WO2016013228A1 - Composition for reducing aldehyde - Google Patents
Composition for reducing aldehyde Download PDFInfo
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- WO2016013228A1 WO2016013228A1 PCT/JP2015/003713 JP2015003713W WO2016013228A1 WO 2016013228 A1 WO2016013228 A1 WO 2016013228A1 JP 2015003713 W JP2015003713 W JP 2015003713W WO 2016013228 A1 WO2016013228 A1 WO 2016013228A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- An aldehyde-reducing composition is provided.
- the aldehyde odor of breath after drinking can be removed. Used for the treatment of drunkenness.
- Example 3 The result of Example 3 is shown.
- the result of Example 4 is shown.
- the present invention is at least one selected from jasmine tea extract, tomato powder, blueberry extract, cassis extract, epigallocatechin gallate, tea extract, loaf extract, grape seed extract, assam extract, and safflower extract.
- An aldehyde-reducing composition characterized in that it contains one.
- Jasmine tea is made by scenting the base tea leaves with the scent of jasmine flowers, removing the flowers after flavoring, drying and then flavoring again as needed.
- the extracted jasmine tea is extracted with water or a polar organic solvent, sterilized and freeze-dried through a concentration step such as centrifugation and filtration, and then pulverized.
- the method for extracting jasmine tea is not particularly limited.
- an extraction solvent that can be used for extraction, water, polar organic solvents such as methanol, ethanol, 1-butanol, 2-propanol, and 1-propanol, and a mixture of these polar organic solvents and water can be preferably used.
- water alone cold water or hot water
- a mixture of water and ethanol hydrophilic ethanol
- the extraction solvent may be added in an amount of 10 to 200 times, preferably 20 to 100 times, when the dry weight of jasmine tea is 1.
- the extraction temperature is preferably 40 to 100 ° C, more preferably 70 to 100 ° C.
- the heating time is 1 to 120 minutes, preferably 5 to 60 minutes.
- composition of the present invention can reduce aldehyde in the oral cavity. Moreover, the composition of this invention can reduce the aldehyde in an oral cavity by being chewed.
- the composition of this embodiment can be expected to have a sufficient deodorizing effect by gradually eluting the jasmine tea extract as it is chewed.
- the content of the jasmine tea extract in the composition is not limited, but is preferably 0.1% to 10% by weight in the composition.
- a preferred example of the composition is chewing gum.
- the content of jasmine tea extract in the composition is preferably 1.0% to 10% by weight. This is because if the amount is less than 1.0% by weight, a sufficient aldehyde reduction effect cannot be obtained, while if it exceeds 10% by weight, the binding property is poor, and the shape becomes sober and cannot be molded.
- the composition of the present invention can contain a liquid part.
- the liquid part is a liquid part having an appropriate viscosity, and is intended to flow out into the oral cavity when the composition is encapsulated and the composition is chewed.
- the content of jasmine tea extract in the liquid part is preferably 15% by weight or less per liquid part. This is because if the content ratio of the jasmine tea extract in the liquid part exceeds 15% by weight, the liquid part becomes too viscous and it may be difficult to fill the composition.
- an immediate deodorizing effect can be obtained immediately after chewing the composition.
- composition of the present invention are chewing gum, candy, tablet confectionery, beverage, gummy jelly, chocolate, biscuits, ice cream, sherbet, or a pharmaceutical composition for reducing acetaldehyde. , Breath breath sprays, toothpastes, troches, and pharmaceutical gums.
- Example 1 Screening of substances having an acetaldehyde reducing effect.
- the experiment was conducted as follows. That is, in a glass test tube (capacity 18 mL) that can be sealed, 1 mL of 0.2 M phosphate buffer (pH 7.5), 1 mL of water or sample solution (100 mg of each sample dissolved or dispersed in 1 mL of water), 0.5 mL of acetaldehyde 1/500 (v / v) solution was added, and after sealing and stirring, the solution was left in a 37 ° C. hot water bath for 10 minutes. Ten minutes later, 100 ⁇ L of test tube headspace gas was collected with a syringe, and the amount of acetaldehyde was analyzed by gas chromatography. The acetaldehyde elimination amount was calculated by comparison with water.
- the amount of acetaldehyde in the headspace gas detected when 1 mL of 0.2 M phosphate buffer (pH 7.5), 1 mL of water, and 0.5 mL of acetaldehyde 1/500 (v / v) solution was added was 22.3 ⁇ g / tube (Table 1).
- Table 2 shows the amount of elimination of acetaldehyde in the headspace gas by each substance.
- the jasmine tea extract erased 3.0 ⁇ g / tube, or 13.3% by weight, of acetaldehyde in the headspace gas.
- tomato powder (the amount of elimination of acetaldehyde in the headspace gas is 3.4 ⁇ g / tube, ie 15.2% by weight), blueberry extract (3.3 ⁇ g) as an ingredient that showed the same erasing ability as jasmine tea extract / Tube, ie 15.0% by weight), cassis extract (3.3 ⁇ g / tube, ie 15.0% by weight), EGCg high purity product (3.0 ⁇ g / tube, ie 13.4% by weight), tea extraction Product (2.9 ⁇ g / tube, ie 13.1% by weight), loaf extract (2.9 ⁇ g / tube, ie 12.9% by weight), grape seed extract (2.6 ⁇ g / tube, ie 11.7% by weight) %), Assam extract (2.1 ⁇ g / tube, ie 9.2 wt%), safflower extract (2.0 ⁇ g / tube, ie 9. There was a 9 material of weight%). Table 9 shows detailed experimental results for these nine materials.
- tomato powder is a dried fruit powder using tomato pulp with a Brix value of 5.
- the blueberry extract is an extract from blueberry fruits, and the total amount of anthocyanidins is 25.0% or more.
- a cassis extract is an extract from a cassis (black currant) fruit, and the total amount of anthocyanins is 30.0% or more.
- the EGCg high-purity product is an extract derived from green tea, and the EGCg content is 90.0% or more.
- the tea extract is a tan powder, and the content of catechins is 30.0% or more.
- the yoyohi extract is obtained by extracting with water-containing alcohol from the bark of yoyohi (bayberry).
- the grape seed extract is an extract from grape seeds, and the proanthocyanidin content is 95.0% or more.
- Assam extract is a hot water extraction using 100% Assam tea leaves.
- the safflower extract is an extract derived from dried safflower.
- the jasmine tea extract is as described above.
- the numerical values in Table 2 indicate the acetaldehyde elimination amount ( ⁇ g / tube) in the headspace gas and the acetaldehyde elimination rate (% by weight).
- Suitable as a reducing composition characterized by reducing the aldehyde in the oral cavity by chewing which is one of the embodiments of the present invention, from the above-mentioned nine types of acetaldehyde-reducing effects.
- Selected material. Tomato powder and blueberry extract are not optimal as chewing compositions because of the strong taste peculiar to the material and limited flavor and variety. Tomato powder is highly hygroscopic and has a large effect on the physical properties of the composition.
- Cassis extract, Assam extract, and safflower extract have strong astringency, and EGCg high-purity product and tea extract have particularly strong bitterness and astringency, and their flavor and variety are limited, so they are not optimal as chewing compositions.
- jasmine tea extract When included in the composition, the yoihihi extract or grape seed extract gives a feeling of tooth tingling (such as teeth and gum rubbing) during chewing, and is therefore not optimal for use as a chewing composition.
- jasmine tea extract is excellent as a chewing composition in terms of taste and fragrance, and also has good compatibility with mint flavor and menthol flavor. In addition, it is a fine powder compared to other plant extracts, and is an example of a chewing composition. When used in gum, it is excellent in terms of dispersibility in the gum and dispersibility in the liquid part. It was. For the above reasons, in the present invention, jasmine tea extract was selected as the optimum substance as the substance having an acetaldehyde reducing effect.
- Example 2 As an example of the composition of the present invention, jasmine tea extract-containing liquid center gum 1, jasmine tea extract-containing liquid center gum 2 and a control liquid center gum were prepared. These liquid center gums consist of a gum part, a sugar coating part and a liquid part, and one gum is 2.5 grams. Each formulation is shown in Table 4.
