WO2010004699A1 - Agent for eliminating bad breath and method for producing the same - Google Patents

Abstract

Bad breath is certainly eliminated without causing any side effect. An agent for eliminating bad breath which contains hypochlorous acid and sodium hydrogencarbonate, wherein the effective chlorine concentration is controlled to 201 to 700 ppm and the pH value is controlled to 6.3 or more but not more than 8, desirably 7 or more but not more than 8.  To eliminate bad breath by using the above-described agent for eliminating bad breath, the agent for eliminating bad breath is held in the oral cavity and the oral cavity is rinsed therewith for, e.g., several seconds to several ten seconds.  Thus, sodium hydrogencarbonate contained in the agent for eliminating bad breath breaks biofilms while hypochlorous acid certainly kills bacteria in the oral cavity (mainly periodontal bacteria), which produce volatile sulfur compounds such as methyl mercaptan, hydrogen sulfide and dimethyl sulfide, within a short period of time.  Moreover, the above-described volatile sulfur compounds are deodorized owing to the oxidizing effect of hypochlorous acid or the deodorizing effect of sodium hydrogencarbonate contained in the agent for eliminating bad breath.

Description

Bad breath odor suppressor and method for producing the same

The present invention relates to a bad breath suppressant for suppressing or improving bad breath and a method for producing the same.

The odor emitted from the oral cavity not only makes the people around you uncomfortable, but it can also worsen bad breath due to serious disease. Research and development on substances that reduce bad breath and cause of bad breath from various viewpoints Has been done.

Here, components such as acetone and trimethylamine may be detected in the breath of patients with visceral diseases such as liver dysfunction, renal dysfunction or pancreatic disease (diabetes). It is well known that most of them are volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and dimethyl sulfide.

Such volatile sulfur compounds are produced by the metabolism of anaerobic bacteria that inhabit the oral cavity. High VSC production by bacteria such as Intermedia (Prevotella intermedia), Tanerella forcicensis, Campylobacter rectus, Treponema denticola (T.denticola), Fusobacterium nucleatum (Fusobacterium nucleatum) Therefore, a particularly strong odor is generated from the oral cavity of periodontal disease patients.

In order to reduce such bad breath, conventionally, components such as chlorhexidine (CHX), cetylpyridinium chloride (CPC), triclosan, popidone iodine, benzethonium chloride, and zinc chloride are often mixed in the mouthwash.

JP 2008-31070 A JP 2004-155681 A International Publication No. 2007-72697 “Hortic odor medical treatment manual: diagnosis and treatment based on EBM” (Hideo Miyazaki, Daiichi Dental Publishing Co., Ltd.)

Here, although chlorhexidine (CHX) has been confirmed to have a certain sterilizing action against bacteria in the oral cavity, it is effective only for bacteria, so that the tongue becomes black due to fungi grown by the fungal substitution phenomenon, so-called black hair tongue It has also been pointed out that it causes side effects called “causes” and causes allergies. In Japan, the concentration used is limited.

Cetylpyridinium chloride (CPC) is contained in conventional mouthwashes and dentifrices, and although it has been confirmed to suppress plaque formation and improve gingivitis, it is sufficient for oral bacteria. As a result, there was a problem that the bad breath could not be sufficiently suppressed.

Incidentally, although the fragrance has an effect of masking the bad breath component, since it does not sterilize the volatile sulfur compound (VSC), it does not substantially improve the bad breath.

The present invention has been made in consideration of the above-described circumstances, and an object of the present invention is to provide a bad breath inhibitor capable of reliably suppressing bad breath without causing side effects and a method for producing the bad breath.

In order to achieve the above object, the bad breath suppressant according to the present invention has an effective chlorine concentration of 50 to 700 ppm, a pH of 6.3 to 8, and hypochlorous acid and hydrogen carbonate. It contains sodium.

The halitosis suppressor according to the present invention has an effective chlorine concentration of 201 to 700 ppm instead of 50 to 700 ppm.

In addition, the bad breath suppressant according to the present invention has an effective chlorine concentration of 400 to 700 ppm instead of 201 to 700 ppm.

In addition, the bad breath suppressant according to the present invention has a pH of 7 to 8 instead of 6.3 to 8.

The halitosis suppressor according to the present invention has an effective chlorine concentration of 500 to 700 ppm instead of 50 to 700 ppm, and a pH of 7 to 8 instead of 6.3 to 8. .

The bad breath odor suppressor according to the present invention has an effective chlorine concentration of 50 to 300 ppm instead of 50 to 700 ppm, and a pH of 7 to 8 instead of 6.3 to 8. .

In addition, as described in claim 7, the method for producing a halitosis inhibitor according to the present invention uses an aqueous solution to which sodium chloride and carbon dioxide are added as a stock solution, and the stock solution has an effective chlorine concentration of 50 to 700 ppm and a pH of Electrolysis is performed so that 6.3 to 8 is obtained and hypochlorous acid and sodium hydrogen carbonate are generated.

Further, the method for producing a bad breath odor suppressor according to the present invention comprises adding the stock solution to water through a reverse osmosis membrane, adding sodium chloride to the passing water, and simultaneously with or before or after the sodium chloride addition step. This is produced by blowing or adding dry ice.

In addition, the method for producing the bad breath odor suppressor according to the present invention comprises adding the sodium chloride to the stock solution, pure water or distilled water, and blowing carbon dioxide gas or dry ice before or after the sodium chloride addition step. It is produced by adding.

