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WO2016013023A2 - Procédé et système de mesure de l'hémoglobine - Google Patents

Procédé et système de mesure de l'hémoglobine Download PDF

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Publication number
WO2016013023A2
WO2016013023A2 PCT/IN2015/000292 IN2015000292W WO2016013023A2 WO 2016013023 A2 WO2016013023 A2 WO 2016013023A2 IN 2015000292 W IN2015000292 W IN 2015000292W WO 2016013023 A2 WO2016013023 A2 WO 2016013023A2
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WO
WIPO (PCT)
Prior art keywords
image
conjunctiva
haemoglobin
hsv
rgb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2015/000292
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English (en)
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WO2016013023A3 (fr
Inventor
Abhishek Sen
Aman Midha
Sreyas V. Pariyath
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Biosense Technologies Pvt Ltd
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Biosense Technologies Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of WO2016013023A2 publication Critical patent/WO2016013023A2/fr
Publication of WO2016013023A3 publication Critical patent/WO2016013023A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes

Definitions

  • the present invention relates to haemoglobin measurement, more particularly, to non-invasive systems for haemoglobin measurement and method thereof.
  • Haemoglobin is an iron containing protein in blood cells which carries oxygen around the body. Lack of haemoglobin in blood results in inadequate supply of oxygen to the body and causes various complications such as anaemia. Some of the main causes of anaemia are loss of blood, nutritional deficiency, bone marrow problems, kidney failure, abnormal haemoglobin structure, etc. Also, a high level of haemoglobin in blood leads to several complications since it can impair circulation and also lead to abnormal clotting. Measurement of haemoglobin in blood is thus an important routine procedure for monitoring patients under treatment and for screening of anemia. Several invasive and non-invasive techniques are available for measurement of haemoglobin. Invasive techniques include drawing of blood sample which is a painful experience for a patient. Also, it exposes a health care provider handling the blood sample to risk of infectious diseases.
  • Non-invasive techniques include use of devices similar to oximeters on a thumb or an ear of patient to measure the level of haemoglobin.
  • these oximeters are expensive and are mostly used in intensive care units for continous monitoring of the patient.
  • Another conventional method of checking for low levels of haemoglobin i.e. checking for anaemic conditions of the subject is to check conjunctiva of the eye of the subject visually by a healthcare worker.
  • the conjunctiva is a thin membrane that covers inner surface of the eyelid and white part of the eyeball.
  • the conjunctiva is normally visible when the eye is pulled down.
  • Doctors/physicians usually check the conjunctiva for its redness or paleness to examine anaemic condition of the patient.
  • the anterior and the posterior rim of the conjunctiva will be same and will be pale.
  • the anterior rim of the conjunctiva will have more redness and will be dissimilar to that of the posterior part.
  • the present invention preferably provides non-invasive systems for haemoglobin measurement and method thereof.
  • a system for haemoglobin measurement comprises an image capturing device for capturing an image of conjunctiva along with an image of colour mat for correcting the image of conjunctiva; a light source for providing light during imaging of conjunctiva; a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the
  • the present invention provides a system for haemoglobin measurement, the system comprising an external device, comprising: an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a colour mat, adapted to the optical chamber, for correcting an image of conjunctiva; a light source, adapted to the optical chamber, for providing light during imaging of conjunctiva; an external power , source for providing power to the light source; and a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; and an electronic device, adapted to the external device, the electronic device comprising: an image capturing device for capturing the image of conjunctiva along with the image of colour mat; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin measurement
  • a method of haemoglobin measurement comprises capturing an image of conjunctiva along with an image of colour mat, by an image capturing device; correcting the image of conjunctiva based on value of the image of colour mat; determining a RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva; comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva; correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva; measuring the level of haemoglobin by comparing the corrected RGB, HSV, or LAB value of the image of conjunctiva with a calibrated
  • FIG. 1 shows a system for haemoglobin measurement according to the present invention.
  • Figure 2 shows a method of haemoglobin measurement according to the present invention.
  • Various embodiments of the present invention provide a systems and methods for haemoglobin measurement. More particularly the invention is directed to analyzing conjunctiva of an eye for measuring the level of haemoglobin of a subject/patient.
  • the present invention provides a system for haemoglobin measurement, the system comprises an external device, the external device includes a colour mat, an optical chamber, a light source, and a diffuser adapted to the light source, the external device adaptable to an eye of a subject under test; and an electronic device, adaptable to the external device, the electronic device includes an image capturing device a processor, a display, and a-storage means.
  • the image capturing device is for capturing an image of conjunctiva of the eye and an image of the colour mat illuminated by the light source provided on the external device or the electronic device.
  • the processor is configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat; identifying plurality of RGB (Red, Green, and Blue), HSV (Hue, Saturation, and Value), or LAB (L for lightness, and A, and B for the colour-opponent dimensions, based on nonlinearly compressed coordinates) of the image of conjunctiva, determining the RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated color values of haemoglobin to retrieve a value which indicates the level of haemoglobin, and displaying and storing the measured level of haemoglobin on the display and the storage means respectively.
  • RGB Red, Green, and Blue
  • HSV Human, Saturation, and Value
  • LAB L for lightness, and
  • the external device can be retrofitted on electronic devices such as a cell phone, a tablet, a phablet, a camera with a processor or a processing unit, or other portable electronic devices. Accordingly, the external device can be adapted to different types of electronic .... devices and the external device is not limited to the arrangement illustrated.
  • a system for haemoglobin measurement comprises an external device and an electronic device.
  • the external device is capable of being adapted to an eye of a subject/patient, by an eye cap.
  • the external device comprises a first adapter, a fastening base, a light source, an optical chamber, a diffuser, a diffuser fastener, a colour mat, a second adapter, and an eye cap.
  • the first adapter is provided for adapting the electronic device with the external device.
  • the first adapter holds the electronic device such that the image capturing device of the electronic device is aligned with the external device.
  • the first adapter has means for accommodating a power source for the light source of the external device.
  • the light source comprises a switch for illumination of the light. Alternately, the light source of the external device can be powered through the electronic device via suitable means.
  • the fastening base fastens- the optical chamber with the first adapter, and the light source inside the optical chamber.
  • the second adapter is adapted to the optical chamber to hold the colour mat in front of the light source inside the optical chamber, and has a means for holding the eye cap.
  • eye cap is placed on the eye during imaging of conjunctiva.
  • the eye cap is removable.
  • the optical chamber, and the eye cap adapted to the second adapter of the external device are light occluding.
