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WO2009150264A1 - Procédé destiné à améliorer l'état général des ruminants - Google Patents

Procédé destiné à améliorer l'état général des ruminants Download PDF

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Publication number
WO2009150264A1
WO2009150264A1 PCT/ES2009/000213 ES2009000213W WO2009150264A1 WO 2009150264 A1 WO2009150264 A1 WO 2009150264A1 ES 2009000213 W ES2009000213 W ES 2009000213W WO 2009150264 A1 WO2009150264 A1 WO 2009150264A1
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WO
WIPO (PCT)
Prior art keywords
mixture
process according
extract
synthesis
active ingredients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2009/000213
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English (en)
Spanish (es)
Inventor
Joan Carles Ferrater Martorell
Luca Christopher Kamel
Juan Antonio Fernandez Martin
Nuria Sanroma Virgili
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EW Nutrition Carotenoid Technologies SA
Original Assignee
Carotenoid Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carotenoid Technologies SA filed Critical Carotenoid Technologies SA
Publication of WO2009150264A1 publication Critical patent/WO2009150264A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants

Definitions

  • This report describes a procedure to improve the general state of ruminants, which consists in increasing the energy efficiency of the metabolic process of food in the rumen of animals by inhibiting one of the processes of energy loss, perhaps the most important, which constitutes the generation of methane or methanogenesis. In this way it is possible to maintain the necessary balance in said metabolic process between the energy generated and the synthesis of proteins, which leads to an improvement in the general state of the animals and an optimal situation of the productive indicators.
  • the first one consists of an extract or garlic oil, a natural product extracted from the Allium genus plants, their fractions or components, isolated or reproduced by synthesis.
  • the other principle consists of an extract or cinnamon oil, a natural product extracted from the Cinnamomum plants, their fractions or components, isolated or reproduced by synthesis. The mixture of both is conveniently formulated for progressive release and in the right place.
  • the production line (meat, milk, labor force), the nutritional principles to obtain the maximum results (energy and proteins) and the productive indicators (growth curves, production indices, etc.) must be considered. among others).
  • Energy is used, among other things, to generate heat, maintain blood pressure, transmit nerve impulses, transport ions through the membranes, promote reabsorption in the kidneys, synthesize proteins and fats, and depending of the animals considered, to secrete milk, produce eggs and wool and develop work.
  • B It helps to maintain the reaction of various media such as plasma, and in others they are biological catalysts.
  • C They act as transport of gases such as oxygen and carbon dioxide in the blood (hemoglobin).
  • Resistance Collagen is the main integral protein of supportive tissues.
  • the objective, therefore, of the present invention is to achieve said balance in ruminants by modulating ruminal fermentation.
  • the increase in energy efficiency in the rumen of animals is proposed, inhibiting one of the processes, perhaps the most important, of energy loss, the generation of methane or methanogenesis.
  • This inhibition is achieved by the action of a formulated product that is incorporated into animal feed and that is constituted by a mixture of two active ingredients.
  • the first one consists of an extract or garlic oil, a natural product extracted from the Allium genus plants, their fractions or components, isolated or reproduced by synthesis.
  • the other principle consists of an extract or cinnamon oil, a natural product extracted from the Cinnamomum plants, their fractions or components, isolated or reproduced by synthesis.
  • the mixture of both is formulated according to the procedure described below and the resulting product is incorporated as is or as a premix into the animal's feed.
  • European Patent EP0835120 of June 1996 stands out, in which antimicrobial pharmaceutical compositions constituted based on essential oils obtained from Origanum vulgare are claimed, together with a pharmaceutically acceptable carrier.
  • compositions in which the active ingredient, oregano essential oil is formulated by the action of an excipient that is selected from a wide variety of products, paraffin, starch and its derivatives, calcium carbonate, and many others.
  • an excipient that is selected from a wide variety of products, paraffin, starch and its derivatives, calcium carbonate, and many others.
  • the product thus obtained was very useful in the prevention and treatment of gastrointestinal disorders of microbial origin.
  • the generation of methane in the rumen of animals represents a mechanism of energy loss and, therefore, an alteration of the necessary balance between energy and synthesis of proteins
  • the objective of the present invention is the minimization of this mechanism of energy loss through the inhibition of methanogenesis, which translates into a greater use of food by the ruminant and therefore, in a better general state of animals .
  • the inhibition of the methanogenesis that constitutes the object of the present invention, as advanced, is achieved by the combined action of two active principles conveniently formulated to cause the desired optimum effect.
  • the first active ingredient consists of an extract or essential oil of garlic, a natural product extracted from the Allium plants, obtained by the usual methods. Any individual fraction or component of the garlic oil or extract or any mixture of the individual components obtained by extraction from natural sources, or prepared by synthesis, is also included within the scope of the present invention.
  • the second active ingredient that forms the basis of the present invention is the extract or essential oil of cinnamon, a natural product extracted from the Cinnamomum plants, obtained by the usual methods.
  • any individual fraction or component of the extract or essential oil or any mixture obtained by extraction from natural seeds, or prepared by synthesis, is also included within the scope of the invention. In this case, it deserves special Mention the main component of cinnamon extract, cinnamaldehyde, whose activity has proved particularly important.
  • the formulation object of the present invention consists, as described in detail below, in a microencapsulation of the active ingredients by the action of suitable excipients by a novel manufacturing process.
  • the process consists of fixing the mixture of the plant extracts or their components in a porous inorganic support, consisting mainly of precipitated silica, and the subsequent coating with a protective layer, constituted by an emulsifier, of the type mono and / or diglyceride of saturated fatty acids, or their derivatives esterified with acetic acid, lactic acid or the like.