In addition, the method for producing a bad breath odor suppressor according to the present invention is characterized in that the stock solution is passed through a reverse osmosis membrane with water, sodium chloride is added to the passing water, and the carbon dioxide partial pressure in contact with the passing water is reduced in the atmosphere It is produced by making it higher than the partial pressure.

In addition, the method for producing a bad breath suppressant according to the present invention comprises adding the sodium chloride to pure water or distilled water as the stock solution, and changing the partial pressure of carbon dioxide in contact with the pure water or distilled water to the partial pressure in the atmosphere. It is produced by making it higher.

In addition, the method for producing a halitosis suppressor according to the present invention is such that the effective chlorine concentration is 201 to 700 ppm instead of 50 to 700 ppm.

In addition, the method for producing a halitosis inhibitor according to the present invention is such that the effective chlorine concentration is 400 to 700 ppm instead of the 201 to 700 ppm.

Further, in the method for producing a halitosis inhibitor according to the present invention, the pH is changed to 7 to 8 instead of the above 6.3 to 8.

Further, in the method for producing a halitosis inhibitor according to the present invention, the effective chlorine concentration is set to 500 to 700 ppm instead of the 50 to 700 ppm, and the pH is set to 7 to 8 instead of the 6.3 to 8. Is.

Further, in the method for producing a bad breath suppressant according to the present invention, the effective chlorine concentration is set to 50 to 300 ppm instead of 50 to 700 ppm, and the pH is set to 7 to 8 instead of 6.3 to 8. Is.

The present applicant has developed a sterilizing water for periodontal disease treatment using a high concentration of hypochlorous acid as a sterilizing component, and confirmed that it can kill periodontal pathogens in clinical trials (Patent Document 3), R & D was conducted focusing on whether such sterilized water could be used as a bad breath suppressant.

On the other hand, the volatile sulfur compounds that cause halitosis are produced when oral bacteria metabolize proteins such as cysteine and methionine present in saliva, deciduous epithelial cells, or food residues. In order to fundamentally suppress bad breath, it is essential to sterilize oral bacteria.

However, in general, pathogenic bacteria are not protected as floating bacteria, but are protected by a biofilm made of exopolysaccharides produced by themselves, and with the biofilm, the body's body defense mechanisms and antibiotics are used. Prolonged growth slowly while blocking.

Therefore, high-concentration hypochlorous acid alone cannot kill oral bacteria that produce volatile sulfur compounds.

Therefore, as a result of research on biofilm destruction, the present applicant made an aqueous solution to which sodium chloride (NaCl) and carbon dioxide were added as a stock solution. The stock solution had an effective chlorine concentration of 201 to 700 ppm and a pH of 6 Obtain new knowledge that if electrolysis is performed to 3 to 8, not only hypochlorous acid (HClO) but also sodium hydrogen carbonate (NaHCO ₃ ) can be newly generated and contained at a high concentration. In addition, as a result of the test, even carious pathogens that were thought to be difficult to kill because the cell wall was very thick, and were protected by the environment inhabited in the oral cavity, that is, biofilm It was confirmed that even in a certain environment, it can be killed within a few seconds to tens of seconds by simply including it.

This is the cooperative action of sodium bicarbonate and hypochlorous acid, where high concentrations of sodium bicarbonate destroy biofilms and kill bacteria in the destroyed biofilm with high concentrations of hypochlorous acid. Means that the oral bacteria that are responsible for producing the volatile sulfur compounds are completely sterilized.

That is, according to the bad breath odor suppressor according to the present invention, it is possible to completely sterilize oral bacteria and thereby prevent volatile sulfur compounds from being produced in the oral cavity.

As a result of the test of halitosis, even patients with extremely strong halitosis levels before gargle show that volatile sulfur compounds are hardly detected after gargle and the halitosis level decreases dramatically. It was.

In this way, the bad breath intensity could be remarkably suppressed not only because the oral bacteria producing volatile sulfur compounds can be sterilized by the bad breath suppressor according to the present invention as described above, but also solid matter. Volatile sulfur compounds adhering to the tongue and teeth are captured by sodium bicarbonate contained in the bad breath suppressant and discharged during gargle, and volatile sulfur compounds vaporized in the oral cavity are included in the bad breath suppressant This is probably because hypochlorous acid is oxidized and brominated free. In addition, it is considered that one of the reasons why bad breath can be suppressed is that the substrate necessary for metabolism of oral bacteria is oxidized by hypochlorous acid contained in the bad breath suppressant.

On the other hand, since sodium hydrogen carbonate destroys biofilms, hypochlorine is used for sites in the oral cavity excluding periodontal pockets, such as the surface of the crown and the root of the root, even if the effective chlorine concentration is less than 201 ppm. It has also been found that since there are relatively few organic substances that cause a decrease in acid concentration, oral bacteria living in the above-mentioned site can be sufficiently sterilized.

Further, the bad breath suppressant according to the present invention can be used not only to weaken strong bad breath, but also to prevent bad breath deterioration. In particular, if the effective chlorine concentration is 50 to 300 ppm, the patient himself can Sufficient safety is ensured even in daily use, and it can be used at home.

In order to electrolyze so that the effective chlorine concentration is 50 to 700 ppm and the pH is 6.3 to 8, for example, 2 to 5% by mass of sodium chloride is added, and carbon dioxide is also present in the atmosphere. Carbon (380ppm, annual average concentration of carbon dioxide in Japan, excerpted from "Science Chronology (2nd edition of the environment))" is not enough to dissolve naturally. It is necessary to increase the solubility of.

