WO2016013023A2 - Method and system for haemoglobin measurement - Google Patents
Method and system for haemoglobin measurement Download PDFInfo
- Publication number
- WO2016013023A2 WO2016013023A2 PCT/IN2015/000292 IN2015000292W WO2016013023A2 WO 2016013023 A2 WO2016013023 A2 WO 2016013023A2 IN 2015000292 W IN2015000292 W IN 2015000292W WO 2016013023 A2 WO2016013023 A2 WO 2016013023A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- image
- conjunctiva
- haemoglobin
- hsv
- rgb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
Definitions
- the present invention relates to haemoglobin measurement, more particularly, to non-invasive systems for haemoglobin measurement and method thereof.
- Haemoglobin is an iron containing protein in blood cells which carries oxygen around the body. Lack of haemoglobin in blood results in inadequate supply of oxygen to the body and causes various complications such as anaemia. Some of the main causes of anaemia are loss of blood, nutritional deficiency, bone marrow problems, kidney failure, abnormal haemoglobin structure, etc. Also, a high level of haemoglobin in blood leads to several complications since it can impair circulation and also lead to abnormal clotting. Measurement of haemoglobin in blood is thus an important routine procedure for monitoring patients under treatment and for screening of anemia. Several invasive and non-invasive techniques are available for measurement of haemoglobin. Invasive techniques include drawing of blood sample which is a painful experience for a patient. Also, it exposes a health care provider handling the blood sample to risk of infectious diseases.
- Non-invasive techniques include use of devices similar to oximeters on a thumb or an ear of patient to measure the level of haemoglobin.
- these oximeters are expensive and are mostly used in intensive care units for continous monitoring of the patient.
- Another conventional method of checking for low levels of haemoglobin i.e. checking for anaemic conditions of the subject is to check conjunctiva of the eye of the subject visually by a healthcare worker.
- the conjunctiva is a thin membrane that covers inner surface of the eyelid and white part of the eyeball.
- the conjunctiva is normally visible when the eye is pulled down.
- Doctors/physicians usually check the conjunctiva for its redness or paleness to examine anaemic condition of the patient.
- the anterior and the posterior rim of the conjunctiva will be same and will be pale.
- the anterior rim of the conjunctiva will have more redness and will be dissimilar to that of the posterior part.
- the present invention preferably provides non-invasive systems for haemoglobin measurement and method thereof.
- a system for haemoglobin measurement comprises an image capturing device for capturing an image of conjunctiva along with an image of colour mat for correcting the image of conjunctiva; a light source for providing light during imaging of conjunctiva; a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the
- the present invention provides a system for haemoglobin measurement, the system comprising an external device, comprising: an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a colour mat, adapted to the optical chamber, for correcting an image of conjunctiva; a light source, adapted to the optical chamber, for providing light during imaging of conjunctiva; an external power , source for providing power to the light source; and a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; and an electronic device, adapted to the external device, the electronic device comprising: an image capturing device for capturing the image of conjunctiva along with the image of colour mat; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin measurement
- a method of haemoglobin measurement comprises capturing an image of conjunctiva along with an image of colour mat, by an image capturing device; correcting the image of conjunctiva based on value of the image of colour mat; determining a RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva; comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva; correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva; measuring the level of haemoglobin by comparing the corrected RGB, HSV, or LAB value of the image of conjunctiva with a calibrated
- FIG. 1 shows a system for haemoglobin measurement according to the present invention.
- Figure 2 shows a method of haemoglobin measurement according to the present invention.
- Various embodiments of the present invention provide a systems and methods for haemoglobin measurement. More particularly the invention is directed to analyzing conjunctiva of an eye for measuring the level of haemoglobin of a subject/patient.
- the present invention provides a system for haemoglobin measurement, the system comprises an external device, the external device includes a colour mat, an optical chamber, a light source, and a diffuser adapted to the light source, the external device adaptable to an eye of a subject under test; and an electronic device, adaptable to the external device, the electronic device includes an image capturing device a processor, a display, and a-storage means.
- the image capturing device is for capturing an image of conjunctiva of the eye and an image of the colour mat illuminated by the light source provided on the external device or the electronic device.
- the processor is configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat; identifying plurality of RGB (Red, Green, and Blue), HSV (Hue, Saturation, and Value), or LAB (L for lightness, and A, and B for the colour-opponent dimensions, based on nonlinearly compressed coordinates) of the image of conjunctiva, determining the RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated color values of haemoglobin to retrieve a value which indicates the level of haemoglobin, and displaying and storing the measured level of haemoglobin on the display and the storage means respectively.