- the numerical values in Table 4 indicate the weight percentage of each raw material.
- the prepared liquid center gums are each 2.5 grams / grain.
- Example 3 Evaluation of acetaldehyde erasing effect of chewing saliva by using gum containing jasmine tea extract 10 mL of saliva was collected from a subject who chewed 2 tablets of jasmine tea extract-containing liquid center gum 1.
- saliva of a subject who chewed Morita's salvary gum was also collected. The subject was instructed not to swallow any secreted saliva but to discharge it into the collection container. The chewing of the jasmine tea extract-containing liquid center gum 1 and the saliva gum was each continued until 10 mL of saliva was collected.
- the results are shown in FIG.
- the vertical axis of the graph in FIG. 1 indicates the amount of acetaldehyde when the amount of acetaldehyde in the headspace gas when the saliva of a subject chewing saliva gum is used is 100.
- the amount of acetaldehyde in the headspace gas when using the saliva of a subject chewing the jasmine tea extract-containing liquid center gum 1 was 78.7, indicating that the amount of volatile acetaldehyde decreased by more than 20%. Further, a significant difference was detected as a result of the t test (p ⁇ 0.05).
- Example 4 Evaluation of the effects of liquid center gum 1 containing jasmine tea extract on exhaled breath acetaldehyde from 1 drink each of liquid center gum 1 containing jasmine tea extract and control liquid center gum for 5 minutes in 5 mL water using a pestle and mortar Eluted and used as eluent.
- Three male subjects (average 32.3 ⁇ 5.1 years old) ingested 500 mL of beer (Asahi Breweries Super Dry) at their own pace (within 15 minutes) and remained at rest for 30 minutes after drinking. After resting for 30 minutes, the smell bag (3 L) was put in the mouth for 1 minute, and the breath was collected in the smell bag at the pace of one's breath (exhalation before rinsing).
- the mouth was rinsed with 5 mL of either of the two eluates described above for 1 minute, and similarly, the sachet was added to the mouth for 1 minute, and the breath was collected in the sachet at its own breathing pace (exhaled after rinsing). Thereafter, the mouth was rinsed with water, rested for 5 minutes, and the exhaled breath was collected before the second rinse.
- Acetaldehyde was adsorbed on the fiber for 10 minutes from the odor bag by solid-phase microextraction (SPME, manufactured by SUPELCO). After adsorption, it was subjected to gas chromatography. Compared with before rinsing, the amount of acetaldehyde decreased was calculated. For subjects 2 and 3, the same experiment was performed again on the next day (second day) by changing the order of the rinses.
- the amount of acetaldehyde decrease on day 1 and day 2 was 0.7 and 7.0 ppm (before rinsing: 163.7 ppm, 209.3 ppm ⁇ after rinsing: 163.0 ppm, respectively) in the control liquid center gum eluate. , 202.3 ppm) and 26.7, 36.5 ppm (before rinsing: 200.2 ppm, 220.5 ppm ⁇ after rinsing: 173.5 ppm, 184.0 ppm) in the liquid center gum 1 eluate containing jasmine tea extract It was.
- control liquid center gum eluate and the liquid center gum 1 eluate containing jasmine tea extract were used in 3 subjects (subject 1 is the value of 1 time, and subjects 2 and 3 are the average value of 2 times). The amount of acetaldehyde decrease before and after rinsing was shown.
- Example 5 Setting of blending amount of jasmine tea extract in jasmine tea extract-containing liquid center gum
- jasmine tea extract-containing liquid center gum 1 and jasmine tea extract-containing liquid center gum 2 shown in Table 4 the total amount of gum
- the amount of the jasmine tea extract in the mixture is 2.0% by weight and 3.2% by weight, respectively.
- the compounding quantity of the jasmine tea extract in a liquid part is 2.1 weight% and 2.8 weight%, respectively. Both gums show an acetaldehyde deodorizing effect, and it has been found that there is no problem in the moldability of the gum.
- the jasmine tea extract content in the liquid part is preferably 15% by weight or less per liquid part.
- the blending of the liquid center gum 1 containing the jasmine tea extract shown in Table 4 is basically used.
- the compounding quantity of the jasmine tea extract in a liquid part was set to 0. In addition, it adjusted so that the total weight of a gum part might become constant by decreasing the compounding quantity of erythritol by the part which increased the compounding of the jasmine tea extract.
- the gum of (3) that is, the gum containing 4.0% by weight of jasmine tea extract in the total amount of gum
- the gum of (4) that is, the gum containing 5.0% by weight of jasmine tea extract in the total amount of gum
- the gum of (5) ie, the gum containing 10% by weight of jasmine tea extract in the total amount of gum.
- the stickiness is considerably stronger than general gum, but in addition to increasing the blending ratio of softener, by adjusting the blending ratio of reduced maltose starch candy The stickiness is suppressed and molding is possible.
- the gum of (6) that is, the gum containing 11% by weight of the jasmine tea extract in the total amount of the gum, is much stronger than the general gum due to the influence of the jasmine tea extract.
- the amount of blending of the reduced maltose starch candy was reduced to some extent, but this time the entire gum became very soft and it was impossible to mold it.
- the blending ratio of the jasmine tea extract in the total amount of gum is preferably 10% by weight or less.
- the liquid containing jasmine tea extract shown in Table 4 is used. Based on the blend of center gum 1, (7) When the blending amount of jasmine tea extract in the gum part is 1.35% by weight (the blending amount of jasmine tea extract in the total amount of gum is 1.5% by weight) , (8) 0.85% (1.0% by weight in the total amount of gum), (9) Acetaldehyde amount in the case of 0.55% (0.7% by weight in the total amount of gum) The decrease was investigated.
- the blend amount of erythritol was increased.
- the test was conducted in the same manner as in Example 3. 10 mL of saliva was collected from a subject who chewed two of each of the gums (7) to (9).
- saliva of a subject who chewed Morita's salvary gum was also collected.
- the subsequent calculation method of the amount of acetaldehyde was in accordance with Example 3.
- the amount of acetaldehyde in the headspace gas of the subject's saliva was 81.0.
- the amount of acetaldehyde in the headspace gas of the subject's saliva was 84.7.
- the amount of acetaldehyde in the headspace gas of the subject's saliva was 95.2.
- Example 6 As a composition of the present invention, chewing gum, candy, tablet confectionery, beverage, gummy jelly, chocolate, biscuits, ice cream, sorbet, bad breath spray, toothpaste, troche, and pharmaceutical gum based on the following prescriptions Produced according to a conventional method. All of these showed a reduction effect of oral aldehyde after ingestion.
- the jasmine tea extract in each formulation is selected from tomato powder, blueberry extract, cassis extract, EGCg high-purity product, tea extract, loaf extract, grape seed extract, assam extract, safflower extract Even in the case of changing to any one of these or a combination thereof, the effect of reducing the aldehyde in the oral cavity was also shown after taking the composition.
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Abstract
Description
口腔内のアルデヒドの低減。 低 減 Reduction of oral aldehydes.
アルコール飲料を飲んだ後は、口臭が生じ、他人に不快感を生じさせる。このような口臭の原因の一つは、アルコールの代謝過程で生じるアルデヒドである。また、アルコール摂取後、代謝過程で生じるアセトアルデヒドは、頭痛、不快感、倦怠感などといった、宿酔を引き起こす。飲酒後の口臭、あるいは、宿酔の低減、治療のためには、体内のアルデヒドの低減が求められる。なお、アセトアルデヒド臭を消臭する食品に関しては、鉄クロロフィリンまたはその誘導体を有効成分とするものが知られているが(特許文献1)、消臭活性の面や、食品に使用した場合に香味が悪くなってしまう点で望ましくない。 口 After drinking alcoholic beverages, bad breath occurs, causing discomfort to others. One of the causes of such bad breath is an aldehyde generated in the process of alcohol metabolism. In addition, acetaldehyde generated in the metabolic process after alcohol consumption causes drunkenness such as headache, discomfort and fatigue. Reduction of aldehyde in the body is required for the reduction and treatment of bad breath after drinking and stagnation. In addition, regarding foods that deodorize the acetaldehyde odor, those containing iron chlorophyllin or a derivative thereof as an active ingredient are known (Patent Document 1). However, in terms of deodorizing activity and when used in foods, there is a flavor. It is not desirable in that it gets worse.
