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WO2009041062A1 - 血漿中動態が改善されたグリピカン３抗体 - Google Patents

血漿中動態が改善されたグリピカン３抗体 Download PDF

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Publication number
WO2009041062A1
WO2009041062A1 PCT/JP2008/002690 JP2008002690W WO2009041062A1 WO 2009041062 A1 WO2009041062 A1 WO 2009041062A1 JP 2008002690 W JP2008002690 W JP 2008002690W WO 2009041062 A1 WO2009041062 A1 WO 2009041062A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
glypican
plasma
life
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/002690
Other languages
English (en)
French (fr)
Inventor
Tomoyuki Igawa
Taichi Kuramochi
Hirotake Shiraiwa
Hiroyuki Tsunoda
Tatsuhiko Tachibana
Takahiro Ishiguro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40510966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009041062(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CN2008801091960A priority Critical patent/CN101809162B/zh
Priority to MX2010003158A priority patent/MX2010003158A/es
Priority to US12/733,933 priority patent/US8497355B2/en
Priority to HK10111189.6A priority patent/HK1144702B/xx
Priority to AU2008305851A priority patent/AU2008305851B2/en
Priority to NZ584769A priority patent/NZ584769A/en
Priority to DK08834671.3T priority patent/DK2196541T3/da
Priority to KR1020157030933A priority patent/KR20150126724A/ko
Priority to JP2009534190A priority patent/JP4535406B2/ja
Priority to ES08834671T priority patent/ES2394471T3/es
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to EP08834671A priority patent/EP2196541B1/en
Priority to BRPI0817637A priority patent/BRPI0817637A2/pt
Priority to CA2700986A priority patent/CA2700986A1/en
Priority to CL2009000647A priority patent/CL2009000647A1/es
Priority to NZ588913A priority patent/NZ588913A/xx
Priority to HK11105940.7A priority patent/HK1151734B/xx
Priority to ARP090100996A priority patent/AR071003A1/es
Priority to RU2010145177/15A priority patent/RU2523897C2/ru
Priority to SG2013025549A priority patent/SG189754A1/en
Priority to KR1020107024691A priority patent/KR101612139B1/ko
Priority to EP09727052A priority patent/EP2275135A4/en
Priority to CN200980119069.3A priority patent/CN102046200B/zh
Priority to PE2009000413A priority patent/PE20091655A1/es
Priority to CA2720359A priority patent/CA2720359A1/en
Priority to BRPI0911147A priority patent/BRPI0911147A2/pt
Priority to JP2010505322A priority patent/JP5306327B2/ja
Priority to MX2010010954A priority patent/MX2010010954A/es
Priority to PCT/JP2009/001249 priority patent/WO2009122667A1/ja
Priority to AU2009233301A priority patent/AU2009233301B2/en
Priority to UAA201013035A priority patent/UA103614C2/uk
Priority to TW98108942A priority patent/TWI468175B/zh
Publication of WO2009041062A1 publication Critical patent/WO2009041062A1/ja
Priority to IL204754A priority patent/IL204754A0/en
Anticipated expiration legal-status Critical
Priority to MA32777A priority patent/MA31780B1/fr
Priority to ZA2010/02741A priority patent/ZA201002741B/en
Priority to IL208451A priority patent/IL208451A0/en
Priority to CO10133385A priority patent/CO6300964A2/es
Priority to CR11769A priority patent/CR11769A/es
Priority to MA33323A priority patent/MA32360B1/fr
Priority to EC2010010589A priority patent/ECSP10010589A/es
Priority to JP2010291590A priority patent/JP5506654B2/ja
Priority to US13/924,957 priority patent/US20130295612A1/en
Priority to US14/629,967 priority patent/US20150315278A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

【課題】　グリピカン３抗体の血漿中半減期を制御する方法、血漿中半減期が制御されたグリピカン３抗体を有効成分として含有する医薬組成物、並びに、当該グリピカン３抗体および当該グリピカン３抗体を有効成分として含む医薬組成物の製造方法を提供すること。 【解決手段】 　グリピカン３抗体の表面に露出するアミノ酸残基の改変により、グリピカン３抗体の血漿中半減期を制御する方法、アミノ酸残基の改変により血漿中半減期が制御されたグリピカン３抗体、当該抗体を有効成分として含む医薬組成物、並びに、それらの医薬組成物の製造方法が開示される。
PCT/JP2008/002690 2007-09-28 2008-09-26 血漿中動態が改善されたグリピカン３抗体 Ceased WO2009041062A1 (ja)