- RGB Red, Green, and Blue
- HSV Human, Saturation, and Value
- LAB L for lightness, and
- the external device can be retrofitted on electronic devices such as a cell phone, a tablet, a phablet, a camera with a processor or a processing unit, or other portable electronic devices. Accordingly, the external device can be adapted to different types of electronic .... devices and the external device is not limited to the arrangement illustrated.
- a system for haemoglobin measurement comprises an external device and an electronic device.
- the external device is capable of being adapted to an eye of a subject/patient, by an eye cap.
- the external device comprises a first adapter, a fastening base, a light source, an optical chamber, a diffuser, a diffuser fastener, a colour mat, a second adapter, and an eye cap.
- the first adapter is provided for adapting the electronic device with the external device.
- the first adapter holds the electronic device such that the image capturing device of the electronic device is aligned with the external device.
- the first adapter has means for accommodating a power source for the light source of the external device.
- the light source comprises a switch for illumination of the light. Alternately, the light source of the external device can be powered through the electronic device via suitable means.
- the fastening base fastens- the optical chamber with the first adapter, and the light source inside the optical chamber.
- the second adapter is adapted to the optical chamber to hold the colour mat in front of the light source inside the optical chamber, and has a means for holding the eye cap.
- eye cap is placed on the eye during imaging of conjunctiva.
- the eye cap is removable.
- the optical chamber, and the eye cap adapted to the second adapter of the external device are light occluding.
- the optical chamber, and the eye cap adapted the second adapter covers the eye such that the eye is isolated from ambient light.
- the light source of the external device is turned on by a switch and the eye is illuminated.
- the diffuser is provided in front of the light source, by a diffuser fastener, such that that light spreads uniformly over the entire eye area, thereby avoiding any patchy illumination.
- conjunctiva Upon illuminating the eye, conjunctiva is exposed by pulling down lower eyelid of the eye. Subsequently at-least one image of the conjunctiva along with the colour mat is captured via the image capturing device.
- a processing module of the electronic device configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the measured level of haemoglobin from the processing module.
- the present invention provides a system for haemoglobin measurement, the system comprising an image capturing device for capturing an image of conjunctiva along with an image of colour mat for correcting the image of conjunctiva; a light source for providing light during imaging of conjunctiva; a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to receive and
- the colour mat consists of colour combination of red, grey, white, and simulated colours matching those of skin; and the light source is configured to provide stable light during imaging of conjunctiva, includes a power source to provide energy for enabling the light.
- the light source can be included in the external device or the electronic device.
- the optical chamber prevent external light from entering the eye during imaging of conjunctiva; the optical chamber includes a partition for preventing light directly emitted from the light source entering the image capturing device.
- the optical chamber includes a removable eye cap to surround the eye during imaging of conjunctiva.
- pixel by pixel operation is performed, by the processing module, on the image of conjunctiva and the colour mat, captured by the image capturing device, to obtain colour values.
- the colour values of the image of conjunctiva and the colour mat are then, compared with the original colours of the colour mat; and a ratiometric correction using gamma correction and/ or exposure correction are performed.
- the determination of the RGB, HSV, or LAB value of the image of conjunctiva, by the processing module includes determining the RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva, comparing the RGB, HSV, or LAB value of the image of the conjunctiva and the selected portion of the image of conjunctiva, determining an updated RGB, HSV, or LAB value of the image of conjunctiva, and correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva.
- the calibrated colour values of haemoglobin consist of the RGB, HSV, or LAB value and its corresponding level of haemoglobin.
- the display module is adapted to print the displayed measured haemoglobin in gm/dL.
- the display module is configured to transmit the measured haemoglobin to remote server for record and further analysis.
- a method of haemoglobin measurement comprises capturing an image of conjunctiva along with an image of colour mat, by an image capturing device; correcting the image of conjunctiva based on value of the image of colour mat; determining a RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva; comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva; correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva; measuring the level of haemoglobin by comparing the corrected RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour
- the correcting and eliminating of method of image of conjunctiva consist of gamma correction, exposure correction, white balancing, elimination of reflection and artifacts, and other image processing and corrections applied individually or in combination depending on the image of conjunctiva.
- pixel by pixel operation is performed, by the processing module, on the image of conjunctiva and the colour mat, captured by the image capturing device, to obtain colour values.
- the colour values of the image of conjunctiva and the colour mat are then compared with the original colours of the colour mat; and a ratiometric correction using gamma correction and/ or exposure correction are performed.