アルデヒドを低減する組成物の提供。 Provision of compositions that reduce aldehydes.
ジャスミン茶抽出物、トマトパウダー、ブルーベリー抽出物、カシス抽出物、エピガロカテキンガレート、チャ抽出物、ヨウバイヒ抽出物、グレープシード抽出物、アッサム抽出物、およびベニバナ抽出物から選ばれる少なくとも一つを含むことを特徴とするアルデヒド低減用組成物を提供する。 Contains at least one selected from jasmine tea extract, tomato powder, blueberry extract, cassis extract, epigallocatechin gallate, tea extract, bay extract, grape seed extract, assam extract, and safflower extract An aldehyde-reducing composition is provided.
飲酒後の息のアルデヒド臭を除去することができる。宿酔の治療に用いられる。 The aldehyde odor of breath after drinking can be removed. Used for the treatment of drunkenness.
本発明はジャスミン茶抽出物、トマトパウダー、ブルーベリー抽出物、カシス抽出物、エピガロカテキンガレート、チャ抽出物、ヨウバイヒ抽出物、グレープシード抽出物、アッサム抽出物、およびベニバナ抽出物から選ばれる少なくとも一つを含むことを特徴とするアルデヒド低減用組成物を提供する。 The present invention is at least one selected from jasmine tea extract, tomato powder, blueberry extract, cassis extract, epigallocatechin gallate, tea extract, loaf extract, grape seed extract, assam extract, and safflower extract. An aldehyde-reducing composition characterized in that it contains one.
ジャスミン茶は、ベースとなる茶葉にジャスミンの花の香りを吸わせ、着香後に花を除去し、乾燥させたのち、必要に応じて再度着香したものであり、ジャスミン茶抽出物は、得られたジャスミン茶から水や極性有機溶媒などで抽出を行い、遠心分離・濾過などの濃縮工程を経て、殺菌・凍結乾燥したのち、粉砕したものである。 Jasmine tea is made by scenting the base tea leaves with the scent of jasmine flowers, removing the flowers after flavoring, drying and then flavoring again as needed. The extracted jasmine tea is extracted with water or a polar organic solvent, sterilized and freeze-dried through a concentration step such as centrifugation and filtration, and then pulverized.
ジャスミン茶の抽出の方法は特に限定されない。抽出に使用できる抽出溶媒としては、水、もしくはメタノール、エタノール、1-ブタノール、2-プロパノール、1-プロパノール等の極性有機溶媒、およびこれら極性有機溶媒と水との混合物が好適に使用できる。ヒトが摂取することを考慮に入れると、これらの中でも特に、水単独(冷水または熱水)、もしくは水とエタノールとの混合物(含水エタノール)がより好適に使用できる。抽出溶媒の添加量は、ジャスミン茶の乾燥重量を1とした場合、10~200倍重量、好ましくは20~100倍重量となるように添加すればよい。加熱抽出を行う場合の抽出温度は40~100℃が好ましく、更に好ましくは70~100℃である。また加熱時間は1~120分、好ましくは5~60分である。 The method for extracting jasmine tea is not particularly limited. As an extraction solvent that can be used for extraction, water, polar organic solvents such as methanol, ethanol, 1-butanol, 2-propanol, and 1-propanol, and a mixture of these polar organic solvents and water can be preferably used. In consideration of ingestion by human beings, among these, water alone (cold water or hot water) or a mixture of water and ethanol (hydrous ethanol) can be more suitably used. The extraction solvent may be added in an amount of 10 to 200 times, preferably 20 to 100 times, when the dry weight of jasmine tea is 1. In the case of performing heat extraction, the extraction temperature is preferably 40 to 100 ° C, more preferably 70 to 100 ° C. The heating time is 1 to 120 minutes, preferably 5 to 60 minutes.
本発明の組成物は、口腔内のアルデヒドを低減することができる。また、本発明の組成物は、咀嚼されることにより口腔内のアルデヒドを低減することができる。本実施形態の組成物は、咀嚼されるに従い、ジャスミン茶抽出物が徐々に溶出することで、充分な消臭効果を期待することができる。 The composition of the present invention can reduce aldehyde in the oral cavity. Moreover, the composition of this invention can reduce the aldehyde in an oral cavity by being chewed. The composition of this embodiment can be expected to have a sufficient deodorizing effect by gradually eluting the jasmine tea extract as it is chewed.
組成物中のジャスミン茶抽出物の含有量は限定されないが、好ましくは、組成物中0.1重量%から10重量%である。組成物の好ましい例としてチューインガムを挙げることができる。組成物がチューインガムである場合、組成物中のジャスミン茶抽出物の含有割合は好ましくは1.0重量%から10重量%である。これは、1.0重量%未満であると、充分なアルデヒド低減効果を得られず、一方、10重量%を超えると、結着性が悪く、ボソボソになり、成型できないためである。 The content of the jasmine tea extract in the composition is not limited, but is preferably 0.1% to 10% by weight in the composition. A preferred example of the composition is chewing gum. When the composition is chewing gum, the content of jasmine tea extract in the composition is preferably 1.0% to 10% by weight. This is because if the amount is less than 1.0% by weight, a sufficient aldehyde reduction effect cannot be obtained, while if it exceeds 10% by weight, the binding property is poor, and the shape becomes sober and cannot be molded.
また、本発明の組成物はリキッド部を含むことができる。リキッド部とは、適度な粘性を有する液体部分であり、組成物に内包され、組成物が咀嚼された際に、口腔内に流出することを目的とするものである。組成物がリキッド部を含む場合、好ましくは、リキッド部中のジャスミン茶抽出物の含有量はリキッド部あたり15重量%以下である。リキッド部中のジャスミン茶抽出物の含有割合が15重量%を超えると、リキッド部の粘性が高くなりすぎ、組成物内への充填が困難となることが考えられるためである。リキッド部にジャスミン茶抽出物を含有することで、組成物を咀嚼した直後に即効的な消臭効果を得ることができる。 Further, the composition of the present invention can contain a liquid part. The liquid part is a liquid part having an appropriate viscosity, and is intended to flow out into the oral cavity when the composition is encapsulated and the composition is chewed. When the composition includes a liquid part, the content of jasmine tea extract in the liquid part is preferably 15% by weight or less per liquid part. This is because if the content ratio of the jasmine tea extract in the liquid part exceeds 15% by weight, the liquid part becomes too viscous and it may be difficult to fill the composition. By containing the jasmine tea extract in the liquid part, an immediate deodorizing effect can be obtained immediately after chewing the composition.
本発明の組成物の例として、アセトアルデヒド低減のための食品である、チューインガム、キャンディ、錠菓、飲料、グミゼリー、チョコレート、ビスケット、アイスクリーム、シャーベット、あるいは、アセトアルデヒド低減のための医薬組成物である、口臭用スプレー、練り歯磨、トローチ、医薬用ガムを挙げることができる。 Examples of the composition of the present invention are chewing gum, candy, tablet confectionery, beverage, gummy jelly, chocolate, biscuits, ice cream, sherbet, or a pharmaceutical composition for reducing acetaldehyde. , Breath breath sprays, toothpastes, troches, and pharmaceutical gums.
本発明につき以下実施例を挙げて説明する。ただし、本発明は以下実施例に限定されることはない。 The present invention will be described below with reference to examples. However, the present invention is not limited to the following examples.
