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WO2011068131A1 - Ampoule-seringue - Google Patents

Ampoule-seringue Download PDF

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Publication number
WO2011068131A1
WO2011068131A1 PCT/JP2010/071510 JP2010071510W WO2011068131A1 WO 2011068131 A1 WO2011068131 A1 WO 2011068131A1 JP 2010071510 W JP2010071510 W JP 2010071510W WO 2011068131 A1 WO2011068131 A1 WO 2011068131A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
outer cylinder
prefilled syringe
double
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2010/071510
Other languages
English (en)
Japanese (ja)
Inventor
信之介 大津
淳一 小川
智紀 岡山
浩一 立川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of WO2011068131A1 publication Critical patent/WO2011068131A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means

Definitions

  • the present invention relates to a prefilled syringe containing a chemical solution.
  • the upper skin layer refers to the epidermis and dermis (dermis layer) of the skin.
  • a type of syringe that is used with a chemical cartridge mounted thereon is known (for example, see Patent Document 2).
  • this syringe is used with a chemical cartridge and a double-ended needle attached to the syringe body.
  • the syringe body is repeatedly used a plurality of times by performing sterilization treatment, and the drug solution cartridge and the double-ended needle are used only once and are disposable. For this reason, the syringe main body does not need to have a structure capable of maintaining the sterility of the syringe body, and is not actually capable of maintaining the sterility.
  • the conventional dental syringe is a type that is used with a chemical cartridge attached, it is possible to prevent the waste of the chemical solution, but it is necessary to attach a double-ended needle to the syringe body during use. Takes time and effort.
  • the conventional dental syringe cannot be applied to a prefilled syringe in which a double-ended needle is attached in advance because the syringe body does not have a structure capable of maintaining the sterility of the syringe body.
  • An object of the present invention is to prevent the waste of a chemical solution, to easily and quickly prepare for administration of the chemical solution, and to easily and surely puncture the puncture needle to the target puncture depth.
  • the present invention provides an outer cylinder having a distal end and a proximal end, A chemical container having a gasket that can slide within the main body of the chemical liquid container, the chemical liquid is stored in a space surrounded by the main body of the chemical liquid container and the gasket, and is movable with respect to the outer cylinder A chemical container; A pressing portion for moving and operating the chemical container; A puncture needle having one end capable of puncturing a living body and the other end communicating with the inside of the main body of the drug solution container; A needle support portion provided on the distal end side of the outer cylinder and supporting the puncture needle; A contact portion that is provided on the distal end side of the outer cylinder and spaced from the needle tip of the puncture needle in the radial direction, and can contact the surface of
  • the puncture needle is preferably the prefilled syringe according to the above (1), which is a double-ended needle.
  • the prefilled syringe of the present invention it is preferable that the prefilled syringe has a ventilation means for opening the space inside the outer cylinder to the outside.
  • the venting means is configured such that the space inside the contact portion by the protection member is released and the contact portion is in contact with the surface of the living body, It is preferable to open the in-cylinder space to the outside.
  • the ventilation means is formed in the needle support portion, and includes a first ventilation hole that communicates the space inside the outer cylinder and the space inside the contact portion, and the contact portion. It is preferable to have a second ventilation hole that is formed and communicates between the space inside the contact portion and the outside in the contact state.
  • the second vent hole is a side hole formed in a side wall of the contact portion.
  • the protection member is detachably attached to the contact portion, and closes the second vent hole, whereby the space inside the outer cylinder and the space inside the contact portion. It is preferable that the sterility is maintained.
  • the chemical solution container is accommodated in the outer cylinder.
  • the chemical solution container is installed so as to protrude outward from the base end side of the outer cylinder.
  • the puncture needle is a double-ended needle
  • the chemical solution container seals a space surrounded by the main body of the chemical solution container and the gasket, and has a sealing portion through which the needle tip on the proximal end side of the double-ended needle can be pierced, It is preferable that the proximal end side of the double-ended needle is configured so that the proximal end side of the double-ended needle communicates with the inside of the main body of the drug solution container by penetrating the sealing portion.
  • the puncture needle is a double-ended needle
  • the body of the chemical solution container has a cylindrical shape
  • the gasket is provided on the base end side of the main body of the chemical solution container
  • the chemical liquid container seals a space surrounded by the main body of the chemical liquid container and the gasket, and has a sealing portion on the distal end side of the main body of the chemical liquid container through which the needle tip on the proximal end side of the double-ended needle can be pierced.
  • the chemical solution container moves in the distal direction with respect to the outer cylinder, and the needle tip on the proximal end side of the double-ended needle pierces the sealing portion, and then the gasket is It is preferable that the chemical solution is configured to move in the distal direction with respect to the main body of the chemical solution container and to discharge the chemical solution from the tip of the tip of the double-ended needle.
  • the puncture needle is a double-ended needle
  • the proximal end side of the double-ended needle is configured to communicate with the inside of the main body of the chemical solution container when the needle tip on the proximal end side of the double-ended needle pierces the gasket.