  • the optical chamber, and the eye cap adapted the second adapter covers the eye such that the eye is isolated from ambient light.
  • the light source of the external device is turned on by a switch and the eye is illuminated.
  • the diffuser is provided in front of the light source, by a diffuser fastener, such that that light spreads uniformly over the entire eye area, thereby avoiding any patchy illumination.
  • conjunctiva Upon illuminating the eye, conjunctiva is exposed by pulling down lower eyelid of the eye. Subsequently at-least one image of the conjunctiva along with the colour mat is captured via the image capturing device.
  • a processing module of the electronic device configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the measured level of haemoglobin from the processing module.
  • the present invention provides a system for haemoglobin measurement, the system comprising an image capturing device for capturing an image of conjunctiva along with an image of colour mat for correcting the image of conjunctiva; a light source for providing light during imaging of conjunctiva; a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to receive and
  • the colour mat consists of colour combination of red, grey, white, and simulated colours matching those of skin; and the light source is configured to provide stable light during imaging of conjunctiva, includes a power source to provide energy for enabling the light.
  • the light source can be included in the external device or the electronic device.
  • the optical chamber prevent external light from entering the eye during imaging of conjunctiva; the optical chamber includes a partition for preventing light directly emitted from the light source entering the image capturing device.
  • the optical chamber includes a removable eye cap to surround the eye during imaging of conjunctiva.
  • pixel by pixel operation is performed, by the processing module, on the image of conjunctiva and the colour mat, captured by the image capturing device, to obtain colour values.
  • the colour values of the image of conjunctiva and the colour mat are then, compared with the original colours of the colour mat; and a ratiometric correction using gamma correction and/ or exposure correction are performed.
  • the determination of the RGB, HSV, or LAB value of the image of conjunctiva, by the processing module includes determining the RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva, comparing the RGB, HSV, or LAB value of the image of the conjunctiva and the selected portion of the image of conjunctiva, determining an updated RGB, HSV, or LAB value of the image of conjunctiva, and correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva.
  • the calibrated colour values of haemoglobin consist of the RGB, HSV, or LAB value and its corresponding level of haemoglobin.
  • the display module is adapted to print the displayed measured haemoglobin in gm/dL.
  • the display module is configured to transmit the measured haemoglobin to remote server for record and further analysis.
  • a method of haemoglobin measurement comprises capturing an image of conjunctiva along with an image of colour mat, by an image capturing device; correcting the image of conjunctiva based on value of the image of colour mat; determining a RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva; comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva; correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva; measuring the level of haemoglobin by comparing the corrected RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour
  • the correcting and eliminating of method of image of conjunctiva consist of gamma correction, exposure correction, white balancing, elimination of reflection and artifacts, and other image processing and corrections applied individually or in combination depending on the image of conjunctiva.
  • pixel by pixel operation is performed, by the processing module, on the image of conjunctiva and the colour mat, captured by the image capturing device, to obtain colour values.
  • the colour values of the image of conjunctiva and the colour mat are then compared with the original colours of the colour mat; and a ratiometric correction using gamma correction and/ or exposure correction are performed.
  • the method of capturing the image of conjunctiva includes enabling a light of a light source; surrounding an eye, by an optical chamber, to prevent external light from entering the eye during imaging of conjunctiva; and capturing the image of conjunctiva along with the image of colour mat, by the image capturing device.
  • the system (100) comprises an image capturing device (110) for capturing an image of conjunctiva (185) along with an image of colour mat (140) for correcting the image of conjunctiva (185); a light source (150) for providing stable light during imaging of conjunctiva; a diffuser (160) adapted to the light source (150) for providing uniform light during imaging of conjunctiva; an optical barrier (170) for preventing external light (190) from entering an eye (180) during imaging of conjunctiva; a processing module (120) for processing the captured image and measuring the level of haemoglobin; and a display module (130) for displaying the measured level of haemoglobin from the processing module (120).
  • an image capturing device for capturing an image of conjunctiva (185) along with an image of colour mat (140) for correcting the image of conjunctiva (185)
  • a light source (150) for providing stable light during imaging of conjunctiva
  • the processing module (120) configured to receive and process the image captured from the image capturing device (110), for correcting the image of conjunctiva (185) based on value of the image of colour mat (140), determing a RGB, HSV, or LAB value of the image of the conjunctiva (185), and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva (185) with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin.
  • the image capturing device (110) is adapted to the optical chamber (170) for capturing the image of conjunctiva (185) and the colour mat (140).
  • the optical chamber (170) is adapted to include the light source (150), the color mat (140), and the diffuser (160) adapted to the light source (150) according to an embodiment of the present invention.
  • the optical chamber (170) includes a partition (175) for preventing light directly emitted from the light source (150) entering the image capturing device (110) during imaging of the conjunctiva.
  • the image of conjunctiva and colour mat captured from the image capturing device (110) is transferred to the processing module (120) for processing and measuring the level of haemoglobin, and the display module (130) displays the measured level of haemoglobin received from the processing module (120).
  • the image capturing device (110), processing module (120), and the display module (130) can be elements of single electronic device.
  • the method (200) comprises the steps of capturing an image of conjunctiva along with an image of colour mat, by an image capturing device (210); correcting the image of conjunctiva based on value of the image of colour mat (220); determining a RGB, HSV, or LAB value of the image of conjunctiva (230); selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva (240); comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva (250); correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva (260); measuring the level of haemoglobin, a a gamma correction, exposure correction and reflection of the image of conjunctiva (260); measuring
  • the method of capturing the image of conjunctiva along with the image of colour mat (210), the method (2 0) includes enabling a light of a light source; surrounding an eye, by an optical chamber, to prevent external light from entering the eye during imaging of conjunctiva; and capturing the image of conjunctiva along with the image of colour mat, by the image capturing device.
  • the correcting and eliminating of method of image of conjunctiva consist of gamma correction, exposure correction, white balancing, elimination of reflection and artifacts, and other image processing and corrections applied individually or in combination depending on the image of conjunctiva.
  • the calibrated colour values of haemoglobin of method of measuring the level of haemoglobin consists of the RGB, HSV, or LAB value and its corresponding level of haemoglobin.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
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  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

