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WO2008126770A1 - Method for producing triarylcarboxylic acid derivative - Google Patents

Method for producing triarylcarboxylic acid derivative Download PDF

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Publication number
WO2008126770A1
WO2008126770A1 PCT/JP2008/056708 JP2008056708W WO2008126770A1 WO 2008126770 A1 WO2008126770 A1 WO 2008126770A1 JP 2008056708 W JP2008056708 W JP 2008056708W WO 2008126770 A1 WO2008126770 A1 WO 2008126770A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzene ring
producing
acid derivative
compound
inhibitory effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/056708
Other languages
French (fr)
Japanese (ja)
Inventor
Masaru Hayashi
Hiroyuki Tsuboi
Junji Sato
Tatsuya Sawada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of WO2008126770A1 publication Critical patent/WO2008126770A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

It is intended to provide a highly safe and novel therapeutic or preventive agent for hyperuricemia, gout, an inflammatory bowel disease, diabetic nephropathy, diabetic retinitis or the like based on an excellent xanthine oxidase inhibitory effect by an industrially useful production method thereof and a production intermediate thereof. The present inventors made intensive studies of a method for producing a triarylcarboxlic acid derivative, characterized by having a carboxyl-substituted azole group and a phenyl group substituted in the para-position of a benzene ring and further a cyano group on the benzene ring based on the finding that the compound has a potent xanthine oxidase inhibitory effect, and as a result, they found that the compound can be efficiently obtained by a method of binding the azole group to the benzene ring, and thus completed the invention.
PCT/JP2008/056708 2007-04-05 2008-04-03 Method for producing triarylcarboxylic acid derivative Ceased WO2008126770A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007099936 2007-04-05
JP2007-099936 2007-04-05

Publications (1)

Publication Number Publication Date
WO2008126770A1 true WO2008126770A1 (en) 2008-10-23

Family

ID=39863870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056708 Ceased WO2008126770A1 (en) 2007-04-05 2008-04-03 Method for producing triarylcarboxylic acid derivative

Country Status (1)

Country Link
WO (1) WO2008126770A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011043568A2 (en) 2009-10-07 2011-04-14 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
WO2014119681A1 (en) * 2013-01-31 2014-08-07 帝人ファーマ株式会社 Azole benzene derivative
WO2014192977A1 (en) * 2013-05-31 2014-12-04 帝人ファーマ株式会社 Thiazole derivative
WO2016017708A1 (en) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Azole benzene derivative and crystal thereof
WO2016017826A1 (en) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Xanthine oxidase inhibitor
WO2016017696A1 (en) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Crystal of azole benzene derivative
US9617240B2 (en) 2013-03-29 2017-04-11 Teijin Pharma Limited Pyrazole derivative
CN110204493A (en) * 2019-07-01 2019-09-06 华南理工大学 Tricyclic antidepressants XOR inhibitor and its preparation method and application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003821A1 (en) * 1987-10-19 1989-05-05 The Secretary Of State For Defence In Her Britanni Laterally cyano- and fluoro-substituted terphenyls
JPH04327586A (en) * 1991-03-08 1992-11-17 Merck & Co Inc Heterocyclic compound with acidic group as angiotensin ii antagonist
WO2007043457A1 (en) * 2005-10-07 2007-04-19 Astellas Pharma Inc. Triarylcarboxylic acid derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003821A1 (en) * 1987-10-19 1989-05-05 The Secretary Of State For Defence In Her Britanni Laterally cyano- and fluoro-substituted terphenyls
JPH04327586A (en) * 1991-03-08 1992-11-17 Merck & Co Inc Heterocyclic compound with acidic group as angiotensin ii antagonist
WO2007043457A1 (en) * 2005-10-07 2007-04-19 Astellas Pharma Inc. Triarylcarboxylic acid derivative

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011043568A2 (en) 2009-10-07 2011-04-14 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
WO2014119681A1 (en) * 2013-01-31 2014-08-07 帝人ファーマ株式会社 Azole benzene derivative
JP5734532B2 (en) * 2013-01-31 2015-06-17 帝人ファーマ株式会社 Azolbenzene derivatives
KR20150112955A (en) * 2013-01-31 2015-10-07 데이진 화-마 가부시키가이샤 Azole benzene derivative
KR102199258B1 (en) 2013-01-31 2021-01-06 데이진 화-마 가부시키가이샤 Azole benzene derivative
RU2641891C2 (en) * 2013-01-31 2018-01-23 Тейдзин Фарма Лимитед Azole derivatives of benzene
US9388174B2 (en) 2013-01-31 2016-07-12 Teijin Pharma Limited Azole benzene derivative
US9617240B2 (en) 2013-03-29 2017-04-11 Teijin Pharma Limited Pyrazole derivative
WO2014192977A1 (en) * 2013-05-31 2014-12-04 帝人ファーマ株式会社 Thiazole derivative
CN106661014A (en) * 2014-07-30 2017-05-10 帝人制药株式会社 Azole benzene derivative and crystal thereof
US10179780B2 (en) 2014-07-30 2019-01-15 Teijin Pharma Limited Azole benzene derivative and crystalline form thereof
JPWO2016017696A1 (en) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 Crystals of azolebenzene derivatives
JPWO2016017826A1 (en) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 Xanthine oxidase inhibitor
JPWO2016017708A1 (en) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 Azolbenzene derivatives and crystals thereof
WO2016017696A1 (en) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Crystal of azole benzene derivative
US9815826B2 (en) 2014-07-30 2017-11-14 Teijin Pharma Limited Crystal of azole benzene derivative
WO2016017826A1 (en) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Xanthine oxidase inhibitor
RU2675854C2 (en) * 2014-07-30 2018-12-25 Тейдзин Фарма Лимитед Crystal of azole benzene derivative
CN106536519A (en) * 2014-07-30 2017-03-22 帝人制药株式会社 Crystals of azole derivatives
CN106536519B (en) * 2014-07-30 2019-03-29 帝人制药株式会社 Crystals of oxazole derivatives
US10301300B2 (en) 2014-07-30 2019-05-28 Teijin Limited Xanthine oxidase inhibitor
WO2016017708A1 (en) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Azole benzene derivative and crystal thereof
AU2015297489B2 (en) * 2014-07-30 2019-09-19 Teijin Limited Crystal of azole benzene derivative
RU2701515C2 (en) * 2014-07-30 2019-09-27 Тейдзин Фарма Лимитед Azobenzene derivative and crystalline form thereof
CN106661014B (en) * 2014-07-30 2019-12-24 帝人制药株式会社 Azole benzene derivatives and their crystals
CN110204493A (en) * 2019-07-01 2019-09-06 华南理工大学 Tricyclic antidepressants XOR inhibitor and its preparation method and application
WO2021000527A1 (en) * 2019-07-01 2021-01-07 华南理工大学 Tricyclic xor inhibitor, preparation method therefor and application thereof
CN110204493B (en) * 2019-07-01 2021-05-14 华南理工大学 Tricyclic XOR inhibitor and preparation method and application thereof

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