  • the first one consists of an extract or garlic oil, a natural product extracted from the Allium genus plants, their fractions or components, isolated or reproduced by synthesis.
  • the other principle was in an extract or cinnamon oil, a natural product extracted from the Cinnamomum plants, their fractions or components, isolated or reproduced by synthesis. The mixture of both is conveniently formulated for progressive release and in the right place.
  • the individual components can be obtained by fractionation of the extract or essential oil or they can be prepared by synthesis according to any of the methods described in the literature. In all cases they should be considered within the scope of the present invention.
  • cinnamon oil cinnamaldehyde
  • cinnamaldehyde cinnamaldehyde
  • the relative proportion in which the two active ingredients are formulated can be very variable. It should be noted that in all the cases tested, even maintaining very unequal relative proportions, a very marked synergy of its effects is detected. The best results have been obtained maintaining a weight ratio between the first active ingredient, garlic oil or extract, and the second, cinnamon oil or extract, from 0.01 to 0.50, preferably from 0.05 to 0.2. These proportions are similar when the product is formulated using instead of natural oils or extracts, their fractions and / or components.
  • the formulation object of the present invention represents, as justified above, an aspect of great importance for obtaining the desired results.
  • it can be described as a microencapsulation of the active ingredients by the action of suitable excipients by a novel manufacturing process.
  • the mixture of the plant extracts, or of their main components is fixed, by adsorption and / or absorption on a porous inorganic support constituted, mainly, by precipitated silica, and coated with a protective layer constituted by an emulsifier.
  • a porous inorganic support constituted, mainly, by precipitated silica, and coated with a protective layer constituted by an emulsifier.
  • the inorganic support consisting basically of precipitated silica is completely inert, in the sense that it does not react with any of the active ingredients and, therefore, does not cause or induce any type of degradation process.
  • the physicochemical characteristics of this support are perfectly suitable for the intended purpose. They are spherical particles with an approximate size of between 80 to 500 microns. Precipitated silica has an optimal characteristic for liquid formulation. It is about its microporosity. The particles contain a multitude of pores that, logically, increase the specific surface area with respect to similar particle sizes of other types of supports. But, in addition, the active principle penetrates these pores and is occluded in them. The result is evident, increases the load capacity and also guarantees its fixation in the support.
  • the support is kept in continuous motion and the mixture of plant extracts is sprayed or fogged on it.
  • the mixing is kept under stirring at the appropriate temperature until reaching the level of fixation of the oil in the support.
  • acceptable results are achieved with mixing times of 3 minutes to 2 hours at temperatures between 15 0 C and 4O 0 C.
  • the mixture of the plant extracts or their components previously dissolved in a suitable solvent can be added.
  • these solvents are hexane, methanol, ethanol and the like.
  • the product will It undergoes a complete solvent removal process using the usual methods, such as vacuum evaporation, drying in the fluid bed, or some other.
  • the concentration values of the mixture of active ingredients that are considered suitable for this type of products are reached, that is, between 20% and 50% of the total weight of the formulated product, preferably between 30 % and 45%.
  • the second phase in the preparation of the product object of the present invention consists in coating the plant extract deposited on the precipitated silica with a protective layer.
  • an emulsifying agent commonly used as a feed additive has been selected. It is mono- and di-glycerides of saturated fatty acids, additive to which the code E-471 corresponds.
  • This emulsifying agent is added directly to the fluid bed or to the mixer, where the plant extract is fixed on the support, producing a homogeneous dispersion on the surface of the support and, therefore, giving rise to a very effective protective layer.
  • concentrations of the order of 10-25% of mono- and di-glycerides are sufficient to carry out an effective coating.
  • Values of the order of 15% to 20% emulsifier are common.
  • fatty acid esters are used in order to be solid at room temperature and, with melting points greater than 7O 0 C. This parameter is very important since a solid coating of the Active ingredient in the support is less permeable to degrading agents than a liquid one.
  • E-471 being a non-ionic surfactant, exhibits excellent performance in terms of hydrophilic fixation and lipophilic resistance.
  • the coating based on mono and di-glycerides of fatty acids can be replaced by their corresponding esterified derivative.
  • Short-chain organic acids such as acetic, lactic and the like, are used to make this last product. These are additives authorized in food and included in the code E-472.
  • the correct dosage of the protective agent is achieved by spraying in the fluid bed or in the mixer used in the previous phase.
  • the emulsifying agent is usually dosed molten, that is, at temperatures between 7O 0 C and 8O 0 C or higher.
  • the product thus obtained is usually incorporated into the food of the animals after preparing a premix with different usual ingredients in the formulation of rations for animals such as soybean meal, hazelnut husks or calcium carbonate, among many others.
  • Example 1 In a 5 liter capacity reactor equipped with mechanical agitation, the following are introduced:
  • each particle contains a portion of plant extract and maintains a remaining ability to absorb more liquid.
  • Example 2 On the granular product obtained while maintaining a strong stirring, 420 g of a mixture of mono and diglycerides of stearic acid (E-471) previously heated until melting are added, around 7O 0 C. In this way it is deposited on the surface of the particles of plant-sipernat extract. Subsequent cooling to room temperature allows the final product to be isolated in the form of granular powder, suitable for use as an additive for animal feed.
  • E-471 a mixture of mono and diglycerides of stearic acid
  • 370 kg of sipernat 2200 are arranged in an industrial fluid-type dryer unit operated by air flow under conditions such that a high fluidization of the pulverulent solid is ensured.
  • Example 3 In a Forberg type shovel mixer, enter:

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)

Abstract

L'invention concerne un procédé destiné à améliorer l'état général des ruminants et consistant à augmenter le rendement énergétique du processus métabolique des aliments en inhibant la production de méthane dans le rumen par action conjointe et simultanée de deux principes actifs utilisés en proportions relatives différentes et préparés de façon appropriée pour garantir une libération progressive. Ces composés sont incorporés aux aliments des animaux et consistent, pour le premier, en un extrait ou de l'huile d'ail, produit naturel extrait des plantes du genre Allium, ses fractions ou ses constituants, isolés ou reproduits par synthèse, et, pour le second, en un extrait ou de l'huile de cannelle, produit naturel extrait des plantes du genre Cinnamomum, ses fractions ou ses constituants, isolés ou reproduits par synthèse.
PCT/ES2009/000213 2008-06-12 2009-04-20 Procédé destiné à améliorer l'état général des ruminants Ceased WO2009150264A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200801814 2008-06-12
ES200801814A ES2332859B1 (es) 2008-06-12 2008-06-12 Procedimiento para mejorar el estado general de los rumiantes.

Publications (1)

Publication Number Publication Date
WO2009150264A1 true WO2009150264A1 (fr) 2009-12-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2009/000213 Ceased WO2009150264A1 (fr) 2008-06-12 2009-04-20 Procédé destiné à améliorer l'état général des ruminants

Country Status (2)