Priority Applications (42)

Application Number Priority Date Filing Date Title
CA2700986A CA2700986A1 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
DK08834671.3T DK2196541T3 (da) 2007-09-28 2008-09-26 Anti-glypican-3-antistof med forbedret kinetik i plasmaet
US12/733,933 US8497355B2 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
HK10111189.6A HK1144702B (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
AU2008305851A AU2008305851B2 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
NZ584769A NZ584769A (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
JP2009534190A JP4535406B2 (ja) 2007-09-28 2008-09-26 血漿中動態が改善されたグリピカン３抗体
CN2008801091960A CN101809162B (zh) 2007-09-28 2008-09-26 血浆中动力学被改善的磷脂酰肌醇蛋白聚糖3抗体
KR1020157030933A KR20150126724A (ko) 2007-09-28 2008-09-26 혈장 중 반응속도가 개선된 항-글리피칸-3 항체
ES08834671T ES2394471T3 (es) 2007-09-28 2008-09-26 Anticuerpo Anti-Glipicano 3 que tiene una cinética mejorada en plasma
MX2010003158A MX2010003158A (es) 2007-09-28 2008-09-26 Anticuerpo anti-glipicano-3 que tiene cinetica mejorada en plasma.
EP08834671A EP2196541B1 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
BRPI0817637A BRPI0817637A2 (pt) 2007-09-28 2008-09-26 anticorpo anti-glipican-3 tendo cinéticas aperfeiçoadas no plasma
CL2009000647A CL2009000647A1 (es) 2008-04-04 2009-03-18 Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
TW98108942A TWI468175B (zh) 2008-04-04 2009-03-19 Liver cancer treatment
EP09727052A EP2275135A4 (en) 2008-04-04 2009-03-19 MEANS FOR THE TREATMENT OF LIVER CANCER
UAA201013035A UA103614C2 (uk) 2008-04-04 2009-03-19 Лікарський засіб, що містить комбінацію інгібітора кінази та анти-гліпікан 3-антитіла, для лікування раку печінки
ARP090100996A AR071003A1 (es) 2008-04-04 2009-03-19 Farmaco contra cancer de higado
RU2010145177/15A RU2523897C2 (ru) 2008-04-04 2009-03-19 Лекарственное средство для лечения рака печени
SG2013025549A SG189754A1 (en) 2008-04-04 2009-03-19 Liver cancer drug
KR1020107024691A KR101612139B1 (ko) 2008-04-04 2009-03-19 간암 치료제
NZ588913A NZ588913A (en) 2008-04-04 2009-03-19 Liver cancer drug
CN200980119069.3A CN102046200B (zh) 2008-04-04 2009-03-19 肝癌治疗剂
PE2009000413A PE20091655A1 (es) 2008-04-04 2009-03-19 Farmaco para el cancer de higado
CA2720359A CA2720359A1 (en) 2008-04-04 2009-03-19 Liver cancer drug
BRPI0911147A BRPI0911147A2 (pt) 2008-04-04 2009-03-19 fármaco contra câncer de fígado
JP2010505322A JP5306327B2 (ja) 2008-04-04 2009-03-19 肝癌治療剤
MX2010010954A MX2010010954A (es) 2008-04-04 2009-03-19 Farmaco contra cancer de higado.
PCT/JP2009/001249 WO2009122667A1 (ja) 2008-04-04 2009-03-19 肝癌治療剤
AU2009233301A AU2009233301B2 (en) 2008-04-04 2009-03-19 Liver cancer drug
HK11105940.7A HK1151734B (en) 2008-04-04 2009-03-19 Therapeutic for hepatic cancer
IL204754A IL204754A0 (en) 2007-09-28 2010-03-25 Anti-glypican - 3 - antibody having improved kinetics in plasma
MA32777A MA31780B1 (fr) 2007-09-28 2010-04-14 Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée
ZA2010/02741A ZA201002741B (en) 2007-09-28 2010-04-19 Anti-glypican-3 antibody having improved kinetics in plasma
IL208451A IL208451A0 (en) 2008-04-04 2010-10-03 Pharmaceutical compositions comprising a chemotherapeutic agent and an anti-glypican 3 antibody for use in treating hepatic cancer
CO10133385A CO6300964A2 (es) 2008-04-04 2010-10-27 Una composicion farmaceutica que comprende una combinacion de un agente quimioterapeutico y un anticuerpo 3 antiglipicano
CR11769A CR11769A (es) 2008-04-04 2010-11-01 Farmaco contra el cancer de higado
MA33323A MA32360B1 (fr) 2008-04-04 2010-11-03 Thérapie pour cancer hépatique
EC2010010589A ECSP10010589A (es) 2008-04-04 2010-11-04 Farmaco contra el cancer de higado
JP2010291590A JP5506654B2 (ja) 2008-04-04 2010-12-28 肝癌治療剤
US13/924,957 US20130295612A1 (en) 2007-09-28 2013-07-25 Anti-glypican-3 antibody having improved kinetics in plasma
US14/629,967 US20150315278A1 (en) 2007-09-28 2015-02-24 Anti-Glypican-3 Antibody Having Improved Kinetics in Plasma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-256063 2007-09-28
JP2007256063 2007-09-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/733,933 A-371-Of-International US8497355B2 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
US13/924,957 Division US20130295612A1 (en) 2007-09-28 2013-07-25 Anti-glypican-3 antibody having improved kinetics in plasma