That is, in this specification, forced dissolution of carbon dioxide means that the solubility of carbon dioxide is higher than the concentration at which it can be dissolved naturally (the solubility under the partial pressure of carbon dioxide present in the atmosphere). To do. Here, in order to forcibly dissolve carbon dioxide, the stock solution may be prepared by any one of the following methods (a) to (d). In any method, acid other than hydrochloric acid, acetic acid and other carbonic acid is used. Do not add at all. Therefore, the main solution composition condition is the amount of sodium chloride added.

(A) Water is passed through a reverse osmosis membrane, sodium chloride is added to the passing water, carbon dioxide gas is blown in or before or after the sodium chloride addition step, or dry ice is added.

(B) Sodium chloride is added to pure water or distilled water, and carbon dioxide gas is blown in or before or after the sodium chloride addition step, or dry ice is added.

(C) Pass water through the reverse osmosis membrane, add sodium chloride to the passing water, and make the partial pressure of carbon dioxide in contact with the passing water higher than the partial pressure in the atmosphere.

(D) Sodium chloride is added to pure water or distilled water, and the partial pressure of carbon dioxide in contact with the pure water or distilled water is made higher than the partial pressure in the atmosphere.

Here, the water that is a component of the stock solution in (a) and (c) can use well water, tap water, etc., and it is not necessary to use pure water. However, it goes without saying that it is better to use pure water that does not contain calcium ions, magnesium ions, etc., in order to prevent electrode damage in the electrolytic cell and reduction in electrode reaction.

In order to suppress bad breath using the bad breath suppressant according to the present invention, the bad breath suppressant is contained in the oral cavity, and is contained for several seconds to several tens of seconds.

In this way, the oral malodor suppressant produces a volatile sulfur compound while destroying the biofilm and gradually losing bactericidal power due to oxidation of organic substances and other cells present in the surroundings. Sterilizes internal bacteria, mainly periodontal pathogens, in a short time and reliably.

Here, the pH was adjusted to 6.3 to 8 because there was a concern about the decalcification of teeth at pH 6.3 or lower, and below pH 6, the concentration of H ₂ CO ₃ , HCO ₃ ⁻ and CO ₃ ²⁻ The proportion of HCO ₃ ^{− in} the rate becomes low, making it difficult to produce sodium bicarbonate that can destroy the biofilm. Above pH 8, the concentration of HClO in the concentration fractions of Cl ₂ , HClO and ClO ⁻ This is because the abundance ratio decreases and it becomes difficult to generate a high concentration of hypochlorous acid that can sterilize bacteria, particularly caries pathogenic bacteria.

The pH is preferably set to 7 or more because lactic acid produced by cariogenic pathogenic bacteria can be neutralized to prevent the oral cavity from being acidified.

The reason why the effective chlorine concentration is set to 50 ppm or more is that sterilization is difficult even if it is less than 50 ppm even in the case of oral bacteria attached to the surface of the crown or the shallow part of the root.

The reason why the effective chlorine concentration is set to 201 ppm or more is that the bacteria of the oral cavity that live deep in the periodontal pocket cannot be sterilized at a concentration of 200 ppm or less. In addition, it is difficult to achieve the following conditions (i) to (iii).

(i) In general, the proportion of bacteria that form biofilms and inhabit them is much larger than the proportion that exists in the floating state. Even if various organic substances and other bacterial cells present in the surroundings are oxidized, it is necessary to maintain sufficient bactericidal power. Hypochlorous acid of about several tens of ppm has too low bactericidal power.

(ii) Sterilizing over a long period of time, for example 60 seconds or more, may cause bacteremia by inducing hundreds of thousands of bacteria into the body (intravascular), leading to systemic disease, and within 30 seconds If possible, it must be killed within 10 seconds.

(iii) 300-400 species of bacteria in the biofilm proliferate parasitically while maintaining a certain equilibrium to form a bacterial flora (so), which may be replaced by other bacteria for some reason. If a small number of bacteria increase abnormally, a change in the bacterial flora called a fungal change phenomenon occurs. That is, when some caries pathogens and periodontal pathogens survive without being sterilized, a fungus replacement phenomenon occurs, and the remaining bacteria rapidly grow. In order to prevent such a situation, all the bacteria that inhabit the biofilm must be killed.

Furthermore, the concentration of 500 ppm or more is desirably set to a concentration of hypochlorous acid that can sterilize or lyse oral bacteria such as caries pathogens and periodontal pathogens even if the ratio of hypochlorous acid is low near pH 8. This is because it can be secured sufficiently.

On the other hand, the reason why the concentration is 700 ppm or less is that the concentration exceeding 700 ppm is an unnecessary concentration for sterilization and achievement of the above (i) to (iii).

Here, when the effective chlorine concentration is set to 300 to 700 ppm, various oral bacteria, particularly periodontal pathogens and caries pathogens can be sterilized or lysed within about 30 seconds. Further, when the effective chlorine concentration is 400 to 700 ppm, sterilization or lysis can be performed within about 10 seconds.

Schematic which showed the apparatus which produces | generates the bad breath inhibitor which concerns on this embodiment. The graph which showed the abundance ratio of hypochlorous acid in low concentration. Schematic which showed the production | generation apparatus of the bad breath inhibitor which concerns on a modification.

