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WO2009066773A1 - 口腔内崩壊錠 - Google Patents

口腔内崩壊錠 Download PDF

Info

Publication number
WO2009066773A1
WO2009066773A1 PCT/JP2008/071254 JP2008071254W WO2009066773A1 WO 2009066773 A1 WO2009066773 A1 WO 2009066773A1 JP 2008071254 W JP2008071254 W JP 2008071254W WO 2009066773 A1 WO2009066773 A1 WO 2009066773A1
Authority
WO
WIPO (PCT)
Prior art keywords
disintegrating tablet
orally disintegrating
tablet
disintegrating
hardness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/071254
Other languages
English (en)
French (fr)
Inventor
Yuki Ikeda
Yasushi Ochiai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Priority to ES08851745.3T priority Critical patent/ES2455195T3/es
Priority to CN200880117311.9A priority patent/CN101868228B/zh
Priority to EP08851745.3A priority patent/EP2218443B1/en
Priority to US12/743,871 priority patent/US8377995B2/en
Priority to JP2009542606A priority patent/JP5409382B2/ja
Publication of WO2009066773A1 publication Critical patent/WO2009066773A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

　適度な錠剤硬度と口腔内での速やかな崩壊性を兼ね備え、かつ加湿条件下で保存しても硬度低下が小さく、良好な口腔内崩壊性が維持される口腔内崩壊錠を提供する。 　本発明は、(a)結晶セルロース、(b)リン酸水素カルシウム類、(c)天然デンプン類及び(d)滑沢剤を含有する口腔内崩壊錠であって、該崩壊錠100重量％に対する配合割合が(a) 9～60重量％、(b) 16～60重量％、(c) 3～40重量％及び(d) 0.01～1.8重量％である口腔内崩壊錠に関する。
PCT/JP2008/071254 2007-11-21 2008-11-21 口腔内崩壊錠 Ceased WO2009066773A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES08851745.3T ES2455195T3 (es) 2007-11-21 2008-11-21 Comprimido que se disgrega en la cavidad oral
CN200880117311.9A CN101868228B (zh) 2007-11-21 2008-11-21 口腔内崩解片
EP08851745.3A EP2218443B1 (en) 2007-11-21 2008-11-21 Orally disintegrating tablet
US12/743,871 US8377995B2 (en) 2007-11-21 2008-11-21 Orally disintegrating tablet
JP2009542606A JP5409382B2 (ja) 2007-11-21 2008-11-21 口腔内崩壊錠

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-302284 2007-11-21
JP2007302284 2007-11-21

Publications (1)

Publication Number Publication Date
WO2009066773A1 true WO2009066773A1 (ja) 2009-05-28

Family

ID=40667595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071254 Ceased WO2009066773A1 (ja) 2007-11-21 2008-11-21 口腔内崩壊錠

Country Status (7)

