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WO2010092015A8 - Dérivés d'urée-triazolo[1,5-a]pyridine en tant qu'inhibiteurs de pi3k - Google Patents

Dérivés d'urée-triazolo[1,5-a]pyridine en tant qu'inhibiteurs de pi3k Download PDF

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Publication number
WO2010092015A8
WO2010092015A8 PCT/EP2010/051462 EP2010051462W WO2010092015A8 WO 2010092015 A8 WO2010092015 A8 WO 2010092015A8 EP 2010051462 W EP2010051462 W EP 2010051462W WO 2010092015 A8 WO2010092015 A8 WO 2010092015A8
Authority
WO
WIPO (PCT)
Prior art keywords
triazolo
urea
compounds
pyridine derivatives
pi3k inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/051462
Other languages
English (en)
Other versions
WO2010092015A1 (fr
Inventor
Nigel Ramsden
Kathryn Bell
Jess Taylor
Mihiro Sunose
David Middlemiss
Katie Ellard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellzome Ltd
Original Assignee
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ltd filed Critical Cellzome Ltd
Publication of WO2010092015A1 publication Critical patent/WO2010092015A1/fr
Publication of WO2010092015A8 publication Critical patent/WO2010092015A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I) dans laquelle X1, R et R1 à R4 ont la signification citée dans la description et les revendications. Lesdits composés sont utiles en tant qu'inhibiteurs de protéine kinases, spécialement des inhibiteurs de la Pi3K, pour le traitement ou la prophylaxie de troubles immunologiques, inflammatoires, auto-immuns ou allergiques. L'invention concerne également des compositions pharmaceutiques renfermant lesdits composés, la préparation de tels composés ainsi que leur production et utilisation en tant que médicaments.
PCT/EP2010/051462 2009-02-10 2010-02-08 Dérivés d'urée-triazolo[1,5-a]pyridine en tant qu'inhibiteurs de pi3k Ceased WO2010092015A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09152430 2009-02-10
EP09152430.6 2009-02-10

Publications (2)

Publication Number Publication Date
WO2010092015A1 WO2010092015A1 (fr) 2010-08-19
WO2010092015A8 true WO2010092015A8 (fr) 2010-11-11

Family

ID=40908620

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/051462 Ceased WO2010092015A1 (fr) 2009-02-10 2010-02-08 Dérivés d'urée-triazolo[1,5-a]pyridine en tant qu'inhibiteurs de pi3k

Country Status (1)

Country Link
WO (1) WO2010092015A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI500614B (zh) 2009-06-05 2015-09-21 Cephalon Inc １，２，４－三唑並〔１，５ａ〕吡啶衍生物之製備和用途
EP2343295A1 (fr) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Dérivés de triazolopyridine
EP2343294A1 (fr) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines substituées
EP2343297A1 (fr) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
UY33452A (es) 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas
UA112096C2 (uk) 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
WO2013135612A1 (fr) 2012-03-14 2013-09-19 Bayer Intellectual Property Gmbh Imidazopyridazines substituées
JP6434416B2 (ja) 2012-11-08 2018-12-05 ライゼン・ファーマシューティカルズ・エスアー ＰＤＥ４阻害剤とＰＩ３δ阻害剤または二重ＰＩ３δ−γキナーゼ阻害剤とを含有する薬学的組成物
MA38654B1 (fr) 2013-06-11 2018-11-30 Bayer Pharma AG Dérivés de type promédicament de triazolopyridines substituées
CN119841829A (zh) * 2023-10-18 2025-04-18 中国科学院合肥物质科学研究院 用于治疗PI3Kγ介导的疾病的化合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008515874A (ja) 2004-10-07 2008-05-15 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 抗菌薬
PE20070978A1 (es) 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
ATE414281T1 (de) 2006-08-03 2008-11-15 Cellzome Ag Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k
WO2008025821A1 (fr) 2006-08-30 2008-03-06 Cellzome Limited Dérivés de triazole en tant qu'inhibiteurs de kinase
KR20100049073A (ko) * 2007-07-18 2010-05-11 노파르티스 아게 비시클릭 헤테로아릴 화합물 및 키나제 억제제로서의 그의 용도

Also Published As

Publication number Publication date
WO2010092015A1 (fr) 2010-08-19

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