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WO2008133297A1 - ジスキネジアの治療または予防剤 - Google Patents

ジスキネジアの治療または予防剤 Download PDF

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Publication number
WO2008133297A1
WO2008133297A1 PCT/JP2008/057930 JP2008057930W WO2008133297A1 WO 2008133297 A1 WO2008133297 A1 WO 2008133297A1 JP 2008057930 W JP2008057930 W JP 2008057930W WO 2008133297 A1 WO2008133297 A1 WO 2008133297A1
Authority
WO
WIPO (PCT)
Prior art keywords
dyskinesia
therapeutic
carbon atoms
prophylactic agent
double
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/057930
Other languages
English (en)
French (fr)
Inventor
Ken Ikeda
Hidenori Mochizuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to AU2008244975A priority Critical patent/AU2008244975B2/en
Priority to US12/597,442 priority patent/US8796301B2/en
Priority to EP08752029.2A priority patent/EP2151240B1/en
Priority to PL08752029T priority patent/PL2151240T3/pl
Priority to ES08752029T priority patent/ES2418104T3/es
Priority to JP2009511900A priority patent/JP5251870B2/ja
Priority to MX2009011449A priority patent/MX2009011449A/es
Priority to CA2685126A priority patent/CA2685126C/en
Priority to CN2008800217478A priority patent/CN101686977B/zh
Publication of WO2008133297A1 publication Critical patent/WO2008133297A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

　本発明は、高いジスキネジア治療または予防効果を有し、原疾患の症状悪化を伴わず、副作用の少ない薬剤を提供することを目的とする。 　すなわち本発明は、下記一般式（Ｉ）で示される４，５－エポキシモルヒナン骨格を有する化合物またはその薬理学的に許容される酸付加塩を有効成分とするジスキネジアの治療または予防剤を提供する。 【化１】 ［式中、点線と実線の二重線は二重結合または単結合を示し、Ｒ1は炭素数４から７のシクロアルキルアルキルを表し、Ｒ2は炭素数１から５の直鎖または分岐アルキルを表し、Ｂは－ＣＨ＝ＣＨ－を表す］
PCT/JP2008/057930 2007-04-24 2008-04-24 ジスキネジアの治療または予防剤 Ceased WO2008133297A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2008244975A AU2008244975B2 (en) 2007-04-24 2008-04-24 Therapeutic or prophylactic agent for dyskinesia
US12/597,442 US8796301B2 (en) 2007-04-24 2008-04-24 Therapeutic or prophylactic agent for dyskinesia
EP08752029.2A EP2151240B1 (en) 2007-04-24 2008-04-24 Therapeutic or prophylactic agent for dyskinesia
PL08752029T PL2151240T3 (pl) 2007-04-24 2008-04-24 Środek terapeutyczny lub profilaktyczny przeciw dyskinezie
ES08752029T ES2418104T3 (es) 2007-04-24 2008-04-24 Agente terapéutico o profiláctico para la discinesia
JP2009511900A JP5251870B2 (ja) 2007-04-24 2008-04-24 ジスキネジアの治療または予防剤
MX2009011449A MX2009011449A (es) 2007-04-24 2008-04-24 Agente terapeutico o profilactico para disquinesia.
CA2685126A CA2685126C (en) 2007-04-24 2008-04-24 Therapeutic or prophylactic agent for dyskinesia
CN2008800217478A CN101686977B (zh) 2007-04-24 2008-04-24 运动障碍的治疗或预防剂

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-114309 2007-04-24
JP2007114309 2007-04-24

Publications (1)

Publication Number Publication Date
WO2008133297A1 true WO2008133297A1 (ja) 2008-11-06

Family

ID=39925745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057930 Ceased WO2008133297A1 (ja) 2007-04-24 2008-04-24 ジスキネジアの治療または予防剤

Country Status (10)