- the method of capturing the image of conjunctiva includes enabling a light of a light source; surrounding an eye, by an optical chamber, to prevent external light from entering the eye during imaging of conjunctiva; and capturing the image of conjunctiva along with the image of colour mat, by the image capturing device.
- the system (100) comprises an image capturing device (110) for capturing an image of conjunctiva (185) along with an image of colour mat (140) for correcting the image of conjunctiva (185); a light source (150) for providing stable light during imaging of conjunctiva; a diffuser (160) adapted to the light source (150) for providing uniform light during imaging of conjunctiva; an optical barrier (170) for preventing external light (190) from entering an eye (180) during imaging of conjunctiva; a processing module (120) for processing the captured image and measuring the level of haemoglobin; and a display module (130) for displaying the measured level of haemoglobin from the processing module (120).
- an image capturing device for capturing an image of conjunctiva (185) along with an image of colour mat (140) for correcting the image of conjunctiva (185)
- a light source (150) for providing stable light during imaging of conjunctiva
- the processing module (120) configured to receive and process the image captured from the image capturing device (110), for correcting the image of conjunctiva (185) based on value of the image of colour mat (140), determing a RGB, HSV, or LAB value of the image of the conjunctiva (185), and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva (185) with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin.
- the image capturing device (110) is adapted to the optical chamber (170) for capturing the image of conjunctiva (185) and the colour mat (140).
- the optical chamber (170) is adapted to include the light source (150), the color mat (140), and the diffuser (160) adapted to the light source (150) according to an embodiment of the present invention.
- the optical chamber (170) includes a partition (175) for preventing light directly emitted from the light source (150) entering the image capturing device (110) during imaging of the conjunctiva.
- the image of conjunctiva and colour mat captured from the image capturing device (110) is transferred to the processing module (120) for processing and measuring the level of haemoglobin, and the display module (130) displays the measured level of haemoglobin received from the processing module (120).
- the image capturing device (110), processing module (120), and the display module (130) can be elements of single electronic device.
- the method (200) comprises the steps of capturing an image of conjunctiva along with an image of colour mat, by an image capturing device (210); correcting the image of conjunctiva based on value of the image of colour mat (220); determining a RGB, HSV, or LAB value of the image of conjunctiva (230); selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva (240); comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva (250); correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva (260); measuring the level of haemoglobin, a a gamma correction, exposure correction and reflection of the image of conjunctiva (260); measuring
- the method of capturing the image of conjunctiva along with the image of colour mat (210), the method (2 0) includes enabling a light of a light source; surrounding an eye, by an optical chamber, to prevent external light from entering the eye during imaging of conjunctiva; and capturing the image of conjunctiva along with the image of colour mat, by the image capturing device.
- the correcting and eliminating of method of image of conjunctiva consist of gamma correction, exposure correction, white balancing, elimination of reflection and artifacts, and other image processing and corrections applied individually or in combination depending on the image of conjunctiva.
- the calibrated colour values of haemoglobin of method of measuring the level of haemoglobin consists of the RGB, HSV, or LAB value and its corresponding level of haemoglobin.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The present invention preferably provides a non-invasive system for haemoglobin measurement and method thereof. The system for haemoglobin measurement comprises an image capturing device for capturing an image of conjunctiva along with an image of colour mat for correcting the image of conjunctiva; a light source for providing light during imaging of conjunctiva; a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the measured level of haemoglobin from the processing module.
Description
METHOD AND SYSTEM FOR HAEMOGLOBIN MEASUREMENT
FIELD OF THE INVENTION
The present invention relates to haemoglobin measurement, more particularly, to non-invasive systems for haemoglobin measurement and method thereof.
BACKGROUND OF THE INVENTION
Haemoglobin is an iron containing protein in blood cells which carries oxygen around the body. Lack of haemoglobin in blood results in inadequate supply of oxygen to the body and causes various complications such as anaemia. Some of the main causes of anaemia are loss of blood, nutritional deficiency, bone marrow problems, kidney failure, abnormal haemoglobin structure, etc. Also, a high level of haemoglobin in blood leads to several complications since it can impair circulation and also lead to abnormal clotting. Measurement of haemoglobin in blood is thus an important routine procedure for monitoring patients under treatment and for screening of anemia. Several invasive and non-invasive techniques are available for measurement of haemoglobin. Invasive techniques include drawing of blood sample which is a painful experience for a patient. Also, it exposes a
health care provider handling the blood sample to risk of infectious diseases.
