[go: up one dir, main page]

IN2012DN03807A - - Google Patents

Download PDF

Info

Publication number
IN2012DN03807A
IN2012DN03807A IN3807DEN2012A IN2012DN03807A IN 2012DN03807 A IN2012DN03807 A IN 2012DN03807A IN 3807DEN2012 A IN3807DEN2012 A IN 3807DEN2012A IN 2012DN03807 A IN2012DN03807 A IN 2012DN03807A
Authority
IN
India
Prior art keywords
methods
cognitive function
dinaline
impairments
metabolite
Prior art date
Application number
Inventor
Li-Huei Tsai
Ji-Song Guan
Stephen J Haggarty
Edward Holson
Florence Wagner
Johannes Graeff
Original Assignee
Massachusetts Inst Technology
Gen Hospital Corp
Broad Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Gen Hospital Corp, Broad Inst Inc filed Critical Massachusetts Inst Technology
Publication of IN2012DN03807A publication Critical patent/IN2012DN03807A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.
IN3807DEN2012 2009-10-30 2010-10-29 IN2012DN03807A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25692709P 2009-10-30 2009-10-30
US26546809P 2009-12-01 2009-12-01
PCT/US2010/054872 WO2011053876A1 (en) 2009-10-30 2010-10-29 The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders

Publications (1)

Publication Number Publication Date
IN2012DN03807A true IN2012DN03807A (en) 2015-08-28

Family

ID=43922604

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3807DEN2012 IN2012DN03807A (en) 2009-10-30 2010-10-29

Country Status (9)

Country Link
US (2) US8563615B2 (en)
EP (1) EP2493298A4 (en)
JP (1) JP2013509441A (en)
CN (1) CN102834002A (en)
AU (1) AU2010313255B2 (en)
CA (1) CA2779497A1 (en)
IN (1) IN2012DN03807A (en)
NZ (1) NZ599757A (en)
WO (1) WO2011053876A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009011795A2 (en) * 2007-07-13 2009-01-22 Massachusetts Institute Of Technology Methods for treating stress induced emotional disorders
US8263547B2 (en) * 2008-05-28 2012-09-11 Massachusetts Institute Of Technology DISC-1 pathway activators in the control of neurogenesis
JP2013509441A (en) * 2009-10-30 2013-03-14 マサチューセッツ インスティテュート オブ テクノロジー Use of CI-994 and ginarine for the treatment of memory / cognitive and anxiety disorders
US8729130B2 (en) 2011-07-01 2014-05-20 The Broad Institute, Inc. Methods of using novel solid forms of tacedinaline
WO2012003413A1 (en) * 2010-06-30 2012-01-05 The Broad Institute, Inc. Novel solid forms of tacedinaline
WO2012149540A1 (en) 2011-04-28 2012-11-01 The Broad Institute Inc Inhibitors of histone deacetylase
TR201901856T4 (en) 2011-07-22 2019-03-21 Massachusetts Inst Technology Activators of class I histone deacetylase (HDACs) and their uses.
CA2880117C (en) * 2012-07-27 2021-04-06 The Broad Institute, Inc. Inhibitors of histone deacetylase
WO2014046871A1 (en) * 2012-09-04 2014-03-27 Massachusetts Institute Of Technology The use of gene expression profiling as a biomarker for assessing the efficacy of hdac inhibitor treatment in neurodegenerative conditions
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
JP2021510733A (en) 2018-01-12 2021-04-30 ケーディーエーシー セラピューティクス，インコーポレーテッドＫｄａｃ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Combination of selective histone deacetylase 3 (HDAC3) inhibitor and immunotherapeutic agent for the treatment of cancer
GB202001023D0 (en) * 2020-01-24 2020-03-11 Univ Leicester HDAC Degrader
CN112062826A (en) * 2020-06-01 2020-12-11 暨南大学 Acetylation modified H2B protein marker molecule related to central nervous senescence and application thereof
WO2023034440A1 (en) * 2021-09-01 2023-03-09 Case Western Reserve University Treatment of neurodegenerative diseases with hdac inhibitors

