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WO2008038149A3 - Procédé de production de cytidine 5'-monophosphate - Google Patents

Procédé de production de cytidine 5'-monophosphate Download PDF

Info

Publication number
WO2008038149A3
WO2008038149A3 PCT/IB2007/003807 IB2007003807W WO2008038149A3 WO 2008038149 A3 WO2008038149 A3 WO 2008038149A3 IB 2007003807 W IB2007003807 W IB 2007003807W WO 2008038149 A3 WO2008038149 A3 WO 2008038149A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
monophosphate
protein
cytidine
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/003807
Other languages
English (en)
Japanese (ja)
Other versions
WO2008038149A2 (fr
Inventor
Hisaya Tanaka
Akihiko Maruyama
Yoshiyuki Yonetani
Ritsuko Katahira
Shingo Kakita
Satoshi Mitsuhashi
Jun-Ichi Saito
Hideki Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2008536202A priority Critical patent/JP5175734B2/ja
Publication of WO2008038149A2 publication Critical patent/WO2008038149A2/fr
Publication of WO2008038149A3 publication Critical patent/WO2008038149A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne une protéine ayant pour activité la production de cytidine 5'-monophosphate (CMP) à partir de cytosine. Cette invention concerne spécifiquement une protéine comprenant une séquence d'acides aminés représentée par SEQ ID NO:1, 2 ou 30, ou une protéine comprenant une séquence d'acides aminés dans laquelle au moins un résidu d'acide aminé sélectionné parmi des résidus d'acides aminés situés aux positions 36, 46, 94, 102, 121, 141, 143, 167 et 198 dans une séquence d'acides aminés représentée par SEQ ID NO:1, 2 ou 30 est substitué par un résidu d'acide aminé différent.
PCT/IB2007/003807 2006-09-27 2007-09-27 Procédé de production de cytidine 5'-monophosphate Ceased WO2008038149A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008536202A JP5175734B2 (ja) 2006-09-27 2007-09-27 シチジン５’−モノリン酸の製造法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006262666 2006-09-27
JP2006-262666 2006-09-27

Publications (2)

Publication Number Publication Date
WO2008038149A2 WO2008038149A2 (fr) 2008-04-03
WO2008038149A3 true WO2008038149A3 (fr) 2008-11-13

Family

ID=39230606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003807 Ceased WO2008038149A2 (fr) 2006-09-27 2007-09-27 Procédé de production de cytidine 5'-monophosphate

Country Status (2)

Country Link
JP (1) JP5175734B2 (fr)
WO (1) WO2008038149A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7693230B2 (en) 1999-04-16 2010-04-06 Parkervision, Inc. Apparatus and method of differential IQ frequency up-conversion
US7072427B2 (en) 2001-11-09 2006-07-04 Parkervision, Inc. Method and apparatus for reducing DC offsets in a communication system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005108562A2 (fr) * 2004-05-10 2005-11-17 Fondazione Centro San Raffaele Del Monte Tabor Enzyme synthetique activant la fluoro-uridine dans les therapies anticancereuses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005108562A2 (fr) * 2004-05-10 2005-11-17 Fondazione Centro San Raffaele Del Monte Tabor Enzyme synthetique activant la fluoro-uridine dans les therapies anticancereuses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FURTH J. J. ET AL.: "The incorporation of adenylic and cytidylic acids into ribonucleic acid", J. BIOL. CHEM., vol. 236, 1961, pages 3317 - 3322, XP055354130 *

Also Published As

Publication number Publication date
WO2008038149A2 (fr) 2008-04-03
JP5175734B2 (ja) 2013-04-03
JPWO2008038149A1 (ja) 2010-01-28

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