Country Link
US (1) US8796301B2 (ja)
EP (1) EP2151240B1 (ja)
JP (1) JP5251870B2 (ja)
KR (1) KR101477043B1 (ja)
CN (1) CN101686977B (ja)
CA (1) CA2685126C (ja)
ES (1) ES2418104T3 (ja)
MX (1) MX2009011449A (ja)
PL (1) PL2151240T3 (ja)
WO (1) WO2008133297A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011093441A1 (ja) 2010-01-29 2011-08-04 東レ株式会社 胆道疾患の治療又は予防剤
WO2012105475A1 (ja) 2011-01-31 2012-08-09 東レ株式会社 悪液質の治療又は予防剤
US11897871B1 (en) 2021-06-14 2024-02-13 Scorpion Therapeutics, Inc. Methods for treating cancer

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2630150B1 (en) * 2010-10-19 2017-04-12 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
CA2983314C (en) 2015-04-30 2024-11-12 Memorial Sloan-Kettering Cancer Center Mitragynine analogues and their uses
US20210015813A1 (en) 2018-03-08 2021-01-21 Victoria Link Ltd. Treatment of demyelinating diseases
EP4173624A4 (en) * 2020-06-30 2024-08-14 Toray Industries, Inc. AMELIORATE OR PROPHYLACTIC AGENT FOR SYMPTOM OF MUSCLE WEAKNESS IN A DISEASE OR SYNDROME ASSOCIATED WITH A METABOLIC DISORDER

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015081A1 (en) 1992-01-23 1993-08-05 Toray Industries, Inc. Morphinan derivative and medicinal use
JPH06505747A (ja) * 1991-02-25 1994-06-30 トラスティーズ・オブ・ボストン・ユニバーシティ 多動運動障害を変調するアヘン剤受容体アンタゴニスト
WO1995001178A1 (en) 1993-06-30 1995-01-12 Toray Industries, Inc. Antitussive
WO1995003307A1 (en) 1993-07-19 1995-02-02 Toray Industries, Inc. Brain cell protective
WO1998023290A1 (en) 1996-11-25 1998-06-04 Toray Industries, Inc. Antipruritic agent
WO1999005146A1 (en) 1997-07-25 1999-02-04 Toray Industries, Inc. Hyponatremia remedies
WO1999011289A1 (en) * 1997-09-02 1999-03-11 Toray Industries, Inc. Remedies for drug addiction
WO2000003715A1 (en) 1998-07-18 2000-01-27 The Victoria University Of Manchester Treatment of dyskinesia
JP2000053572A (ja) 1998-08-11 2000-02-22 Toray Ind Inc ＯＲＬ１（ｏｐｉｏｉｄ ｏｒｐｈａｎ）受容体拮抗薬
WO2001014383A1 (en) 1999-08-24 2001-03-01 Toray Industries, Inc. Remedies for neuropathic pain and model animals of neuropathic pain
JP2001163784A (ja) 1999-12-06 2001-06-19 Toray Ind Inc 角膜または結膜用止痒剤
WO2002078744A1 (en) 2001-03-30 2002-10-10 Toray Industries, Inc. Remedies for psychoneurosis
WO2002089845A1 (fr) 2001-05-08 2002-11-14 Toray Industries, Inc. Remedes contre la sepsie
JP2003512428A (ja) * 1999-10-22 2003-04-02 ザ・ビクトリア・ユニバーシテイ・オブ・マンチエスター ジスキネジーの治療
WO2006095836A1 (ja) 2005-03-10 2006-09-14 Toray Industries, Inc. 多発性硬化症に伴う痒みに対する止痒剤