  • the puncture needle is a double-ended needle
  • the main body of the chemical solution container has a bottomed cylindrical part having a bottom on the base end side
  • the gasket is provided on the distal end side of the main body of the chemical container
  • the prefilled syringe further has a gasket abutting portion that is located in the space inside the outer cylinder and can abut against the gasket;
  • the chemical solution container moves in the distal direction with respect to the outer cylinder, the needle tip on the proximal end side of the double-ended needle pierces the gasket, and then the gasket is
  • the chemical solution is configured to come into contact with the gasket contact portion, move in the proximal direction with respect to the main body of the chemical solution container, and to discharge the chemical solution from the tip end on the distal end side of the double-ended needle.
  • the distal end surface of the contact portion is located on the proximal end side with respect to the needle tip of the puncture needle.
  • the needle support portion has a convex portion that supports the puncture needle and can come into contact with the surface of the living body.
  • FIG. 1 is a partial longitudinal sectional view showing a first embodiment (a state in which a protective member is removed) of a prefilled syringe of the present invention.
  • FIG. 2 is a partial longitudinal sectional view showing a state in which the protective member of the prefilled syringe shown in FIG. 1 is mounted.
  • FIG. 3 is a partial longitudinal sectional view for explaining a method of using the prefilled syringe shown in FIG.
  • FIG. 4 is a partial longitudinal sectional view for explaining a method of using the prefilled syringe shown in FIG.
  • FIG. 5 is a partial longitudinal sectional view for explaining a method of using the prefilled syringe shown in FIG. FIG.
  • FIG. 6 is a partial longitudinal sectional view showing a second embodiment of the prefilled syringe of the present invention.
  • FIG. 7 is a longitudinal sectional view showing a third embodiment of the prefilled syringe of the present invention.
  • FIG. 8 is a longitudinal cross-sectional view which shows the part by the side of the front end in 4th Embodiment of the prefilled syringe of this invention.
  • the present invention can be applied to a prefilled syringe that administers various chemicals to a living body, in the following embodiment, the present invention is typically applied to a prefilled syringe that administers a vaccine. Will be described.
  • FIG. 1 is a partial longitudinal sectional view showing a first embodiment of the prefilled syringe of the present invention (a state in which a protective member is removed)
  • FIG. 2 is a partial longitudinal section showing a state in which the protective member of the prefilled syringe shown in FIG.
  • FIGS. 3 to 5 are partial longitudinal sectional views for explaining a method of using the prefilled syringe shown in FIG.
  • FIGS. 1 to 5 the upper side in FIGS. 1 to 5 is described as “base end”, the lower side is “tip”, the right side is “right”, and the left side is “left”. 4 and 5, the illustration of the living body is omitted.
  • the prefilled syringe 1 includes an outer cylinder (syringe outer cylinder) 2, a chemical liquid container 7 movable with respect to the outer cylinder 2, and the chemical liquid container 7 in the axial direction of the outer cylinder 2 ( A pusher (pressing portion) 3 that is moved along the longitudinal direction), a double-ended needle (puncture needle) 6, a needle support portion 4 that supports the double-ended needle 6, and a double-ended needle 6 on the distal end side of the outer cylinder 2.
  • a pusher (pressing portion) 3 that is moved along the longitudinal direction
  • a double-ended needle (puncture needle) 6 a needle support portion 4 that supports the double-ended needle 6, and a double-ended needle 6 on the distal end side of the outer cylinder 2.
  • a contact portion 5 provided so as to surround the needle tip 61 on the distal end side and capable of contacting the surface of the living body, a seal member 74 that seals between the outer cylinder 2 and the chemical solution container 7, and a protection member (cap) 8 and.
  • the outer cylinder 2 is a cylindrical member, which is a cylindrical member in the illustrated configuration. And in this embodiment, the chemical
  • FIG. 1 is a cylindrical member, which is a cylindrical member in the illustrated configuration.
  • medical solution container 7 is accommodated in this outer cylinder 2.
  • the constituent material of the outer cylinder 2 is not particularly limited.
  • resins such as styrene copolymers, polyesters such as polyethylene terephthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be mentioned.
  • Resin such as polypropylene, cyclic polyolefin, polyester, and poly- (4-methylpentene-1) is preferable because it is easy to mold.
  • the constituent material of the outer cylinder 2 is substantially transparent in order to ensure internal visibility.
  • the chemical liquid container 7 seals a space surrounded by the container main body (main body of the chemical liquid container) 71, a gasket 72 that can slide in the container main body 71, and the container main body 71 and the gasket 72, and is fixed to the container main body 71. And a sealed portion 73. And the chemical
  • the container body 71 has a cylindrical shape, and in the illustrated configuration, has a cylindrical shape.
  • the gasket 72 is provided on the proximal end side of the container body 71, and the sealing portion 73 is provided on the distal end side of the container body 71. Yes.
  • the constituent material of the container main body 71 is substantially transparent in order to ensure internal visibility.
  • a scale not shown is formed on the outer peripheral surface of the container main body 71. Thereby, the quantity of the chemical
  • the gasket 72 is connected to the tip of the pusher 3.
  • the gasket 72 is fixed to the pusher 3 in advance.
  • the present invention is not limited to this.
  • the gasket 72 is configured to be connected to the pusher 3 at the time of use. Also good.
  • the gasket 72 and the pusher 3 may not be connected to each other, but the gasket 72 may be pushed by the tip surface of the pusher 3.
