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WO2008035379A3 - Procédé de production d'antagonistes de leucotriène et produits intermédiaires correspondants - Google Patents

Procédé de production d'antagonistes de leucotriène et produits intermédiaires correspondants Download PDF

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Publication number
WO2008035379A3
WO2008035379A3 PCT/IN2007/000414 IN2007000414W WO2008035379A3 WO 2008035379 A3 WO2008035379 A3 WO 2008035379A3 IN 2007000414 W IN2007000414 W IN 2007000414W WO 2008035379 A3 WO2008035379 A3 WO 2008035379A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
chloro
benzoate
ethenyl
quinolinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2007/000414
Other languages
English (en)
Other versions
WO2008035379A2 (fr
Inventor
Venkata Subbaraju Gottumukkala
Satyanarayana Chava
Someswara Rao Casukhela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptuit Laurus Pvt Ltd
Original Assignee
Aptuit Laurus Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptuit Laurus Pvt Ltd filed Critical Aptuit Laurus Pvt Ltd
Publication of WO2008035379A2 publication Critical patent/WO2008035379A2/fr
Anticipated expiration legal-status Critical
Publication of WO2008035379A3 publication Critical patent/WO2008035379A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne un procédé de synthèse d'un β- cétoester de formule (VII) qui consiste : (a) à transformer de l'acide 3-méthylbenzoïque en alkyle 3-méthylbenzoate; (b) à faire réagir le 3-méthylbenzoate afin d'obtenir de l'alkyle 3-bromométhylbenzoate; (c) à transformer l'alkyle 3-bromométhylbenzoate en alkyle 3-formylbenzoate; (d) à condenser l'alkyle 3-formylbenzoate avec de la 7-chioroquinaldine afin d'obtenir de l'alkyle 3-[((7-chloro-2-quinolinyl)éthényl)]benzoate; (e) à hydrolyser l'alkyle 3-[((7-chloro-2-quinolinyl)éthényl)]benzoate afin d'obtenir de l'acide 3-[((7-chloro-2-quinolinyl)éthényl)]benzoïque; puis (f) à mettre en réaction l'acide 3-[((7-chloro-2-quinolinyl)éthényl)]benzoïque avec du malonate afin d'obtenir un composé de formule développée VII.
PCT/IN2007/000414 2006-09-19 2007-09-14 Procédé de production d'antagonistes de leucotriène et produits intermédiaires correspondants Ceased WO2008035379A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1710/CHE/2006 2006-09-19
IN1710CH2006 2006-09-19

Publications (2)

Publication Number Publication Date
WO2008035379A2 WO2008035379A2 (fr) 2008-03-27
WO2008035379A3 true WO2008035379A3 (fr) 2010-02-18

Family

ID=39200979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000414 Ceased WO2008035379A2 (fr) 2006-09-19 2007-09-14 Procédé de production d'antagonistes de leucotriène et produits intermédiaires correspondants

Country Status (1)

Country Link
WO (1) WO2008035379A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090015186A (ko) 2005-07-05 2009-02-11 테바 파마슈티컬 인더스트리즈 리미티드 몬테루카스트의 정제
CN101891649B (zh) * 2010-07-06 2013-05-08 荆州市腾飞化工有限公司 一种制备3-氰基苯甲酸甲酯的生产方法
CN102617460A (zh) * 2012-03-29 2012-08-01 中国科学院上海有机化学研究所 一种合成孟鲁司特钠所需中间体的合成方法
EP3325464B1 (fr) 2015-07-24 2022-04-20 Basf Se Composés pyridiniques utiles pour lutter contre les champignons phytopathogènes
CN107920509A (zh) 2015-09-03 2018-04-17 巴斯夫农业公司 包含苯嘧磺草胺的微粒组合物
CN108137533A (zh) 2015-10-05 2018-06-08 巴斯夫欧洲公司 防治植物病原性真菌的吡啶化合物
WO2018065182A1 (fr) 2016-10-04 2018-04-12 Basf Se Composés de quinoléine réduits en tant qu'agents antifuni
CN110191881A (zh) 2017-01-23 2019-08-30 巴斯夫欧洲公司 杀真菌的吡啶化合物
WO2019115343A1 (fr) 2017-12-15 2019-06-20 Basf Se Mélange fongicide comprenant des pyridines substituées

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021974A1 (fr) * 2004-08-23 2006-03-02 Morepen Laboratories Limited Procede pour synthetiser un diol (viii), intermediaire du sodium de montelukast
WO2008058118A2 (fr) * 2006-11-06 2008-05-15 Dr. Reddy's Labortories, Ltd. Préparation de montélukast et de ses sels
WO2009001374A2 (fr) * 2007-06-25 2008-12-31 Aptuit Laurus Pvt Ltd Préparation de éthyl-3'-[((7-chloro-2-quinolinyl)ethenyl)phényl]-3-oxopropanoate, clé intermédiaire pour le sodium de montelukast

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021974A1 (fr) * 2004-08-23 2006-03-02 Morepen Laboratories Limited Procede pour synthetiser un diol (viii), intermediaire du sodium de montelukast
WO2008058118A2 (fr) * 2006-11-06 2008-05-15 Dr. Reddy's Labortories, Ltd. Préparation de montélukast et de ses sels
WO2009001374A2 (fr) * 2007-06-25 2008-12-31 Aptuit Laurus Pvt Ltd Préparation de éthyl-3'-[((7-chloro-2-quinolinyl)ethenyl)phényl]-3-oxopropanoate, clé intermédiaire pour le sodium de montelukast

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Vogel's Textbook of Practical Organic Chemistry", LONGMAN SCIENTIFIC & TECHNICAL, pages: 738, 999 *
OKAMOTO ET AL.: "A Novel Dual Antagonist of Thromboxane A2 and Leukotriene D4 Receptors: Synthesis and Structure-Activity Relationships of Chloroquinolylvinyl Derivatives", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 54, no. 5, 2006, pages 603 - 610 *
The Combined Chemical Dictionary *
WIERENGA W. ET AL.: "ALIPHATIC AND AROMATIC beta-KETO ESTERS FROM MONOETHYL MALONATE: ETHYL 2- BUTYRYLACETATE", ORGANIC SYNTHESES, vol. 61, 1983, pages 5 - 8, Retrieved from the Internet <URL:http://www.orgsyn.org/orgsyn/pdfs/CV7P0213.pdf> *

Also Published As

Publication number Publication date
WO2008035379A2 (fr) 2008-03-27

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