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WO2016114340A1 - Agent de protection contre les uv - Google Patents

Agent de protection contre les uv Download PDF

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Publication number
WO2016114340A1
WO2016114340A1 PCT/JP2016/050945 JP2016050945W WO2016114340A1 WO 2016114340 A1 WO2016114340 A1 WO 2016114340A1 JP 2016050945 W JP2016050945 W JP 2016050945W WO 2016114340 A1 WO2016114340 A1 WO 2016114340A1
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WO
WIPO (PCT)
Prior art keywords
oxide particles
titanium oxide
ultraviolet
mass
protective agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2016/050945
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English (en)
Japanese (ja)
Inventor
卓人 長野
貴三郎 野口
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Kaneka Corp
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Kaneka Corp
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Filing date
Publication date
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Publication of WO2016114340A1 publication Critical patent/WO2016114340A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof

Definitions

  • the present invention relates to an ultraviolet protective agent comprising titanium oxide particles and / or zinc oxide particles as an active ingredient and excellent in dispersibility of titanium oxide particles and zinc oxide particles.
  • UV light is classified into UV-A having a relatively long wavelength (400 to 320 nm), UV-B having a medium wavelength (320 to 280 nm), and UV-C having a short wavelength (not more than 280 nm) depending on the wavelength.
  • UV-A having a relatively long wavelength (400 to 320 nm)
  • UV-B having a medium wavelength (320 to 280 nm)
  • UV-C having a short wavelength (not more than 280 nm) depending on the wavelength.
  • UV-A and UV-B are also contained in sunlight and are known to damage human skin and hair. However, some UV-B and UV-C do not reach the ground, causing problems. Are UV-A and UV-B.
  • UV-A penetrates deep into the skin and stimulates melanin producing cells to produce melanin and darken the skin.
  • aging of the skin is promoted by prolonged UV-A irradiation.
  • UV-B is even more harmful and can cause acute inflammation (erythema), burns, and pigmentation of the skin, and may cause skin aging and skin cancer.
  • keratin constituting hair is a protein, it is naturally affected by ultraviolet rays.
  • ultraviolet protective agents it is important to protect the skin from ultraviolet rays in order to prevent the skin and hair from aging and to prevent the generation and deterioration of spots and freckles.
  • it is considered that applying ultraviolet protective agents to the skin is a simple and effective means.
  • the main active ingredient of the UV protection agent is to reflect and scatter the irradiated UV light in addition to the UV absorbing material that absorbs the irradiated UV light and converts it into visible light and infrared light on the skin surface.
  • An ultraviolet reflective material is mentioned.
  • powders such as titanium oxide and zinc oxide are mainly used.
  • titanium oxide particles and zinc oxide particles do not dissolve in the solvent and tend to precipitate. Therefore, titanium oxide particles and the like that have been improved in affinity for aqueous or oily solvents by hydrophilization treatment or hydrophobic treatment have been developed.
  • UV protection agents are generally composed of emulsions containing both aqueous and oily solvents from the viewpoints of safety and usability, titanium oxide particles and zinc oxide particles are resistant to both aqueous and oily solvents. Dispersibility is required. For this reason, UV protection products containing titanium oxide particles and zinc oxide particles may be given precautions such as shaking the container well before use to disperse the particles, but the titanium oxide particles and zinc oxide particles Various ingenuity has been made to increase the dispersibility.
  • Patent Document 1 discloses an oil-in-water cosmetic containing an acrylic-silicone graft copolymer and a silicone surfactant in order to enhance the dispersibility of metal oxide particles.
  • Patent Document 2 discloses a water-in-oil type sunscreen cosmetic containing polyether-modified silicone, titanium oxide, zinc oxide, volatile oil, elastomer organopolysiloxane, and cetyl dimethicone.
  • Patent Document 3 discloses a composition comprising a nonionic surfactant and an anionic surfactant, an oil phase, and inorganic colloidal particles.
  • an object of the present invention is to provide an ultraviolet protective agent that is safe and excellent in dispersibility of titanium oxide particles and zinc oxide particles even though the blending amount of the surfactant is reduced. .
  • the inventors of the present invention have made extensive studies to solve the above problems.
  • the cyclic lipopeptide biosurfactant particularly improves the dispersibility of titanium oxide particles and zinc oxide particles. Therefore, the use of cyclic lipopeptide biosurfactant as a surfactant provides an ultraviolet protective agent with good dispersion stability. And the present invention has been completed by finding that the amount of the surfactant used can be reduced.