Non-invasive techniques include use of devices similar to oximeters on a thumb or an ear of patient to measure the level of haemoglobin. However these oximeters are expensive and are mostly used in intensive care units for continous monitoring of the patient.
Another conventional method of checking for low levels of haemoglobin i.e. checking for anaemic conditions of the subject is to check conjunctiva of the eye of the subject visually by a healthcare worker. The conjunctiva is a thin membrane that covers inner surface of the eyelid and white part of the eyeball. The conjunctiva is normally visible when the eye is pulled down. Doctors/physicians usually check the conjunctiva for its redness or paleness to examine anaemic condition of the patient. In case of anaemia, the anterior and the posterior rim of the conjunctiva will be same and will be pale. For a healthy subject, the anterior rim of the conjunctiva will have more redness and will be dissimilar to that of the posterior part. However this technique is subjective and is only indicative of low level of haemoglobin or anaemic condition and does not give a quantitative analysis of the amount of haemoglobin in blood. In view of the above, there is a need in the art for a method and system for haemoglobin measurement addressing at-least the above mentioned problems.
SUMMARY OF THE INVENTION
The present invention preferably provides non-invasive systems for haemoglobin measurement and method thereof.
In one embodiment, a system for haemoglobin measurement is provided. The system comprises an image capturing device for capturing an image of conjunctiva along with an image of colour mat for correcting the image of conjunctiva; a light source for providing light during imaging of conjunctiva; a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the measured level of haemoglobin from the processing module.
In another embodiment, the present invention provides a system for haemoglobin measurement, the system comprising an external device, comprising: an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; a colour mat, adapted to the optical
chamber, for correcting an image of conjunctiva; a light source, adapted to the optical chamber, for providing light during imaging of conjunctiva; an external power , source for providing power to the light source; and a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; and an electronic device, adapted to the external device, the electronic device comprising: an image capturing device for capturing the image of conjunctiva along with the image of colour mat; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the measured level of haemoglobin from the processing module.
Yet in another embodiment, a method of haemoglobin measurement is provided. The method comprises capturing an image of conjunctiva along with an image of colour mat, by an image capturing device; correcting the image of conjunctiva based on value of the image of colour mat; determining a RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB,
HSV, or LAB value of the selected portion of the image of conjunctiva; comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva; correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva; measuring the level of haemoglobin by comparing the corrected RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and displaying the measured level of haemoglobin.
BRIEF DESCRIPTION OF DRAWINGS
Reference will be made to embodiments of the invention, example of which may be illustrated in the accompanying figures. These figures are intended to be illustrative, not limiting. Although the invention is generally described in the context of these embodiments, it should be understood that it is not intended to limit the scope of the invention to these particular embodiments. Figure 1 shows a system for haemoglobin measurement according to the present invention; and
Figure 2 shows a method of haemoglobin measurement according to the present invention.
DETAILED DESCRIPTION OF THE INVENTSON
Various embodiments of the present invention provide a systems and methods for haemoglobin measurement. More particularly the invention is directed to analyzing conjunctiva of an eye for measuring the level of haemoglobin of a subject/patient.
In one embodiment, the present invention provides a system for haemoglobin measurement, the system comprises an external device, the external device includes a colour mat, an optical chamber, a light source, and a diffuser adapted to the light source, the external device adaptable to an eye of a subject under test; and an electronic device, adaptable to the external device, the electronic device includes an image capturing device a processor, a display, and a-storage means. The image capturing device is for capturing an image of conjunctiva of the eye and an image of the colour mat illuminated by the light source provided on the external device or the electronic device. The processor is configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat; identifying plurality of RGB (Red, Green, and Blue), HSV (Hue, Saturation, and Value), or LAB (L for lightness, and A, and B for the colour-opponent dimensions, based on nonlinearly compressed coordinates) of the image of conjunctiva, determining the RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of
haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated color values of haemoglobin to retrieve a value which indicates the level of haemoglobin, and displaying and storing the measured level of haemoglobin on the display and the storage means respectively.
In an embodiment of the invention, the external device can be retrofitted on electronic devices such as a cell phone, a tablet, a phablet, a camera with a processor or a processing unit, or other portable electronic devices. Accordingly, the external device can be adapted to different types of electronic .... devices and the external device is not limited to the arrangement illustrated.