  • the material constituting the gasket 72 is not particularly limited.
  • various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.
  • the gasket 72 only needs to have at least an outer peripheral portion made of the elastic material as described above.
  • the gasket 72 has a core portion (not shown) made of a resin material.
  • positioned so that it may cover may be used.
  • the sealing portion 73 is configured such that the needle tip 62 on the proximal end side of the double-ended needle 6 can be pierced.
  • the constituent material of the sealing portion 73 is not particularly limited.
  • the same constituent material as that of the gasket 72 can be used.
  • the amount of the chemical solution stored in the space 75 is not particularly limited, but is preferably about 0.02 to 2.0 mL, and more preferably about 0.05 to 0.8 mL. That is, the prefilled syringe 1 is particularly suitable when such a small amount of drug solution is administered.
  • the seal member 74 is a member that seals between the outer cylinder 2 and the chemical liquid container 7, and is provided on the outer cylinder 2 side or the chemical liquid container 7 side. In the illustrated configuration, the seal member 74 is fixed to the outer peripheral surface of the container main body 71.
  • the seal member 74 is composed of ribs provided so as to protrude laterally from the outer peripheral surface of the container main body 71, and is provided over the entire circumference of the container main body 71.
  • the end of the seal member 74 on the outer cylinder 2 side is in close contact with the inner peripheral surface of the outer cylinder 2 over the entire circumference thereof, whereby the inner peripheral surface of the outer cylinder 2 and the chemical container 7
  • the space between the outer peripheral surface of the container body 71 is hermetically sealed.
  • the chemical liquid container 7 can smoothly slide in the outer cylinder 2 by the seal member 74.
  • the constituent material of the seal member 74 is not particularly limited.
  • the same constituent material as that of the gasket 72 can be used.
  • the seal member 74 may be fixed to the inner peripheral surface of the outer cylinder 2 instead of the outer peripheral surface of the container body 71. Further, the seal member 74 may be integrally formed with the outer cylinder 2 (for example, integral molding or the like).
  • the pusher 3 has a rod-like main body 31 whose cross section is, for example, a cross or circular shape, and a gasket 72 is fixed to the tip of the main body 31 as described above. That is, the pusher 3 is connected to the chemical solution container 7 and provided at the base end (base end portion) of the chemical solution container 7.
  • a disc-shaped flange 32 is formed at the base end of the main body 31.
  • the method for fixing the gasket 72 to the main body 31 is not particularly limited.
  • a male screw is formed on the main body 31, and a female screw that is screwed to the male screw is formed on the gasket 72. And the like.
  • the constituent material of the pusher 3 is not particularly limited, but for example, the same constituent material as that of the outer cylinder 2 can be used.
  • the double-ended needle 6 has a sharp needle tip 61 that can pierce a living body on the distal end side, and a sharp needle tip 62 that can pierce the sealing portion 73 of the drug solution container 7 on the proximal end side. Then, the proximal end side of the double-ended needle 6 is configured to pierce the sealing portion 73 so that the proximal end side of the double-ended needle 6 communicates with the inside of the container main body 71.
  • the double-ended needle 6 one having a size of 26 to 33 G (outer diameter: 0.2 to 0.45 mm) according to the ISO medical needle tube standard (ISO9626: 1991 / Amd.1: 2001 (E)) is used. It is preferable to use one having a size of 30 to 33G.
  • a blade edge having a blade surface is formed on each of the distal end side and the proximal end side of the double-ended needle 6, and the axial length of the double-ended needle 6 on the distal end side blade surface (hereinafter referred to as “bevel length”).
  • B is preferably 1.4 mm (adult) or less, which is the thinnest thickness of the upper skin layer, and is a bevel length when a short bevel is formed on a 33G double-ended needle (puncture needle). It is preferable that it is 0.5 mm or more. That is, the bevel length B is preferably set within a range of 0.5 to 1.4 mm.
  • the bevel length B is more preferably 0.9 mm (child) or less, which is the thinnest thickness of the upper skin layer. That is, the bevel length B is more preferably set within a range of 0.5 to 0.9 mm.
  • the depth (puncture depth) punctured into the upper skin portion of the double-ended needle 6 is the length of the portion of the double-ended needle 6 that protrudes from the distal end surface of the convex portion 42 described later (hereinafter referred to as “projected length”). Say) determined by L.
  • the thickness of the upper skin portion corresponds to the depth from the surface of the skin to the dermis layer, and is generally 0.5 to 3.0 mm. Therefore, the protruding length L of the double-ended needle 6 is 0.5 to 3.0 mm. It is preferable to set within the range.
  • the administration site of influenza vaccine is generally the deltoid muscle.
  • the thickness of the upper skin layer in the pediatric deltoid muscle is 0.9 to 1.6 mm, and the upper skin thickness in the adult deltoid muscle is 1.4 to 2.6 mm in the distal portion.
  • the central portion is 1.4 to 2.5 mm, and the proximal portion is 1.5 to 2.5 mm.
  • the protruding length L of the double-ended needle 6 can be set within a range of 0.9 to 1.4 mm.
  • the constituent material of the double-ended needle 6 is not particularly limited.