  • An ultraviolet protective agent comprising titanium oxide particles and / or zinc oxide particles, a cyclic lipopeptide biosurfactant, and a solvent.
  • An ultraviolet protection method comprising a step of applying to the skin an ultraviolet protective agent comprising at least one ultraviolet reflector selected from titanium oxide particles and zinc oxide particles, a cyclic lipopeptide biosurfactant, and a solvent.
  • the cyclic lipopeptide biosurfactant used in the present invention can remarkably improve the dispersion stability of titanium oxide particles and zinc oxide particles. Therefore, by blending cyclic lipopeptide biosurfactant as a surfactant, a UV protective agent with extremely good dispersion stability can be obtained, and the amount of surfactant in the UV protective agent can be reduced. Become.
  • the cyclic lipopeptide biosurfactant is a peptide compound, so that it is safe for the living body, and since it is easily biodegraded, the load on the environment is small. Therefore, this invention is very useful industrially as what enables provision of the ultraviolet protective agent excellent in dispersion stability and safety
  • FIG. 1 is a photograph after a mixture of hydrophilic titanium oxide particles, a surfactant and an oily solvent was allowed to stand for 42 days.
  • FIG. 2 is a photograph after a mixture of hydrophilic titanium oxide particles, a surfactant, glycerin, and an oily solvent was allowed to stand for 41 days.
  • FIG. 3 is a photograph immediately after the preparation of a mixture of hydrophilic titanium oxide particles, surfactant, glycerin and oily solvent and after leaving at 50 ° C. for 37 days or 36 days.
  • FIG. 4 is a photograph after a mixture of a relatively high concentration of hydrophilic titanium oxide particles, a surfactant, glycerin, and an oily solvent was allowed to stand at 50 ° C. for 33 days.
  • FIG. 1 is a photograph after a mixture of hydrophilic titanium oxide particles, a surfactant and an oily solvent was allowed to stand for 42 days.
  • FIG. 2 is a photograph after a mixture of hydrophilic titanium oxide particles
  • FIG. 5 is a photograph after a mixture of hydrophobic titanium oxide particles, surfactant, glycerin, and water was allowed to stand for 5 days.
  • FIG. 6 is a photograph after a mixture containing hydrophobic titanium oxide particles, surfactin sodium, glycerin, and water and having different blending amounts of glycerin is allowed to stand for 5 days.
  • FIG. 7 is a photograph after a mixture of hydrophobic titanium oxide particles, surfactant, 1,3-butylene glycol and water was allowed to stand for 6 days.
  • the ultraviolet protective agent according to the present invention includes at least one or more ultraviolet reflectors selected from titanium oxide particles and / or zinc oxide particles, that is, titanium oxide particles and zinc oxide particles, a cyclic lipopeptide biosurfactant, and a solvent. It is characterized by.
  • the titanium oxide particles and the zinc oxide particles are mainly used as an ultraviolet reflecting material that reflects and scatters irradiated ultraviolet rays, and may also act as an ultraviolet absorbing material that absorbs ultraviolet rays.
  • titanium oxide particles are commercially available. For example, there are those whose surface hydrophobicity and hydrophilicity are adjusted by surface treatment. Some are manufactured by different methods such as a firing method and a wet method, and others are different in particle size. In the present invention, an appropriate selection may be made according to the purpose. The same applies to the zinc oxide particles, and various products such as ultrafine zinc oxide are commercially available. In addition, titanium oxide particles and zinc oxide particles can be produced using a known method.
  • the characteristics of the titanium oxide particles and the zinc oxide particles may differ depending on the particle size, particles having an appropriate particle size may be appropriately selected and used according to the purpose.
  • the particle size distribution of particles is measured under a normal condition using a laser diffraction particle size distribution measuring device, and the average secondary particle size obtained from the obtained data is 0.5 ⁇ m or more and 50 ⁇ m or less. it can.
  • the average particle diameter obtained by the method includes volume average particle diameter, number average particle diameter, area average diameter and the like, and the type of average particle diameter is not particularly limited in the present invention, but the average particle diameter is the volume average particle diameter. Is preferably determined.
  • the average primary particle diameter obtained from the enlarged photograph of the particles using image processing software or the like is preferably 1 nm or more and 500 nm or less.
  • titanium oxide particles and zinc oxide particles Only one kind of titanium oxide particles and zinc oxide particles may be used, or two or more kinds may be mixed and used.