Explanation of symbols

51, 51a Breath odor suppressor generator 52 Stock solution 3 Stock solution tank 5 Electrolyzer 6 Discharge pipe 57 Diluted water 60 Secondary product water, bad breath suppressor 63 Tertiary product water, bad breath suppressant 8 Diluted water tank 14 Tertiary product water tank

Hereinafter, embodiments of a bad breath suppressant and a method for producing the same according to the present invention will be described with reference to the accompanying drawings. Note that components that are substantially the same as those of the prior art are assigned the same reference numerals, and descriptions thereof are omitted.

The bad breath suppressant according to this embodiment includes hypochlorous acid (HClO) and sodium hydrogen carbonate (NaHCO ₃ ), and the effective chlorine concentration is 201 to 700 ppm, preferably 400 to 700 ppm, and more preferably 500 to 700 ppm. At the same time, the pH is 6.3 or more and 8 or less, preferably 7 or more and 8 or less.

FIG. 1 shows an apparatus for producing a bad breath suppressant according to this embodiment.

As can be seen in the figure, the bad breath odor suppressor generating apparatus 51 according to this embodiment includes a stock solution tank 3 for storing a stock solution 52, a stroke pump 4 connected to the stock solution tank, and a communication connection to the stroke pump. And a diluting water tank 8 in which the diluting water 57 is stored, and the tip of the discharging pipe 6 is stored in the diluting water tank 8. The installation position of the dilution water tank 8 relative to the tip position of the discharge pipe 6 is relatively positioned so as to be equal to or lower than the water level of the dilution water 57.

The stock solution 52 is prepared by any of the methods described below, but no acid other than hydrochloric acid, acetic acid or other carbonic acid is added in any of the methods.

Diluent water 57 may be well water, tap water, pure water, or any other water, but the pH is appropriately selected so that the pH of the mouth odor suppressant to be produced is in the above-described range.

The generation apparatus 51 according to the present embodiment further includes a deaeration module 11 in which the water injection side is communicated with the secondary generation water 60 obtained by diluting the primary generation water with the dilution water 57 in the dilution water tank 8. The deaeration module is adapted to remove dissolved oxygen from the secondary product water 60 by reducing the pressure by the vacuum pump 12, and to remove the tertiary product water from which the dissolved oxygen has been removed from the secondary product water 60 from the bad breath. A tertiary product water tank 14 is stored as 63.

It should be noted that the tubes used in the generation device 51 or the electromagnetic valve provided as necessary may be deteriorated by oxidation with a high concentration of hypochlorous acid, so that it is desirable to form with fluorine.

In order to produce the bad breath suppressor 63 using the bad breath suppressant producing apparatus 51 according to this embodiment, the effective chlorine concentration of the tertiary product water is 201 to 700 ppm, desirably 400 to 700 ppm, more desirably 500 to 700 ppm. The composition conditions of the stock solution 52 (mainly the amount of sodium chloride added) and the operating conditions during electrolysis (eg voltage value and current value) so that the pH is 6.3 to 8, preferably 7 to 8. In addition, the dilution conditions (dilution ratio and pH of dilution water) are determined, and the blended stock solution 52 is stored in the stock solution tank 3.

Sodium chloride is added, for example, 2 to 5% by mass.

In order to increase the solubility of carbon dioxide, passing water, pure water or distilled water passed through a reverse osmosis membrane is used as a solvent, and carbon dioxide is forcibly mixed in the solvent to temporarily reduce the solubility of carbon dioxide. To increase the partial pressure of carbon dioxide in contact with the solvent, and to reduce the temperature of the solvent, it is possible to increase the water temperature due to heat generated during electrolysis. It is desirable to select either a method of forcibly mixing or a method of increasing the partial pressure of carbon dioxide.

The method for temporarily increasing the solubility of carbon dioxide can be further classified into either a method by blowing carbon dioxide or a method by adding dry ice. Here, the term “temporary” means that the partial pressure of carbon dioxide in contact with the solvent is equal to the partial pressure of carbon dioxide present in the atmosphere. In other words, since carbon dioxide is mixed at atmospheric pressure, Even when forced press-fitting is performed, the solubility of carbon dioxide decreases with time due to pressure equilibrium with the partial pressure of carbon dioxide contained in the air. In this case, it is necessary to perform electrolytic treatment promptly before the solubility of carbon dioxide decreases.

As a method for increasing the solubility of carbon dioxide by increasing the partial pressure of carbon dioxide, the water is passed through a reverse osmosis membrane, pure water or distilled water is used as a solvent, and the solvent is sealed in an airtight tank. A method in which carbon dioxide is injected or carbon dioxide gas is blown into a solvent in an airtight tank or dry ice is added to the solvent can be employed.

In this case, since it is necessary to dissolve carbon dioxide in a solvent at a predetermined partial pressure of carbon dioxide and to carry out electrolysis by feeding the stock solution 52 into the electrolytic cell 5 while maintaining the partial pressure, the partial pressure of carbon dioxide is reduced. What is necessary is just to comprise the undiluted | stock solution tank 3, the stroke pump 4, and the electrolytic vessel 5 as a whole so that it may not fall.

In summary, the forced dissolution of carbon dioxide is made by selecting one of the following methods.

(a-1) Tap water is passed through the reverse osmosis membrane, sodium chloride is added to the passing water, and carbon dioxide is blown into the passing water at the same time or before and after the sodium chloride adding step. Force to dissolve.