  • various metal materials such as stainless steel, aluminum or aluminum alloy, titanium or titanium alloy, superelastic alloy such as Ni-Ti alloy, and various hard materials such as polyphenylene sulfide. Resin material etc. are mentioned.
  • the needle support portion 4 has a base portion 40 and a convex portion 42 fixed to the center portion of the tip surface of the base portion 40, and is fixed to the tip end of the outer cylinder 2.
  • the base portion 40 has a disk shape
  • the convex portion 42 has a cylindrical shape.
  • the tip surface of the convex portion 42 is a part that comes into contact with the surface (skin) of the living body when a drug solution is administered (when the double-ended needle 6 is punctured).
  • the base 40 and the convex part 42 may be formed integrally.
  • the needle support portion 4 may be formed integrally with the outer cylinder 2.
  • the double-ended needle 6 is fixed to the center portion of the needle support portion 4 and is supported by the base portion 40 and the convex portion 42, and the needle tip 61 on the tip side is located on the tip side from the needle support portion 4,
  • the proximal end needle tip 62 is located closer to the proximal end side than the needle support portion 4. Since the needle support part 4 has the convex part 42, when the double-ended needle 6 is punctured into a predetermined part of the living body, the convex part 42 comes into contact with the epidermis, and thereby the epidermis is brought into contact with the axis of the double-ended needle 6.
  • the needle tip 61 of the double-ended needle 6 can be punctured so as to be perpendicular to the epidermis.
  • the distance S from the outer peripheral edge (outer peripheral surface) of the convex portion 42 to the outer peripheral surface of the double-ended needle 6 is preferably set to 1.4 mm or less, and is set within a range of 0.3 to 1.4 mm. Is more preferable.
  • This distance S is set in consideration of the pressure applied to the blisters formed by administering the drug solution to the upper skin layer. That is, the distance S is set so that the size of the tip surface of the convex portion 42 is sufficiently smaller than the blisters formed on the upper skin layer and does not hinder the formation of the blisters. Thereby, it can prevent that the chemical
  • the base 40 of the needle support portion 4 has a portion that comes into contact with the epidermis when the double-ended needle 6 is punctured.
  • the abutment portion 5 and the double-ended needle 6 press the epidermis by pressing the abutment portion 5 against the epidermis until the portion of the base 40 that abuts the epidermis abuts the epidermis.
  • the distance Y from the distal end surface (lower end surface) of the base 40 to the distal end surface of the contact portion 5 is such that when the double-ended needle 6 is punctured, the contact portion 5 and the double-ended needle 6 press the epidermis with an appropriate pressing force.
  • the double-ended needle 6 is set so as to be punctured with certainty.
  • This distance Y is appropriately determined based on the inner diameter d of the contact portion 5 and the distance X from the outer wall surface (outer peripheral surface) of the base portion 40 to the outer wall surface (outer peripheral surface) of the contact portion 5. For example, when the inner diameter d is 11 mm and the distance X is 0.5 mm, the distance Y is preferably set within a range of 0.75 to 2.6 mm.
  • the pressing force with which the contact portion 5 and the double-ended needle 6 press the epidermis is reliably transmitted (guided) to the epidermis by the base 40, and the needle tip 61 of the double-ended needle 6 is reliably positioned on the upper skin portion. be able to.
  • the needle support portion 4 is formed with a vent hole (first vent hole) 41 penetrating the needle support portion 4.
  • the vent hole 41 is formed at a position where the convex portion 42 is not provided in the base portion 40.
  • the vent hole 41 allows communication between the outer cylinder inner space 21 surrounded by the outer cylinder 2, the needle support portion 4, and the seal member 74 and the space 52 inside the contact portion 5 described later.
  • the number of vent holes 41 is one in the present embodiment, but is not limited to this and may be plural.
  • the thing similar to the constituent material of the said outer cylinder 2 can be used.
  • the abutting portion 5 has a cylindrical shape, a cylindrical shape in the illustrated configuration, and is fixed to the tip surface (tip portion) of the base portion 40 of the needle support portion 4.
  • the contact portion 5 is provided away from the needle tip 61 on the distal end side of the double-ended needle 6 in the radial direction of the double-ended needle 6.
  • the distal end surface of the abutting portion 5 is located on the proximal side with respect to the distal end side 61 of the double-ended needle 6 and on the proximal side with respect to the distal end surface of the convex portion 42.
  • the front end surface of the contact portion 5 may be located at the same position as the front end surface of the convex portion 42 (on the same plane as the front end surface of the convex portion 42) in the axial direction of the double-ended needle 6. You may be located in the front end side rather than the front end surface of the convex part 42. FIG. Also in these cases, the double-ended needle 6 can be maintained in a posture perpendicular to the epidermis.
  • the distance r between the tip surface of the contact portion 5 and the tip surface of the convex portion 42 in the axial direction of the double-ended needle 6 is 1.3 mm. It is preferable to set as follows.
  • the distance T from the inner wall surface (inner circumferential surface) of the contact portion 5 to the outer peripheral edge of the convex portion 42 is preferably set to 4 mm or more, and there is no particular upper limit.
  • the distance T is preferably set to 15 mm or less in consideration of the thinness of the child's arm and the like. That is, the distance T is preferably set within a range of 4 to 15 mm.