Country Link
US (1) US8377995B2 (ja)
EP (1) EP2218443B1 (ja)
JP (1) JP5409382B2 (ja)
KR (1) KR101554374B1 (ja)
CN (1) CN101868228B (ja)
ES (1) ES2455195T3 (ja)
WO (1) WO2009066773A1 (ja)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011019043A1 (ja) * 2009-08-11 2011-02-17 大日本住友製薬株式会社 ２種以上の粒子を含有する口腔内速崩壊錠
JP2013087061A (ja) * 2011-10-14 2013-05-13 Lion Corp 積層錠
JP2013087074A (ja) * 2011-10-17 2013-05-13 Daido Kasei Kogyo Kk 医薬用結合剤及び該結合剤を用いた製剤
CN103211776A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 含有一种布南色林的口腔崩解片的药物组合物及制备方法
WO2013115171A1 (ja) * 2012-02-03 2013-08-08 旭化成ケミカルズ株式会社 苦味マスク顆粒含有口腔内崩壊錠
WO2015008825A1 (ja) 2013-07-19 2015-01-22 株式会社三和化学研究所 口腔内崩壊錠
WO2017142001A1 (ja) * 2016-02-16 2017-08-24 テイカ製薬株式会社 口腔内速崩壊性錠剤用造粒物
WO2018047789A1 (ja) * 2016-09-06 2018-03-15 沢井製薬株式会社 口腔内崩壊錠添加用組成物
JP2019529525A (ja) * 2016-08-05 2019-10-17 トーラス・ディベロップメント・カンパニー・エルエルシー 室温で安定な経口カルシトニン製剤
JP2020169143A (ja) * 2019-04-04 2020-10-15 ニプロ株式会社 アジルサルタンを含有する錠剤
JP2020200321A (ja) * 2019-06-06 2020-12-17 キョーリンリメディオ株式会社 エスゾピクロン含有錠
JP2021004210A (ja) * 2019-06-26 2021-01-14 日医工株式会社 保存安定性に優れたレボセチリジン医薬組成物
US11173122B2 (en) 2016-07-27 2021-11-16 Sawai Pharmaceutical Co., Ltd. Additive composition for orally disintegrating tablet
JP2023522247A (ja) * 2020-04-24 2023-05-29 アストラゼネカ・アクチエボラーグ 医薬製剤

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US20050203175A1 (en) * 2001-12-18 2005-09-15 Ioulia Tseti Parenteral composition of paracetamol
US9173925B2 (en) * 2010-07-15 2015-11-03 Tedee Meiji Farma, S.A. Ferrimannitol-ovalbumin tablet composition
US9433620B2 (en) * 2011-05-13 2016-09-06 Cadila Healthcare Limited Pharmaceutical compositions of lurasidone
US9549563B2 (en) * 2011-10-24 2017-01-24 Kickass Candy Llc Sweet tart energy tablet
CN102688209A (zh) * 2012-06-21 2012-09-26 李兴惠 鲁拉西酮片和制备方法
CN102688210A (zh) * 2012-06-21 2012-09-26 李兴惠 鲁拉西酮的药物组合物和制备方法
CN102793629B (zh) * 2012-07-13 2013-10-23 李津明 一种能在口腔中迅速崩解的速崩纸型干糊药片的制备方法
JP5775223B2 (ja) * 2012-09-05 2015-09-09 テイカ製薬株式会社 口腔内速崩壊性錠剤用造粒物
CN103494784A (zh) * 2013-09-26 2014-01-08 天津市聚星康华医药科技有限公司 一种盐酸甲氯芬酯口腔崩解片及其制备方法
CN104997740B (zh) * 2014-04-22 2017-12-15 四川科瑞德制药股份有限公司 一种坦度螺酮分散片或包衣分散片及其制备方法
ES2826603T3 (es) 2014-06-16 2021-05-18 Johnson Matthey Plc Procesos para la preparación de compuestos de arilpiperazina alquilada y arilpiperidina alquilada que incluyen productos intermedios novedosos
CN104306345B (zh) * 2014-09-11 2017-07-21 丽珠医药集团股份有限公司 一种布南色林的口服缓释制剂
KR20160104847A (ko) 2015-02-26 2016-09-06 동명대학교산학협력단 스마트폰 충전 플렛폼이 구비된 전동이동보조기구
WO2017038455A1 (ja) * 2015-09-04 2017-03-09 株式会社ダイセル 超速崩壊錠剤及びその製造方法
MX376624B (es) 2015-12-23 2025-03-07 Colgate Palmolive Co Composicion de peroximonosulfato solido de almacenamiento estable.
CN109689165B (zh) 2016-08-11 2022-08-26 高露洁-棕榄公司 针对顽渍的过一硫酸盐牙粉组合物
CN108403650A (zh) * 2018-04-28 2018-08-17 南安市创培电子科技有限公司 一种布南色林片的制备工艺
KR102149080B1 (ko) 2018-05-16 2020-08-27 코오롱제약주식회사 에틸 셀룰로오스로 개질된 당 또는 당알코올 과립을 포함하는 구강붕해정
CN116829122A (zh) 2021-01-25 2023-09-29 高露洁-棕榄公司 包含pvp和hec作为粘合剂体系的固体口腔护理组合物
EP4199881A1 (en) 2021-02-19 2023-06-28 Colgate-Palmolive Company Peroxymonosulfate whitening strips
KR102585458B1 (ko) * 2021-04-19 2023-10-05 정유택 타블렛 제형의 구강청결제 조성물
US20220339082A1 (en) 2021-04-23 2022-10-27 Colgate-Palmolive Company Solid Oral Care Compositions
EP4358748A1 (en) * 2021-06-25 2024-05-01 Nicoventures Trading Limited Oral products and method of manufacture