実施例1
アセトアルデヒド低減効果を有する物質のスクリーニング
アセトアルデヒド低減効果を有する物質のスクリーニングを行った。スクリーニングの対象としたのは、以下の物質である。すなわち、トマトパウダー、ブルーベリー抽出物、カシス抽出物、EGCg高純度品、ジャスミン茶抽出物、チャ抽出物、ヨウバイヒ抽出物、グレープシード抽出物、アッサム抽出物、ベニバナ抽出物、青シソ抽出物、フェンネルシード、シークワーサー、柿粉末、花椒抽出物末、セイロン抽出物、ユーカリ香料、カメリア抽出物、月見草抽出物、ライム香料、ローズマリー抽出物、ペパーミント香料、生豆コーヒー、パッションフラワー、紅茶抽出物、ダージリン抽出物、キャロットパウダー、赤シソ抽出物、カルダモン、カモミール抽出物、ミルク、マテ茶、レモンバーベナ、リンゴンベリー、ザクロ花、ルイボス茶抽出物、ノブドウ乾燥、ザクロ果実、ベルガモット抽出物、甜茶抽出物、エルダーベリー、セイヨウサンザシ、紅麹抽出物、金時草抽出物、グァバ抽出物、ホーステイル、クエン酸、プルーン抽出物、マンゴスチンアクア、ライチ種子、麦茶抽出物、ミントポリフェノール、マリアアザミ、バラ花、ほうじ茶抽出物、ソバの実抽出物、キンセンカ、ワサビ抽出物、レモンパウダー、レモンバーム、レッドクローバー、硫酸亜鉛、ユズポリフェノール、モリンガ、ムラサキサツマイモ、マキベリー、ブラッククミン、ヒハツ抽出物、バレリアン、ハトムギ、ドクダミ抽出物、銅クロロフィル、デビルスクロー、鉄クロロフィリンNa、タンポポ葉、セージ、セイヨウトネリコ、ジンジャー抽出物、ザクロエラグ酸、桜の花抽出物、玄米茶、ゲッケイジュ葉、クランベリー、クチナシ黄、クチナシ青、金時しょうが、キウイ種子、カクタス、オリーブ果実、うんしゅうみかん、ウメ抽出物、ウーロン茶抽出物、イチゴポリフェノール、アラニン、アムラ抽出、アマチャ、赤ブドウ葉、赤キャベツである。
Example 1
Screening of substances having an acetaldehyde reducing effect A substance having an acetaldehyde reducing effect was screened. The following substances were screened. That is, tomato powder, blueberry extract, cassis extract, EGCg high-purity product, jasmine tea extract, tea extract, sweet potato extract, grape seed extract, assam extract, safflower extract, blue perilla extract, fennel Seed, seeker, strawberry powder, flower bud extract powder, ceylon extract, eucalyptus fragrance, camellia extract, evening primrose extract, lime fragrance, rosemary extract, peppermint fragrance, green coffee, passion flower, tea extract, darjeeling Extract, carrot powder, red perilla extract, cardamom, chamomile extract, milk, mate tea, lemon verbena, lingonberry, pomegranate flower, rooibos tea extract, dried grapes, pomegranate fruit, bergamot extract, strawberry tea extract, Elderberry, hawthorn, red yeast rice extract , Kintoki grass extract, guava extract, horsetail, citric acid, prune extract, mangosteen aqua, lychee seed, barley tea extract, mint polyphenol, maria thistle, rose flower, roasted tea extract, buckwheat fruit extract, Calendula, Wasabi extract, Lemon powder, Lemon balm, Red clover, Zinc sulfate, Yuzu polyphenol, Moringa, Murasaki sweet potato, Macki berry, Black cumin, Hibatsu extract, Valerian, pearl barley, Dokudami extract, Copper chlorophyll, Devil's claw, Iron chlorophyllin Na, dandelion leaf, sage, ash, ginger extract, pomegranate ellagic acid, cherry blossom extract, brown rice tea, bay leaf, cranberry, gardenia yellow, gardenia blue, golden ginger, kiwi seed, cactus, olive fruit, sardine Tangerine, plum extract, oolong tea extract, strawberry polyphenols, alanine, Amla extract, hydrangea, red grape leaf, a red cabbage.
実験は、次の通り行った。すなわち、密栓可能なガラス試験管(容積18mL)に、0.2Mリン酸緩衝液(pH7.5)1mL、水あるいは試料溶液1mL(各試料100mgを1mLの水に溶解または分散させたもの)、アセトアルデヒド1/500(v/v)液0.5mLを添加し、密栓、撹拌後、37℃湯浴中で10分間放置した。10分後シリンジにて試験管ヘッドスペースガスを100μL回収し、ガスクロマトグラフィーでアセトアルデヒド量を分析した。水との比較でアセトアルデヒド消去量を算出した。
The experiment was conducted as follows. That is, in a glass test tube (capacity 18 mL) that can be sealed, 1 mL of 0.2 M phosphate buffer (pH 7.5), 1 mL of water or sample solution (100 mg of each sample dissolved or dispersed in 1 mL of water), 0.5 mL of
0.2Mリン酸緩衝液(pH7.5)1mL、水1mL、アセトアルデヒド1/500(v/v)液0.5mLを添加した場合に検出されたヘッドスペースガス中のアセトアルデヒド量は22.3μg/tubeであった(表1)。それぞれの物質によるヘッドスペースガス中のアセトアルデヒド消去量を表2に示す。ジャスミン茶抽出物はヘッドスペースガス中のアセトアルデヒドを3.0μg/tube、すなわち13.3重量%消去した。また、ジャスミン茶抽出物と同等の消去能を示した成分として、トマトパウダー(ヘッドスペースガス中のアセトアルデヒド消去量は3.4μg/tube、すなわち15.2重量%)、ブルーベリー抽出物(3.3μg/tube、すなわち15.0重量%)、カシス抽出物(3.3μg/tube、すなわち15.0重量%)、EGCg高純度品(3.0μg/tube、すなわち13.4重量%)、チャ抽出物(2.9μg/tube、すなわち13.1重量%)、ヨウバイヒ抽出物(2.9μg/tube、すなわち12.9重量%)、グレープシード抽出物(2.6μg/tube、すなわち11.7重量%)、アッサム抽出物(2.1μg/tube、すなわち9.2重量%)、ベニバナ抽出物(2.0μg/tube、すなわち9.1重量%)の9素材があった。これら9素材については、詳細な実験結果を表3に記載する。
The amount of acetaldehyde in the headspace gas detected when 1 mL of 0.2 M phosphate buffer (pH 7.5), 1 mL of water, and 0.5 mL of
なお、用いられた試料の詳細は以下の通りである。すなわち、トマトパウダーは、ブリックス値5のトマト果肉を使用した乾燥果実粉末である。ブルーベリー抽出物は、ブルーベリー果実からの抽出物であり、総アントシアニジン量は25.0%以上である。カシス抽出物は、カシス(クロスグリ)果実からの抽出物であり、総アントシアニン量は30.0%以上である。EGCg高純度品は、緑茶由来の抽出物であり、EGCg含量は90.0%以上である。チャ抽出物は、黄褐色の粉末であり、カテキン類の含量は30.0%以上である。ヨウバイヒ抽出物は、ヨウバイヒ(ヤマモモ)の樹皮から含水アルコールにて抽出を行ったものである。 The details of the samples used are as follows. That is, tomato powder is a dried fruit powder using tomato pulp with a Brix value of 5. The blueberry extract is an extract from blueberry fruits, and the total amount of anthocyanidins is 25.0% or more. A cassis extract is an extract from a cassis (black currant) fruit, and the total amount of anthocyanins is 30.0% or more. The EGCg high-purity product is an extract derived from green tea, and the EGCg content is 90.0% or more. The tea extract is a tan powder, and the content of catechins is 30.0% or more. The yoyohi extract is obtained by extracting with water-containing alcohol from the bark of yoyohi (bayberry).
グレープシード抽出物は、ブドウ種子からの抽出物であり、プロアントシアニジン含量は95.0%以上である。アッサム抽出物は、アッサム茶の茶葉を100%使用し、熱水抽出を行ったものである。ベニバナ抽出物は、乾燥した紅花由来の抽出物である。ジャスミン茶抽出物については、上記のとおりである。 The grape seed extract is an extract from grape seeds, and the proanthocyanidin content is 95.0% or more. Assam extract is a hot water extraction using 100% Assam tea leaves. The safflower extract is an extract derived from dried safflower. The jasmine tea extract is as described above.
表2中の数値は、ヘッドスペースガス中のアセトアルデヒド消去量(μg/tube)、並びにアセトアルデヒド消去率(重量%)を示す。
The numerical values in Table 2 indicate the acetaldehyde elimination amount (μg / tube) in the headspace gas and the acetaldehyde elimination rate (% by weight).