  • the inner diameter d of the contact portion 5 is preferably set to a value equal to or larger than the diameter of the blister formed in the upper skin layer.
  • the distance S from the outer periphery of the convex part 42 to the outer peripheral surface of the double-ended needle 6 is 0.3 mm or more, the convex part 42 does not enter the skin. Therefore, considering the preferable value (4 mm or more) of the distance T from the inner wall surface of the contact part 5 to the outer peripheral edge of the convex part 42 and the preferable value (0.3 mm or more) of the distance S, the contact part 5
  • the inner diameter d is preferably set to 9 mm or more.
  • the tip surface of the contact portion 5 and the tip surface of the convex portion 42 are brought into contact with the epidermis in the target region of the living body, Press with strength.
  • the epidermis of the part that is not in contact with the tip surface of the contact part 5 on the inner side of the contact part 5 rises in a mountain shape, and the epidermis of the part that is in contact with the tip surface of the convex part 42 is the double-ended needle 6.
  • the needle tip 61 on the tip side of the double-ended needle 6 is punctured into the living body.
  • the puncture depth of the double-ended needle 6 is such that the positional relationship between the double-ended needle 6 and the epidermis is regulated by the front end surface of the contact portion 5 and the front end surface of the convex portion 42 being in contact with the epidermis. Become deep.
  • the state shown in FIG. 3A is a state before reaching the state shown in FIG.
  • vent hole 51 penetrating the abutting portion 5 is formed in the abutting portion 5.
  • the vent hole 51 allows the space 52 inside the contact portion 5 to communicate with the outside in a contact state in which the tip surface of the contact portion 5 contacts the surface of the living body. Therefore, the vent hole 51 and the vent hole 41 of the needle support portion 4 constitute a vent means for opening the outer cylinder space 21 to the outside.
  • vent hole 51 is a side hole formed in the side wall of the contact portion 5, and is arranged on the proximal end side of the contact portion 5 in the illustrated configuration.
  • the vent hole 51 is blocked by a skin that swells in a mountain shape when the distal end surface of the abutment portion 5 is pressed against the epidermis in the target region of the living body. This can be prevented.
  • vent holes 51 is one in the present embodiment, the number is not limited to this and may be plural.
  • the protection member 8 is a member that seals the space 52 inside the contact portion 5, and is detachably attached to the contact portion 5 in an unused state.
  • the protective member 8 has a bottomed cylindrical shape having a bottom portion on the distal end side, and has a bottomed cylindrical shape in the configuration shown in the drawing. Is closed, and the space 52 inside the contact portion 5 is hermetically sealed.
  • the space 52 inside the contact portion 5 is hermetically sealed by the protection member 8, and the seal member 74 provides a space between the inner peripheral surface of the outer cylinder 2 and the outer peripheral surface of the container main body 71.
  • the seal member 74 provides a space between the inner peripheral surface of the outer cylinder 2 and the outer peripheral surface of the container main body 71.
  • the protective member 8 is removed from the contact portion 5 as shown in FIG. Thereby, sealing of the space 52 inside the contact part 5 is cancelled
  • FIG. 3B in the contact state in which the space 52 inside the contact part 5 is released and the tip surface of the contact part 5 is in contact with the surface of the living body, the contact is made.
  • the vent hole 51 of the portion 5 and the vent hole 41 of the needle support portion 4 the outer cylinder inner space 21 and the space 52 inside the contact portion 5 are opened to the outside.
  • a vent hole (third vent hole) 43 penetrating the base portion 40 may be formed.
  • the vent hole 43 opens the outer cylinder inner space 21 and the space 52 inside the contact portion 5 to the outside.
  • the ventilation means is constituted by the ventilation holes 41, 43 and 51.
  • 3C corresponds to FIG. 3A
  • FIG. 3D corresponds to FIG. 3B.
  • the number of the vent holes 43 is one in the illustrated configuration, but is not limited to this and may be plural.
  • the protective member 8 is attached to the contact part 5, and as described above, the outer cylinder inner space 21 and the space 52 inside the contact part 5. The sterility is maintained, whereby the sterility of the double-ended needle 6 is maintained.
  • the prefilled syringe 1 When using the prefilled syringe 1, first, as shown in FIG. 1, the protective member 8 is removed from the contact portion 5 of the prepared prefilled syringe 1. Thereby, the preparation for administering the drug solution is completed. As described above, the prefilled syringe 1 can easily and quickly prepare for the administration of the drug solution.
  • the front end surface of the contact portion 5 and the front end surface of the convex portion 42 are, for example, It is brought into contact with the epidermis at the site to which a drug solution such as an arm is administered and pressed with a predetermined strength.
  • a drug solution such as an arm
  • the epidermis of the part that is not in contact with the tip surface of the contact part 5 on the inner side of the contact part 5 rises in a mountain shape, and the epidermis of the part that is in contact with the tip surface of the convex part 42 is the double-ended needle 6.
  • the needle tip 61 on the tip side of the double-ended needle 6 is punctured into the living body.
  • the needle tip 61 reaches the dermis by restricting the positional relationship between the double-ended needle 6 and the epidermis by the contact portion 5 and the convex portion 42.