(a-2) Tap water is passed through a reverse osmosis membrane, sodium chloride is added to the passing water, and carbon dioxide is passed through by adding dry ice simultaneously with or before and after the sodium chloride adding step. Forcibly dissolve.

(B-1) While adding sodium chloride to pure water or distilled water, carbon dioxide is forcibly dissolved by blowing carbon dioxide at the same time as or before and after the sodium chloride addition step.

(B-2) While adding sodium chloride to pure water or distilled water, carbon dioxide is forcibly dissolved by adding dry ice simultaneously with or before and after the sodium chloride addition step.

(c) Passing the brine through the reverse osmosis membrane, adding sodium chloride to the passing water, and increasing the partial pressure of carbon dioxide in contact with the passing water to be higher than the partial pressure in the atmosphere. Carbon dioxide is dissolved in the passing water with a solubility higher than that in

(d) 塩 化 ナ ト リ ウ ム Solubility at atmospheric carbon dioxide partial pressure by adding sodium chloride to pure water or distilled water and making the partial pressure of carbon dioxide in contact with pure water or distilled water higher than the partial pressure in the atmosphere Carbon dioxide is dissolved in the passing water with higher solubility.

The water that passes through the reverse osmosis membrane may be of any property, but it is purified to some extent in the sense of reducing the burden on the reverse osmosis membrane and the water purifier using it, or reducing the amount of waste water as much as possible. Water is desirable. For example, ground water, tap water, or commercially available mineral water (commercial water) can be used. Hereinafter, in this embodiment, tap water is used as the water that passes through the reverse osmosis membrane.

When the stock solution 52 is produced by passing tap water through a reverse osmosis membrane, water purifiers equipped with a reverse osmosis membrane are commercially available from several manufacturers. In addition, when carbon dioxide is dissolved in passing water, pure water or distilled water in an environment where the partial pressure of carbon dioxide is high, a conventionally known carbon dioxide dissolving apparatus can be used as appropriate.

Once the stock solution 52 has been prepared, the stock solution 52 is then weighed in an amount corresponding to one batch of bad breath suppressant and stored in the stock solution tank 3, and diluted water in an amount corresponding to one batch of bad breath suppressant. 57 is stored in the dilution water tank 8. The amount of the dilution water 57 corresponding to one batch of bad breath odor suppressor may be appropriately determined according to the dilution rate and the pH of the dilution water.

Next, the stock solution 52 is sent to the electrolytic cell 5 by the stroke pump 4, and the electrolytic cell 5 is operated under predetermined operating conditions to electrolyze the stock solution 52.

Next, the primary generated water generated in the electrolytic cell 5 is injected into the diluted water 57 previously stored in the diluted water tank 8 through the discharge pipe 6 connected to the electrolytic cell.

Here, the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 57 stored in the dilution water tank 8.

Therefore, the primary product water is injected into the dilution water 57 through the discharge pipe 6 without coming into contact with air (outside air). In addition, since the primary product water is injected into the diluting water 57 weighed in advance in a so-called batch system, the primary product water is diluted with the dilution water unlike conventional mixing in the pipe. 57 is mixed homogeneously.

Next, by passing the secondary product water 60 through the degassing module 11, the tertiary product water from which dissolved gas, particularly dissolved oxygen is removed, is generated, and this is used as the bad breath suppressor 63 in the tertiary product water tank 14. Store.

In order to suppress bad breath using the bad breath suppressant 63 according to this embodiment, the bad breath suppressant 63 is included in the oral cavity, for example, for several seconds to several tens of seconds.

In this way, sodium hydrogen carbonate contained in the bad breath suppressor 63 destroys the biofilm, while hypochlorous acid gradually loses its bactericidal power due to oxidation of organic substances and other bacterial cells present in the surroundings. It sterilizes oral bacteria that produce volatile sulfur compounds in a short time.

In addition, hypochlorous acid contained in the bad breath suppressor 63 oxidizes volatile sulfur compounds vaporized in the oral cavity to make no bromide, and sodium hydrogen carbonate contained in the bad breath suppressor 63. Captures volatile sulfur compounds adhering to the tongue and teeth as solids and substrates necessary for the metabolism of oral bacteria and excretes them during garnishing.

As described above, according to the bad breath suppressant 63, the production method thereof, and the production apparatus 51 according to this embodiment, an aqueous solution to which sodium chloride and carbon dioxide are added is used as a stock solution, and the stock solution has an effective chlorine concentration of 201. Electrolysis is performed so that the pH is 6.3-8, preferably 7-8, so that the biofilm can be destroyed at a high concentration so that the biofilm can be destroyed. It is possible to produce both sodium hydrogen carbonate and hypochlorous acid at a high concentration that can sterilize oral bacteria such as periodontal pathogens. Innovative action and effect that can sterilize or lyse and wash or remove volatile sulfur compounds in the oral cavity Unlikely to.

Also, according to the method and apparatus 51 for producing bad breath suppressant according to the present embodiment, carbon dioxide is forcibly dissolved, so that high-concentration sodium hydrogen carbonate can be produced, and thereby There is an effect that the biofilm can be destroyed. Of course, since it is not necessary to add acid such as hydrochloric acid or acetic acid, it is possible to produce a tasteless and odorless mouth odor suppressant. For example, even if the effective chlorine concentration is 500 ppm to 700 ppm, there is no discomfort to the patient. It has the effect of being able to completely sterilize or lyse oral bacteria such as periodontal pathogens in a short time of several seconds to several tens of seconds without giving them.