In another embodiment, a system for haemoglobin measurement is provided; the system comprises an external device and an electronic device. The external device is capable of being adapted to an eye of a subject/patient, by an eye cap. The external device comprises a first adapter, a fastening base, a light source, an optical chamber, a diffuser, a diffuser fastener, a colour mat, a second adapter, and an eye cap. The first adapter is provided for adapting the electronic device with the external device. The first adapter holds the electronic device such that the image capturing device of the electronic device is aligned with the external device.
In accordance with the present invention, the first adapter has means for accommodating a power source for the light source of the external device. The light source comprises a switch for illumination of the light. Alternately, the light source of the external device can be powered through the electronic device via suitable means.
In accordance with the present invention, the fastening base fastens- the optical chamber with the first adapter, and the light source inside the optical chamber. The second adapter is adapted to the optical chamber to hold the colour mat in front of the light source inside the optical chamber, and has a means for holding the eye cap.
In accordance with the present invention, eye cap is placed on the eye during imaging of conjunctiva. Advantageously, the eye cap is removable. In an embodiment of the invention, the optical chamber, and the eye cap adapted to the second adapter of the external device are light occluding. In this regard, the optical chamber, and the eye cap adapted the second adapter covers the eye such that the eye is isolated from ambient light. Once the external device is placed on the eye, the light source of the external device is turned on by a switch and the eye is illuminated. In an embodiment, the diffuser is provided in front of the light source, by a
diffuser fastener, such that that light spreads uniformly over the entire eye area, thereby avoiding any patchy illumination.
Upon illuminating the eye, conjunctiva is exposed by pulling down lower eyelid of the eye. Subsequently at-least one image of the conjunctiva along with the colour mat is captured via the image capturing device.
In an embodiment, a processing module of the electronic device, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the measured level of haemoglobin from the processing module.
In another embodiment, the present invention provides a system for haemoglobin measurement, the system comprising an image capturing device for capturing an image of conjunctiva along with an image of colour mat for correcting the image of conjunctiva; a light source for providing light during imaging of conjunctiva; a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; an optical
chamber for preventing external light from entering an eye during imaging of conjunctiva; a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and a display module, configured to display the measured level of haemoglobin from the processing module.
In accordance with the present invention, the colour mat consists of colour combination of red, grey, white, and simulated colours matching those of skin; and the light source is configured to provide stable light during imaging of conjunctiva, includes a power source to provide energy for enabling the light. Advantageously, the light source can be included in the external device or the electronic device.
In accordance with the present invention, the optical chamber prevent external light from entering the eye during imaging of conjunctiva; the optical chamber includes a partition for preventing light directly emitted from the light source entering the image capturing device.
Advantageously, the optical chamber includes a removable eye cap to surround the eye during imaging of conjunctiva.
In accordance with the present invention, pixel by pixel operation is performed, by the processing module, on the image of conjunctiva and the colour mat, captured by the image capturing device, to obtain colour values. The colour values of the image of conjunctiva and the colour mat are then, compared with the original colours of the colour mat; and a ratiometric correction using gamma correction and/ or exposure correction are performed.
In accordance with the present invention, the determination of the RGB, HSV, or LAB value of the image of conjunctiva, by the processing module, includes determining the RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva, comparing the RGB, HSV, or LAB value of the image of the conjunctiva and the selected portion of the image of conjunctiva, determining an updated RGB, HSV, or LAB value of the image of conjunctiva, and correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva.
In accordance with the present invention, the calibrated colour values of haemoglobin consist of the RGB, HSV, or LAB value and its corresponding level of haemoglobin.
In accordance with the present invention, the display module is adapted to print the displayed measured haemoglobin in gm/dL. Advantageously, the display module is configured to transmit the measured haemoglobin to remote server for record and further analysis.
In another embodiment, a method of haemoglobin measurement is provided. The method comprises capturing an image of conjunctiva along with an image of colour mat, by an image capturing device; correcting the image of conjunctiva based on value of the image of colour mat; determining a RGB, HSV, or LAB value of the image of conjunctiva; selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva; comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva; correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva; measuring the level of haemoglobin by comparing the corrected RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a
value which indicated the level of haemoglobin; and displaying the measured level of haemoglobin.
In accordance with the present invention, the correcting and eliminating of method of image of conjunctiva consist of gamma correction, exposure correction, white balancing, elimination of reflection and artifacts, and other image processing and corrections applied individually or in combination depending on the image of conjunctiva. In accordance with the present invention, pixel by pixel operation is performed, by the processing module, on the image of conjunctiva and the colour mat, captured by the image capturing device, to obtain colour values. The colour values of the image of conjunctiva and the colour mat are then compared with the original colours of the colour mat; and a ratiometric correction using gamma correction and/ or exposure correction are performed.