  • the needle tip 61 of the double-ended needle 6 can be punctured into the dermis easily and reliably.
  • the gasket 72 slides in the distal direction in the container body 71, and the chemical solution in the chemical solution container 7 passes through the double-ended needle 6, It is discharged from the needle tip 61 and administered to the target site.
  • the chemical liquid container 7 in which a necessary amount of the chemical liquid is stored is provided, so that waste of the chemical liquid can be prevented and it is economical.
  • the chemical solution container 7 and the double-ended needle 6 are installed in advance, and the sterilized state of the outer cylinder inner space 21 in which the double-ended needle 6 is arranged and the space 52 inside the contact portion 5 is not used. Since it is held, preparation for administration of the drug solution can be performed easily and quickly by simply removing the protective member 8.
  • the positional relationship between the double-ended needle 6 and the epidermis is regulated by the tip surface of the abutment portion 5 and the tip surface of the convex portion 42 coming into contact with the epidermis.
  • the double-ended needle 6 can be punctured to a target puncture depth.
  • the vent holes 41 and 51 are provided. Therefore, when the pusher 3 is moved in the distal direction, the outer cylinder inner space 21 and the inner space 52 of the contact portion 5 are respectively An increase in pressure can be prevented, so that the moving operation of the pusher 3 can be performed easily and smoothly.
  • the prefilled syringe 1 can be easily assembled. That is, when the vent holes 41 and 51 are not provided, the outer cylinder inner space 21 is hermetically sealed. Therefore, when the chemical container 7 provided with the seal member 74 is inserted into the outer cylinder 2, although the process of depressurizing the space 21 is required, the prefilled syringe 1 does not require the depressurization process, takes less time, and can be assembled quickly.
  • the ventilation holes 41 and 51 are provided as ventilation means.
  • the ventilation holes are not limited thereto.
  • a vent hole (not shown) that communicates with each other may be provided.
  • the vent hole is a side hole formed in the side wall of the distal end portion of the outer cylinder 2, and is located on the distal end side with respect to the seal member 74 in a state where the chemical liquid container 7 is in contact with the needle support portion 4. Is preferred.
  • a sterilizing filter that allows air to pass but does not allow bacteria to pass through is provided in the vent hole.
  • FIG. 6 is a partial longitudinal sectional view showing a second embodiment of the prefilled syringe of the present invention.
  • the upper side in FIG. 6 is “base end”, the lower side is “tip”, the right side is “right”, and the left side is “left”.
  • the axial length of the outer cylinder 2 is set shorter than the axial length of the chemical liquid container 7. Further, the seal member 74 is fixed to the proximal end portion of the container main body 71 of the chemical solution container 7. And the chemical
  • the gasket 72 is disposed in the middle of the container main body 71, in the illustrated configuration, closer to the tip than the center of the container main body 71. Accordingly, when the pusher 3 is moved (pressed), the container body 71 serves as a guide for the pusher 3 and can be easily moved.
  • a lubricant is applied to the inner surface of the outer cylinder 2 so that the chemical container 7 can be easily inserted into the outer cylinder 2.
  • the axial length of the outer cylinder 2 is shorter than that in the first embodiment, it is possible to reduce labor and time for applying the lubricant to the inner surface of the outer cylinder 2 when assembling the prefilled syringe 1. This makes it possible to assemble easily and quickly.
  • the seal member 74 may be fixed to the inner peripheral surface of the outer cylinder 2 instead of the outer peripheral surface of the container body 71. Further, the seal member 74 may be integrally formed with the outer cylinder 2 (for example, integral molding or the like).
  • FIG. 7 is a longitudinal sectional view showing a third embodiment of the prefilled syringe of the present invention.
  • the upper side in FIG. 7 is referred to as “base end”, the lower side as “tip”, the right side as “right”, and the left side as “left”.
  • the chemical liquid container 7 in the prefilled syringe 1 of the third embodiment, has a container main body 71 and a gasket 72 that can slide in the container main body 71.
  • the container main body 71 has a partition part (bottom part) 77 that partitions the inside of the container main body 71 into a distal end portion and a proximal end portion in the middle of the axial direction. That is, the container main body 71 has a bottomed cylindrical portion having a bottom portion constituted by the partitioning portion 77 on the proximal end side, and has a bottomed cylindrical portion in the illustrated configuration, and a gasket. 72 is provided at the distal end (front end side) of the container body 71. And the chemical
  • the position of the partition portion 77 of the container main body 71 is the intermediate portion (substantially intermediate position) in the axial direction of the container main body 71 in the configuration shown in the figure, but is not limited to this, for example, in the proximal direction or the distal direction It may be shifted by a predetermined distance, or may be the proximal end portion of the container body 71 in the axial direction.
  • a flange 32 is provided at the base end portion of the container main body 71 as a pressing portion for moving and operating the chemical liquid container 7 along the axial direction (longitudinal direction) of the outer cylinder 2.
  • the container main body 71 and the flange 32 are integrally formed.
  • the present invention is not limited to this, and for example, the container main body 71 and the flange 32 are configured as separate members, and these are adhesives. May be joined by adhesion or fusion.