Citations (8)

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Publication number Priority date Publication date Assignee Title
JPH0532627A (ja) 1991-07-29 1993-02-09 Asta Medica Ag 筋肉痙攣により帰因するか又は筋肉痙攣の結果である疾病及び症候群を治療するための医薬品及びその製法
JP2001069961A (ja) 1999-09-02 2001-03-21 Fuji Chem Ind Co Ltd 苦味マスキング用組成物
JP2002505269A (ja) 1998-03-06 2002-02-19 エウランド インターナショナル ソシエタ ペル アチオニ 急速崩壊錠剤
WO2003075918A1 (fr) * 2002-03-14 2003-09-18 Daiichi Suntory Pharma Co.,Ltd. Comprime contenant du chlorhydrate de pilsicainide (voie humide)
WO2005123040A1 (ja) 2004-06-22 2005-12-29 Shionogi & Co., Ltd. 口腔内速崩壊錠
WO2007018192A1 (ja) 2005-08-10 2007-02-15 Shionogi & Co., Ltd. 口腔内崩壊錠剤
WO2007018190A1 (ja) 2005-08-10 2007-02-15 Shionogi & Co., Ltd. 苦味抑制製剤
JP2007238451A (ja) * 2006-03-03 2007-09-20 Elmed Eisai Kk 医薬組成物及びその製造方法

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CN1778300B (zh) * 2004-11-18 2010-09-08 山东绿叶天然药物研究开发有限公司 一种罗通定口腔崩解片及其制备方法

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JPH0532627A (ja) 1991-07-29 1993-02-09 Asta Medica Ag 筋肉痙攣により帰因するか又は筋肉痙攣の結果である疾病及び症候群を治療するための医薬品及びその製法
JP2002505269A (ja) 1998-03-06 2002-02-19 エウランド インターナショナル ソシエタ ペル アチオニ 急速崩壊錠剤
JP2001069961A (ja) 1999-09-02 2001-03-21 Fuji Chem Ind Co Ltd 苦味マスキング用組成物
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WO2005123040A1 (ja) 2004-06-22 2005-12-29 Shionogi & Co., Ltd. 口腔内速崩壊錠
WO2007018192A1 (ja) 2005-08-10 2007-02-15 Shionogi & Co., Ltd. 口腔内崩壊錠剤
WO2007018190A1 (ja) 2005-08-10 2007-02-15 Shionogi & Co., Ltd. 苦味抑制製剤
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See also references of EP2218443A4 *