  • titanium oxide particles having a small primary particle diameter are said to be excellent in UV-B blocking ability, and large particles are said to be excellent in UV-A blocking ability. Therefore, it is possible to effectively block or absorb harmful UV-A and UV-B that cause sunburn by using a mixture of titanium oxide particle products having different particle sizes at an appropriate ratio.
  • titanium oxide particles and zinc oxide particles may be mixed and used.
  • the mixing ratio of the titanium oxide particles and the zinc oxide particles is not particularly limited and may be appropriately adjusted.
  • the mixing ratio may be 0.1% by mass or more and 30% by mass or less with respect to the entire ultraviolet protective agent. If the said ratio is 0.1 mass% or more, an ultraviolet-ray protective effect can be exhibited more reliably. On the other hand, if the proportion is too large, the particles may be settled. Therefore, the proportion is preferably 30% by mass or less.
  • 0.5 mass% or more is more preferable, 1 mass% or more, 2 mass% or more, or 3 mass% or more is further more preferable, and 30 mass% or less, 20 mass% or less, 15 mass% or less or 10 mass% or less is more preferable, 9 mass% or less or 7 mass% or less is further more preferable, and 5 mass% or less is especially preferable.
  • the cyclic lipopeptide biosurfactant is a cyclic peptide having a lipophilic group such as a long-chain alkyl group and having a surfactant activity.
  • the dispersion stability of titanium oxide particles and zinc oxide particles is remarkably improved by the cyclic lipopeptide biosurfactant.
  • the UV protection product containing titanium oxide particles and zinc oxide particles may be given a precautionary statement such as shaking the container well before use to disperse the particles. In the steady state, the agent is dispersed with titanium oxide particles or zinc oxide particles, and there is a possibility that prior shaking is unnecessary.
  • the amount of the cyclic lipopeptide biosurfactant which is a surfactant can be reduced.
  • cyclic lipopeptide biosurfactant is a peptide compound, biodegradability is extremely high, and there is an advantage that the influence on the living body and the environment is small.
  • UV protection agents formulated with cyclic lipopeptide biosurfactants are superior to conventional UV protection agents formulated with surfactants and may feel better after drying. .
  • the cyclic lipopeptide biosurfactant is not particularly limited as long as it is a peptide compound having a bulky cyclic structure and exhibiting a surface activity, and examples thereof include surfactin, arthrofactin, iturin, serawetin, lykesin, and viscosin. be able to.
  • a plurality of cyclic lipopeptide biosurfactants may be used in combination.
  • Surfactin (I) or a salt thereof can be suitably used as the cyclic lipopeptide biosurfactant.
  • X represents an amino acid residue selected from leucine, isoleucine and valine; R 1 represents a C 9-18 alkyl group]
  • amino acid residue as X may be L-form or D-form, but L-form is preferred.
  • C 9-18 alkyl group refers to a linear or branched monovalent saturated hydrocarbon group having 9 to 18 carbon atoms.
  • One or two or more of the above surfactins (I) may be used.
  • a plurality of surfactins (I) having different C 9-18 alkyl groups of R may be included.
  • Surfactin (I) can be cultivated according to a known method, for example, a strain belonging to Bacillus subtilis and separated from the culture solution. It can also be used. Moreover, what is obtained by a chemical synthesis method can be used similarly.
  • the counter cation constituting the salt of Surfactin (I) is not particularly limited, and examples thereof include alkali metal ions and ammonium ions.
  • the alkali metal ion that can be used for the salt of Surfactin (I) is not particularly limited, and represents a lithium ion, a sodium ion, a potassium ion, or the like. Further, the two alkali metal ions may be the same as or different from each other.
  • Examples of the substituent of the ammonium ion include a C 1-6 alkyl group of a methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl group; an aralkyl group such as benzyl, methylbenzyl, phenylethyl; phenyl, Organic groups such as aryl groups such as toluyl and xylyl can be mentioned.
  • Examples of ammonium ions include tetramethylammonium ions, tetraethylammonium ions, pyridinium ions, and the like.
  • the two counter cations may be the same or different from each other.
  • One of the carboxy groups may be in the state of —COOH or —COO 2 — .
  • the compounding amount of the cyclic lipopeptide biosurfactant is not particularly limited, and may be appropriately adjusted within a range in which dispersibility of the obtained ultraviolet protective agent is ensured.
  • the amount of titanium oxide particles and / or zinc oxide particles to be dispersed is It can be 0.01 mass times or more and 1 mass times or less with respect to the total amount. If the said ratio is 0.01 mass times or more, the dispersibility of the titanium oxide particle and zinc oxide particle in a ultraviolet protective agent will be improved more reliably.
