[go: up one dir, main page]

WO2010017265A3 - Injectable extended release compositions containing an ion channel blocker for the treatment of arthritis - Google Patents

Injectable extended release compositions containing an ion channel blocker for the treatment of arthritis Download PDF

Info

Publication number
WO2010017265A3
WO2010017265A3 PCT/US2009/052796 US2009052796W WO2010017265A3 WO 2010017265 A3 WO2010017265 A3 WO 2010017265A3 US 2009052796 W US2009052796 W US 2009052796W WO 2010017265 A3 WO2010017265 A3 WO 2010017265A3
Authority
WO
WIPO (PCT)
Prior art keywords
arthritis
treatment
compositions containing
extended release
ion channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/052796
Other languages
French (fr)
Other versions
WO2010017265A2 (en
Inventor
Martin Becker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CALOSYN PHARMA
Original Assignee
CALOSYN PHARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CALOSYN PHARMA filed Critical CALOSYN PHARMA
Publication of WO2010017265A2 publication Critical patent/WO2010017265A2/en
Anticipated expiration legal-status Critical
Publication of WO2010017265A3 publication Critical patent/WO2010017265A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Provided herein are compositions, methods, and kits that include compositions suitable for intra- articular administration to a joint of a patient suffering from osteoarthritis and that include a biocompatible matrix; and at least one ion-channel regulator.
PCT/US2009/052796 2008-08-07 2009-08-05 Injectable extended release compositions and methods of treating arthritis using same Ceased WO2010017265A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8698308P 2008-08-07 2008-08-07
US61/086,983 2008-08-07

Publications (2)

Publication Number Publication Date
WO2010017265A2 WO2010017265A2 (en) 2010-02-11
WO2010017265A3 true WO2010017265A3 (en) 2011-09-29

Family

ID=41664181

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/052796 Ceased WO2010017265A2 (en) 2008-08-07 2009-08-05 Injectable extended release compositions and methods of treating arthritis using same

Country Status (1)

Country Link
WO (1) WO2010017265A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3981388A1 (en) 2013-03-21 2022-04-13 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
ES2672993T3 (en) 2015-10-27 2018-06-19 Eupraxia Pharmaceuticals Inc. Sustained release formulations of local anesthetics
WO2022219089A1 (en) 2021-04-16 2022-10-20 Fondazione Istituto Italiano Di Tecnologia Polymeric microparticles for the local treatment of chronic inflammatory diseases
US20250134908A1 (en) 2021-08-06 2025-05-01 Calosyn Pharma Inc. Therapeutics and method for treating osteoarthritis
CN115364046B (en) * 2022-08-16 2024-04-30 上海交通大学医学院附属第九人民医院 A thermosensitive sol for treating vasospasm and its preparation method and application

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478848A (en) * 1994-01-26 1995-12-26 Bayer Corporation Inhibition of arthritis by L-type calcium channel antagonists nimodipine, nisoldipine and nifedipine
US5942241A (en) * 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
US6221861B1 (en) * 1998-07-10 2001-04-24 The Regents Of The University Of California Reducing pyrophosphate deposition with calcium antagonists
WO2002076344A1 (en) * 2001-03-23 2002-10-03 Durect Corporation Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space
US20060270716A1 (en) * 2005-05-25 2006-11-30 Musculoskeletal Research Llc Method for treating osteoarthritis
WO2009129531A2 (en) * 2008-04-18 2009-10-22 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060269579A1 (en) 2005-05-25 2006-11-30 Musculoskeletal Research Llc Compositions for treating osteoarthritis

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478848A (en) * 1994-01-26 1995-12-26 Bayer Corporation Inhibition of arthritis by L-type calcium channel antagonists nimodipine, nisoldipine and nifedipine
US5942241A (en) * 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
US6221861B1 (en) * 1998-07-10 2001-04-24 The Regents Of The University Of California Reducing pyrophosphate deposition with calcium antagonists
WO2002076344A1 (en) * 2001-03-23 2002-10-03 Durect Corporation Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space
US20060270716A1 (en) * 2005-05-25 2006-11-30 Musculoskeletal Research Llc Method for treating osteoarthritis
WO2009129531A2 (en) * 2008-04-18 2009-10-22 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier

Also Published As

Publication number Publication date
WO2010017265A2 (en) 2010-02-11

Similar Documents

Publication Publication Date Title
AU2010233994A8 (en) Bispecific anti-ErbB-3/anti-c-Met antibodies
WO2009076676A3 (en) Compositions and methods for producing isoprene
WO2009129246A3 (en) Compositions and methods for preparing and using same
WO2010025295A3 (en) Compounds that modulate intracellular calcium
MY175979A (en) Certain chemical entities, compositions and methods
WO2009047644A3 (en) Method of treating vitamin d insufficiency and deficiency
WO2008091835A3 (en) Implantable medical endoprostheses
MX2011007930A (en) Crystalline insulin-conjugates.
WO2009035818A8 (en) Compounds that modulate intracellular calcium
IL205360A0 (en) Methods, kits, and compositions for administering pharmaceutical compounds
WO2009076454A3 (en) Compounds that modulate intracellular calcium
AU2009331669A8 (en) Dihydropyridone amides as P2X7 modulators
EP4327867A3 (en) Pharmaceutical composition comprising glucopyranosyl diphenylmethane derivatives, pharmaceutical dosage form thereof, process for their preparation and uses thereof for improved glycemic control in a patient
WO2010037059A3 (en) Heteroaryl antagonists of prostaglandin d2 receptors
WO2011041729A3 (en) Compounds as lysophosphatidic acid receptor antagonists
WO2011017350A3 (en) Compounds as lysophosphatidic acid receptor antagonists
WO2011041462A3 (en) Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2009121039A3 (en) Administration of benzodiazepine compositions
WO2012021629A3 (en) Novel d3 dopamine receptor agonists to treat dyskinesia in parkinson's disease
WO2010039977A3 (en) Heteroaryl antagonists of prostaglandin d2 receptors
WO2009082038A3 (en) Ampa receptor antagonists and zonisamide for epilepsy
WO2010034011A3 (en) Phenylthiophenyldihydrobenzothiazepine inhibitors of store operated calcium release
IN2012DN03807A (en)
WO2011034962A3 (en) Compounds that modulate intracellular calcium
MX2010002926A (en) Thieno-and furo-pyrimidine modulators of the histamine h4 receptor.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09797211

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09797211

Country of ref document: EP

Kind code of ref document: A2