La présente invention concerne, de préférence, un système non invasif de mesure de l'hémoglobine et un procédé associé. Ce système de mesure de l'hémoglobine comprend un dispositif de capture d'image permettant de capturer une image de la conjonctive en même temps qu'une image d'un nuancier destiné à corriger l'image de la conjonctive ; une source de lumière destinée à fournir de la lumière pendant la formation de l'image de la conjonctive ; un diffuseur adapté à la source de lumière et destiné à fournir une lumière uniforme pendant la formation de l'image de la conjonctive ; une chambre optique destinée à empêcher la lumière extérieure d'entrer dans l'œil pendant la formation de l'image de la conjonctive ; un module de traitement, configuré pour recevoir et traiter l'image capturée par le dispositif de capture d'image, corriger l'image de la conjonctive sur la base de la valeur de l'image du nuancier, déterminer la valeur RGB, HSV ou LAB de l'image de la conjonctive et mesurer le niveau d'hémoglobine en comparant la valeur RGB, HSV ou LAB de l'image de la conjonctive avec des valeurs de couleur étalonnées de l'hémoglobine pour obtenir une valeur indiquant le niveau d'hémoglobine ; et un module d'affichage, configuré pour afficher le niveau que le module de traitement aura mesuré pour l'hémoglobine.
PCT/IN2015/000292 2014-07-19 2015-07-20 Procédé et système de mesure de l'hémoglobine Ceased WO2016013023A2 (fr)