表3中の数値は、ヘッドスペースガス中のアセトアルデヒド消去量(μg/tube)を示す。
The numerical values in Table 3 indicate the amount of elimination of acetaldehyde (μg / tube) in the headspace gas.
上記の9種類のアセトアルデヒド低減効果が認められた物質から、本発明の実施形態の一つである、咀嚼されることにより口腔内のアルデヒドを低減することを特徴とする低減用組成物として、適した物質を選んだ。トマトパウダーやブルーベリー抽出物は素材特有の味が強く、香味や品種が限定されるため、咀嚼用組成物として最適でない。トマトパウダーは吸湿性が強く、組成物の物性に与える影響が大きい。カシス抽出物、アッサム抽出物、ベニバナ抽出物は渋みが強く、EGCg高純度品やチャ抽出物は苦み・渋みが特に強く、香味や品種が限定されるため、咀嚼用組成物として最適でない。ヨウバイヒ抽出物、グレープシード抽出物は組成物に含めると、咀嚼時、歯がうずくような(歯とガムがこすれ合うような)感触を与えるため、咀嚼用組成物として用いるのに最適でない。一方、ジャスミン茶抽出物は味・香りの点で、咀嚼用組成物として優れており、また、ミント香料、メントール香料との相性も良い。また、他の植物抽出物と比較して細かな粉末であり、咀嚼用組成物の一例である、ガムに用いる場合、ガムへの分散性および、リキッド部への分散性の点において、優れていた。以上を理由に、本発明においては、アセトアルデヒド低減効果を有する物質として最適な物質として、ジャスミン茶抽出物を選んだ。 Suitable as a reducing composition characterized by reducing the aldehyde in the oral cavity by chewing, which is one of the embodiments of the present invention, from the above-mentioned nine types of acetaldehyde-reducing effects. Selected material. Tomato powder and blueberry extract are not optimal as chewing compositions because of the strong taste peculiar to the material and limited flavor and variety. Tomato powder is highly hygroscopic and has a large effect on the physical properties of the composition. Cassis extract, Assam extract, and safflower extract have strong astringency, and EGCg high-purity product and tea extract have particularly strong bitterness and astringency, and their flavor and variety are limited, so they are not optimal as chewing compositions. When included in the composition, the yoihihi extract or grape seed extract gives a feeling of tooth tingling (such as teeth and gum rubbing) during chewing, and is therefore not optimal for use as a chewing composition. On the other hand, jasmine tea extract is excellent as a chewing composition in terms of taste and fragrance, and also has good compatibility with mint flavor and menthol flavor. In addition, it is a fine powder compared to other plant extracts, and is an example of a chewing composition. When used in gum, it is excellent in terms of dispersibility in the gum and dispersibility in the liquid part. It was. For the above reasons, in the present invention, jasmine tea extract was selected as the optimum substance as the substance having an acetaldehyde reducing effect.
実施例2
本発明の組成物の一例として、ジャスミン茶抽出物含有リキッドセンターガム1,ジャスミン茶抽出物含有リキッドセンターガム2および対照である対照リキッドセンターガムを作製した。これらのリキッドセンターガムは、ガム部、糖衣部、リキッド部からなり、ガム1粒は2.5グラムである。それぞれの配合を表4に示す。
Example 2
As an example of the composition of the present invention, jasmine tea extract-containing
表4中の数値はそれぞれの原料の重量%を示す。作製されたリキッドセンターガムはそれぞれ2.5グラム/粒である。
The numerical values in Table 4 indicate the weight percentage of each raw material. The prepared liquid center gums are each 2.5 grams / grain.
実施例3
ジャスミン茶抽出物配合ガムによる咀嚼唾液のアセトアルデヒド消去効果の評価
ジャスミン茶抽出物含有リキッドセンターガム1を2粒を咀嚼した被験者より唾液を10mL回収した。比較試料としてモリタ社製サリバリーガムを咀嚼した被験者の唾液も回収した。なお、被験者に対し、分泌された唾液は一切飲み込まずに回収容器に吐出するように指示を行った。ジャスミン茶抽出物含有リキッドセンターガム1とサリバリーガムの咀嚼はそれぞれ、唾液が10mL回収されるまで継続して行われた。密栓可能なガラス試験管(容積18mL)に、0.2Mリン酸緩衝液(pH7.5)1mL、それぞれの唾液1mL、アセトアルデヒド1/10000(v/v)液0.5mLを添加し、密栓、撹拌後、37℃湯浴中で30分間放置した。30分後シリンジにて試験管ヘッドスペースガスを100μL回収し、ガスクロマトグラフィーでアセトアルデヒド量を分析した。サリバリーガム咀嚼唾液でのヘッドスペースガス中のアセトアルデヒド量を100とした時のジャスミン茶抽出物含有リキッドセンターガム1咀嚼唾液のアセトアルデヒド量を算出した。
Example 3
Evaluation of acetaldehyde erasing effect of chewing saliva by using gum containing
結果を図1に示す。図1のグラフの縦軸は、サリバリーガムを咀嚼した被験者の唾液を用いた場合のヘッドスペースガス中のアセトアルデヒド量を100とした時のアセトアルデヒド量を示す。ジャスミン茶抽出物含有リキッドセンターガム1を咀嚼した被験者の唾液を用いた場合のヘッドスペースガス中のアセトアルデヒド量は78.7となり、揮発アセトアルデヒド量が2割強減少したことが示された。また、t検定の結果有意差が検出された(p<0.05)。
The results are shown in FIG. The vertical axis of the graph in FIG. 1 indicates the amount of acetaldehyde when the amount of acetaldehyde in the headspace gas when the saliva of a subject chewing saliva gum is used is 100. The amount of acetaldehyde in the headspace gas when using the saliva of a subject chewing the jasmine tea extract-containing
実施例4
ジャスミン茶抽出物含有リキッドセンターガム1溶出液の飲酒後呼気アセトアルデヒドへの影響評価
ジャスミン茶抽出物含有リキッドセンターガム1および対照リキッドセンターガムそれぞれ1粒から、乳棒・乳鉢を用い5mLの水で5分間溶出し、溶出液として用いた。
男性被験者3名(平均32.3±5.1歳)はビール(アサヒビール株式会社製スーパードライ)500mLを自分のペース(15分以内)を摂取し、飲酒後30分間安静を保った。30分の安静後、におい袋(3L)を1分間口にくわえ、自分の呼吸のペースで呼気をにおい袋に回収した(すすぎ前呼気)。次に、上記、溶出液2種のどちらか5mLで口を1分間すすぎ、同様ににおい袋を1分間口にくわえ、自分の呼吸ペースで呼気をにおい袋に回収した(すすぎ後呼気)。その後水で口をすすぎ、5分安静にし、2回目のすすぎ前呼気回収を行い、もう一方の溶出液5mLで口をすすぎ、すすぎ後の呼気回収を行った。におい袋から固相マイクロ抽出(SPME、SUPELCO社製)法によりアセトアルデヒドをファイバーに10分間吸着させた。吸着後、ガスクロマトグラフィーに供した。すすぎ前と比較し、減少したアセトアルデヒド量を算出した。なお、被験者2,3については上記の翌日(2日目)に、再度、すすぐ溶出液の順番を変更して、同様の実験を行った。
Example 4
Evaluation of the effects of
Three male subjects (average 32.3 ± 5.1 years old) ingested 500 mL of beer (Asahi Breweries Super Dry) at their own pace (within 15 minutes) and remained at rest for 30 minutes after drinking. After resting for 30 minutes, the smell bag (3 L) was put in the mouth for 1 minute, and the breath was collected in the smell bag at the pace of one's breath (exhalation before rinsing). Next, the mouth was rinsed with 5 mL of either of the two eluates described above for 1 minute, and similarly, the sachet was added to the mouth for 1 minute, and the breath was collected in the sachet at its own breathing pace (exhaled after rinsing). Thereafter, the mouth was rinsed with water, rested for 5 minutes, and the exhaled breath was collected before the second rinse. Acetaldehyde was adsorbed on the fiber for 10 minutes from the odor bag by solid-phase microextraction (SPME, manufactured by SUPELCO). After adsorption, it was subjected to gas chromatography. Compared with before rinsing, the amount of acetaldehyde decreased was calculated. For subjects 2 and 3, the same experiment was performed again on the next day (second day) by changing the order of the rinses.
