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WO2010092015A8 - Urea triazolo [1, 5-a] pyridine derivatives as pi3k inhibitors - Google Patents

Urea triazolo [1, 5-a] pyridine derivatives as pi3k inhibitors Download PDF

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Publication number
WO2010092015A8
WO2010092015A8 PCT/EP2010/051462 EP2010051462W WO2010092015A8 WO 2010092015 A8 WO2010092015 A8 WO 2010092015A8 EP 2010051462 W EP2010051462 W EP 2010051462W WO 2010092015 A8 WO2010092015 A8 WO 2010092015A8
Authority
WO
WIPO (PCT)
Prior art keywords
triazolo
urea
compounds
pyridine derivatives
pi3k inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/051462
Other languages
French (fr)
Other versions
WO2010092015A1 (en
Inventor
Nigel Ramsden
Kathryn Bell
Jess Taylor
Mihiro Sunose
David Middlemiss
Katie Ellard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellzome Ltd
Original Assignee
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ltd filed Critical Cellzome Ltd
Publication of WO2010092015A1 publication Critical patent/WO2010092015A1/en
Publication of WO2010092015A8 publication Critical patent/WO2010092015A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to compounds of formula (I) wherein X1,R and R1 to R4 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of PI3K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
PCT/EP2010/051462 2009-02-10 2010-02-08 Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors Ceased WO2010092015A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09152430 2009-02-10
EP09152430.6 2009-02-10

Publications (2)

Publication Number Publication Date
WO2010092015A1 WO2010092015A1 (en) 2010-08-19
WO2010092015A8 true WO2010092015A8 (en) 2010-11-11

Family

ID=40908620

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/051462 Ceased WO2010092015A1 (en) 2009-02-10 2010-02-08 Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors

Country Status (1)

Country Link
WO (1) WO2010092015A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI500614B (en) 2009-06-05 2015-09-21 Cephalon Inc Preparation and uses of 1,2,4-triazolo(1,5a)pyridine derivatives
EP2343295A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridine derivates
EP2343294A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
UY33452A (en) 2010-06-16 2012-01-31 Bayer Schering Pharma Ag REPLACED TRIAZOLOPIRIDINS
UA112096C2 (en) 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх SUBSTITUTED TRIASOLOPYRIDINES AND THEIR APPLICATIONS AS TTK INHIBITORS
WO2013135612A1 (en) 2012-03-14 2013-09-19 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
JP6434416B2 (en) 2012-11-08 2018-12-05 ライゼン・ファーマシューティカルズ・エスアー Pharmaceutical composition comprising a PDE4 inhibitor and a PI3δ inhibitor or a dual PI3δ-γ kinase inhibitor
MA38654B1 (en) 2013-06-11 2018-11-30 Bayer Pharma AG Derivatives of the prodrug type of substituted triazolopyridines
CN119841829A (en) * 2023-10-18 2025-04-18 中国科学院合肥物质科学研究院 Compounds for the treatment of PI3K gamma mediated diseases and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008515874A (en) 2004-10-07 2008-05-15 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Antibacterial drugs
PE20070978A1 (en) 2006-02-14 2007-11-15 Novartis Ag HETEROCICLIC COMPOUNDS AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASES (PI3Ks)
ATE414281T1 (en) 2006-08-03 2008-11-15 Cellzome Ag METHOD FOR IDENTIFYING MOLECULES THAT INTERACT WITH PI3K AND METHOD FOR PURIFYING PI3K
WO2008025821A1 (en) 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
KR20100049073A (en) * 2007-07-18 2010-05-11 노파르티스 아게 Bicyclic heteroaryl compounds and their use as kinase inhibitors

Also Published As

Publication number Publication date
WO2010092015A1 (en) 2010-08-19

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