Fig. 2 is a graph showing the existing abundance ratio of available chlorine (extracted from "Water Purification Technology", published by Gihodo Publishing Co., Ltd.). As can be seen from the figure, conventionally, the abundance ratio of hypochlorous acid was drastically lowered at pH 7 or higher, and the abundance ratio was 20% at pH 8.

However, when the applicant conducted a clinical trial (details will be described later), it was found that caries pathogens can be killed in the pH range of 6-8. As described above for caries pathogenic bacteria, so-called lysis, which permeates the cell wall and denatures internal proteins, is considered difficult in the dental field even with hypochlorous acid. It is recognized that acid ions (ClO ⁻ ) cannot completely destroy the cell walls of carious pathogenic bacteria.

Therefore, the fact that caries pathogenic bacteria were able to be killed in the pH range of 6 to 8, that is, the fact that the high concentration of hypochlorous acid was produced indirectly in such a pH range is another reason. Don't be.

Since it is difficult to directly measure hypochlorous acid in available chlorine, further research and development is necessary. However, considering the fact that caries pathogens have been killed and the results of pH measurement, the pH should be 7-8. Even so, there is a high possibility that a sufficient concentration of hypochlorous acid has been produced.

That is, according to the bad breath suppressant 63 according to the present embodiment, hypochlorous acid can kill bacteria with sufficient bactericidal power in a pH range of 7 to 8, which has not been attracting attention in the past, and such pH range This is a synergistic effect with the biofilm destroying action of sodium hydrogen carbonate, which has a high abundance ratio, and has an industrially significant effect that bacteria in the biofilm can be killed without removing the biofilm in advance. is there. In addition, the killing of bacteria by the bad breath odor suppressor leads to a so-called lysis state in which cell walls are broken and internal proteins are denatured, and there is no risk that resistant bacteria appear.

In addition, according to the bad breath odor suppressor generating device 51 according to the present embodiment, the dilution water tank 8 is configured such that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 57 stored in the dilution water tank 8. The primary generation water is injected into the dilution water 57 in a non-contact state with air (outside air), and thus the mixing ratio of the stock solution 52 and the electrolytic cell 5 Even if chlorine gas is generated due to the operating conditions differing from the design values, the chlorine gas is changed to hypochlorous acid in diluted water 57 whose pH environment is close to neutral. At the same time, there is no concern of volatilization in the air as chlorine gas.

In addition, since the primary product water generated in the electrolytic cell 5 is poured into the dilution water 57 measured in advance in a batch system, it is possible to perform homogeneous mixing unlike conventional mixing in piping. It becomes possible to adjust the pH of the secondary product water 60 and the effective chlorine concentration contained therein as designed values.

Moreover, according to the production method of the bad breath suppressant according to the present embodiment, the dissolved gas is removed from the secondary produced water 60 to produce the tertiary produced water 63, which is used as the bad breath suppressant. The foaming phenomenon can be prevented in advance, and the situation where bacteria in the oral cavity are sent into the body (in the blood vessel) can be prevented.

In the present embodiment, the dissolved gas in the secondary product water 60 is removed using the degassing module 11, but there is a concern that a foaming phenomenon may occur because the concentration of the dissolved gas in the secondary product water 60 is low. If not, the step of removing the dissolved gas may be omitted. In such a case, the secondary product water 60 serves as a bad breath suppressant.

FIG. 3 is a diagram showing a generating device 51a used when the dissolved gas removal step is omitted, and the degassing module 11, the vacuum pump 12, and the tertiary generated water tank 14 are omitted from the generating device 21.

In this embodiment, the stock solution 52 and the dilution water 57 in an amount corresponding to one batch of bad breath suppressant are weighed and stored in the stock solution tank 3 and the dilution water tank 8 in advance. Instead, if stock solution 52 of an amount larger than one batch of bad breath suppressant, for example, an amount corresponding to several batches, is stored in stock solution tank 3 in advance, stock solution 52 corresponding to one batch of bad breath suppressant is stored. It is sufficient to provide a water level measuring means for measuring the amount of water. Such water level measuring means can be appropriately configured by, for example, an ultrasonic sensor, an electrode type sensor or the like.

In this embodiment, the stock solution is electrolyzed and then diluted to produce a halitosis inhibitor (post-dilution). Instead, the stock solution is diluted, and then the diluted water is used. May be electrolyzed to obtain a halitosis suppressant (pre-dilution). In the case of such a modified example, the dilution water tank 8 is omitted, and instead, a diluted stock solution tank for storing the diluted stock solution is separately provided between the stock solution tank 3 and the electrolytic cell 5. That's fine.

In this embodiment, the effective chlorine concentration is set to 201 to 700 ppm. However, the concentration of hypochlorous acid is reduced in the oral cavity excluding the periodontal pocket, for example, the surface of the crown surface or the shallow root portion. Since the organic matter is relatively small, even if the effective chlorine concentration is less than 201 ppm, it is possible to sufficiently sterilize oral bacteria that inhabit the site. That is, even when the effective chlorine concentration is 50 ppm or more and less than 201 ppm, it can be used as a bad breath suppressant.

In addition, in this embodiment, the bad breath suppressant used mainly when bad breath is strong has been described, but the bad breath suppressant according to the present invention can be used not only to weaken strong bad breath but also to prevent bad breath deterioration. .

In particular, if the effective chlorine concentration is 50 to 300 ppm, sufficient safety will be ensured even when patients themselves use it daily to prevent bad breath and can be used at home. It becomes.