結果を図2に示す。被験者1では、対照リキッドセンターガム溶出液ですすいだ時は0.0ppm(すすぎ前のアセトアルデヒド量:11.4ppm→すすぎ後:11.4ppm)、ジャスミン茶抽出物含有リキッドセンターガム1溶出液ですすいだ時は2.8ppm(すすぎ前:11.4ppm→すすぎ後:8.6ppm)呼気中のアセトアルデヒド量が減少した。被験者2では、1日目(対照リキッドセンターガム溶出液→ジャスミン茶抽出物含有リキッドセンターガム1溶出液)、2日目(ジャスミン茶抽出物含有リキッドセンターガム1溶出液→対照リキッドセンターガム溶出液)のアセトアルデヒド減少量はそれぞれ、対照リキッドセンターガム溶出液では7.0、0.4ppm(すすぎ前:103.3ppm、52.1ppm→すすぎ後:96.3ppm、51.7ppm)、ジャスミン茶抽出物含有リキッドセンターガム1溶出液では16.8、2.8ppm(すすぎ前:106.8ppm、53.8ppm→すすぎ後:90.0ppm、51.0ppm)であった。被験者3では、1日目、2日目のアセトアルデヒド減少量はそれぞれ、対照リキッドセンターガム溶出液では0.7、7.0ppm(すすぎ前:163.7ppm、209.3ppm→すすぎ後:163.0ppm、202.3ppm)、ジャスミン茶抽出物含有リキッドセンターガム1溶出液では26.7、36.5ppm(すすぎ前:200.2ppm、220.5ppm→すすぎ後:173.5ppm、184.0ppm)であった。被験者1の1回の結果並びに、被験者2,3のすすぐ順番を入れ替えた場合でも、ジャスミン茶抽出物含有リキッドセンターガム1溶出液ですすいだ場合の方が、対照リキッドセンターガム溶出液ですすいだ場合よりも呼気中アセトアルデヒドの減少量は大きかった。
The results are shown in FIG. In
図2には、3被験者(被験者1は1回の値、被験者2,3については2回の平均値)における、対照リキッドセンターガム溶出液、ジャスミン茶抽出物含有リキッドセンターガム1溶出液で口をすすいだ前後でのアセトアルデヒド減少量を示した。
In FIG. 2, the control liquid center gum eluate and the
実施例5
ジャスミン茶抽出物含有リキッドセンターガムにおける、ジャスミン茶抽出物の配合量の設定
表4にて示したジャスミン茶抽出物含有リキッドセンターガム1、並びにジャスミン茶抽出物含有リキッドセンターガム2においては、ガム総量中のジャスミン茶抽出物の配合量はそれぞれ、2.0重量%、3.2重量%である。また、リキッド部中のジャスミン茶抽出物の配合量はそれぞれ、2.1重量%、2.8重量%である。どちらのガムも、アセトアルデヒド消臭効果を示し、また、ガムの成形性に問題が無いことが判明している。
Example 5
Setting of blending amount of jasmine tea extract in jasmine tea extract-containing liquid center gum In jasmine tea extract-containing
まず、表4のジャスミン茶抽出物含有リキッドセンターガム1の配合を基本として、(1)リキッド部中のジャスミン茶抽出物の配合量を、ガム総量中1.07重量%(リキッド中15重量%)とした場合、(2)ガム総量中1.14%(リキッド中16重量%)とした場合、について、リキッドセンターガムの成形性について調べた。なお、ジャスミン茶抽出物の配合の増加分については、還元麦芽糖水あめ、グリセリン、ソルビトールシロップの配合量を、三者の配合比を保ちつつそれぞれ減少させることで、リキッド部総量が同じになるように各々調整を行った。
First, based on the formulation of Jasmine tea extract-containing
その結果、(1)のガム、すなわちリキッド中に15重量%のジャスミン茶抽出物を含有するガムについては、リキッド部の粘性が高いもののガム部への充填が可能であったが、(2)のガム、すなわちリキッド中に16重量%のジャスミン茶抽出物を含有するガムについては、リキッド部の粘性が高すぎてガム部内にリキッド部がうまく充填されない不良品が多く発生する結果となってしまった。 As a result, although the gum of (1), that is, the gum containing 15% by weight of jasmine tea extract in the liquid, although the viscosity of the liquid part was high, it was possible to fill the gum part, (2) In other words, a gum containing 16% by weight of jasmine tea extract in the liquid has a high viscosity of the liquid part, resulting in many defective products that do not fill the liquid part well. It was.
以上の結果より、リキッド部中のジャスミン茶抽出物の含有割合は、リキッド部あたり15重量%以下が好ましいことが判明した。 From the above results, it was found that the jasmine tea extract content in the liquid part is preferably 15% by weight or less per liquid part.
また、ガム総量中のジャスミン茶抽出物の配合量を変更した場合のガムの成形性がどのように変化するのかを確認するため、表4のジャスミン茶抽出物含有リキッドセンターガム1の配合を基本として、(3)ガム部中のジャスミン茶抽出物の配合量をガム総量中4.0重量%とした場合、(4)5.0重量%とした場合、(5)10重量%とした場合、(6)11重量%とした場合、について成形性を確認した。なお、リキッド部中のジャスミン茶抽出物の配合量は0とした。なお、ジャスミン茶抽出物の配合を増加させた分、エリスリトールの配合量をそれぞれ減少させることで、ガム部の総重量が一定になるように調整を行った。
In addition, in order to confirm how the moldability of the gum changes when the blending amount of the jasmine tea extract in the total gum amount is changed, the blending of the
その結果、(3)のガム、すなわちガム総量中4.0重量%のジャスミン茶抽出物を含有するガムについては、ジャスミン茶抽出物の影響により、一般的なガムよりもボソつきが若干強くなる傾向が見られたが、軟化剤の配合割合を増量して調整することでボソつきが抑えられ、成形することが可能となった。(4)のガム、すなわちガム総量中5.0重量%のジャスミン茶抽出物を含有するガム、並びに(5)のガム、すなわちガム総量中10重量%のジャスミン茶抽出物を含有するガムについては、ジャスミン茶抽出物の影響により、一般的なガムよりもボソつきがかなり強くなったが、軟化剤の配合割合を増量することに加え、還元麦芽糖水あめの配合割合を増量して調整することでボソつきが抑えられ、成形することが可能となった。 As a result, the gum of (3), that is, the gum containing 4.0% by weight of jasmine tea extract in the total amount of gum, is slightly stronger than general gum due to the influence of jasmine tea extract. Although a tendency was seen, by adjusting the blending ratio of the softener to increase, the stickiness was suppressed and molding became possible. Regarding the gum of (4), that is, the gum containing 5.0% by weight of jasmine tea extract in the total amount of gum, and the gum of (5), ie, the gum containing 10% by weight of jasmine tea extract in the total amount of gum. However, due to the influence of jasmine tea extract, the stickiness is considerably stronger than general gum, but in addition to increasing the blending ratio of softener, by adjusting the blending ratio of reduced maltose starch candy The stickiness is suppressed and molding is possible.
しかし、(6)のガム、すなわちガム総量中11重量%のジャスミン茶抽出物を含有するガムについては、ジャスミン茶抽出物の影響により、一般的なガムよりもボソつきが非常に強く、軟化剤と還元麦芽糖水あめの配合割合を大きく増量することで何とかボソつきが抑えられたものの、今度はガム全体が非常に柔らかくなってしまい、成形することが不可能となってしまった。 However, the gum of (6), that is, the gum containing 11% by weight of the jasmine tea extract in the total amount of the gum, is much stronger than the general gum due to the influence of the jasmine tea extract. However, the amount of blending of the reduced maltose starch candy was reduced to some extent, but this time the entire gum became very soft and it was impossible to mold it.