  • the prefilled syringe 1 has a gasket abutting portion 9 that is located in the outer cylinder inner space 21 and can abut against the gasket 72.
  • the gasket contact portion 9 has a cylindrical shape and is installed at the center of the proximal end surface of the needle support portion 4.
  • the double-ended needle 6 is inserted through the gasket contact portion 9, and the proximal end side needle tip 62 is located on the proximal end side with respect to the gasket contact portion 9.
  • the chemical container 7 moves in the distal direction with respect to the outer cylinder.
  • the needle tip 62 on the proximal end side of the double-ended needle 6 penetrates the gasket 72 of the chemical solution container 7, and the proximal end side of the double-ended needle 6 communicates with the inside of the container main body 71.
  • the gasket 72 can move in the proximal direction with respect to the container body 71.
  • the gasket 72 comes into contact with the gasket contact portion 9 and slides in the proximal direction in the container body 71, and the chemical solution in the chemical solution container 7 passes through the double-ended needle 6, It is discharged from the needle tip 61 on the distal end side and administered to a target site.
  • the seal member 74 may be fixed to the inner peripheral surface of the outer cylinder 2 instead of the outer peripheral surface of the container body 71. Further, as shown in FIG. 7B, the seal member 74 may be integrally formed with the outer cylinder 2 (for example, integral molding or the like).
  • the distal end portion of the pusher (pressing portion) 3 is fixed to the proximal end portion of the container main body 71 can also be adopted.
  • the container main body 71 and the pusher 3 or its main-body part 31 may be integrally formed.
  • the base end portion of the chemical solution container 7 may be used as it is as the pressing portion. That is, the base end portion of the container main body 71 may also serve as the pressing portion.
  • FIG. 8 is a longitudinal cross-sectional view which shows the part by the side of the front end in 4th Embodiment of the prefilled syringe of this invention.
  • the upper side in FIG. 8 is “base end”, the lower side is “tip”, the right side is “right”, and the left side is “left”.
  • the distal end portion of the outer cylinder 2 constitutes a contact portion 5.
  • a rib 22 is provided on the inner peripheral surface of the distal end portion of the outer cylinder 2 over the entire circumference of the outer cylinder 2 as a positioning portion for positioning the needle support portion 4. In addition, the rib 22 may be provided partially.
  • the needle support portion 4 is fixed to the inner peripheral surface of the distal end portion of the outer cylinder 2.
  • the base portion 40 of the needle support portion 4 has a bottomed cylindrical shape having a bottom portion on the proximal end side, and has a bottomed cylindrical shape in the illustrated configuration.
  • the protective member 8 is mounted inside the contact portion 5.
  • the protective member 8 is made of an elastic material and is in close contact with the contact portion 5 with certainty.
  • the needle support 4 when the needle support 4 is fixed to the outer cylinder 2, the needle support 4 is inserted into the outer cylinder 2 from the tip thereof. At this time, the needle support portion 4 is in contact with the rib 22 of the outer cylinder 2, whereby the needle support portion 4 is positioned with respect to the outer cylinder 2. Then, the needle support portion 4 is fixed to the outer cylinder 2 by adhesion or fusion with an adhesive.
  • the present invention may be a combination of any two or more configurations of the above embodiments.
  • the cap was used as the protection member 8 which seals the space 52 inside the contact part 5, in this invention, it is not limited to this, For example, a film etc. may be used. .
  • prefilled syringe of the present invention is not limited to vaccine administration, and can be applied to prefilled syringes for administering various chemical solutions.
  • the present invention since there is a chemical solution container in which a required amount of chemical solution is stored, waste of the chemical solution can be prevented. And since the drug solution container and the puncture needle are installed in advance and the aseptic condition of the necessary part such as the space around the puncture needle is kept unused, the drug solution can be administered easily and quickly. Preparation can be done. In addition, since the contact portion is provided, the puncture needle can be punctured to the target puncture depth easily and reliably when the drug solution is administered. Therefore, it has industrial applicability.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention porte sur une ampoule-seringue (1) qui est munie d'un tube extérieur (2), d'un contenant de liquide médical (7) dans lequel un liquide médical est contenu préalablement et qui peut se déplacer par rapport au tube extérieur (2), d'un poussoir (3) qui déplace et actionne le contenant de liquide médical (7), d'une aiguille à double tête (6), d'une section de support d'aiguille (4) qui porte l'aiguille à double tête (6), d'une section de contact (5) placée à l'extrémité antérieure du tube extérieur (2) de façon à entourer la pointe de l'aiguille (61) située à l'extrémité antérieure de l'aiguille à double tête (6) et qui peut venir en contact avec la surface d'un corps vivant, d'un élément d'étanchéité (74) qui assure l'étanchéité entre le tube extérieur (2) et le contenant de liquide médical (7), et d'un élément de protection (8). Un trou de passage d'air (41) est ménagé dans la section de support d'aiguille (4) et un trou de passage d'air (51) est ménagé dans la section de contact (5). Dans un état préalable à l'utilisation, l'élément de protection (8) est fixé sur la section de contact (5) afin de maintenir dans un état aseptique l'espace (21) intérieur du tube extérieur et l'espace (52) intérieur de la section de contact (5).