In accordance with the present invention, the method of capturing the image of conjunctiva includes enabling a light of a light source; surrounding an eye, by an optical chamber, to prevent external light from entering the eye during imaging of conjunctiva; and capturing the image of conjunctiva along with the image of colour mat, by the image capturing device.
The subject matter is now described with reference to the drawings, wherein like reference numerals are used to refer to like elements throughout. In the following description, for purpose of explanation, numerous specific details are set forth in order to provide a thorough understanding of the claimed subject matter. It may be evident however, that such matter can be practiced with these specific details. In other instances, well-known structures as shown in diagram form in order to facilitate describing the invention. Referring Figure 1 shows a system (100) for haemoglobin measurement in accordance with an embodiment of the present invention, the system (100) comprises an image capturing device (110) for capturing an image of conjunctiva (185) along with an image of colour mat (140) for correcting the image of conjunctiva (185); a light source (150) for providing stable light during imaging of conjunctiva; a diffuser (160) adapted to the light source (150) for providing uniform light during imaging of conjunctiva; an optical barrier (170) for preventing external light (190) from entering an eye (180) during imaging of conjunctiva; a processing module (120) for processing the captured image and measuring the level of haemoglobin; and a display module (130) for displaying the measured level of haemoglobin from the processing module (120).
As shown in Figure 1 , the processing module (120), configured to receive and process the image captured from the image capturing device (110), for correcting the image of conjunctiva (185) based on value of the image of colour mat (140), determing a RGB, HSV, or LAB value of the image of the conjunctiva (185), and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva (185) with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin. As shown in Figure 1 , the image capturing device (110) is adapted to the optical chamber (170) for capturing the image of conjunctiva (185) and the colour mat (140). The optical chamber (170) is adapted to include the light source (150), the color mat (140), and the diffuser (160) adapted to the light source (150) according to an embodiment of the present invention. Advantageously, the optical chamber (170) includes a partition (175) for preventing light directly emitted from the light source (150) entering the image capturing device (110) during imaging of the conjunctiva.
As shown in Figure 1 , the image of conjunctiva and colour mat captured from the image capturing device (110) is transferred to the processing module (120) for processing and measuring the level of haemoglobin, and the display module (130) displays the measured level of haemoglobin received from the processing module (120). Advantageously, the image
capturing device (110), processing module (120), and the display module (130) can be elements of single electronic device.
Referring Figure 2, shows a method (200) of haemoglobin measurement in accordance with an embodiment of the present invention, the method (200) comprises the steps of capturing an image of conjunctiva along with an image of colour mat, by an image capturing device (210); correcting the image of conjunctiva based on value of the image of colour mat (220); determining a RGB, HSV, or LAB value of the image of conjunctiva (230); selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva (240); comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva (250); correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva (260); measuring the level of haemoglobin by comparing the corrected RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin (270); and displaying the measured level of haemoglobin (280).
As shown in Figure 2, the method of capturing the image of conjunctiva along with the image of colour mat (210), the method (2 0) includes
enabling a light of a light source; surrounding an eye, by an optical chamber, to prevent external light from entering the eye during imaging of conjunctiva; and capturing the image of conjunctiva along with the image of colour mat, by the image capturing device.
As shown in Figure 2, the correcting and eliminating of method of image of conjunctiva (260) consist of gamma correction, exposure correction, white balancing, elimination of reflection and artifacts, and other image processing and corrections applied individually or in combination depending on the image of conjunctiva.
As shown in Figure 2, the calibrated colour values of haemoglobin of method of measuring the level of haemoglobin (270) consists of the RGB, HSV, or LAB value and its corresponding level of haemoglobin.
While the present invention has been described herein with respect to the various exemplary embodiments, it will be apparent to one of the ordinary skill in the art that many modifications, improvements and sub combinations of the various embodiments, adaptations and variations can be made to the invention without departing from the scope thereof as claimed in the following claims.
Claims
1. A system for haemoglobin measurement, the system comprising:
an image capturing device for capturing an image of conjunctiva along with an image of colour mat for correcting the image of - conjunctiva;
a light source for providing light during imaging of conjunctiva;
a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva;
an optical chamber for preventing external light from entering an eye during imaging of conjunctiva; ,
a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and
a display module, configured to display the measured level of haemoglobin from the processing module.