以上の結果より、ガム総量中のジャスミン茶抽出物の配合割合は、10重量%以下が好ましいことが判明した。 From the above results, it was found that the blending ratio of the jasmine tea extract in the total amount of gum is preferably 10% by weight or less.
更に、ガム総量中のジャスミン茶抽出物の配合量を低減させた場合、ガム咀嚼における呼気中のアセトアルデヒド量の減少がどのように変化するのかを確認するため、表4のジャスミン茶抽出物含有リキッドセンターガム1の配合を基本として、(7)ガム部中のジャスミン茶抽出物の配合量を1.35重量%(ガム総量中のジャスミン茶抽出物配合量は1.5重量%)とした場合、(8)0.85%(ガム総量中については1.0重量%)とした場合、(9)0.55%(ガム総量中については0.7重量%)とした場合、におけるアセトアルデヒド量の減少について調べた。なお、ジャスミン茶抽出物の配合の減少分を補うために、エリスリトールの配合量をそれぞれ増量させた。
試験は実施例3と同様にして行った。(7)~(9)のガムそれぞれ2粒を咀嚼した被験者から、唾液を10mL回収した。比較試料としてモリタ社製サリバリーガムを咀嚼した被験者の唾液も回収した。その後のアセトアルデヒド量の算出方法は、実施例3に準じた。
Furthermore, in order to confirm how the decrease in the amount of acetaldehyde in the breath during gum chewing changes when the blending amount of the jasmine tea extract in the total amount of gum is reduced, the liquid containing jasmine tea extract shown in Table 4 is used. Based on the blend of
The test was conducted in the same manner as in Example 3. 10 mL of saliva was collected from a subject who chewed two of each of the gums (7) to (9). As a comparative sample, saliva of a subject who chewed Morita's salvary gum was also collected. The subsequent calculation method of the amount of acetaldehyde was in accordance with Example 3.
その結果、(7)のガム、すなわちガム総量中1.5重量%のジャスミン茶抽出物を含有するガムについては、被験者の唾液のヘッドスペースガス中のアセトアルデヒド量は81.0であった。(8)のガム、すなわちガム総量中1.0重量%のジャスミン茶抽出物を含有するガムについては、被験者の唾液のヘッドスペースガス中のアセトアルデヒド量は84.7であった。一方、(9)のガム、すなわちガム総量中0.7重量%のジャスミン茶抽出物を含有するガムについては、被験者の唾液のヘッドスペースガス中のアセトアルデヒド量は95.2であった。このことにより、ガム総量中1.0重量%以上のジャスミン茶抽出物を配合するガムを咀嚼した場合はある程度のアセトアルデヒド低減効果が見られたものの、ガム総量中1.0重量%未満のジャスミン茶抽出物を配合するガムを咀嚼した場合は、アセトアルデヒド低減効果が急激に低くなることが判明した。 As a result, for the gum of (7), that is, the gum containing 1.5% by weight of jasmine tea extract in the total amount of gum, the amount of acetaldehyde in the headspace gas of the subject's saliva was 81.0. Regarding the gum of (8), that is, the gum containing 1.0% by weight of jasmine tea extract in the total amount of gum, the amount of acetaldehyde in the headspace gas of the subject's saliva was 84.7. On the other hand, for the gum of (9), that is, the gum containing 0.7% by weight of jasmine tea extract in the total amount of gum, the amount of acetaldehyde in the headspace gas of the subject's saliva was 95.2. As a result, when chewing gum containing 1.0% by weight or more of jasmine tea extract in the total gum amount, a certain degree of acetaldehyde reduction effect was seen, but less than 1.0% by weight of jasmine tea in the total gum amount It was found that the effect of reducing acetaldehyde was drastically reduced when chewing gum containing the extract.
実施例6
本発明の組成物として、チューインガム、キャンディ、錠菓、飲料、グミゼリー、チョコレート、ビスケット、アイスクリーム、シャーベット、口臭用スプレー、練り歯磨、トローチ、医薬用ガムのそれぞれについて、以下の処方をもとに、常法に従って製造した。これらはいずれも、摂取後に口腔内のアルデヒドの低減効果が示された。なお、各処方におけるジャスミン茶抽出物を、トマトパウダー、ブルーベリー抽出物、カシス抽出物、EGCg高純度品、チャ抽出物、ヨウバイヒ抽出物、グレープシード抽出物、アッサム抽出物、ベニバナ抽出物から選択されるいずれか1つ、もしくはこれらの組み合わせに変更した場合においても、組成物の摂取後に同様に、口腔内のアルデヒドの低減効果が示された。
Example 6
As a composition of the present invention, chewing gum, candy, tablet confectionery, beverage, gummy jelly, chocolate, biscuits, ice cream, sorbet, bad breath spray, toothpaste, troche, and pharmaceutical gum based on the following prescriptions Produced according to a conventional method. All of these showed a reduction effect of oral aldehyde after ingestion. The jasmine tea extract in each formulation is selected from tomato powder, blueberry extract, cassis extract, EGCg high-purity product, tea extract, loaf extract, grape seed extract, assam extract, safflower extract Even in the case of changing to any one of these or a combination thereof, the effect of reducing the aldehyde in the oral cavity was also shown after taking the composition.
チューインガムの処方
ガムベース 20.00重量%
マルチトール 52.70
キシリトール 15.30
エリスリトール 7.50
香料 0.50
ジャスミン茶抽出物 4.00
計 100.0
Chewing gum formula Gum base 20.00% by weight
Maltitol 52.70
Xylitol 15.30
Erythritol 7.50
Fragrance 0.50
Jasmine tea extract 4.00
Total 100.0
キャンディの処方
砂糖 50.0重量%
水飴 34.0
クエン酸 1.0
香料 0.2
ジャスミン茶抽出物 0.4
水 残
計 100.0
Candy formula Sugar 50.0% by weight
Minamata 34.0
Citric acid 1.0
Fragrance 0.2
Jasmine tea extract 0.4
Water balance 100.0
錠菓の処方
ソルビトール 95.1重量%
ショ糖脂肪酸エステル 0.2
香料 0.2
ジャスミン茶抽出物 0.5
水 残
計 100.0
Tablet Confectionery Sorbitol 95.1% by weight
Sucrose fatty acid ester 0.2
Fragrance 0.2
Jasmine tea extract 0.5
Water balance 100.0
飲料の処方
オレンジ果汁 30.00重量%
異性化糖 15.24
クエン酸 0.10
ビタミンC 0.04
香料 0.10
ジャスミン茶抽出物 0.10
水 残
計 100.0
Beverage formula Orange juice 30.00% by weight
Isomerized sugar 15.24
Citric acid 0.10
Vitamin C 0.04
Fragrance 0.10
Jasmine tea extract 0.10
Water balance 100.0
グミゼリーの処方
ゼラチン 59.05重量%
水飴 23.00
砂糖 8.50
植物油脂 4.50
マンニトール 2.95
レモン果汁 1.00
ジャスミン茶抽出物 1.00
計 100.0
Gummy jelly formula Gelatin 59.05% by weight
Minamata 23.00
Sugar 8.50
Vegetable oil 4.50
Mannitol 2.95
Lemon juice 1.00
Jasmine tea extract 1.00
Total 100.0
チョコレートの処方
粉糖 40.80重量%
カカオビター 20.00
全脂粉乳 20.00
カカオバター 17.00
マンニトール 1.00
香料 0.20
ジャスミン茶抽出物 1.00
計 100.0
Chocolate formula Powdered sugar 40.80% by weight
Cocoa bitter 20.00
Whole milk powder 20.00
Cocoa butter 17.00
Mannitol 1.00
Fragrance 0.20
Jasmine tea extract 1.00
Total 100.0
ビスケットの処方
薄力粉1級 25.59重量%
中力粉1級 22.22
精白糖 4.80
食塩 0.73
ブドウ糖 0.78
パームショートニング 11.78
炭酸水素ナトリウム 0.17
重亜硫酸ナトリウム 0.16
米粉 1.45
全脂粉乳 1.16
代用粉乳 0.29
ジャスミン茶抽出物 0.50
水 残
計 100.0
Biscuit prescription
Medium strength powder 1st class 22.22
Refined sugar 4.80
Salt 0.73
Glucose 0.78
Palm shortening 11.78
Sodium bicarbonate 0.17
Sodium bisulfite 0.16
Rice flour 1.45
Whole milk powder 1.16
Substitute milk powder 0.29
Jasmine tea extract 0.50
Water balance 100.0
アイスクリームの処方
脱脂粉乳 50.0重量%
生クリーム 25.0
砂糖 10.0
卵黄 10.0
ジャスミン茶抽出物 0.5
香料 0.1
水 残
計 100.0
Ice cream formula Nonfat dry milk 50.0% by weight
