448-7A priority patent/BR112018003448A2/ja
Priority to JP2017540028A priority patent/JP6944372B2/ja
Priority to EP16846662.1A priority patent/EP3351542B1/en
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to CN201680054242.6A priority patent/CN108026068A/zh
Priority to SG11201801295WA priority patent/SG11201801295WA/en
Priority to KR1020187010338A priority patent/KR102587705B1/ko
Priority to DK16846662.1T priority patent/DK3351542T3/da
Priority to ES16846662T priority patent/ES2901157T3/es
Publication of WO2017047791A1 publication Critical patent/WO2017047791A1/ja
Publication of WO2017047791A9 publication Critical patent/WO2017047791A9/ja
Priority to PH12018500399A priority patent/PH12018500399A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

本発明が解決すべき課題は、保存安定性及び非吸湿性が良好で、特に再現性良く取得可能な結晶を提供することである。本発明は、４－（（１－メチルピロール－２－イル）－カルボニル）－Ｎ－（４－（４－モルホリン－１－イル－カルボニルピペリジン－１－イル）－フェニル）－１－ピペラジンカルボキサミド・１水和物の結晶を提供する。
PCT/JP2016/077547 2015-09-17 2016-09-16 ピペラジン化合物の新規結晶 Ceased WO2017047791A1 (ja)

Priority Applications (17)

Application Number Priority Date Filing Date Title
EP16846662.1A EP3351542B1 (en) 2015-09-17 2016-09-16 New crystal of piperazine compound
CA2999009A CA2999009C (en) 2015-09-17 2016-09-16 Crystal form of 4-((1-methylpyrrol-2-yl)-carbonyl)-n-(4-(4-morpholin-1-yl-carbonylpiperidin-1-yl)-phenyl)-1-piperazinecarboxamide monohydrate
PL16846662T PL3351542T3 (pl) 2015-09-17 2016-09-16 Nowy kryształ związku piperazyny
MYPI2018700802A MY193595A (en) 2015-09-17 2016-09-16 New crystal of piperazine compound
US15/760,366 US20180258069A1 (en) 2015-09-17 2016-09-16 New crystal of piperazine compound
MX2018003320A MX383936B (es) 2015-09-17 2016-09-16 Cristal novedoso de compuesto piperazina.
HK18107367.0A HK1247921A1 (zh) 2015-09-17 2016-09-16 哌嗪化合物的新晶体
BR112018003448-7A BR112018003448A2 (ja) 2015-09-17 2016-09-16 A new crystal of a Piperazine compound
CN201680054242.6A CN108026068A (zh) 2015-09-17 2016-09-16 哌嗪化合物的新晶体
AU2016324121A AU2016324121B2 (en) 2015-09-17 2016-09-16 New crystal of piperazine compound
RU2018113722A RU2018113722A (ru) 2015-09-17 2016-09-16 Новый кристалл пиперазинового соединения
JP2017540028A JP6944372B2 (ja) 2015-09-17 2016-09-16 ピペラジン化合物の新規結晶
SG11201801295WA SG11201801295WA (en) 2015-09-17 2016-09-16 New crystal of piperazine compound
KR1020187010338A KR102587705B1 (ko) 2015-09-17 2016-09-16 피페라진 화합물의 신규 결정
DK16846662.1T DK3351542T3 (da) 2015-09-17 2016-09-16 Nyt krystal af piperazinforbindelse
ES16846662T ES2901157T3 (es) 2015-09-17 2016-09-16 Nuevo cristal de compuesto de piperazina
PH12018500399A PH12018500399A1 (en) 2015-09-17 2018-02-22 New crystal of piperazine compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-184022 2015-09-17
JP2015184022 2015-09-17

Publications (2)

Publication Number Publication Date
WO2017047791A1 WO2017047791A1 (ja) 2017-03-23
WO2017047791A9 true WO2017047791A9 (ja) 2017-05-18

Family

ID=58289428

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2016/077547 Ceased WO2017047791A1 (ja) 2015-09-17 2016-09-16 ピペラジン化合物の新規結晶