2. The system as claimed in claim 1 , wherein
the image capturing device, the processing module, and the display module are preferably included in an electronic device; and
the light source, the diffuser, the optical chamber, and the colour mat are preferably included in an external devrce;
wherein the external device is removably adapted to the electronic device.
3. The system as claimed in claim 2, wherein the electronic device comprises a camera, a cell phone, or other portable electronic devices.
4. The system as claimed in claim 1 , wherein the colour mat consist of colour combination of red, grey, white, and other simulated colours matching those of skin.
5. The system as claimed in claim 1 , wherein the light source preferably includes an external power source to provide stable light during imaging of conjunctiva.
6. The system as claimed in claim 1 , wherein the optical chamber includes a partition for preventing light directly emitted from the light source entering the image capturing device.
7. The system as claimed in claim 1 or 6, wherein the optical chamber includes a removable eye cap to surround the eye during imaging of conjunctiva.
8. The system as claimed in claim 1 or 2, wherein the display module, is adapted to print the displayed measured haemoglobin in gm/dL.
9. The system as claimed in claim 1 or 2, wherein the display module, is configured to transmit the measured haemoglobin to remote server for record and further analysis.
10. A system for haemoglobin measurement, the system comprising:
an external device, comprising:
an optical chamber for preventing external light from entering an eye during imaging of conjunctiva;
a colour mat, adapted to the optical chamber, for correcting an image of conjunctiva;
a light source, adapted to the optical chamber, for providing light during imaging of conjunctiva;
an external power source for providing power to the light source; and
a diffuser adapted to the light source for providing uniform light during imaging of conjunctiva; and an electronic device, adapted to the external device, the electronic device comprising:
an image capturing device for capturing the image of conjunctiva along with the image of colour mat;
a processing module, configured to receive and process the image captured from the image capturing device, for correcting the image of conjunctiva based on value of the image of colour mat, determining a RGB, HSV, or LAB value of the image of conjunctiva, and measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin; and
a display module, configured to display the measured level of haemoglobin from the processing module.
11. A method of haemoglobin measurement, the method comprising:
capturing an image of conjunctiva along with an image of colour mat by an image capturing device;
correcting the image of conjunctiva based on value of the image of colour mat by a processing module;
determining a RGB, HSV, or LAB value of the image of conjunctiva by the processing module;
measuring the level of haemoglobin by comparing the RGB, HSV, or LAB value of the image of conjunctiva with a calibrated colour values of haemoglobin to retrieve a value which indicates the level of haemoglobin by the processing module; and
displaying the measured level of haemoglobin on a display module.
12. The method as claimed in claim 11 , wherein the step of determination of the RGB, HSV, or LAB value of the image of conjunctiva, includes: determining the RGB, HSV, or LAB value of the image of conjunctiva;
selecting a portion on the image of conjunctiva and determining the RGB, HSV, or LAB value of the selected portion of the image of conjunctiva;
comparing the RGB, HSV, or LAB value of the image of conjunctiva and the selected portion of the image of conjunctiva, and determining an updated RGB, HSV, or LAB value of the image of conjunctiva; and correcting and eliminating, a gamma correction, exposure correction and reflection of the image of conjunctiva.
13. The method as claimed in claim 12, wherein the correcting and eliminating of image of conjunctiva comprises gamma correction,
exposure correction, white balancing, elimination of reflection and artifacts, and other image processing and corrections applied individually or in combination depending on the image of conjunctiva.
14. The method as claimed in claim 11 , wherein the calibrated colour values of haemoglobin comprises the RGB, HSV, or LAB value and its corresponding level of haemoglobin.