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06505747A (ja) * 1991-02-25 1994-06-30 トラスティーズ・オブ・ボストン・ユニバーシティ 多動運動障害を変調するアヘン剤受容体アンタゴニスト
WO1993015081A1 (en) 1992-01-23 1993-08-05 Toray Industries, Inc. Morphinan derivative and medicinal use
JP2525552B2 (ja) 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
WO1995001178A1 (en) 1993-06-30 1995-01-12 Toray Industries, Inc. Antitussive
WO1995003307A1 (en) 1993-07-19 1995-02-02 Toray Industries, Inc. Brain cell protective
WO1998023290A1 (en) 1996-11-25 1998-06-04 Toray Industries, Inc. Antipruritic agent
WO1999005146A1 (en) 1997-07-25 1999-02-04 Toray Industries, Inc. Hyponatremia remedies
WO1999011289A1 (en) * 1997-09-02 1999-03-11 Toray Industries, Inc. Remedies for drug addiction
WO2000003715A1 (en) 1998-07-18 2000-01-27 The Victoria University Of Manchester Treatment of dyskinesia
JP2000053572A (ja) 1998-08-11 2000-02-22 Toray Ind Inc ＯＲＬ１（ｏｐｉｏｉｄ ｏｒｐｈａｎ）受容体拮抗薬
WO2001014383A1 (en) 1999-08-24 2001-03-01 Toray Industries, Inc. Remedies for neuropathic pain and model animals of neuropathic pain
JP2003512428A (ja) * 1999-10-22 2003-04-02 ザ・ビクトリア・ユニバーシテイ・オブ・マンチエスター ジスキネジーの治療
JP2001163784A (ja) 1999-12-06 2001-06-19 Toray Ind Inc 角膜または結膜用止痒剤
WO2002078744A1 (en) 2001-03-30 2002-10-10 Toray Industries, Inc. Remedies for psychoneurosis
WO2002089845A1 (fr) 2001-05-08 2002-11-14 Toray Industries, Inc. Remedes contre la sepsie
WO2006095836A1 (ja) 2005-03-10 2006-09-14 Toray Industries, Inc. 多発性硬化症に伴う痒みに対する止痒剤

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIOORG. MED. CHEM. LETT., vol. 5, 1995, pages 1505
CHEM. PHARM. BULL., vol. 52, 2004, pages 664
COX H ET AL., EXP NEURAL., vol. 205, no. 1, 2007, pages 101 - 107
COX H ET AL., EXP NEUROL., vol. 205, no. 1, 2007, pages 101 - 107
HEREROCYCLE, vol. 63, 2004, pages 865
LUNDBLAD M ET AL., EUR. J NEUROSCI., vol. 15, 2002, pages 120
See also references of EP2151240A4

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011093441A1 (ja) 2010-01-29 2011-08-04 東レ株式会社 胆道疾患の治療又は予防剤
CN102711759A (zh) * 2010-01-29 2012-10-03 东丽株式会社 胆道疾病的治疗或预防药
AU2011211223B2 (en) * 2010-01-29 2014-10-23 Toray Industries, Inc. Therapeutic or prophylactic agent for biliary diseases
CN102711759B (zh) * 2010-01-29 2015-05-13 东丽株式会社 胆道疾病的治疗或预防药
KR101732042B1 (ko) * 2010-01-29 2017-05-02 도레이 카부시키가이샤 담도 질환의 치료 또는 예방제
US10131672B2 (en) 2010-01-29 2018-11-20 Toray Industries, Inc. Therapeutic or prophylactic agent for biliary diseases
WO2012105475A1 (ja) 2011-01-31 2012-08-09 東レ株式会社 悪液質の治療又は予防剤
US9006262B2 (en) 2011-01-31 2015-04-14 Toray Industries, Inc. Therapeutic or prophylactic agent for cachexia
US11897871B1 (en) 2021-06-14 2024-02-13 Scorpion Therapeutics, Inc. Methods for treating cancer
US12084434B2 (en) 2021-06-14 2024-09-10 Scorpion Therapeutics, Inc. Methods for treating cancer
US12312341B2 (en) 2021-06-14 2025-05-27 Scorpion Therapeutics, Inc. Methods for treating cancer

Also Published As

Publication number Publication date
KR20090130079A (ko) 2009-12-17
US20100130524A1 (en) 2010-05-27
EP2151240A1 (en) 2010-02-10
CN101686977A (zh) 2010-03-31
PL2151240T3 (pl) 2014-01-31
EP2151240A4 (en) 2011-08-10
JPWO2008133297A1 (ja) 2010-07-29
US8796301B2 (en) 2014-08-05
JP5251870B2 (ja) 2013-07-31
ES2418104T3 (es) 2013-08-12
CN101686977B (zh) 2012-09-05
AU2008244975A1 (en) 2008-11-06
KR101477043B1 (ko) 2014-12-29
EP2151240B1 (en) 2013-06-12
MX2009011449A (es) 2010-01-25
CA2685126A1 (en) 2008-11-06
CA2685126C (en) 2015-04-14

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