(Generation of halitosis suppressor)
First, tap water is poured into a water purifier equipped with a reverse osmosis membrane, then 3% by mass of sodium chloride is added to the water that has passed through the reverse osmosis membrane, and dry ice is added to obtain a stock solution. The stock solution was diluted 5 times (pre-dilution).

Next, the diluted stock solution was electrolyzed in an electrolytic cell to obtain a bad breath suppressant.

The electrolytic cell used was an electrolytic neutral water generating device sold by Sakai Engineering Co., Ltd. under the trade name “Epios Eco”.

As a result of electrolysis by the above process, it was possible to produce a halitosis inhibitor having an effective chlorine concentration of 600 to 700 ppm within a pH range of 6.3 to 8. In measuring the concentration of effective chlorine in the bad breath suppressant, there was no meter, test paper or reagent capable of measuring concentrations exceeding 200 ppm. Therefore, the effective chlorine concentration was measured by repeating twice the dilution twice. .

In addition, as a control (standard reagent) for confirming the effect of the 500 ppm halitosis inhibitor, a 40 ppm halitosis inhibitor was also prepared in the same procedure.

(Clinical trial of halitosis inhibitor against periodontal pathogens)
It is said that the site in the oral cavity where the most volatile sulfur compounds are produced is the back of the tongue, not the periodontal pockets. Periodontal pocket was selected as the site.

That is, in this clinical trial, a bad breath suppressant was injected into the periodontal pocket, then the probe was inserted into the bottom of the periodontal pocket without touching saliva, and plaque adhered to the root surface was collected. Was placed on a slide glass and suspended in physiological saline, and then covered with a cover glass, which was observed with a high-resolution phase-contrast microscope at 3600 times.

Table 1 shows the observation results with a microscope.

When the above clinical trials were conducted on 10 patients, as can be seen from the table, periodontal pathogens were lysed in all patients and their death was confirmed.

(Clinical trial of halitosis inhibitor against carious pathogens)
Next, clinical trials against caries pathogenic bacteria were conducted.
In conducting the test, the oral malodor suppressant is contained in the oral cavity for 10 seconds, and then saliva is collected and cultured for a predetermined period of time. The number of cells (in 1 ml of saliva) of Sobrinas (Streptococcus sobrinus) and Lactobacilli was examined.

The test used “CA 21 Fast” (short-term caries activity test) sold by Morita Co., Ltd. The culture was carried out in two cases: after 20 minutes (37 ° C) and after 24 hours (37 ° C).

First, in the case of the control reagent, 10 ² to 10 ³ (safety range to caution range) after 20 minutes of incubation, 10 ⁵ to 10 ⁶ (dangerous range) after 24 hours of incubation, and the effective chlorine concentration is about 40 ppm. It was found that the cariogenic bacteria could not be sufficiently sterilized.

On the other hand, as shown in Table 2, in the case of the halitosis suppressor according to the present invention, it was found that all patients became safe after gargle and the caries pathogenic bacteria could be lysed. This is probably because the biofilm destruction action by sodium hydrogen carbonate and the bactericidal action by hypochlorous acid synergized, and caries pathogens could be killed.

(Generation of halitosis suppressor 2)
1) Stock solution The following four test solutions were prepared as stock solutions.

Test solution A;
By adding 5% (w / v) of dry ice to distilled water at atmospheric pressure and at room temperature, carbon dioxide constituting the dry ice is dissolved in the distilled water (saturated carbonated water). 0.6% (w / v) was dissolved.

Test solution B;
Saturated carbonated water, which is an intermediate product of test solution A, was diluted 5-fold with distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.

Test solution C;
Saturated carbonated water, which is an intermediate product of the test solution A, was diluted 10 times with distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.

Test solution D;
By exposing distilled water to the atmosphere under atmospheric pressure and room temperature, carbon dioxide in the air was dissolved in the distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.

2) Test method 4 L of the above stock solution was put into a non-membrane type electrolytic cell, and electrolysis was performed with a direct current of 2.8 A.

3) Results Table 3 shows the test results.

As can be seen from the table, in test solution A to test solution C using saturated carbonated water, the pH range in which hypochlorous acid and sodium hydrogen carbonate can be present in sufficient concentrations is 6-8. On the other hand, the pH of the test solution D in which carbon dioxide in the air was naturally dissolved was 9.2. Therefore, it seems that it is difficult to produce both hypochlorous acid and sodium hydrogen carbonate at a sufficient concentration by the method of spontaneously dissolving carbon dioxide in the air.

(Foul breath suppression test of bad breath suppressant)
There are three types of bad breath: physiological bad breath detected immediately after getting up, bad breath caused by oral diseases such as periodontal disease, and diseases caused by visceral diseases other than oral cavity. It is important to measure the halitosis intensity in a state where these are distinguished.

In this clinical trial, OralChroma (Oral Chroma, registered trademark) sold by Abi Medical Co., Ltd. was used. The device can individually measure the concentration of three components of volatile sulfur compounds, hydrogen sulfide, methyl mercaptan, and dimethyl sulfide. If only hydrogen sulfide is detected, there is a possibility of physiological bad breath. If only dimethyl sulfide is detected, it is highly likely that it is a bad breath caused by a visceral disease rather than an oral disease, and when two major causative substances such as hydrogen sulfide and methyl mercaptan are detected. It can be determined that there is a high possibility of bad breath caused by oral disease.