15. The method as claimed in claim 11 , wherein the step of capturing the image, includes:
enabling a light of a light source;
surrounding an eye, by an optical chamber, to prevent external light from entering the eye during imaging of conjunctiva; and
capturing the image of conjunctiva along with the image of colour mat by the image capturing device.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1677MU2014 | 2014-07-19 | ||
| IN1677/MUM/2014 | 2014-07-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2016013023A2 true WO2016013023A2 (en) | 2016-01-28 |
| WO2016013023A3 WO2016013023A3 (en) | 2016-03-24 |
Family
ID=55163915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2015/000292 Ceased WO2016013023A2 (en) | 2014-07-19 | 2015-07-20 | Method and system for haemoglobin measurement |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2016013023A2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201700043624A1 (en) * | 2017-04-20 | 2018-10-20 | Giovanni Dimauro | Immediate and non-invasive estimation of hemoglobin concentration in the blood |
| WO2023275774A1 (en) * | 2021-06-29 | 2023-01-05 | Universita' Degli Studi Di Bari Aldo Moro | Non-invasive device for quickly estimating anaemia |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4998533A (en) * | 1986-07-15 | 1991-03-12 | Winkelman James W | Apparatus and method for in vivo analysis of red and white blood cell indices |
| US7711403B2 (en) * | 2001-04-05 | 2010-05-04 | Rhode Island Hospital | Non-invasive determination of blood components |
| FR2833827B1 (en) * | 2001-12-21 | 2004-12-10 | Oreal | PROCESS FOR EVALUATING THE EYE CONTOUR REGION AND DEVICE FOR CARRYING OUT SUCH A METHOD |
| WO2008050234A2 (en) * | 2006-10-27 | 2008-05-02 | Hemohue Ltd | Device for measuring haemoglobin level |
| CN102917634A (en) * | 2010-03-23 | 2013-02-06 | 神经视觉成像有限责任公司 | Apparatus and method for imaging an eye |
| US9854970B2 (en) * | 2012-02-21 | 2018-01-02 | Massachusetts Eye & Ear Infirmary | Calculating conjunctival redness |
| SG11201406239YA (en) * | 2012-04-23 | 2014-11-27 | Univ Nanyang Tech | Portable optics adapter to digital camera for fundus imaging |
| CN104837404B (en) * | 2012-12-10 | 2018-05-18 | 皇家飞利浦有限公司 | The medical supply or system of hemoglobin level are measured during accident using camera-projector system |
-
2015
- 2015-07-20 WO PCT/IN2015/000292 patent/WO2016013023A2/en not_active Ceased
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201700043624A1 (en) * | 2017-04-20 | 2018-10-20 | Giovanni Dimauro | Immediate and non-invasive estimation of hemoglobin concentration in the blood |
| WO2023275774A1 (en) * | 2021-06-29 | 2023-01-05 | Universita' Degli Studi Di Bari Aldo Moro | Non-invasive device for quickly estimating anaemia |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016013023A3 (en) | 2016-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6097629B2 (en) | Lesion evaluation information generator | |
| KR20150115971A (en) | A strip and method for urine test based on application | |
| US10022045B1 (en) | Method and apparatus for vision acuity testing | |
| ES2925208T3 (en) | Procedures and devices for performing an analytical measurement | |
| US9968282B2 (en) | Medical device or system for measuring hemoglobin levels during accidents using a camera-projector system | |
| US12368812B2 (en) | Image display system and image display method | |
| WO2016046202A1 (en) | Visual field measuring device and system | |
| CN109526123B (en) | Breath guidance method, device, medical imaging device and storage medium | |
| WO2013157573A1 (en) | Color-viewing function measuring means and color-viewing function measurement system | |
| CN104316527A (en) | Automatic detection method for discharged dialyzate, and automatic detection device for discharged dialyzate | |
| WO2016013023A2 (en) | Method and system for haemoglobin measurement | |
| WO2017012675A1 (en) | Method and device for smartphone mapping of tissue compounds | |
| JP7039602B2 (en) | Methods and equipment for visual acuity test | |
| KR20130083613A (en) | Method and apparatus for processing image of tongue using three band image | |
| Sufian et al. | Chromatic techniques for in vivo monitoring jaundice in neonate tissues | |
| CN210204672U (en) | Optical parameter testing system of capsule endoscope | |
| KR101785529B1 (en) | Medical apparatus for tongue diagnosis and control method thereof | |
| CN109632654B (en) | Plasma chyle and hemolysis detection device and implementation method thereof | |
| US20240185418A1 (en) | System and method for intraoral identification | |
| JP2002209851A (en) | Optometry device | |
| US12022048B2 (en) | Display unit color-correction method | |
| TWI489306B (en) | Health status assessment methods and the use of the method of health assessment system | |
| US20250213138A1 (en) | System for monitoring tissue health | |
| IT202300020169A1 (en) | PORTABLE MODULAR SYSTEM FOR DIAGNOSTIC INSTRUMENTS | |
| IT202300020181A1 (en) | PORTABLE MODULAR SYSTEM FOR DIAGNOSTIC INSTRUMENTS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 15824830 Country of ref document: EP Kind code of ref document: A2 |
|
| DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) | ||
| NENP | Non-entry into the national phase in: |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 15824830 Country of ref document: EP Kind code of ref document: A2 |
|
| 32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 22.06.2017) |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 15824830 Country of ref document: EP Kind code of ref document: A2 |