Country Status (22)

Country Link
US (1) US20180258069A1 (ja)
EP (1) EP3351542B1 (ja)
JP (1) JP6944372B2 (ja)
KR (1) KR102587705B1 (ja)
CN (1) CN108026068A (ja)
AU (1) AU2016324121B2 (ja)
BR (1) BR112018003448A2 (ja)
CA (1) CA2999009C (ja)
DK (1) DK3351542T3 (ja)
ES (1) ES2901157T3 (ja)
HK (1) HK1247921A1 (ja)
HU (1) HUE057813T2 (ja)
MA (1) MA42839A (ja)
MX (1) MX383936B (ja)
MY (1) MY193595A (ja)
PH (1) PH12018500399A1 (ja)
PL (1) PL3351542T3 (ja)
PT (1) PT3351542T (ja)
RU (1) RU2018113722A (ja)
SG (2) SG11201801295WA (ja)
TW (1) TWI707851B (ja)
WO (1) WO2017047791A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2024143236A1 (ja) * 2022-12-26 2024-07-04

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006249847B2 (en) * 2005-05-23 2012-12-20 Novartis Ag Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts
GB0706793D0 (en) * 2007-04-05 2007-05-16 Evotec Ag Compounds
MX2011009423A (es) * 2009-03-09 2011-09-28 Taiho Pharmaceutical Co Ltd Compuesto de piperazina capaz de inhibir prostaglandina d sintasa.
KR101723707B1 (ko) * 2010-01-22 2017-04-05 다이호야쿠힌고교 가부시키가이샤 Ｐｇｄｓ 저해 작용을 갖는 피페라진 화합물
JP6130701B2 (ja) * 2012-04-01 2017-05-17 エシャシ ファーマ リミテッドＥｓｈｙａｓｉ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ （２ｒｓ）−１−ジメチルアミノ−３−｛２−［２−（３−メトキシフェニル）エチル］フェノキシ｝プロパン−２−イルコハク酸水素塩酸塩の工業的製造方法
JP5999686B2 (ja) * 2012-04-05 2016-09-28 ロンシール工業株式会社 耐熱性ポリ乳酸系成形体、およびその製造方法
MX345435B (es) * 2012-09-19 2017-01-30 Taiho Pharmaceutical Co Ltd Composicion farmaceutica para la administracion oral con disolucion y/o absorcion mejorada.

Also Published As

Publication number Publication date
ES2901157T3 (es) 2022-03-21
CN108026068A (zh) 2018-05-11
HK1247921A1 (zh) 2018-10-05
WO2017047791A1 (ja) 2017-03-23
SG11201801295WA (en) 2018-03-28
PT3351542T (pt) 2021-12-21
RU2018113722A (ru) 2019-10-18
RU2018113722A3 (ja) 2019-12-23
SG10201912021VA (en) 2020-02-27
KR102587705B1 (ko) 2023-10-12
PL3351542T3 (pl) 2022-02-14
US20180258069A1 (en) 2018-09-13
CA2999009A1 (en) 2017-03-23
MX383936B (es) 2025-03-14
AU2016324121B2 (en) 2020-08-20
CA2999009C (en) 2023-05-23
AU2016324121A1 (en) 2018-04-26
KR20180051628A (ko) 2018-05-16
HUE057813T2 (hu) 2022-06-28
MA42839A (fr) 2018-07-25
DK3351542T3 (da) 2022-01-03
MY193595A (en) 2022-10-19
TWI707851B (zh) 2020-10-21
BR112018003448A2 (ja) 2018-09-25
EP3351542A4 (en) 2019-04-24
PH12018500399A1 (en) 2018-08-29
JP6944372B2 (ja) 2021-10-06
MX2018003320A (es) 2018-05-30
EP3351542A1 (en) 2018-07-25
JPWO2017047791A1 (ja) 2018-07-05
EP3351542B1 (en) 2021-11-17
TW201720818A (zh) 2017-06-16

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