Fresh cream 25.0
Sugar 10.0
Egg yolk 10.0
Jasmine tea extract 0.5
Fragrance 0.1
Water balance 100.0
シャーベットの処方
オレンジ果汁 25.0重量%
砂糖 25.0
卵白 10.0
ジャスミン茶抽出物 1.0
水 残
計 100.0
Sherbet prescription Orange juice 25.0% by weight
Sugar 25.0
Egg white 10.0
Jasmine tea extract 1.0
Water balance 100.0
口臭用スプレーの処方
エタノール 10.0重量%
グリセリン 5.0
香料 0.05
着色料 0.001
ジャスミン茶抽出物 1.0
水 残
計 100.0
Formula for spray of bad breath ethanol 10.0% by weight
Glycerin 5.0
Fragrance 0.05
Coloring 0.001
Jasmine tea extract 1.0
Water balance 100.0
練り歯磨の処方
炭酸カルシウム 50.0重量%
グリセリン 20.0
カルボキシメチルセルロース 2.0
ラウリル硫酸ナトリウム 2.0
香料 1.0
サッカリン 0.1
ジャスミン茶抽出物 1.0
クロルヘキシジン 0.01
水 残
計 100.0
Toothpaste prescription Calcium carbonate 50.0% by weight
Glycerin 20.0
Carboxymethylcellulose 2.0
Sodium lauryl sulfate 2.0
Fragrance 1.0
Saccharin 0.1
Jasmine tea extract 1.0
Chlorhexidine 0.01
Water balance 100.0
トローチの処方
ブドウ糖 72.3重量%
乳糖 19.0
アラビアガム 6.0
香料 1.0
モノフルオロリン酸ナトリウム 0.7
ジャスミン茶抽出物 1.0
計 100.0
Lozenges glucose 72.3% by weight
Lactose 19.0
Gum arabic 6.0
Fragrance 1.0
Sodium monofluorophosphate 0.7
Jasmine tea extract 1.0
Total 100.0
医薬用ガムの処方
ガムベース 20.0重量%
マルチトール 50.7
キシリトール 9.3
エリスリトール 6.0
ジャスミン茶抽出物 10.0
軟化剤 2.0
還元麦芽糖水あめ 2.0
計 100.0
Pharmaceutical gum formulation Gum base 20.0% by weight
Maltitol 50.7
Xylitol 9.3
Erythritol 6.0
Jasmine tea extract 10.0
Softener 2.0
Reduced maltose syrup 2.0
Total 100.0
この出願は2014年7月25日に出願された日本国特許出願第2014-152066号からの優先権を主張するものであり、その内容を引用してこの出願の一部とするものである。
This application claims priority from Japanese Patent Application No. 2014-152066 filed on July 25, 2014, the contents of which are incorporated herein by reference.
Claims (7)
The composition for reducing aldehyde according to claim 6, wherein the composition comprises a liquid part, and the jasmine tea extract in the liquid part is 15% by weight or less.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020177004535A KR20170038842A (en) | 2014-07-25 | 2015-07-24 | Composition for reducing aldehyde |
| CN201580041150.XA CN106573027A (en) | 2014-07-25 | 2015-07-24 | Aldehyde reducing composition |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014152066A JP2016030723A (en) | 2014-07-25 | 2014-07-25 | Composition for aldehyde reduction |
| JP2014-152066 | 2014-07-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2016013228A1 true WO2016013228A1 (en) | 2016-01-28 |
| WO2016013228A9 WO2016013228A9 (en) | 2017-03-02 |
Family
ID=55162768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2015/003713 Ceased WO2016013228A1 (en) | 2014-07-25 | 2015-07-24 | Composition for reducing aldehyde |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2016030723A (en) |
| KR (1) | KR20170038842A (en) |
| CN (1) | CN106573027A (en) |
| WO (1) | WO2016013228A1 (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4913368A (en) * | 1972-05-26 | 1974-02-05 | ||
| JPH0930941A (en) * | 1995-07-21 | 1997-02-04 | Pola Chem Ind Inc | Composition for oral cavity |
| JPH11123068A (en) * | 1997-10-22 | 1999-05-11 | Toshio Imanaka | Foul breath preventing tea |
| JP2003310213A (en) * | 2002-04-30 | 2003-11-05 | Kanebo Ltd | Food for lean figure |
| WO2009020227A1 (en) * | 2007-08-09 | 2009-02-12 | Lotte Co., Ltd. | Liquid-centered gum composition |
| CN101416926A (en) * | 2008-11-21 | 2009-04-29 | 福建福泽医药器械科技有限公司 | Grapefruit mouth spraying agent and preparation method thereof |
| JP2011030575A (en) * | 2003-11-14 | 2011-02-17 | Cadbury Holdings Ltd | Liquid-filled confectionery composition |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3334725B2 (en) * | 1993-03-12 | 2002-10-15 | 株式会社 伊藤園 | Accelerator for reducing alcohol in the body, its metabolites and oral freshener |
| JP3875733B2 (en) * | 1994-12-16 | 2007-01-31 | 株式会社 伊藤園 | Body acetaldehyde metabolism promoter and method for producing the same |
| JPH08266604A (en) | 1995-03-30 | 1996-10-15 | Tama Seikagaku Kk | Deodorizing/antibacterial agent |
| CN1254186C (en) * | 2004-06-01 | 2006-05-03 | 裘泉法 | Tea taste chewing gum without sugar and its preparation |
| CN102599324B (en) * | 2012-03-16 | 2013-06-26 | 常熟市汇丰食品有限公司 | Fragrant plant gum and preparation method thereof |
| CN104161231A (en) * | 2014-07-09 | 2014-11-26 | 孙祥 | Scented tea jelly capable of refreshing breath and preparation method thereof |
-
2014
- 2014-07-25 JP JP2014152066A patent/JP2016030723A/en active Pending
-
2015
- 2015-07-24 CN CN201580041150.XA patent/CN106573027A/en active Pending
- 2015-07-24 KR KR1020177004535A patent/KR20170038842A/en not_active Withdrawn
- 2015-07-24 WO PCT/JP2015/003713 patent/WO2016013228A1/en not_active Ceased
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4913368A (en) * | 1972-05-26 | 1974-02-05 | ||
| JPH0930941A (en) * | 1995-07-21 | 1997-02-04 | Pola Chem Ind Inc | Composition for oral cavity |
| JPH11123068A (en) * | 1997-10-22 | 1999-05-11 | Toshio Imanaka | Foul breath preventing tea |
| JP2003310213A (en) * | 2002-04-30 | 2003-11-05 | Kanebo Ltd | Food for lean figure |
| JP2011030575A (en) * | 2003-11-14 | 2011-02-17 | Cadbury Holdings Ltd | Liquid-filled confectionery composition |
| WO2009020227A1 (en) * | 2007-08-09 | 2009-02-12 | Lotte Co., Ltd. | Liquid-centered gum composition |
| CN101416926A (en) * | 2008-11-21 | 2009-04-29 | 福建福泽医药器械科技有限公司 | Grapefruit mouth spraying agent and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| SEIKI TANADA ET AL.: "Sick House Syndrome Kanren Formaldehyde ni Taisuru Seiyu Seibun Masking Koka", JAPANESE SOCIETY OF PUBLIC HEALTH SOKAI SHOROKUSHU, vol. 63 rd, 15 October 2004 (2004-10-15), pages 921 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106573027A (en) | 2017-04-19 |
| JP2016030723A (en) | 2016-03-07 |
| WO2016013228A9 (en) | 2017-03-02 |
| KR20170038842A (en) | 2017-04-07 |
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