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WO2008033990A3 - Compositions and methods for modulating the notch signal transduction pathway - Google Patents

Compositions and methods for modulating the notch signal transduction pathway Download PDF

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Publication number
WO2008033990A3
WO2008033990A3 PCT/US2007/078375 US2007078375W WO2008033990A3 WO 2008033990 A3 WO2008033990 A3 WO 2008033990A3 US 2007078375 W US2007078375 W US 2007078375W WO 2008033990 A3 WO2008033990 A3 WO 2008033990A3
Authority
WO
WIPO (PCT)
Prior art keywords
signal transduction
p180nack
polypeptide
methods
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/078375
Other languages
French (fr)
Other versions
WO2008033990A2 (en
Inventor
Anthony J Capobianco
Maria-Clotilde Alves Guerra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wistar Institute of Anatomy and Biology
Original Assignee
Wistar Institute of Anatomy and Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Institute of Anatomy and Biology filed Critical Wistar Institute of Anatomy and Biology
Publication of WO2008033990A2 publication Critical patent/WO2008033990A2/en
Publication of WO2008033990A3 publication Critical patent/WO2008033990A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a p180NACK polypeptide which binds to Notch and modulates Notch-mediated signal transduction. Nucleic acid molecules encoding the p180NACK polypeptide, antibodies that selectively bind the p180NACK polypeptide, and iRNA molecules which inhibit the expression of the p180NACK polypeptide are provided, as are methods for identifying agents which modulate the expression or activity of the p180NACK polypeptide. A method for modulating Notch-mediated signal transduction using agents of the invention is also provided.
PCT/US2007/078375 2006-09-15 2007-09-13 Compositions and methods for modulating the notch signal transduction pathway Ceased WO2008033990A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82577306P 2006-09-15 2006-09-15
US60/825,773 2006-09-15

Publications (2)

Publication Number Publication Date
WO2008033990A2 WO2008033990A2 (en) 2008-03-20
WO2008033990A3 true WO2008033990A3 (en) 2008-11-06

Family

ID=39184584

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/078375 Ceased WO2008033990A2 (en) 2006-09-15 2007-09-13 Compositions and methods for modulating the notch signal transduction pathway

Country Status (1)

Country Link
WO (1) WO2008033990A2 (en)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Glycine-Glutamine bioactive peptide", SIGMA CHEMICAL 1993 CATALOG, pages 1089 *
DATABASE GENBANK [online] September 2006 (2006-09-01), CARCINI ET AL.: "Unnamed Protein Product", Database accession no. (BAC29528) *
TANAKA ET AL.: "Pragmin, a Novel Effector of Rnd2 GTPase, Stimulates RhoA Activity", J. BIOL. CHEM., vol. 281, 2006, pages 10355 - 10364, XP002501195 *

Also Published As

Publication number Publication date
WO2008033990A2 (en) 2008-03-20

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