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ES (1) ES2332859B1 (fr)
WO (1) WO2009150264A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011070133A1 (fr) 2009-12-11 2011-06-16 Dsm Ip Assets B.V. Acides nitrooxy-alcanoïques et dérivés de ceux-ci en tant qu'aliment pour réduire l'émission de méthane chez des ruminants, et/ou pour améliorer les performances des ruminants
WO2012084629A1 (fr) 2010-12-20 2012-06-28 Dsm Ip Assets B.V. Utilisation de molécules organiques nitrooxy dans l'alimentation animale pour réduire l'émission de méthane chez les ruminants, et/ou pour améliorer la performance des ruminants
WO2015186956A1 (fr) * 2014-06-02 2015-12-10 씨제이제일제당 (주) Composition d'additif alimentaire pour réduire la production de méthane des ruminants
WO2018153702A1 (fr) 2017-02-21 2018-08-30 Dsm Ip Assets B.V. Utilisation d'une composition alimentaire pour animaux pour réduire les émissions de méthane chez les ruminants, et/ou améliorer le rendement des ruminants
WO2019145345A1 (fr) * 2018-01-24 2019-08-01 Dsm Ip Assets B.V. Nouvelle utilisation
WO2019145346A1 (fr) * 2018-01-24 2019-08-01 Dsm Ip Assets B.V. Nouvelle utilisation

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3908123A4 (fr) * 2019-01-11 2022-10-12 Novus International Inc. Particules d'huile essentielle à stabilité améliorée et compositions associées

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089108A1 (fr) * 2003-04-14 2004-10-21 Phytosynthese Complement alimentaire destine a l'animal, en particulier la volaille

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089108A1 (fr) * 2003-04-14 2004-10-21 Phytosynthese Complement alimentaire destine a l'animal, en particulier la volaille

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUSQUET, M. ET AL.: "Effects of Cinnamaldehyde and Garlic Oil on Rumen Microbial Fermentation in a Dual Flow Continuous Culture", J. DAIRY SCI., vol. 88, 2005, pages 2508 - 2516 *
CALSAMIGLIA, S. ET AL., INVITED REVIEW: ESSENTIAL OILS AS MODIFIERS OF RUMEN MICROBIAL FERMENTATION, vol. 90, 2007, pages 2580 - 2595 *
KAMEL, C. ET AL.: "Garlic and Cinnamon for a Healthy Working Rumen", IM PRACTICE. FROM RESEARCH TO THE FIELD, HOW PRODUCERS CAN BENEFIT FROM NUTRITIONAL ADVANCES-, FEED MIX, vol. 15, no. 4, 7 September 2007 (2007-09-07), pages 2 - 5, Retrieved from the Internet <URL:http://www.bioferm.com/downloads/prospekty/%C4%8Cesnek%20a%20sko%C5%99ice%20pro%20zdrav%C3%BD%20funk%C4%8Dn%C3%AD%20bachor.pdf> [retrieved on 20090817] *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011070133A1 (fr) 2009-12-11 2011-06-16 Dsm Ip Assets B.V. Acides nitrooxy-alcanoïques et dérivés de ceux-ci en tant qu'aliment pour réduire l'émission de méthane chez des ruminants, et/ou pour améliorer les performances des ruminants
WO2012084629A1 (fr) 2010-12-20 2012-06-28 Dsm Ip Assets B.V. Utilisation de molécules organiques nitrooxy dans l'alimentation animale pour réduire l'émission de méthane chez les ruminants, et/ou pour améliorer la performance des ruminants
WO2015186956A1 (fr) * 2014-06-02 2015-12-10 씨제이제일제당 (주) Composition d'additif alimentaire pour réduire la production de méthane des ruminants
US10440975B2 (en) 2014-06-02 2019-10-15 Cj Cheiljedang Corporation Feed additive composition for reducing methane gas produced by ruminant animals
WO2018153702A1 (fr) 2017-02-21 2018-08-30 Dsm Ip Assets B.V. Utilisation d'une composition alimentaire pour animaux pour réduire les émissions de méthane chez les ruminants, et/ou améliorer le rendement des ruminants
WO2019145345A1 (fr) * 2018-01-24 2019-08-01 Dsm Ip Assets B.V. Nouvelle utilisation
WO2019145346A1 (fr) * 2018-01-24 2019-08-01 Dsm Ip Assets B.V. Nouvelle utilisation
US11712424B2 (en) 2018-01-24 2023-08-01 Dsm Ip Assets B.V. Non-therapeutic methods for alleviating or reducing stress symptoms of ruminants
US11793768B2 (en) 2018-01-24 2023-10-24 Dsm Ip Assets B.V. Methods for the non-therapeutic alleviation or prophylaxis of symptoms of oxidative stress, reduced immune system or cartilage damage of ruminants
US12370151B2 (en) 2018-01-24 2025-07-29 Dsm Ip Assets B.V. Non-therapeutic methods for alleviating or reducing stress symptoms of ruminants

Also Published As

Publication number Publication date
ES2332859A1 (es) 2010-02-12
ES2332859B1 (es) 2010-09-22

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