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525727A (en) 1982-05-18 1996-06-11 University Of Florida Brain-specific drug delivery
US5994392A (en) 1988-02-26 1999-11-30 Neuromedica, Inc. Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
US5177064A (en) 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
US6110697A (en) 1995-09-20 2000-08-29 Merck & Co., Inc. Histone deacetylase as target for antiprotozoal agents
DE60034688T2 (en) 1999-09-08 2008-01-17 Sloan-Kettering Institute For Cancer Research CRYSTAL STRUCTURE OF A DEACETYLASE AND ITS INHIBITORS
US6713454B1 (en) 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
PT1233958E (en) 1999-11-23 2011-09-20 Methylgene Inc Inhibitors of histone deacetylase
JP2001149081A (en) 1999-11-29 2001-06-05 Cyclex Co Ltd Method for assaying activities of deacetylases, and method for screening inhibitor or activator of these enzymes
NZ525439A (en) * 2000-09-29 2004-11-26 Topotarget Uk Ltd Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
US20060148743A1 (en) 2001-05-18 2006-07-06 Vasant Jadhav RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA)
CA2450129A1 (en) 2001-06-14 2002-12-27 Donald G. Jackson Novel human histone deacetylases
WO2003024448A2 (en) 2001-09-14 2003-03-27 Methylgene, Inc. Inhibitors of histone deacetylase
WO2003032921A2 (en) * 2001-10-16 2003-04-24 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases and cancer of the brain
EP1456664A1 (en) 2001-12-07 2004-09-15 Novartis AG Use of alpha-tubulin acetylation levels as a biomarker for protein deacetylase inhibitors
AU2003209060A1 (en) 2002-02-07 2003-09-02 Axys Pharmaceuticals, Inc. Assay for acytyltransferase or deacetylase activity
EP1476565A2 (en) 2002-02-08 2004-11-17 Novartis AG Method for screening for compounds having hdac inhibitory activity
CA2476434A1 (en) * 2002-02-15 2003-08-28 Sloan-Kettering Institute For Cancer Research Method of treating trx mediated diseases
US20050288227A1 (en) 2002-02-15 2005-12-29 Marks Paul A Use of thioredoxin measurements for diagnostics and treatments
US7456219B2 (en) * 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
AU2003226014A1 (en) * 2002-03-28 2003-10-13 Brigham And Women's Hospital, Inc. Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and alzheimer's disease
US20030224473A1 (en) 2002-05-23 2003-12-04 Mccafferty Dewey G. Methods for screening for histone deacetylase activity and for identifying histone deacetylase inhibitors
AU2003273701A1 (en) 2002-10-17 2004-05-04 Methylgene Inc. Inhibitors of histone deacetylase
TW200424174A (en) 2003-02-06 2004-11-16 Hoffmann La Roche New TP diamide
US20050037992A1 (en) * 2003-07-22 2005-02-17 John Lyons Composition and method for treating neurological disorders
WO2005030704A1 (en) 2003-09-24 2005-04-07 Methylgene, Inc. Inhibitors of histone deacetylase
US20050227929A1 (en) * 2003-11-13 2005-10-13 Masferrer Jaime L Combination therapy comprising a Cox-2 inhibitor and an antineoplastic agent
JP5319113B2 (en) 2004-03-26 2013-10-16 メチルジーン インコーポレイテッド Inhibitors of histone deacetylase
JP2007533745A (en) * 2004-04-20 2007-11-22 アールエヌディー・ファーマシューティカルズ Pharmaceutical compositions and methods of use of lipophilic silicon-substituted cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs and derivatives
PL1591109T3 (en) 2004-04-30 2008-11-28 Topotarget Germany Ag Formulation comprising histone deacetylase inhibitor exhibiting biphasic release
US20060008517A1 (en) * 2004-07-09 2006-01-12 Lynch Marina A Treatment of age-related memory impairment
US20060018921A1 (en) * 2004-07-16 2006-01-26 Baylor College Of Medicine Histone deacetylase inhibitors and cognitive applications
CA2587013A1 (en) 2004-11-08 2006-05-18 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
JP2008540574A (en) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド Histone deacetylase inhibitor
US20070015183A1 (en) 2005-06-03 2007-01-18 The General Hospital Corporation Biomarkers for huntington's disease
EP1904452A2 (en) 2005-07-14 2008-04-02 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2006287378A1 (en) 2005-09-07 2007-03-15 Braincells, Inc. Modulation of neurogenesis by HDac inhibition
WO2007049262A1 (en) * 2005-10-27 2007-05-03 Berand Limited Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders
AU2006312084A1 (en) 2005-11-03 2007-05-18 Merck Sharp & Dohme Corp. Substituted nicotinamide compounds
WO2007056435A2 (en) * 2005-11-08 2007-05-18 The General Hospital Corporation Dynamin mediated diseases and associated methods and products
AU2007221207A1 (en) 2006-02-28 2007-09-07 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase
CN101466670B (en) 2006-04-07 2013-04-17 梅特希尔基因公司 Inhibitors of histone deacetylase
AU2007243519A1 (en) 2006-04-26 2007-11-08 Merck Sharp & Dohme Corp. Disubstituted aniline compounds
US8119652B2 (en) 2006-05-18 2012-02-21 Merck Sharp & Dohme Corp. Aryl-fused spirocyclic compounds
US20100112600A1 (en) 2006-07-13 2010-05-06 Azard Bonni Methods and compositions for modulating synapse formation
US8088951B2 (en) 2006-11-30 2012-01-03 Massachusetts Institute Of Technology Epigenetic mechanisms re-establish access to long-term memory after neuronal loss
US8030344B2 (en) 2007-03-13 2011-10-04 Methylgene Inc. Inhibitors of histone deacetylase
WO2009011795A2 (en) * 2007-07-13 2009-01-22 Massachusetts Institute Of Technology Methods for treating stress induced emotional disorders
US8263547B2 (en) * 2008-05-28 2012-09-11 Massachusetts Institute Of Technology DISC-1 pathway activators in the control of neurogenesis
CA2734991A1 (en) * 2008-07-23 2010-01-28 Massachusetts Institute Of Technology Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival
NZ593447A (en) * 2008-12-03 2012-12-21 Harvard College Inhibition of hdac2 to promote memory
US9265764B2 (en) * 2009-02-27 2016-02-23 Massachusetts Institute Of Technology Uses of chemicals to modulate GSK-3 signaling for treatment of bipolar disorder and other brain disorders
JP2013509441A (en) 2009-10-30 2013-03-14 マサチューセッツ インスティテュート オブ テクノロジー Use of CI-994 and ginarine for the treatment of memory / cognitive and anxiety disorders
TR201901856T4 (en) * 2011-07-22 2019-03-21 Massachusetts Inst Technology Activators of class I histone deacetylase (HDACs) and their uses.

