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WO2016178350A1 - Système de détection et substance de modification - Google Patents

Système de détection et substance de modification Download PDF

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Publication number
WO2016178350A1
WO2016178350A1 PCT/JP2016/061173 JP2016061173W WO2016178350A1 WO 2016178350 A1 WO2016178350 A1 WO 2016178350A1 JP 2016061173 W JP2016061173 W JP 2016061173W WO 2016178350 A1 WO2016178350 A1 WO 2016178350A1
Authority
WO
WIPO (PCT)
Prior art keywords
growth
specimen
modifying substance
substance
starting point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2016/061173
Other languages
English (en)
Japanese (ja)
Inventor
川口　裕一
菊川　隆
祥生 坪池
春希 柚賀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TDK Corp
Original Assignee
TDK Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TDK Corp filed Critical TDK Corp
Publication of WO2016178350A1 publication Critical patent/WO2016178350A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C18/00—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating
    • C23C18/16—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by reduction or substitution, e.g. electroless plating
    • C23C18/18—Pretreatment of the material to be coated
    • C23C18/20—Pretreatment of the material to be coated of organic surfaces, e.g. resins
    • C23C18/28—Sensitising or activating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Definitions

  • the detection system of the present invention is characterized in that the growth starting point is a metal catalyst, and a metal is grown as the growth material by metal deposition by an electroless plating method in the growth step.
  • the growth starting point is a hydroxyl group
  • a metal salt aqueous solution and an oxidizing agent are supplied to the modifying substance, and a metal oxide is deposited as the growing substance to grow. It is characterized by.
  • Pd is well known as a metal catalyst for electroless plating, but may be, for example, Fe, Co, Ni, Cu, Ru, Rh, Os, Ir, Pt, Ag, Au, or an alloy combining them. .
  • a metal as the growth material 6 for example, Co, Ni, Cu, Ru, Rh, Pd, Pt, Ag, Au, or an alloy thereof can be used.
  • the electroless plating solution is prepared by combining a water-soluble halide, sulfate and sulfamate aqueous solution of the above metal with a reducing agent such as an amine borane compound, a hydrazine compound, phosphorous acid, hypophosphorous acid or a salt thereof.
  • a metal oxide can be used as the growth material 6.
  • the growth starting point 4 of the modifying substance 5 is a hydroxyl group, and an aqueous metal salt solution and an oxidizing agent are supplied to the modifying substance 5 (support 2 on which the specimen 1 bound to the modifying substance 5 is fixed) in the growth step 10, thereby oxidizing the metal.
  • the material growth material 6 can be deposited and grown.
  • the aqueous metal salt solution and the oxidizing agent may be mixed before being supplied to the support 2, but in order to prevent unnecessary reaction, it is preferable to supply the aqueous solution and the oxidizing agent to the support 2 separately. Can be alternately supplied to the support 2.
  • Detection by an optical microscope has a large system such as a lens configuration, an illumination device, and an image processing device, and resolution is limited by the wavelength of light, but magnetic detection has no wavelength limitation and is highly sensitive.
  • the system can be miniaturized.
  • the growth substance 6 can be detected with higher sensitivity by applying an external magnetic field.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Mechanical Engineering (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Electrochemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Le système de détection de la présente invention est caractérisé en ce qu'il comprend : une étape de fixation 7 permettant de fixer un échantillon sur un corps de support ; une étape de liaison 8 permettant de lier à l'échantillon une substance de modification ayant un point de départ de croissance et un groupe de liaison sélective pour l'échantillon ; une étape d'élimination 9 permettant d'éliminer la substance de modification qui n'est pas liée à l'échantillon ; et une étape de croissance 10 permettant de faire croître une substance de croissance au niveau du point de départ de croissance, et en ce qu'il détecte la substance de croissance développée.
PCT/JP2016/061173 2015-05-07 2016-04-05 Système de détection et substance de modification Ceased WO2016178350A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-094761 2015-05-07
JP2015094761 2015-05-07

Publications (1)

Publication Number Publication Date
WO2016178350A1 true WO2016178350A1 (fr) 2016-11-10

Family

ID=57217690

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2016/061173 Ceased WO2016178350A1 (fr) 2015-05-07 2016-04-05 Système de détection et substance de modification

Country Status (1)

Country Link
WO (1) WO2016178350A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002202307A (ja) * 2000-12-27 2002-07-19 Iatron Lab Inc イムノクロマトグラフ法
JP2007248349A (ja) * 2006-03-17 2007-09-27 Toyohashi Univ Of Technology 生体高分子検出方法およびその検出装置
JP2008268186A (ja) * 2007-03-27 2008-11-06 Canon Inc 磁気センサーの感度向上材料及び方法
JP2009287952A (ja) * 2008-05-27 2009-12-10 Fujifilm Corp イムノクロマトグラフ方法
WO2014160192A1 (fr) * 2013-03-13 2014-10-02 Meso Scale Technologies, Llc. Méthodes de dosage amélioré

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002202307A (ja) * 2000-12-27 2002-07-19 Iatron Lab Inc イムノクロマトグラフ法
JP2007248349A (ja) * 2006-03-17 2007-09-27 Toyohashi Univ Of Technology 生体高分子検出方法およびその検出装置
JP2008268186A (ja) * 2007-03-27 2008-11-06 Canon Inc 磁気センサーの感度向上材料及び方法
JP2009287952A (ja) * 2008-05-27 2009-12-10 Fujifilm Corp イムノクロマトグラフ方法
WO2014160192A1 (fr) * 2013-03-13 2014-10-02 Meso Scale Technologies, Llc. Méthodes de dosage amélioré

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SU ,YAN-LEI: "Immunoassay signal amplification on glass slides based on electroless deposition", COLLOIDS AND SURFACES B:BIOINTERFACES, vol. 44, August 2005 (2005-08-01), pages 99 - 103, XP027803452 *
TERUOMI SANO ET AL.: "Development of high sensitivity immunochromatography combined with nonelectrolyte copper plating", THE 91ST ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2011) KOEN YOKOSHU III, 11 March 2011 (2011-03-11), pages 701 *

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