  • the ratio is preferably 1 mass times or less.
  • the proportion is more preferably 0.05 times by mass or more, further preferably 0.1 times by mass or more, more preferably 0.8 times by mass or less, still more preferably 0.5 times by mass or less, and 0.2
  • the mass ratio or less is particularly preferable.
  • the ratio of the cyclic lipopeptide biosurfactant to the whole UV protection agent can be 0.01% by mass or more and 5% by mass or less.
  • 0.05 mass% or more is more preferable, 0.1 mass% or more is further more preferable, 2 mass% or less is more preferable, and 1 mass% or less is further more preferable.
  • the “solvent” used in the present invention is not particularly limited as long as it is less harmful to the human body when applied to human skin, is a liquid at room temperature and normal pressure, and can disperse titanium oxide particles or zinc oxide particles suitably.
  • water alcohol solvents such as methanol, ethanol, isopropanol; cetyl 2-ethylhexanoate, methyl palm fatty acid, methyl laurate, isopropyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, octyldodecyl myristate, stearin Long chain fatty acid ester solvents such as 2-ethylhexyl acid, isotridecyl stearate, methyl oleate; monoglyceride oleate, triglyceride 2-ethylhexanoate, monoglyceride caprylate, triglyceride caprylate, fatty acids (C 8
  • a common UV protection agent is an emulsion containing both an aqueous solvent and an oily solvent. Therefore, it is preferable to use a mixture of an aqueous solvent and an oily solvent.
  • an aqueous solvent means the organic solvent which is miscible with water unlimitedly, such as water and the said alcohol solvent.
  • the oily solvent refers to organic solvents that are not miscible with water, such as the above-mentioned long-chain fatty acid ester solvents, glyceride ester solvents, silicone oils, and terpenoid solvents.
  • a polyhydric alcohol may be blended.
  • the polyhydric alcohol has an effect of imparting an appropriate viscosity to the ultraviolet protective agent when used in combination with an appropriate surfactant and further improving the dispersibility of the titanium oxide particles and the zinc oxide particles.
  • polyhydric alcohol examples include diols such as ethylene glycol, propylene glycol, 1,3-butanediol, 1,4-butanediol, and 2,3-butanediol; triols such as glycerin; and a molecular weight of 200 to 600.
  • diols such as ethylene glycol, propylene glycol, 1,3-butanediol, 1,4-butanediol, and 2,3-butanediol
  • triols such as glycerin
  • glycerin a molecular weight of 200 to 600.
  • Polyols such as polyethylene glycol can be mentioned, and glycerin is most preferred.
  • the blending amount of the polyhydric alcohol is not particularly limited, and may be appropriately adjusted within a range in which the effect of improving the dispersibility of the UV protection agent is recognized. For example, 1% by mass or more and 40% by mass with respect to the total UV protection agent % Or less. If the said ratio is 1 mass% or more, the improvement effect of the dispersibility of a titanium oxide particle or a zinc oxide particle will be improved more reliably. On the other hand, if the ratio is too high, the composition may be phase-separated, and therefore the ratio is preferably 40% by mass or less. The proportion is more preferably 2% by mass or more, further preferably 3% by mass or more, particularly preferably 5% by mass or more, more preferably 30% by mass or less, and further preferably 20% by mass or less.
  • components other than those described above may be blended.
  • Such components include, for example, ultraviolet reflectors other than titanium oxide and zinc oxide, such as cerium oxide, kaolin, and talc; , Parsole A, guaiazulene, paraaminobenzoic acid ester, phenyl salicylate, and other UV absorbing materials; thickening polysaccharides such as guar gum and xanthan gum; celluloses such as hydroxypropyl cellulose and carboxymethyl cellulose; acrylic acid polymers and acrylic acid copolymers Carboxyvinyl polymers such as: colorants; pH adjusters; plant extracts; antiseptics; chelating agents; vitamin agents; medicinal ingredients such as anti-inflammatory agents; fragrances;
  • the method for producing the ultraviolet protective agent according to the present invention is not particularly limited. For example, it can be produced by simply mixing the components. However, uniform mixing may be difficult, particularly when mixing components having low affinity such as titanium oxide particles or zinc oxide particles and a solvent. Therefore, after determining the components to be used, it is preferable to appropriately determine an appropriate production method by a small amount of preliminary experiments.
  • a cyclic lipopeptide biosurfactant and a polyhydric alcohol such as those having a relatively high affinity for titanium oxide particles or zinc oxide particles, are mixed in advance, and titanium oxide particles or zinc oxide particles are stirred while the mixture is stirred. Add and disperse.
  • a production method is preferred in which a mixture having a relatively low affinity with titanium oxide particles or zinc oxide particles such as a solvent is added little by little while mixing the obtained mixture.
