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WO2009069764A1 - Opioid analgesic agent - Google Patents

Opioid analgesic agent Download PDF

Info

Publication number
WO2009069764A1
WO2009069764A1 PCT/JP2008/071689 JP2008071689W WO2009069764A1 WO 2009069764 A1 WO2009069764 A1 WO 2009069764A1 JP 2008071689 W JP2008071689 W JP 2008071689W WO 2009069764 A1 WO2009069764 A1 WO 2009069764A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
analgesic
analgesic agent
opioid analgesic
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/071689
Other languages
French (fr)
Japanese (ja)
Inventor
Hiromitsu Takayama
Mariko Kitajima
Syunji Horie
Kenjiro Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiba University NUC
JOSAI UNIV CORP
Original Assignee
Chiba University NUC
JOSAI UNIV CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiba University NUC, JOSAI UNIV CORP filed Critical Chiba University NUC
Priority to JP2009543879A priority Critical patent/JP5308352B2/en
Publication of WO2009069764A1 publication Critical patent/WO2009069764A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The object is to provide: a compound having an analgesic activity; a pharmaceutical composition and an analgesic agent, each of which comprises the compound; an analgesic treatment method using the compound; and use of the compound in an analgesic treatemnt. Disclosed is a compound represented by the formula (I) or a salt thereof. (I) wherein R1 represents a hydrogen atom or a halogen atom; R2, R3, R4 and R5 independently represent a hydrogen atom, a hydroxy group, an alkoxy group which may have a substituent or the like; and R6 represents an alkoxycarbonyl group which may have a substituent or a carboxy group.
PCT/JP2008/071689 2007-11-30 2008-11-28 Opioid analgesic agent Ceased WO2009069764A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009543879A JP5308352B2 (en) 2007-11-30 2008-11-28 Opioid analgesics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007310939 2007-11-30
JP2007-310939 2007-11-30

Publications (1)

Publication Number Publication Date
WO2009069764A1 true WO2009069764A1 (en) 2009-06-04

Family

ID=40678653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071689 Ceased WO2009069764A1 (en) 2007-11-30 2008-11-28 Opioid analgesic agent

Country Status (2)

Country Link
JP (1) JP5308352B2 (en)
WO (1) WO2009069764A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013543378A (en) * 2010-10-01 2013-12-05 エヌエスジーン・アクティーゼルスカブ Treatment of allodynia, hyperalgesia, spontaneous pain and phantom limb pain
CN103588669A (en) * 2013-10-28 2014-02-19 史克勇 Compound having activity of releasing cancer pain
CN104016879A (en) * 2014-05-30 2014-09-03 西安交通大学 Diphenyl amide compound with anti-tumor activity as well as preparation method and application of diphenyl amide compound
WO2015064573A1 (en) * 2013-10-29 2015-05-07 国立大学法人 千葉大学 Opioid analgesic
JP7791620B1 (en) * 2025-08-05 2025-12-24 国立大学法人千葉大学 Compounds, analgesics and pharmaceutical compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09291091A (en) * 1996-04-25 1997-11-11 Soyaku Gijutsu Kenkyusho:Kk Indol alkaloid derivative, its production and antiviral agent
US8247428B2 (en) * 2007-11-08 2012-08-21 National University Corporation Chiba University Indole alkaloid derivatives having opioid receptor agonistic effect, and therapeutic compositions and methods relating to same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HERLEM,D. ET AL.: "Photochemical oxidation of tertiary amines and alkaloids.XI. Sensitized photooxidation of corynantheidine. Transformation of corynantheine-type derivatives into sarpagine-type derivatives", TETRAHEDRON, vol. 38, no. 2, 1982, pages 271 - 278 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013543378A (en) * 2010-10-01 2013-12-05 エヌエスジーン・アクティーゼルスカブ Treatment of allodynia, hyperalgesia, spontaneous pain and phantom limb pain
CN103588669A (en) * 2013-10-28 2014-02-19 史克勇 Compound having activity of releasing cancer pain
WO2015064573A1 (en) * 2013-10-29 2015-05-07 国立大学法人 千葉大学 Opioid analgesic
JPWO2015064573A1 (en) * 2013-10-29 2017-03-09 国立大学法人 千葉大学 Opioid analgesics
CN104016879A (en) * 2014-05-30 2014-09-03 西安交通大学 Diphenyl amide compound with anti-tumor activity as well as preparation method and application of diphenyl amide compound
CN104016879B (en) * 2014-05-30 2016-02-24 西安交通大学 Dibenzoyl amine compound with anti-tumor activity and its preparation method and application
JP7791620B1 (en) * 2025-08-05 2025-12-24 国立大学法人千葉大学 Compounds, analgesics and pharmaceutical compositions

Also Published As

Publication number Publication date
JPWO2009069764A1 (en) 2011-04-21
JP5308352B2 (en) 2013-10-09

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