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WO2010093191A3 - Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same - Google Patents

Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same Download PDF

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Publication number
WO2010093191A3
WO2010093191A3 PCT/KR2010/000893 KR2010000893W WO2010093191A3 WO 2010093191 A3 WO2010093191 A3 WO 2010093191A3 KR 2010000893 W KR2010000893 W KR 2010000893W WO 2010093191 A3 WO2010093191 A3 WO 2010093191A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
preparing
pharmaceutical composition
novel compounds
xanthine oxidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/000893
Other languages
French (fr)
Other versions
WO2010093191A2 (en
Inventor
Sung Pil Choi
Geun Tae Kim
Jeong Uk Song
Tae Hun Kim
Dong Chul Lim
Seung Wan Kang
Hyung Jin Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG Chem Ltd
Original Assignee
LG Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LG Life Sciences Ltd filed Critical LG Life Sciences Ltd
Publication of WO2010093191A2 publication Critical patent/WO2010093191A2/en
Publication of WO2010093191A3 publication Critical patent/WO2010093191A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to novel compounds which are effective as an inhibitor for xanthine oxidase, a process for preparing the same, and a pharmaceutical composition comprising a therapeutically effective amount of the same.
PCT/KR2010/000893 2009-02-13 2010-02-12 Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same Ceased WO2010093191A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0011963 2009-02-13
KR20090011963 2009-02-13

Publications (2)

Publication Number Publication Date
WO2010093191A2 WO2010093191A2 (en) 2010-08-19
WO2010093191A3 true WO2010093191A3 (en) 2010-12-09

Family

ID=42562195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/000893 Ceased WO2010093191A2 (en) 2009-02-13 2010-02-12 Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same

Country Status (2)

Country Link
KR (1) KR20100092909A (en)
WO (1) WO2010093191A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156845B2 (en) 2012-06-29 2015-10-13 Pfizer Inc. 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011036130A1 (en) * 2009-09-24 2011-03-31 F. Hoffmann-La Roche Ag Indole derivatives as crac modulators
MX2013008560A (en) 2011-01-28 2013-08-21 Du Pont Method for preparing 2-aminobenzamide derivatives.
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
AU2014219575B2 (en) 2013-02-20 2017-07-06 Lg Chem, Ltd. Sphingosine-1-phosphate receptor agonists, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent
EP2898891B1 (en) 2013-08-13 2020-07-01 Natreon Inc. Terminalia bellerica extract for inhibition of xanthine oxidase and lowering serum uric acid
EP3083618B1 (en) 2013-12-17 2018-02-21 Pfizer Inc Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
JP6086105B2 (en) 2014-09-24 2017-03-01 信越半導体株式会社 Manufacturing method of SOI wafer
CN106478619B (en) * 2015-08-29 2019-09-24 江苏新元素医药科技有限公司 A kind of xanthine oxidase inhibitor and its application
AU2016316278B2 (en) 2015-09-02 2020-06-04 Sunshine Lake Pharma Co., Ltd. Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof
EP3350178B1 (en) 2015-09-14 2021-10-20 Pfizer Inc. Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors
KR102269305B1 (en) 2016-06-13 2021-06-25 길리애드 사이언시즈, 인코포레이티드 FXR (NR1H4) modulating compound
CA3252823A1 (en) 2016-06-13 2025-02-25 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
WO2018157801A1 (en) * 2017-02-28 2018-09-07 广东东阳光药业有限公司 Cyano group-substituted fused bicyclic derivative, preparation method therefor, and application thereof
KR20220119520A (en) 2017-03-28 2022-08-29 길리애드 사이언시즈, 인코포레이티드 Therapeutic combinations for treating liver diseases
BR112021011762A2 (en) 2019-01-15 2021-11-03 Gilead Sciences Inc Compounds for fxr modulation (nr1h4)
KR102725082B1 (en) 2019-02-19 2024-11-04 길리애드 사이언시즈, 인코포레이티드 Solid form of FXR agonist
EP3971186B1 (en) * 2019-06-19 2023-08-02 LG Chem, Ltd. Preparation method for indole or indazole compound
EP3971183A4 (en) * 2019-06-19 2022-08-10 LG Chem, Ltd. PROCESS FOR THE PREPARATION OF INDOLE OR INDAZOLE COMPOUNDS
CN111072634B (en) * 2020-01-03 2022-07-22 中国医科大学 1-substituted-3-substituted-5-substituted amide-1H-indole compound and preparation method and application thereof
AU2022270242B2 (en) * 2021-05-07 2025-12-18 Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd. Class of xanthine oxidase inhibitors
CN117355513A (en) * 2021-05-21 2024-01-05 江苏恒瑞医药股份有限公司 Preparation method of BTK inhibitor intermediate
CN115925682B (en) * 2021-10-04 2025-11-25 山东新时代药业有限公司 A method for synthesizing topipusta
EP4516781A1 (en) * 2022-04-27 2025-03-05 Atom Therapeutics Co., Ltd. Compound for reducing uric acid
CN116283946B (en) * 2023-03-27 2024-05-07 武汉工程大学 5- (N-substituted indole-5-yl) isoxazole-3-formic acid derivative and synthetic method and application thereof
WO2025188963A1 (en) 2024-03-06 2025-09-12 Fmc Corporation Metal catalyzed synthesis of 2-aminobenzamide derivatives
WO2025237255A1 (en) * 2024-05-14 2025-11-20 广州市联瑞制药有限公司 Compound as xanthine oxidase inhibitor and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055882A1 (en) * 2001-12-24 2003-07-10 Merck Patent Gmbh Pyrrolopyrimidines as phosphodiesterase vii inhibitors
US20040034009A1 (en) * 2002-08-13 2004-02-19 Roark William Howard 1,6-Fused uracil derivatives as matrix metalloproteinase inhibitors
WO2008126898A1 (en) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. (aza)indole derivative and use thereof for medical purposes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055882A1 (en) * 2001-12-24 2003-07-10 Merck Patent Gmbh Pyrrolopyrimidines as phosphodiesterase vii inhibitors
US20040034009A1 (en) * 2002-08-13 2004-02-19 Roark William Howard 1,6-Fused uracil derivatives as matrix metalloproteinase inhibitors
WO2008126898A1 (en) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. (aza)indole derivative and use thereof for medical purposes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RACHID BENHIDA ET AL., TETRAHEDRON LETTERS, vol. 40, 1999, pages 5701 - 5703 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156845B2 (en) 2012-06-29 2015-10-13 Pfizer Inc. 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors

Also Published As

Publication number Publication date
KR20100092909A (en) 2010-08-23
WO2010093191A2 (en) 2010-08-19

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