  • it may be heated to a temperature such that the components are not distilled off, such as 40 ° C. or higher and 80 ° C. or lower.
  • the composition having the same composition as the ultraviolet protective agent according to the present invention is excellent in dispersibility of titanium oxide particles and zinc oxide particles, and is highly safe white. It is also useful as a paint.
  • the ultraviolet protection method according to the present invention includes a step of applying the ultraviolet protective agent according to the present invention to the skin.
  • the ultraviolet protective agent according to the present invention When the ultraviolet protective agent according to the present invention is applied to the skin, the solvent spontaneously evaporates due to body temperature or the like, and the titanium oxide particles and / or zinc oxide particles as active ingredients cover the skin. At that time, in the ultraviolet protective agent according to the present invention, since the titanium oxide particles and / or the zinc oxide particles are well dispersed, the skin is uniformly coated with the active ingredient particles. As a result, the reflection and absorption of ultraviolet rays are exhibited uniformly and effectively. In addition, the UV protection agent according to the present invention may not need to be shaken because of dispersion of particles before use.
  • the application amount of the UV protection agent may be appropriately adjusted according to the type and concentration of the active ingredient particles blended, and can be, for example, about 0.1 mg to 5 mg per 1 cm 2 of skin.
  • Example 1 Dispersibility test of hydrophilic titanium oxide particles in an oily solvent The effect of improving the dispersibility of hydrophilic titanium oxide particles ("Taipeku CR-60” manufactured by Ishihara Sangyo Co., Ltd.) with various surfactants in an oily solvent investigated.
  • Surfactant sodium SFNa, “Kaneka Surfactin” manufactured by Kaneka
  • NIKKOL stearic acid PEG-40
  • Example 2 Dispersibility test of hydrophilic titanium oxide particles in an oily solvent
  • a mixture containing glycerin as a polyhydric alcohol the effect of improving the dispersibility of hydrophilic titanium oxide particles in an oily solvent by various surfactants investigated.
  • each of the surfactants shown in Table 2 was dissolved in glycerin in a beaker, and then the hydrophilic titanium oxide particles were mixed.
  • Table 2 “NIKKOL Decaglyn 3-SV” manufactured by Nikko Chemicals Co., Ltd. was used as PEG-20 glyceryl triisostearate, and “NIKKOL Decaglyn 1-LVEX” manufactured by Nikko Chemicals Co., Ltd. was used as polyglyceryl laurate-10.
  • the operation of adding a small amount of ethylhexyl palmitate as an oily solvent and stirring with a stirring bar each time was repeated 17 times or 18 times.
  • FIG. 2 shows a photograph of the preparation example 5 containing surfactin sodium after standing.
  • Example 3 Dispersibility Test of Hydrophilic Titanium Oxide Particles in Oily Solvent
  • the oily solvent was changed from ethylhexyl palmitate to dimethylpolysiloxane.
  • surfactin sodium was dissolved in glycerin at a ratio shown in Table 3 in a beaker, and then hydrophilic titanium oxide particles were mixed.
  • a small amount of dimethylpolysiloxane (“KF-96A-20cs” manufactured by Shin-Etsu Silicone Co., Ltd.) was added as an oily solvent, and the operation of stirring with a stirring bar was repeated 18 times.
  • Example 4 Dispersibility Test of Hydrophobic Titanium Oxide Particles in Aqueous Solvent Hydrophobic Titanium Oxide Particles with Various Surfactants (“Ultrafine Titanium Oxide TTO-55 (C)” manufactured by Ishihara Sangyo Co., Ltd.) The effect of improving dispersibility was examined.
  • Surfactant sodium SFNa, “Kaneka Surfactin” manufactured by Kaneka
  • POE sorbitan monostearate NIKKOL, manufactured by Nikko Chemicals
  • TS-10V a linear sodium alkylbenzene sulfonate (LAS), which is a synthetic anionic surfactant, was used.
  • LAS linear sodium alkylbenzene sulfonate
  • each surfactant was added to glycerin at a ratio shown in Table 4 in a beaker, heated to 70 ° C. and mixed, then added with titanium oxide, and mixed at 70 ° C. While stirring the mixture at 1200 rpm, water heated to 70 ° C. was added little by little over 2 minutes. Next, stirring was once stopped, and the titanium oxide particles adhering to the bottom and wall surfaces of the beaker were scraped with a spatula, and again stirred at 1200 rpm for 3 minutes.
  • Example 5 Dispersibility Test of Hydrophobic Titanium Oxide Particles in Aqueous Solvent Dispersibility was tested in the same manner as in Example 4 except that the blending ratio of glycerin was changed as shown in Table 5. The results are shown in FIG.
  • Example 6 Dispersibility Test of Hydrophobic Titanium Oxide Particles in Aqueous Solvent
  • glycerin was changed to 1,3-butylene glycol as shown in Table 6, and the resulting mixture was allowed to stand at room temperature for 6 days.
  • the dispersibility was tested in the same manner except that. The results are shown in FIG.

