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WO2008016995A3 - Methods of identifying modulators of insulin signalling - Google Patents

Methods of identifying modulators of insulin signalling Download PDF

Info

Publication number
WO2008016995A3
WO2008016995A3 PCT/US2007/075001 US2007075001W WO2008016995A3 WO 2008016995 A3 WO2008016995 A3 WO 2008016995A3 US 2007075001 W US2007075001 W US 2007075001W WO 2008016995 A3 WO2008016995 A3 WO 2008016995A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
identifying modulators
insulin signalling
insulin
signalling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/075001
Other languages
French (fr)
Other versions
WO2008016995A2 (en
Inventor
Cullen Taniguchi
Koji Ueki
C Ronald Kahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joslin Diabetes Center Inc
Original Assignee
Joslin Diabetes Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joslin Diabetes Center Inc filed Critical Joslin Diabetes Center Inc
Publication of WO2008016995A2 publication Critical patent/WO2008016995A2/en
Publication of WO2008016995A3 publication Critical patent/WO2008016995A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention relates to methods of identifying drugs for the treatment of insulin resistance and diabetes.
PCT/US2007/075001 2006-08-01 2007-08-01 Methods of identifying modulators of insulin signalling Ceased WO2008016995A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82111806P 2006-08-01 2006-08-01
US60/821,118 2006-08-01

Publications (2)

Publication Number Publication Date
WO2008016995A2 WO2008016995A2 (en) 2008-02-07
WO2008016995A3 true WO2008016995A3 (en) 2008-11-27

Family

ID=38997846

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/075001 Ceased WO2008016995A2 (en) 2006-08-01 2007-08-01 Methods of identifying modulators of insulin signalling

Country Status (1)

Country Link
WO (1) WO2008016995A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085396A1 (en) * 2001-04-24 2002-10-31 President And Fellows Of Harvard College Inhibition of jun kinase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085396A1 (en) * 2001-04-24 2002-10-31 President And Fellows Of Harvard College Inhibition of jun kinase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
TANIGUCHI C.M. ET AL.: "Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN", PROC. NATL. ACAD. SCI. USA, vol. 103, no. 32, July 2006 (2006-07-01), pages 12093 - 12097 *
THIRONE A.C.P. ET AL.: "Opposite Effect of JAK2 on Insulin-Dependent Activation of Mitogen-Activated Protein Kinases and Akt in Muscle Cells", DIABETES, vol. 55, April 2006 (2006-04-01), pages 942 - 951 *
TUNCMAN G. ET AL.: "Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance", PROC. NATL. ACAD. SCI. USA, vol. 103, no. 28, July 2006 (2006-07-01), pages 10741 - 10746 *
USUI I. ET AL.: "Cdc-42 Is a Rho GTPase Family Member That Can Mediate Insulin Signaling to Glucose Transport in 3T3-L1 Adipocytes", J. BIOL. CHEM., vol. 278, no. 16, April 2003 (2003-04-01), pages 13765 - 13774 *

Also Published As

Publication number Publication date
WO2008016995A2 (en) 2008-02-07

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