Publications (1)

Publication Number Publication Date
WO2009041062A1 true WO2009041062A1 (ja) 2009-04-02

Family

ID=40510966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002690 Ceased WO2009041062A1 (ja) 2007-09-28 2008-09-26 血漿中動態が改善されたグリピカン３抗体

Country Status (25)

Country Link
US (3) US8497355B2 (ja)
EP (3) EP2196541B1 (ja)
JP (3) JP4535406B2 (ja)
KR (2) KR20100085067A (ja)
CN (1) CN101809162B (ja)
AR (1) AR066172A1 (ja)
AU (1) AU2008305851B2 (ja)
BR (1) BRPI0817637A2 (ja)
CA (1) CA2700986A1 (ja)
CL (1) CL2008002873A1 (ja)
CO (1) CO6270266A2 (ja)
CR (1) CR11369A (ja)
DK (1) DK2196541T3 (ja)
EC (1) ECSP10010135A (ja)
ES (1) ES2394471T3 (ja)
IL (1) IL204754A0 (ja)
MA (1) MA31780B1 (ja)
MX (1) MX2010003158A (ja)
MY (1) MY148637A (ja)
NZ (1) NZ584769A (ja)
PE (1) PE20091218A1 (ja)
RU (2) RU2010116756A (ja)
TW (1) TWI418363B (ja)
WO (1) WO2009041062A1 (ja)
ZA (1) ZA201002741B (ja)

Cited By (61)

* Cited by examiner, † Cited by third party
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WO2009077569A1 (en) * 2007-12-19 2009-06-25 General Electric Company Biokinetics of fast-clearing polypeptides
US20110104157A1 (en) * 2008-04-04 2011-05-05 Chugai Seiyaku Kabushiki Kaisha Liver cancer drug
US8124725B2 (en) 2007-12-19 2012-02-28 General Electric Company PDGF-Rβ binders
WO2012115241A1 (ja) 2011-02-25 2012-08-30 中外製薬株式会社 FcγRIIb特異的Fc抗体
WO2012133782A1 (ja) 2011-03-30 2012-10-04 中外製薬株式会社 抗原結合分子の血漿中滞留性と免疫原性を改変する方法
WO2013002362A1 (ja) 2011-06-30 2013-01-03 中外製薬株式会社 ヘテロ二量化ポリペプチド
JPWO2011108714A1 (ja) * 2010-03-04 2013-06-27 中外製薬株式会社 抗体定常領域改変体
WO2013100120A1 (ja) 2011-12-28 2013-07-04 中外製薬株式会社 ヒト化抗Epiregulin抗体および当該抗体を有効成分として含む癌治療剤
JP2013539361A (ja) * 2010-07-29 2013-10-24 ゼンコア インコーポレイテッド 改変された等電点を有する抗体
WO2013187495A1 (ja) 2012-06-14 2013-12-19 中外製薬株式会社 改変されたFc領域を含む抗原結合分子
KR20140015501A (ko) * 2011-03-30 2014-02-06 추가이 세이야쿠 가부시키가이샤 항원 결합 분자의 혈장 체류성과 면역원성을 개변하는 방법
WO2014030728A1 (ja) 2012-08-24 2014-02-27 中外製薬株式会社 FcγRIIb特異的Fc領域改変体
JPWO2012073992A1 (ja) * 2010-11-30 2014-05-19 中外製薬株式会社 複数分子の抗原に繰り返し結合する抗原結合分子
WO2014097648A1 (ja) 2012-12-21 2014-06-26 中外製薬株式会社 Gpc3標的治療剤療法が有効である患者に投与されるgpc3標的治療剤
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