The test results are shown in Table 4.

In patient No. 1, the measured values of the three components exceeded the cognitive threshold before gargle, and a strong halitosis was confirmed. However, after gargle, the measured value of hydrogen sulfide was almost zero, and the halitosis based on oral disease Is considered to have improved significantly. Since methyl mercaptan was rarely detected separately from hydrogen sulfide, it was considered a measurement error due to malfunction of the sensor or other reasons, and the measured value of methyl mercaptan was ignored.

In patient No. 2, the measured values of the three components exceeded the recognition threshold, and a strong bad breath was confirmed. However, after gargle, the measured value of hydrogen sulfide was almost zero, and the bad breath was greatly improved. The measured value of methyl mercaptan was ignored.

In patient No. 3, the measured values of the three components exceeded the cognitive threshold, and a strong halitosis was confirmed, but after gargle, the measured values of the two major causative substances, hydrogen sulfide and methyl mercaptan, were almost zero. Therefore, it is considered that the bad breath based on the oral disease is greatly improved.

In patient Nos. 4 and 5, although the measured value of hydrogen sulfide is above the cognitive threshold, the measured value of methyl mercaptan is below the cognitive threshold, so it is considered that bad breath based on oral disease has not occurred. After gargling, the measured values of the three components were zero, and the bad breath was greatly improved.

In patient Nos. 6, 12, and 14, the measured values of the three components exceeded the recognition threshold, and strong bad breath was confirmed. However, after the gargle, the measured values of the three components became zero, and the bad breath was greatly improved. It was.

In patient Nos. 7, 8, 11, and 13, the measured values of the two major causative substances exceeded the cognitive threshold, and strong bad breath was confirmed. Greatly improved.

In patient Nos. 9 and 10, only the measured value of hydrogen sulfide exceeded the recognition threshold, and a moderate halitosis was confirmed. However, after gargle, the measured values of the three components became zero, and the halitosis was greatly improved. It was done.

Claims (18)

A halitosis inhibitor having an effective chlorine concentration of 50 to 700 ppm, a pH of 6.3 to 8, and containing hypochlorous acid and sodium hydrogen carbonate. The bad breath suppressant according to claim 1, wherein the effective chlorine concentration is 201 to 700 ppm instead of 50 to 700 ppm. The bad breath suppressant according to claim 2, wherein the effective chlorine concentration is 400 to 700 ppm instead of 201 to 700 ppm. The bad breath suppressant according to any one of claims 1 to 3, wherein the pH is 7 to 8 instead of 6.3 to 8. The bad breath suppressing agent according to claim 1, wherein the effective chlorine concentration is 500 to 700 ppm instead of the 50 to 700 ppm, and the pH is 7 to 8 instead of the 6.3 to 8. The bad breath suppressant according to claim 1, wherein the effective chlorine concentration is 50 to 300 ppm instead of 50 to 700 ppm, and the pH is 7 to 8 instead of 6.3 to 8. An aqueous solution to which sodium chloride and carbon dioxide are added is used as a stock solution, and hypochlorite and sodium hydrogen carbonate are produced from the stock solution so that the effective chlorine concentration is 50 to 700 ppm and the pH is 6.3 to 8. The method of producing a bad breath suppressant characterized by electrolysis. The stock solution is prepared by passing water through a reverse osmosis membrane, adding sodium chloride to the passing water, blowing carbon dioxide or adding dry ice simultaneously with or before the sodium chloride addition step. 8. A method for producing the bad breath suppressant according to 7. The halitosis inhibitor according to claim 7, wherein the stock solution is prepared by adding sodium chloride to pure water or distilled water, and blowing carbon dioxide gas or adding dry ice simultaneously with or before and after the sodium chloride addition step. Generation method. 8. The stock solution is prepared by passing water through a reverse osmosis membrane, adding sodium chloride to the passing water, and making the partial pressure of carbon dioxide in contact with the passing water higher than the partial pressure in the atmosphere. Of producing bad breath odor inhibitor. The bad breath according to claim 7, wherein the stock solution is prepared by adding sodium chloride to pure water or distilled water, and making a partial pressure of carbon dioxide in contact with the pure water or the distilled water higher than a partial pressure in the atmosphere. Method for producing inhibitor. The method for producing a halitosis suppressor according to any one of claims 7 to 11, wherein the effective chlorine concentration is 201 to 700 ppm instead of the 50 to 700 ppm. The method for producing a halitosis suppressor according to claim 12, wherein the effective chlorine concentration is 400 to 700 ppm instead of the 201 to 700 ppm. The method for producing a halitosis suppressor according to any one of claims 7 to 11, wherein the pH is 7 to 8 instead of 6.3 to 8. 13. The method for producing a bad breath suppressant according to claim 12, wherein the pH is changed to 7 to 8 instead of 6.3 to 8. The method for producing a halitosis suppressor according to claim 13, wherein the pH is set to 7 to 8 instead of 6.3 to 8. The bad breath according to any one of claims 7 to 11, wherein the effective chlorine concentration is 500 to 700 ppm instead of the 50 to 700 ppm, and the pH is 7 to 8 instead of the 6.3 to 8. Method for producing inhibitor. The bad breath according to any one of claims 7 to 11, wherein the effective chlorine concentration is 50 to 300 ppm instead of the 50 to 700 ppm, and the pH is 7 to 8 instead of the 6.3 to 8. Method for producing inhibitor.

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