Applications Claiming Priority (2)

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IN1677MU2014 2014-07-19
IN1677/MUM/2014 2014-07-19

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WO2016013023A2 true WO2016013023A2 (fr) 2016-01-28
WO2016013023A3 WO2016013023A3 (fr) 2016-03-24

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700043624A1 (it) * 2017-04-20 2018-10-20 Giovanni Dimauro Stima immediata e non invasiva della concentrazione dell’emoglobina nel sangue
WO2023275774A1 (fr) * 2021-06-29 2023-01-05 Universita' Degli Studi Di Bari Aldo Moro Dispositif non invasif pour l'estimation rapide de l'anémie

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US4998533A (en) * 1986-07-15 1991-03-12 Winkelman James W Apparatus and method for in vivo analysis of red and white blood cell indices
US7711403B2 (en) * 2001-04-05 2010-05-04 Rhode Island Hospital Non-invasive determination of blood components
FR2833827B1 (fr) * 2001-12-21 2004-12-10 Oreal Procede d'evaluation de la region du contour de l'oeil et dispositif pour la mise en oeuvre d'un tel procede
WO2008050234A2 (fr) * 2006-10-27 2008-05-02 Hemohue Ltd Dispositif pour mesurer le taux d'hémoglobine.
CN102917634A (zh) * 2010-03-23 2013-02-06 神经视觉成像有限责任公司 对眼睛成像的装置和方法
US9854970B2 (en) * 2012-02-21 2018-01-02 Massachusetts Eye & Ear Infirmary Calculating conjunctival redness
SG11201406239YA (en) * 2012-04-23 2014-11-27 Univ Nanyang Tech Portable optics adapter to digital camera for fundus imaging
CN104837404B (zh) * 2012-12-10 2018-05-18 皇家飞利浦有限公司 使用相机-投影机系统在事故期间测量血红蛋白水平的医学设备或系统

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700043624A1 (it) * 2017-04-20 2018-10-20 Giovanni Dimauro Stima immediata e non invasiva della concentrazione dell’emoglobina nel sangue
WO2023275774A1 (fr) * 2021-06-29 2023-01-05 Universita' Degli Studi Di Bari Aldo Moro Dispositif non invasif pour l'estimation rapide de l'anémie

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