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4920798B2 (ja) * 2009-08-11 2012-04-18 大日本住友製薬株式会社 ２種以上の粒子を含有する口腔内速崩壊錠
CN102548542A (zh) * 2009-08-11 2012-07-04 大日本住友制药株式会社 含有两种以上粒子的口腔速崩片
CN102548542B (zh) * 2009-08-11 2013-11-20 大日本住友制药株式会社 含有两种以上粒子的口腔速崩片
US8591955B2 (en) 2009-08-11 2013-11-26 Dainippon Sumitomo Pharma Co., Ltd. Orally rapidly disintegrating tablet that contains two or more types of particles
WO2011019043A1 (ja) * 2009-08-11 2011-02-17 大日本住友製薬株式会社 ２種以上の粒子を含有する口腔内速崩壊錠
JP2013087061A (ja) * 2011-10-14 2013-05-13 Lion Corp 積層錠
JP2013087074A (ja) * 2011-10-17 2013-05-13 Daido Kasei Kogyo Kk 医薬用結合剤及び該結合剤を用いた製剤
US9744134B2 (en) 2012-02-03 2017-08-29 Asahi Kasei Chemicals Corporation Orally disintegrating tablet containing bitterness-masking granules
WO2013115171A1 (ja) * 2012-02-03 2013-08-08 旭化成ケミカルズ株式会社 苦味マスク顆粒含有口腔内崩壊錠
JPWO2013115171A1 (ja) * 2012-02-03 2015-05-11 旭化成ケミカルズ株式会社 苦味マスク顆粒含有口腔内崩壊錠
CN103211776A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 含有一种布南色林的口腔崩解片的药物组合物及制备方法
WO2015008825A1 (ja) 2013-07-19 2015-01-22 株式会社三和化学研究所 口腔内崩壊錠
CN109069653A (zh) * 2016-02-16 2018-12-21 特华制药株式会社 口腔内速崩性片剂用造粒物
WO2017142001A1 (ja) * 2016-02-16 2017-08-24 テイカ製薬株式会社 口腔内速崩壊性錠剤用造粒物
US11191729B2 (en) 2016-02-16 2021-12-07 Teika Pharmaceutical Co., Ltd. Granular material for orally fast disintegrating tablets
US11173122B2 (en) 2016-07-27 2021-11-16 Sawai Pharmaceutical Co., Ltd. Additive composition for orally disintegrating tablet
JP2019529525A (ja) * 2016-08-05 2019-10-17 トーラス・ディベロップメント・カンパニー・エルエルシー 室温で安定な経口カルシトニン製剤
JP7300793B2 (ja) 2016-08-05 2023-06-30 パーク・セラピューティクス，インコーポレーテッド 室温で安定な経口カルシトニン製剤
US11167031B2 (en) 2016-09-06 2021-11-09 Sawai Pharmaceutical Co., Ltd. Additive composition for orally disintegrating tablet
WO2018047789A1 (ja) * 2016-09-06 2018-03-15 沢井製薬株式会社 口腔内崩壊錠添加用組成物
JPWO2018047789A1 (ja) * 2016-09-06 2019-06-24 沢井製薬株式会社 口腔内崩壊錠添加用組成物
JP2020169143A (ja) * 2019-04-04 2020-10-15 ニプロ株式会社 アジルサルタンを含有する錠剤
JP7322474B2 (ja) 2019-04-04 2023-08-08 ニプロ株式会社 アジルサルタンを含有する錠剤
JP2020200321A (ja) * 2019-06-06 2020-12-17 キョーリンリメディオ株式会社 エスゾピクロン含有錠
JP7572798B2 (ja) 2019-06-06 2024-10-24 キョーリンリメディオ株式会社 エスゾピクロン含有錠
JP2021004210A (ja) * 2019-06-26 2021-01-14 日医工株式会社 保存安定性に優れたレボセチリジン医薬組成物
JP2023522247A (ja) * 2020-04-24 2023-05-29 アストラゼネカ・アクチエボラーグ 医薬製剤
JP7719796B2 (ja) 2020-04-24 2025-08-06 アストラゼネカ・アクチエボラーグ 医薬製剤

Also Published As

Publication number Publication date
ES2455195T3 (es) 2014-04-14
JPWO2009066773A1 (ja) 2011-04-07
US20100286286A1 (en) 2010-11-11
EP2218443A4 (en) 2010-12-01
JP5409382B2 (ja) 2014-02-05
KR20100096179A (ko) 2010-09-01
EP2218443A1 (en) 2010-08-18
CN101868228A (zh) 2010-10-20
CN101868228B (zh) 2016-12-07
KR101554374B1 (ko) 2015-09-18
EP2218443B1 (en) 2014-03-26
US8377995B2 (en) 2013-02-19

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