PCT/JP2010/071510 2009-12-02 2010-12-01 Ampoule-seringue Ceased WO2011068131A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009-274839 2009-12-02
JP2009274839 2009-12-02

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WO2011068131A1 true WO2011068131A1 (fr) 2011-06-09

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PCT/JP2010/071510 Ceased WO2011068131A1 (fr) 2009-12-02 2010-12-01 Ampoule-seringue

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WO (1) WO2011068131A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8882706B2 (en) 2009-12-04 2014-11-11 Becton, Dickinson And Company Pen needle removal device for a drug delivery device
EP3403729A1 (fr) * 2017-05-17 2018-11-21 Sulzer Mixpac AG Déchargeur, piston statique et procédé de décharge
EP3403730A1 (fr) * 2017-05-17 2018-11-21 Sulzer Mixpac AG Déchargeur et procédé de décharge
CN110538358A (zh) * 2019-09-12 2019-12-06 刘靖宇 注射用药物容器和预灌封注射用药物容器
CN110662706A (zh) * 2017-05-17 2020-01-07 苏尔寿混合技术有限公司 容器、排放器和用于组装排放器的方法
WO2023110893A1 (fr) * 2021-12-15 2023-06-22 Sanofi Ensemble pour dispositif d'injection, dispositif d'injection comprenant un tel ensemble, récipient de médicament pour un tel ensemble et procédé de fabrication d'un tel récipient de médicament
US12324905B2 (en) 2019-04-26 2025-06-10 Becton Dickinson France Needle cover with undercut

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07124256A (ja) * 1993-10-29 1995-05-16 Ajinomoto Takara Corp:Kk 注射器
JPH09266939A (ja) * 1996-03-29 1997-10-14 Minoru Tomita 注射剤を密封したアンプル兼使い捨て注射筒本体、注射剤を密封できるアンプル兼使い捨て注射筒本体、および、アンプル兼使い捨て注射筒本体に注射剤を密封する方法
JP2000202026A (ja) * 1999-01-18 2000-07-25 Shiseido Co Ltd カ―トリッジ式注射器
JP2004532677A (ja) * 2001-04-13 2004-10-28 ベクトン・ディキンソン・アンド・カンパニー 皮内針
JP2009516572A (ja) * 2005-11-21 2009-04-23 ベクトン・ディキンソン・アンド・カンパニー 皮内送出装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07124256A (ja) * 1993-10-29 1995-05-16 Ajinomoto Takara Corp:Kk 注射器
JPH09266939A (ja) * 1996-03-29 1997-10-14 Minoru Tomita 注射剤を密封したアンプル兼使い捨て注射筒本体、注射剤を密封できるアンプル兼使い捨て注射筒本体、および、アンプル兼使い捨て注射筒本体に注射剤を密封する方法
JP2000202026A (ja) * 1999-01-18 2000-07-25 Shiseido Co Ltd カ―トリッジ式注射器
JP2004532677A (ja) * 2001-04-13 2004-10-28 ベクトン・ディキンソン・アンド・カンパニー 皮内針
JP2009516572A (ja) * 2005-11-21 2009-04-23 ベクトン・ディキンソン・アンド・カンパニー 皮内送出装置

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8882706B2 (en) 2009-12-04 2014-11-11 Becton, Dickinson And Company Pen needle removal device for a drug delivery device
US9861760B2 (en) 2009-12-04 2018-01-09 Becton, Dickinson And Company Pen needle removal device for a drug delivery device
US11786670B2 (en) 2009-12-04 2023-10-17 Becton, Dickinson And Company Pen needle removal device for a drug delivery device
US10744273B2 (en) 2009-12-04 2020-08-18 Becton, Dickinson And Company Pen needle removal device for a drug delivery device
CN110662706A (zh) * 2017-05-17 2020-01-07 苏尔寿混合技术有限公司 容器、排放器和用于组装排放器的方法
WO2018210922A1 (fr) * 2017-05-17 2018-11-22 Sulzer Mixpac Ag Déchargeur, piston statique et méthode de déchargement
CN110612167A (zh) * 2017-05-17 2019-12-24 苏尔寿混合技术有限公司 排放器、静态活塞和排放方法
CN110612166A (zh) * 2017-05-17 2019-12-24 苏尔寿混合技术有限公司 排放器和用于排放的方法
WO2018210916A1 (fr) * 2017-05-17 2018-11-22 Sulzer Mixpac Ag Déchargeur et méthode de déchargement
EP3403730A1 (fr) * 2017-05-17 2018-11-21 Sulzer Mixpac AG Déchargeur et procédé de décharge
EP3403729A1 (fr) * 2017-05-17 2018-11-21 Sulzer Mixpac AG Déchargeur, piston statique et procédé de décharge
US12324905B2 (en) 2019-04-26 2025-06-10 Becton Dickinson France Needle cover with undercut
CN110538358A (zh) * 2019-09-12 2019-12-06 刘靖宇 注射用药物容器和预灌封注射用药物容器
WO2023110893A1 (fr) * 2021-12-15 2023-06-22 Sanofi Ensemble pour dispositif d'injection, dispositif d'injection comprenant un tel ensemble, récipient de médicament pour un tel ensemble et procédé de fabrication d'un tel récipient de médicament

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