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WO2010084088A3 - Nanoparticules d'amidon destinées à des systèmes d'administration de médicaments - Google Patents

Nanoparticules d'amidon destinées à des systèmes d'administration de médicaments Download PDF

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Publication number
WO2010084088A3
WO2010084088A3 PCT/EP2010/050488 EP2010050488W WO2010084088A3 WO 2010084088 A3 WO2010084088 A3 WO 2010084088A3 EP 2010050488 W EP2010050488 W EP 2010050488W WO 2010084088 A3 WO2010084088 A3 WO 2010084088A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
delivery systems
starch
starch nanoparticles
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/050488
Other languages
English (en)
Other versions
WO2010084088A2 (fr
Inventor
Manuel J. Santander Ortega
Thomas Stauner
Brigitta Loretz
Gerhard Wenz
Ulrich Schaefer
Claus-Michael Lehr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of WO2010084088A2 publication Critical patent/WO2010084088A2/fr
Publication of WO2010084088A3 publication Critical patent/WO2010084088A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/10—Alkyl or cycloalkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/04—Starch derivatives, e.g. crosslinked derivatives
    • C08L3/06—Esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/04—Starch derivatives, e.g. crosslinked derivatives
    • C08L3/08—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

La présente invention concerne des nanoparticules polymères comprenant des dérivés hydrophobes et/ou amphiphiles de l'amidon, leur préparation et leur utilisation pour la préparation de systèmes d'administration de médicaments. Les nanoparticules préférées comprennent au moins un dérivé d'amidon, le dérivé d'amidon étant un dérivé hydrophobe d'amidon ayant un degré de substitution moyen des groupes hydroxyles (Ds) dans la plage allant de 0,5 à 2,75.
PCT/EP2010/050488 2009-01-21 2010-01-18 Nanoparticules d'amidon destinées à des systèmes d'administration de médicaments Ceased WO2010084088A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09151010.7 2009-01-21
EP09151010 2009-01-21

Publications (2)

Publication Number Publication Date
WO2010084088A2 WO2010084088A2 (fr) 2010-07-29
WO2010084088A3 true WO2010084088A3 (fr) 2011-04-14

Family

ID=42061054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/050488 Ceased WO2010084088A2 (fr) 2009-01-21 2010-01-18 Nanoparticules d'amidon destinées à des systèmes d'administration de médicaments

Country Status (1)

Country Link
WO (1) WO2010084088A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120141551A1 (en) 2010-12-02 2012-06-07 Ecosynthetix Ltd. Aptamer bioconjugate drug delivery device
US20120309246A1 (en) 2011-06-03 2012-12-06 Alexander Tseitlin Curable biopolymer nanoparticle latex binder for mineral, natural organic, or synthetic fiber products and non-woven mats
US9616696B2 (en) 2013-10-23 2017-04-11 Ecosynthetix Inc. Coating for paper adapted for inkjet printing
JP2016539235A (ja) 2013-12-05 2016-12-15 エコシンセティックス リミテッド ホルムアルデヒド非含有バインダーおよび多成分ナノ粒子
CN115990272A (zh) 2014-10-03 2023-04-21 纳米提克斯有限责任公司 用于抑制可溶生物分子的生物活性的组合物以及方法
WO2017070578A1 (fr) 2015-10-21 2017-04-27 The Regents Of The University Of Michigan Détection et traitement de caries et de microcavités avec des nanoparticules
WO2017176762A1 (fr) 2016-04-06 2017-10-12 Nanotics, Llc Particules comprenant des sous-particules ou des échafaudages d'acide nucléique
WO2018105779A1 (fr) * 2016-12-07 2018-06-14 서울대학교산학협력단 Bio-timbre, bio-chauffage, biocapteur et dispositif de timbre bioélectronique
US11666515B2 (en) 2018-03-28 2023-06-06 Greenmark Biomedical Inc. Phosphate crosslinked starch nanoparticle and dental treatments

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19857995A1 (de) * 1998-12-16 2000-06-21 Buna Sow Leuna Olefinverb Gmbh Verfahren zur Herstellung von gefällten Stärkeestern
WO2005030844A1 (fr) * 2003-10-02 2005-04-07 Valtion Teknillinen Tutkimuskeskus Pigment et excipient et procede de fabrication associe

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW493991B (en) 1995-05-08 2002-07-11 Novartis Ag Pharmaceutical composition for oral administration of active agent having low water solubility and process for preparation of the same
US20050227911A1 (en) 2001-09-28 2005-10-13 Solubest Ltd. Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19857995A1 (de) * 1998-12-16 2000-06-21 Buna Sow Leuna Olefinverb Gmbh Verfahren zur Herstellung von gefällten Stärkeestern
WO2005030844A1 (fr) * 2003-10-02 2005-04-07 Valtion Teknillinen Tutkimuskeskus Pigment et excipient et procede de fabrication associe

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NURMI ET AL: "Controlled grafting of acetylated starch by atom transfer radical polymerization of MMA", EUROPEAN POLYMER JOURNAL, PERGAMON PRESS LTD. OXFORD, GB, vol. 43, no. 4, 29 March 2007 (2007-03-29), pages 1372 - 1382, XP022008176, ISSN: 0014-3057, DOI: DOI:10.1016/J.EURPOLYMJ.2007.01.038 *
SIMI C K ET AL: "Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery", BIOPROCESS AND BIOSYSTEMS ENGINEERING, SPRINGER, BERLIN, DE, vol. 30, no. 3, 4 February 2007 (2007-02-04), pages 173 - 180, XP019518083, ISSN: 1615-7605, DOI: DOI:10.1007/S00449-007-0112-5 *
TUOVINEN L ET AL: "Starch acetate microparticles for drug delivery into retinal pigment epithelium-in vitro study", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 98, no. 3, 27 August 2004 (2004-08-27), pages 407 - 413, XP004527193, ISSN: 0168-3659, DOI: DOI:10.1016/J.JCONREL.2004.05.016 *

Also Published As

Publication number Publication date
WO2010084088A2 (fr) 2010-07-29

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