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WO2008033745A3 - Pyrimidines bicycliques fusionnées servant d'inhibiteurs de ptk contenant un groupe de liaison au zinc - Google Patents

Pyrimidines bicycliques fusionnées servant d'inhibiteurs de ptk contenant un groupe de liaison au zinc Download PDF

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Publication number
WO2008033745A3
WO2008033745A3 PCT/US2007/077968 US2007077968W WO2008033745A3 WO 2008033745 A3 WO2008033745 A3 WO 2008033745A3 US 2007077968 W US2007077968 W US 2007077968W WO 2008033745 A3 WO2008033745 A3 WO 2008033745A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding moiety
fused bicyclic
zinc binding
inhibitors containing
ptk inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/077968
Other languages
English (en)
Other versions
WO2008033745A2 (fr
Inventor
Xiong Cai
Changgeng Qian
Stephen Gould
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of WO2008033745A2 publication Critical patent/WO2008033745A2/fr
Publication of WO2008033745A3 publication Critical patent/WO2008033745A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne une pyrimidine bicyclique fusionnée présentant des propriétés uniques, contenant des dérivés fondés sur un groupe de liaison au zinc. Les pyrimidines de l'invention servent d'inhibiteurs de la protéine tyrosine kinase (PTK). L'invention concerne également un procédé d'utilisation de ces pyrimidines visant à traiter des maladies associées à PTK et des troubles comme le cancer. Les dérivés susmentionnés peuvent également servir d'inhibiteurs de l'histone désacétylase (HDAC).
PCT/US2007/077968 2006-09-11 2007-09-10 Pyrimidines bicycliques fusionnées servant d'inhibiteurs de ptk contenant un groupe de liaison au zinc Ceased WO2008033745A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84364606P 2006-09-11 2006-09-11
US60/843,646 2006-09-11
US89589407P 2007-03-20 2007-03-20
US60/895,894 2007-03-20

Publications (2)

Publication Number Publication Date
WO2008033745A2 WO2008033745A2 (fr) 2008-03-20
WO2008033745A3 true WO2008033745A3 (fr) 2009-01-08

Family

ID=39184474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/077968 Ceased WO2008033745A2 (fr) 2006-09-11 2007-09-10 Pyrimidines bicycliques fusionnées servant d'inhibiteurs de ptk contenant un groupe de liaison au zinc

Country Status (3)

Country Link
US (1) US20080161320A1 (fr)
TW (1) TW200829250A (fr)
WO (1) WO2008033745A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10975019B2 (en) 2016-04-18 2021-04-13 Vivoryon Therapeutics Ag Inhibitors of meprin α and β

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017321B2 (en) 2004-01-23 2011-09-13 The Regents Of The University Of Colorado, A Body Corporate Gefitinib sensitivity-related gene expression and products and methods related thereto
ES2677562T3 (es) 2004-05-27 2018-08-03 The Regents Of The University Of Colorado Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer
EP2061772A4 (fr) * 2006-09-11 2011-06-29 Curis Inc Petites molécules multifonctionnelles servant d'agents anti-prolifératifs
JO3239B1 (ar) 2008-09-22 2018-03-08 Novartis Ag تركيبات جالينية من مركبات عضوية
WO2010080996A1 (fr) 2009-01-08 2010-07-15 Curis, Inc. Inhibiteurs de phosphoinositide 3-kinase avec une fraction de liaison au zinc
SI3111938T1 (sl) 2011-04-01 2019-08-30 Curis, Inc. Fosfoinozitid 3-kinazni inhibitor z delom, ki veže cink
CN103396417B (zh) * 2013-08-14 2015-02-04 冯子侠 新型羟肟酸衍生物及其医疗应用
EP3116876A4 (fr) * 2014-03-13 2017-10-25 Agency For Science, Technology And Research Dérivés d'hydroxamate à base de pyrimidine fusionnée
US10106506B2 (en) 2015-07-02 2018-10-23 Boehringer Ingelheim International Gmbh General process for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid
CA3112177A1 (fr) 2018-09-11 2020-03-19 Curis, Inc. Polytherapie avec un inhibiteur de phosphoinositide 3-kinase ayant une fraction de liaison au zinc

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095419A1 (fr) * 2004-04-01 2005-10-13 Takeda Pharmaceutial Company Limited Dérivé de thiazolopyrimidine
WO2005118588A1 (fr) * 2004-06-02 2005-12-15 Takeda Pharmaceutical Company Limited Composé heterocyclique fusionné

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369108A (en) * 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US6395733B1 (en) * 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
SI9620103A (sl) * 1995-07-06 1998-10-31 Novartis Ag Pirolopirimidini in postopki za njihovo pripravo
EP0888349B1 (fr) * 1996-01-23 2002-05-22 Novartis AG Pyrrolopyrimidines et leurs procedes de preparation
US6777217B1 (en) * 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
EP0929553B1 (fr) * 1996-10-02 2005-03-16 Novartis AG Derives de pyrimidine et procedes de preparation de ces derniers
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
DZ3248A1 (fr) * 1999-12-10 2001-06-14 Pfizer Prod Inc Composés à base de pyrrolo[2,3-d]pyrimidine
US7323469B2 (en) * 2001-08-07 2008-01-29 Novartis Ag 7H-pyrrolo[2,3-d]pyrimidine derivatives
WO2003106446A1 (fr) * 2002-06-13 2003-12-24 Pfizer Inc. Agents anti-gnrh non peptidiques, compositions pharmaceutiques et procedes d'utilisation
WO2004014384A2 (fr) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Composes cycliques contenant des groupes liant le zinc en tant qu'inhibiteurs de metalloprotease de matrice
TW200418806A (en) * 2003-01-13 2004-10-01 Fujisawa Pharmaceutical Co HDAC inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095419A1 (fr) * 2004-04-01 2005-10-13 Takeda Pharmaceutial Company Limited Dérivé de thiazolopyrimidine
WO2005118588A1 (fr) * 2004-06-02 2005-12-15 Takeda Pharmaceutical Company Limited Composé heterocyclique fusionné

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10975019B2 (en) 2016-04-18 2021-04-13 Vivoryon Therapeutics Ag Inhibitors of meprin α and β
US12378186B2 (en) 2016-04-18 2025-08-05 Vivoryon Therapeutics N.V. Inhibitors of meprin α and β

Also Published As

Publication number Publication date
US20080161320A1 (en) 2008-07-03
TW200829250A (en) 2008-07-16
WO2008033745A2 (fr) 2008-03-20

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