Also Published As

Publication number Publication date
AU2010313255B2 (en) 2015-04-30
EP2493298A1 (en) 2012-09-05
US20120322879A1 (en) 2012-12-20
US8563615B2 (en) 2013-10-22
JP2013509441A (en) 2013-03-14
CN102834002A (en) 2012-12-19
US8841346B2 (en) 2014-09-23
US20110224303A1 (en) 2011-09-15
NZ599757A (en) 2014-08-29
WO2011053876A1 (en) 2011-05-05
AU2010313255A1 (en) 2012-05-31
EP2493298A4 (en) 2013-04-10
CA2779497A1 (en) 2011-05-05

Similar Documents

Publication Publication Date Title
IN2012DN03807A (en)
MX2011007930A (en) Crystalline insulin-conjugates.
IN2014CN02616A (en)
MX356210B (en) Acrylic polymer formulations.
AP2012006189A0 (en) 2'-fluoro substituted carbanucleoside analogs for antiviral treatment.
IL219865A0 (en) Acid salt forms of polymer-drug conjugates, compositions comprising the same, methods of producing the same and uses thereof
EP2130909A4 (en) Method for production of tooth, and tooth produced by the method
WO2011057262A3 (en) Treatment of infections with tp receptor antagonists
IL232914A0 (en) New azetidine derivatives, pharmaceutical compositions and uses thereof
ZA201301463B (en) Pharmaceutical compositions for calonolides,their derivatives and analogues,and process for producing the same
UA86731C2 (en) Divisible galenic form of the modified drug release
TW200942530A (en) Pyridine compounds
WO2011009938A3 (en) Stambomycin and derivatives, their production and their use as drugs
MY155330A (en) Methods for salt production
ZA201108292B (en) New compounds,pharmaceutical composition and methods relating thereto
WO2012016683A3 (en) Oral dosage form of pregabalin
GB2482817A (en) Novel use
WO2009011901A3 (en) Methods for promoting wakefulness
IN2014MN01382A (en)
MX2012010317A (en) β-hydroxyalkylamides, method for their production and use thereof.
MX349563B (en) Pharmaceutical formulation of nanonised fenofibrate.
UA96476C2 (en) Pharmaceutical composition comprising irbesartan
WO2012082942A3 (en) Neuropeptide analogs, compositions, and methods for treating pain
WO2012174243A8 (en) D -serine for the treatment of visual system disorders
WO2010083240A9 (en) Methods for treating inflammatory disorders using 2,4-pyrimidinediamine compounds