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MX2009011449A - Agente terapeutico o profilactico para disquinesia. - Google Patents

Agente terapeutico o profilactico para disquinesia.

Info

Publication number
MX2009011449A
MX2009011449A MX2009011449A MX2009011449A MX2009011449A MX 2009011449 A MX2009011449 A MX 2009011449A MX 2009011449 A MX2009011449 A MX 2009011449A MX 2009011449 A MX2009011449 A MX 2009011449A MX 2009011449 A MX2009011449 A MX 2009011449A
Authority
MX
Mexico
Prior art keywords
sup
dyskinesia
therapeutic
carbon atoms
prophylactic agent
Prior art date
Application number
MX2009011449A
Other languages
English (en)
Inventor
Ken Ikeda
Hidenori Mochizuki
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of MX2009011449A publication Critical patent/MX2009011449A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un objeto de la presente invención es proporcionar un fármaco con un efecto terapéutico o profiláctico alto sobre disquinesia, sin agravasión acompañante de síntomas de la enfermedad primaria, y con pocos efectos secundarios.De manera acorde, la presente invención proporciona un agente terapéutico o profiláctico para disquinesia, comprendiendo como un componente efectivo un compuesto que tiene un esqueleto de 4,5-epoxi morfinano, el cual compuesto es representado por la fórmula (I) siguiente, o una sal de adición de ácido farmacéuticamente aceptable del mismo: donde la línea doble compuesta de una línea punteada y una línea sólida representa un doble enlace o un enlace sencillo, R1 es cicloalquilo C4-C2, R2 es un alquilo recto o ramificado C1-C5 y B es -CH=CH-.
MX2009011449A 2007-04-24 2008-04-24 Agente terapeutico o profilactico para disquinesia. MX2009011449A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007114309 2007-04-24
PCT/JP2008/057930 WO2008133297A1 (ja) 2007-04-24 2008-04-24 ジスキネジアの治療または予防剤

Publications (1)

Publication Number Publication Date
MX2009011449A true MX2009011449A (es) 2010-01-25

Family

ID=39925745

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011449A MX2009011449A (es) 2007-04-24 2008-04-24 Agente terapeutico o profilactico para disquinesia.

Country Status (10)

Country Link
US (1) US8796301B2 (es)
EP (1) EP2151240B1 (es)
JP (1) JP5251870B2 (es)
KR (1) KR101477043B1 (es)
CN (1) CN101686977B (es)
CA (1) CA2685126C (es)
ES (1) ES2418104T3 (es)
MX (1) MX2009011449A (es)
PL (1) PL2151240T3 (es)
WO (1) WO2008133297A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2529739B1 (en) 2010-01-29 2016-07-13 Toray Industries, Inc. Therapeutic or prophylactic agent for biliary diseases
WO2012054566A2 (en) * 2010-10-19 2012-04-26 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
EP3291676B1 (en) 2015-04-30 2022-08-17 Memorial Sloan Kettering Cancer Center Mitragynine analogs and uses thereof
AU2019229892B2 (en) 2018-03-08 2025-01-30 University Of Kansas Treatment of demyelinating diseases
JP7735862B2 (ja) * 2020-06-30 2025-09-09 東レ株式会社 代謝異常を伴う疾患又は症候群における筋力低下症状の改善剤又は予防剤
IL309232A (en) 2021-06-14 2024-02-01 Scorpion Therapeutics Inc Urea derivatives which can be used to treat cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2104229C (en) 1991-02-25 1997-04-15 Conan Kornetsky Opiate receptor antagonist modulates movement disorder
US6323212B1 (en) 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
EP0657163B1 (en) 1993-06-30 1998-10-14 Toray Industries, Inc. Antitussive
JP3948026B2 (ja) 1993-07-19 2007-07-25 東レ株式会社 脳細胞保護剤
EP1310251A1 (en) 1996-11-25 2003-05-14 Toray Industries, Inc. Antipruritic agent
WO1999005146A1 (en) 1997-07-25 1999-02-04 Toray Industries, Inc. Hyponatremia remedies
US6583151B2 (en) 1997-09-02 2003-06-24 Toray Industries, Inc. Remedies for drug addiction
GB9815618D0 (en) 1998-07-18 1998-09-16 Univ Manchester Treatment of dyskinesia
JP2000053572A (ja) 1998-08-11 2000-02-22 Toray Ind Inc ＯＲＬ１（ｏｐｉｏｉｄ ｏｒｐｈａｎ）受容体拮抗薬
WO2001014383A1 (en) 1999-08-24 2001-03-01 Toray Industries, Inc. Remedies for neuropathic pain and model animals of neuropathic pain
GB9924941D0 (en) 1999-10-22 1999-12-22 Univ Manchester Treatment of dyskinesia
JP2001163784A (ja) 1999-12-06 2001-06-19 Toray Ind Inc 角膜または結膜用止痒剤
JP4453254B2 (ja) 2001-03-30 2010-04-21 東レ株式会社 レストレス・レッグズ症候群治療薬
JP4239592B2 (ja) 2001-05-08 2009-03-18 東レ株式会社 敗血症治療剤
PL1870413T3 (pl) 2005-03-10 2013-12-31 Toray Industries Środek przeciwświądowy w przypadku świądu spowodowanego stwardnieniem rozsianym

Also Published As

Publication number Publication date
CA2685126C (en) 2015-04-14
JPWO2008133297A1 (ja) 2010-07-29
ES2418104T3 (es) 2013-08-12
AU2008244975A1 (en) 2008-11-06
CN101686977A (zh) 2010-03-31
CN101686977B (zh) 2012-09-05
KR101477043B1 (ko) 2014-12-29
WO2008133297A1 (ja) 2008-11-06
EP2151240A1 (en) 2010-02-10
CA2685126A1 (en) 2008-11-06
KR20090130079A (ko) 2009-12-17
US20100130524A1 (en) 2010-05-27
US8796301B2 (en) 2014-08-05
EP2151240B1 (en) 2013-06-12
EP2151240A4 (en) 2011-08-10
PL2151240T3 (pl) 2014-01-31
JP5251870B2 (ja) 2013-07-31

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