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Abstract

L'objectif de la présente invention est de fournir un agent de protection contre les UV qui est sans danger et présente d'exceptionnelles caractéristiques de dispersibilité des particules d'oxyde de titane et des particules d'oxyde de zinc, même lorsque la quantité de tensioactif mélangée est diminuée. L'agent de protection contre les UV selon la présente invention est caractérisé en ce qu'il contient des particules d'oxyde de titane et/ou des particules d'oxyde de zinc, un tensioactif biologique lipopeptidique cyclique et un solvant.
PCT/JP2016/050945 2015-01-15 2016-01-14 Agent de protection contre les uv Ceased WO2016114340A1 (fr)

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Cited By (4)

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Publication number Priority date Publication date Assignee Title
WO2018079620A1 (fr) * 2016-10-28 2018-05-03 株式会社カネカ Composition gélatineuse
CN108271776A (zh) * 2017-12-25 2018-07-13 武汉科诺生物科技股份有限公司 芽孢杆菌脂肽类代谢产物用作微生物菌剂助剂的用途
JP2019044015A (ja) * 2017-08-30 2019-03-22 株式会社パイロットコーポレーション 筆記具用油性インキ組成物及びそれを収容したマーキングペン
CN114395818A (zh) * 2022-01-25 2022-04-26 杭州瑞成辉化纤有限公司 一种冰爽型防紫外涤纶化纤及其制备方法

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JP2003128512A (ja) * 2001-10-18 2003-05-08 Showa Denko Kk 化粧料用抗菌性組成物
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WO2009044279A2 (fr) * 2007-09-30 2009-04-09 Umo Inc., Co. Ltd. Peptide présentant une activité antimicrobienne et/ou bio-tensioactive
WO2012096276A1 (fr) * 2011-01-13 2012-07-19 株式会社カネカ Promoteur d'absorption percutanée et préparation cutanée externe

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WO2018079620A1 (fr) * 2016-10-28 2018-05-03 株式会社カネカ Composition gélatineuse
CN109562050A (zh) * 2016-10-28 2019-04-02 株式会社钟化 凝胶状组合物
JPWO2018079620A1 (ja) * 2016-10-28 2019-09-19 株式会社カネカ ゲル状組成物
JP7002461B2 (ja) 2016-10-28 2022-01-20 株式会社カネカ ゲル状組成物
CN109562050B (zh) * 2016-10-28 2022-05-10 株式会社钟化 凝胶状组合物
JP2019044015A (ja) * 2017-08-30 2019-03-22 株式会社パイロットコーポレーション 筆記具用油性インキ組成物及びそれを収容したマーキングペン
CN108271776A (zh) * 2017-12-25 2018-07-13 武汉科诺生物科技股份有限公司 芽孢杆菌脂肽类代谢产物用作微生物菌剂助剂的用途
CN114395818A (zh) * 2022-01-25 2022-04-26 杭州瑞成辉化纤有限公司 一种冰爽型防紫外涤纶化纤及其制备方法

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